The discovery of purine-based agents targeting triple-negative breast cancer and the αB-crystallin/VEGF protein–protein interaction

αB-Crystallin interacts and attenuates the tyrosine phosphatase activity of Shp2 in cardiomyocytes under mechanical stress

(2016) Danieli C. Gonçalves et al.   FEBS LETTERS

Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization

(2016) Brittany Haynes et al.   Nanomedicine-Nanotechnology Biology and Medicine

Advances in small-molecule drug discovery for triple-negative breast cancer

(2015) Nelly Fosu-Mensah et al.   Future Medicinal Chemistry

Discovery of structure-based small molecular inhibitor of αB-crystallin against basal-like/triple-negative breast cancer development in vitro and in vivo

(2014) Zhijuan Chen et al.   BREAST CANCER RESEARCH AND TREATMENT

Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

(2014) Michelle R. Arkin et al.   CHEMISTRY & BIOLOGY

New Strategies for Triple-Negative Breast Cancer--Deciphering the Heterogeneity

(2014) I. A. Mayer et al.   CLINICAL CANCER RESEARCH

Peroxide-Shunt Substrate-Specificity for the Salmonella typhimurium O2-Dependent tRNA Modifying Monooxygenase (MiaE)

(2013) Andra L. Corder et al.   BIOCHEMISTRY

αB-crystallin is a useful marker for triple negative and basal breast cancers

(2012) Julia Y S Tsang et al.   HISTOPATHOLOGY

The small heat shock proteins family: The long forgotten chaperones

(2012) C. Garrido et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Expression of αB-crystallin overrides the anti-apoptotic activity of XIAP

(2012) Jee Suk Lee et al.   NEURO-ONCOLOGY

Bevacizumab Added to Neoadjuvant Chemotherapy for Breast Cancer

(2012) Harry D. Bear et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treatment-Related Mortality With Bevacizumab in Cancer Patients

(2011) Vishal Ranpura et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Unfolded Protein Response Is Required innu/nuMice Microvasculature for Treating Breast Tumor with Tunicamycin

(2011) Aditi Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

(2011) Brian D. Lehmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Avastin Hearing Leads to More Uncertainty Over Drug's Future

(2011) M. Goozner   JNCI-Journal of the National Cancer Institute

 B-Crystallin, an Effector of Unfolded Protein Response, Confers Anti-VEGF Resistance to Breast Cancer via Maintenance of Intracrine VEGF in Endothelial Cells

(2011) Q. Ruan et al.   MOLECULAR CANCER RESEARCH

Synthesis, biological evaluation and docking studies of 4-amino-tetrahydroquinazolino[3,2-e]purine derivatives

(2010) Valerie Verones et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Serine 59 Phosphorylation of αB-Crystallin Down-regulates Its Anti-apoptotic Function by Binding and Sequestering Bcl-2 in Breast Cancer Cells

(2010) Nathalie Launay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solid-state NMR and SAXS studies provide a structural basis for the activation of αB-crystallin oligomers

(2010) Stefan Jehle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Clofarabine in leukemia

(2010) Hady Ghanem et al.   Expert Review of Hematology

High-Yielding Two-Step Synthesis of 6,8-Disubstituted N-9-Unprotected Purines

(2009) Nada Ibrahim et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Clinical pharmacology and pharmacogenetics of thiopurines

(2008) Srikumar Sahasranaman et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Protein–protein interactions as targets for small-molecule therapeutics in cancer

(2008) Alex W. White et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE