mmCSM-AB: guiding rational antibody engineering through multiple point mutations
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Title
mmCSM-AB: guiding rational antibody engineering through multiple point mutations
Authors
Keywords
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Journal
NUCLEIC ACIDS RESEARCH
Volume -, Issue -, Pages -
Publisher
Oxford University Press (OUP)
Online
2020-05-16
DOI
10.1093/nar/gkaa389
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Note: Only part of the references are listed.- Structure guided prediction of Pyrazinamide resistance mutations in pncA
- (2020) Malancha Karmakar et al. Scientific Reports
- Homogentisate 1,2-dioxygenase (HGD) gene variants, their analysis and genotype–phenotype correlations in the largest cohort of patients with AKU
- (2019) David B. Ascher et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- mCSM-PPI2: predicting the effects of mutations on protein–protein interactions
- (2019) Carlos H M Rodrigues et al. NUCLEIC ACIDS RESEARCH
- Experimentally guided computational antibody affinity maturation with de novo docking, modelling and rational design
- (2019) Daniel A. Cannon et al. PLoS Computational Biology
- Empirical ways to identify novel Bedaquiline resistance mutations in AtpE
- (2019) Malancha Karmakar et al. PLoS One
- dendPoint: a web resource for dendrimer pharmacokinetics investigation and prediction
- (2019) Lisa M. Kaminskas et al. Scientific Reports
- Analysis of a Novel pncA Mutation for Susceptibility to Pyrazinamide Therapy
- (2018) Malancha Karmakar et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Parapred: antibody paratope prediction using convolutional and recurrent neural networks
- (2018) Edgar Liberis et al. BIOINFORMATICS
- NGL viewer: web-based molecular graphics for large complexes
- (2018) Alexander S Rose et al. BIOINFORMATICS
- SKEMPI 2.0: An updated benchmark of changes in protein-protein binding energy, kinetics and thermodynamics upon mutation
- (2018) Justina Jankauskaitė et al. BIOINFORMATICS
- Flex ddG: Rosetta Ensemble-Based Estimation of Changes in Protein–Protein Binding Affinity upon Mutation
- (2018) Kyle A. Barlow et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation
- (2018) Aleš Hnízda et al. LEUKEMIA
- Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam
- (2018) Kathryn E. Holt et al. NATURE GENETICS
- Kinact: a computational approach for predicting activating missense mutations in protein kinases
- (2018) Carlos HM Rodrigues et al. NUCLEIC ACIDS RESEARCH
- DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability
- (2018) Carlos HM Rodrigues et al. NUCLEIC ACIDS RESEARCH
- Exploring additivity effects of double mutations on the binding affinity of protein-protein complexes
- (2018) Sherlyn Jemimah et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae
- (2018) Sundeep Chaitanya Vedithi et al. Scientific Reports
- Application of Assisted Design of Antibody and Protein Therapeutics (ADAPT) improves efficacy of a Clostridium difficile toxin A single-domain antibody
- (2018) Traian Sulea et al. Scientific Reports
- RosettaAntibodyDesign (RAbD): A general framework for computational antibody design
- (2018) Jared Adolf-Bryfogle et al. PLoS Computational Biology
- Understanding molecular consequences of putative drug resistant mutations in Mycobacterium tuberculosis
- (2018) Stephanie Portelli et al. Scientific Reports
- Antibody interface prediction with 3D Zernike descriptors and SVM
- (2018) Sebastian Daberdaku et al. BIOINFORMATICS
- Arpeggio: A Web Server for Calculating and Visualising Interatomic Interactions in Protein Structures
- (2017) Harry C Jubb et al. JOURNAL OF MOLECULAR BIOLOGY
- SDM: a server for predicting effects of mutations on protein stability
- (2017) Arun Prasad Pandurangan et al. NUCLEIC ACIDS RESEARCH
- mCSM–NA: predicting the effects of mutations on protein–nucleic acids interactions
- (2017) Douglas E.V. Pires et al. NUCLEIC ACIDS RESEARCH
- Familial STAG2 germline mutation defines a new human cohesinopathy
- (2017) Fernanda C. Soardi et al. npj Genomic Medicine
- Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins
- (2016) M. B. Coelho et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance
- (2016) Jody Phelan et al. BMC Medicine
- Conjugation of 10 kDa Linear PEG onto Trastuzumab Fab′ Is Sufficient to Significantly Enhance Lymphatic Exposure while Preserving in Vitro Biological Activity
- (2016) Linda J. Chan et al. MOLECULAR PHARMACEUTICS
- mCSM-AB: a web server for predicting antibody–antigen affinity changes upon mutation with graph-based signatures
- (2016) Douglas E.V. Pires et al. NUCLEIC ACIDS RESEARCH
- CSM-lig: a web server for assessing and comparing protein–small molecule affinities
- (2016) Douglas E.V. Pires et al. NUCLEIC ACIDS RESEARCH
- mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance
- (2016) Douglas E. V. Pires et al. Scientific Reports
- Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on ‘black bone disease’ in Italy
- (2015) Martina Nemethova et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures
- (2015) Douglas E. V. Pires et al. JOURNAL OF MEDICINAL CHEMISTRY
- PEGylation Does Not Significantly Change the Initial Intravenous or Subcutaneous Pharmacokinetics or Lymphatic Exposure of Trastuzumab in Rats but Increases Plasma Clearance after Subcutaneous Administration
- (2015) Linda J. Chan et al. MOLECULAR PHARMACEUTICS
- AB-Bind: Antibody binding mutational database for computational affinity predictions
- (2015) Sarah Sirin et al. PROTEIN SCIENCE
- Germline Mutations in the CDKN2B Tumor Suppressor Gene Predispose to Renal Cell Carcinoma
- (2015) M. Jafri et al. Cancer Discovery
- Do current therapeutic anti-Aβ antibodies for Alzheimer’s disease engage the target?
- (2014) Andrew D. Watt et al. ACTA NEUROPATHOLOGICA
- Platinum: a database of experimentally measured effects of mutations on structurally defined protein–ligand complexes
- (2014) Douglas E.V. Pires et al. NUCLEIC ACIDS RESEARCH
- DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach
- (2014) D. E. V. Pires et al. NUCLEIC ACIDS RESEARCH
- Second antibody modeling assessment (AMA-II)
- (2014) Juan C. Almagro et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA
- (2014) David B. Ascher et al. Scientific Reports
- Prediction of site-specific interactions in antibody-antigen complexes: the proABC method and server
- (2013) Pier Paolo Olimpieri et al. BIOINFORMATICS
- mCSM: predicting the effects of mutations in proteins using graph-based signatures
- (2013) Douglas E. V. Pires et al. BIOINFORMATICS
- Application of asymmetric statistical potentials to antibody-protein docking
- (2012) R. Brenke et al. BIOINFORMATICS
- Assessing Predictors of Changes in Protein Stability upon Mutation Using Self-Consistency
- (2012) Grant Thiltgen et al. PLoS One
- OptCDR: a general computational method for the design of antibody complementarity determining regions for targeted epitope binding
- (2010) R. J. Pantazes et al. PROTEIN ENGINEERING DESIGN & SELECTION
- SnugDock: Paratope Structural Optimization during Antibody-Antigen Docking Compensates for Errors in Antibody Homology Models
- (2010) Aroop Sircar et al. PLoS Computational Biology
- Mutation-Specific Antibodies for the Detection of EGFR Mutations in Non-Small-Cell Lung Cancer
- (2009) J. Yu et al. CLINICAL CANCER RESEARCH
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