A deep learning genome-mining strategy for biosynthetic gene cluster prediction

Mut2Vec: distributed representation of cancerous mutations

(2018) Sunkyu Kim et al.   BMC Medical Genomics

Current status and future directions of cancer immunotherapy

(2018) Hongming Zhang et al.   Journal of Cancer

PRISM 3: expanded prediction of natural product chemical structures from microbial genomes

(2017) Michael A. Skinnider et al.   NUCLEIC ACIDS RESEARCH

Biosynthesis of isonitrile lipopeptides by conserved nonribosomal peptide synthetase gene clusters in Actinobacteria

(2017) Nicholas C. Harris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Underexplored Opportunities for Natural Products in Drug Discovery

(2016) Bart L. DeCorte   JOURNAL OF MEDICINAL CHEMISTRY

The evolution of genome mining in microbes – a review

(2016) Nadine Ziemert et al.   NATURAL PRODUCT REPORTS

A New Golden Age of Natural Products Drug Discovery

(2015) Ben Shen   CELL

Deep learning

(2015) Yann LeCun et al.   NATURE

Minimum Information about a Biosynthetic Gene cluster

(2015) Marnix H Medema et al.   Nature Chemical Biology

Computational approaches to natural product discovery

(2015) Marnix H Medema et al.   Nature Chemical Biology

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation

(2015) Nuala A. O'Leary et al.   NUCLEIC ACIDS RESEARCH

The Pfam protein families database: towards a more sustainable future

(2015) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

Continuous Distributed Representation of Biological Sequences for Deep Proteomics and Genomics

(2015) Ehsaneddin Asgari et al.   PLoS One

Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters

(2014) Peter Cimermancic et al.   CELL

Mining the Metabiome: Identifying Novel Natural Products from Microbial Communities

(2014) Aleksandr Milshteyn et al.   CHEMISTRY & BIOLOGY

Comparative Genomic Insights Into the Biosynthesis and Regulation of Mycobacterial Siderophores

(2013) Wu Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Clinical relevance of the ESKAPE pathogens

(2013) Jack N Pendleton et al.   Expert Review of Anti-Infective Therapy

Complete Genome Sequence of the Frog Pathogen Mycobacterium ulcerans Ecovar Liflandii

(2012) N. J. Tobias et al.   JOURNAL OF BACTERIOLOGY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Mutational and Phylogenetic Analyses of the Mycobacterial mbt Gene Cluster

(2011) S. S. Chavadi et al.   JOURNAL OF BACTERIOLOGY

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

(2011) Marnix H. Medema et al.   NUCLEIC ACIDS RESEARCH

Prodigal: prokaryotic gene recognition and translation initiation site identification

(2010) Doug Hyatt et al.   BMC BIOINFORMATICS

Hidden Markov Models and their Applications in Biological Sequence Analysis

(2009) Byung-Jun Yoon   CURRENT GENOMICS

CLUSEAN: A computer-based framework for the automated analysis of bacterial secondary metabolite biosynthetic gene clusters

(2009) T. Weber et al.   JOURNAL OF BIOTECHNOLOGY