The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia

Innate Immune Defenses Mediated by Two ILC Subsets Are Critical for Protection against Acute Clostridium difficile Infection

(2015) Michael C. Abt et al.   Cell Host & Microbe

Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis

(2015) Thibault Griseri et al.   IMMUNITY

Thymic stromal lymphopoietin and IL-33 modulate migration of hematopoietic progenitor cells in patients with allergic asthma

(2015) Steven G. Smith et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interaction of theClostridium difficileBinary Toxin CDT and Its Host Cell Receptor, Lipolysis-stimulated Lipoprotein Receptor (LSR)

(2015) Sarah Hemmasi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Burden of Clostridium difficile Infection in the United States

(2015) Fernanda C. Lessa et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inflammasome Activation Contributes to Interleukin-23 Production in Response to Clostridium difficile

(2015) Carrie A. Cowardin et al.   mBio

Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections

(2015) Glen P. Carter et al.   mBio

Selection of Nanobodies that Block the Enzymatic and Cytotoxic Activities of the Binary Clostridium Difficile Toxin CDT

(2015) Mandy Unger et al.   Scientific Reports

Interleukin-22 Regulates the Complement System to Promote Resistance against Pathobionts after Pathogen-Induced Intestinal Damage

(2014) Mizuho Hasegawa et al.   IMMUNITY

Functionally Competent Eosinophils Differentiated Ex Vivo in High Purity from Normal Mouse Bone Marrow

(2014) K. D. Dyer et al.   JOURNAL OF IMMUNOLOGY

Roles and Regulation of Gastrointestinal Eosinophils in Immunity and Disease

(2014) Y. Jung et al.   JOURNAL OF IMMUNOLOGY

Clostridium difficiletoxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence

(2014) Carsten Schwan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clostridium and Bacillus Binary Enterotoxins: Bad for the Bowels, and Eukaryotic Being

(2014) Bradley Stiles et al.   Toxins

Role of Interleukin 23 Signaling in Clostridium difficile Colitis

(2013) Erica L. Buonomo et al.   JOURNAL OF INFECTIOUS DISEASES

Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain

(2013) Sarah A. Kuehne et al.   JOURNAL OF INFECTIOUS DISEASES

Intestinal Inflammatory Biomarkers and Outcome in Pediatric Clostridium difficile Infections

(2013) Rana E. El Feghaly et al.   JOURNAL OF PEDIATRICS

TLR-2 Activation Induces Regulatory T Cells and Long-Term Suppression of Asthma Manifestations in Mice

(2013) Martijn C. Nawijn et al.   PLoS One

Spo0A Differentially Regulates Toxin Production in Evolutionarily Diverse Strains of Clostridium difficile

(2013) Kate E. Mackin et al.   PLoS One

Eosinophil adoptive transfer system to directly evaluate pulmonary eosinophil trafficking in vivo

(2013) T. Wen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAPK-Activated Protein Kinase 2 Contributes to Clostridium difficile-Associated Inflammation

(2012) Linda D. Bobo et al.   INFECTION AND IMMUNITY

Analysis of the 'angulin' proteins LSR, ILDR1 and ILDR2 - tricellulin recruitment, epithelial barrier function and implication in deafness pathogenesis

(2012) T. Higashi et al.   JOURNAL OF CELL SCIENCE

Predicting Recurrence of C. difficile Colitis Using Bacterial Virulence Factors: Binary Toxin Is the Key

(2012) David B. Stewart et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT)

(2011) P. Papatheodorou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Murine Model ofClostridium difficileInfection with Aged Gnotobiotic C57BL/6 Mice and a BI/NAP1 Strain

(2010) S. W. Pawlowski et al.   JOURNAL OF INFECTIOUS DISEASES

Clostridium difficile infection in Europe: a hospital-based survey

(2010) Martijn P Bauer et al.   LANCET

The role of toxin A and toxin B in Clostridium difficile infection

(2010) Sarah A. Kuehne et al.   NATURE

Clostridium difficile infection: epidemiology, risk factors and management

(2010) Ashwin N. Ananthakrishnan   Nature Reviews Gastroenterology & Hepatology

Haemopoietic processes in allergic disease: eosinophil/basophil development

(2009) G. M. Gauvreau et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Clostridium difficile infection: new developments in epidemiology and pathogenesis

(2009) Maja Rupnik et al.   NATURE REVIEWS MICROBIOLOGY

Clostridium difficile Toxin CDT Induces Formation of Microtubule-Based Protrusions and Increases Adherence of Bacteria

(2009) Carsten Schwan et al.   PLoS Pathogens

Eosinophil Progenitors in Airway Diseases

(2008) Judah A. Denburg et al.   CHEST

A Mouse Model of Clostridium difficile–Associated Disease

(2008) Xinhua Chen et al.   GASTROENTEROLOGY

Clostridium difficile toxin A promotes dendritic cell maturation and chemokine CXCL2 expression through p38, IKK, and the NF-κB signaling pathway

(2008) Jin Young Lee et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Eosinophil progenitors in allergy and asthma — Do they matter?

(2008) Madeleine Rådinger et al.   PHARMACOLOGY & THERAPEUTICS