Understanding molecular consequences of putative drug resistant mutations in Mycobacterium tuberculosis

Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis

(2018) Francesc Coll et al.   NATURE GENETICS

Arpeggio: A Web Server for Calculating and Visualising Interatomic Interactions in Protein Structures

(2017) Harry C Jubb et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition

(2017) Wei Lin et al.   MOLECULAR CELL

SDM: a server for predicting effects of mutations on protein stability

(2017) Arun Prasad Pandurangan et al.   NUCLEIC ACIDS RESEARCH

mCSM–NA: predicting the effects of mutations on protein–nucleic acids interactions

(2017) Douglas E.V. Pires et al.   NUCLEIC ACIDS RESEARCH

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

(2017) Keertan Dheda et al.   Lancet Respiratory Medicine

Diversity and evolution of drug resistance mechanisms in Mycobacterium tuberculosis

(2017) Mashael Al-Saeedi et al.   Infection and Drug Resistance

Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance

(2016) Jody Phelan et al.   BMC Medicine

Development of efflux pump inhibitors in antituberculosis therapy

(2016) Lele Song et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Computational approaches for predicting mutant protein stability

(2016) Shweta Kulshreshtha et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules

(2016) Haim Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance

(2016) Douglas E. V. Pires et al.   Scientific Reports

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

(2016) Vinayak Singh et al.   ACS Infectious Diseases

Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis

(2016) Yumi Park et al.   ACS Infectious Diseases

In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity

(2016) Douglas E. V. Pires et al.   Scientific Reports

Computational approaches to study the effects of small genomic variations

(2015) Kamil Khafizov et al.   JOURNAL OF MOLECULAR MODELING

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

CHOPIN: a web resource for the structural and functional proteome of Mycobacterium tuberculosis

(2015) Bernardo Ochoa-Montaño et al.   Database-The Journal of Biological Databases and Curation

Efflux Pump Gene Expression in Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates

(2015) Guilian Li et al.   PLoS One

Structure-Function Dissection of Myxococcus xanthus CarD N-Terminal Domain, a Defining Member of the CarD_CdnL_TRCF Family of RNA Polymerase Interacting Proteins

(2015) Diego Bernal-Bernal et al.   PLoS One

Binding of the Antitubercular Pro-Drug Isoniazid in the Heme Access Channel of Catalase-Peroxidase (KatG). A Combined Structural and Metadynamics Investigation

(2014) Pietro Vidossich et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Fitness costs of rifampicin resistance inMycobacterium tuberculosisare amplified under conditions of nutrient starvation and compensated by mutation in the β′ subunit of RNA polymerase

(2014) Taeksun Song et al.   MOLECULAR MICROBIOLOGY

DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach

(2014) D. E. V. Pires et al.   NUCLEIC ACIDS RESEARCH

Structural and biochemical analyses of alanine racemase from the multidrug-resistantClostridium difficilestrain 630

(2014) Oluwatoyin A. Asojo et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

mCSM: predicting the effects of mutations in proteins using graph-based signatures

(2013) Douglas E. V. Pires et al.   BIOINFORMATICS

The re-emergence of tuberculosis: what have we learnt from molecular epidemiology?

(2013) M.W. Borgdorff et al.   CLINICAL MICROBIOLOGY AND INFECTION

Mutation rate and the emergence of drug resistance in Mycobacterium tuberculosis

(2013) M. McGrath et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

ModBase, a database of annotated comparative protein structure models and associated resources

(2013) Ursula Pieper et al.   NUCLEIC ACIDS RESEARCH

Crystal structure ofMycobacterium tuberculosisCarD, an essential RNA polymerase binding protein, reveals a quasidomain-swapped dimeric structural architecture

(2013) Gundeep Kaur et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Efficient a Priori Identification of Drug Resistant Mutations Using Dead-End Elimination and MM-PBSA.

(2012) Maria Safi et al.   Journal of Chemical Information and Modeling

Dynamic Population Changes in Mycobacterium tuberculosis During Acquisition and Fixation of Drug Resistance in Patients

(2012) Gang Sun et al.   JOURNAL OF INFECTIOUS DISEASES

A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function

(2012) C. L. Araya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strain diversity, epistasis and the evolution of drug resistance in Mycobacterium tuberculosis

(2011) S. Borrell et al.   CLINICAL MICROBIOLOGY AND INFECTION

Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs

(2011) P. E. Almeida Da Silva et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes

(2011) Iñaki Comas et al.   NATURE GENETICS

SDM--a server for predicting effects of mutations on protein stability and malfunction

(2011) C. L. Worth et al.   NUCLEIC ACIDS RESEARCH

A biophysical protein folding model accounts for most mutational fitness effects in viruses

(2011) C. S. Wylie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin

(2010) Radhika Gupta et al.   NATURE MEDICINE

TubercuList – 10 years after

(2010) Jocelyne M. Lew et al.   TUBERCULOSIS

Complete Structural Model of Escherichia coli RNA Polymerase from a Hybrid Approach

(2010) Natacha Opalka et al.   PLOS BIOLOGY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Stability effects of mutations and protein evolvability

(2009) Nobuhiko Tokuriki et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mycobacterium tuberculosis: drug resistance and future perspectives

(2009) Giovanna Riccardi et al.   Future Microbiology

Tuberculosis in the age of biologic therapy

(2008) Claudia Hernandez et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Extensively drug-resistant tuberculosis

(2008) Mandeep Jassal et al.   LANCET INFECTIOUS DISEASES

The RNA Polymerase II Trigger Loop Functions in Substrate Selection and Is Directly Targeted by α-Amanitin

(2008) Craig D. Kaplan et al.   MOLECULAR CELL