Therapy and clinical trials in frontotemporal dementia: past, present, and future

Specific Targeting of Tau Oligomers in Htau Mice Prevents Cognitive Impairment and Tau Toxicity Following Injection with Brain-Derived Tau Oligomeric Seeds

(2016) Diana L. Castillo-Carranza et al.   JOURNAL OF ALZHEIMERS DISEASE

Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers

(2015) Ian R. A. Mackenzie et al.   ACTA NEUROPATHOLOGICA

Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

(2015) Marta Marquié et al.   ANNALS OF NEUROLOGY

Tau positron emission tomographic imaging in aging and early Alzheimer disease

(2015) Keith A. Johnson et al.   ANNALS OF NEUROLOGY

Treatment of Primary Progressive Aphasia

(2015) Donna C. Tippett et al.   Current Treatment Options in Neurology

Behavioral Evolution of Progressive Semantic Aphasia in Comparison with Nonfluent Aphasia

(2015) Estrella Gómez-Tortosa et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Cognitive–behavioural features of progressive supranuclear palsy syndrome overlap with frontotemporal dementia

(2015) Christopher Kobylecki et al.   JOURNAL OF NEUROLOGY

18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease

(2015) R. Harada et al.   JOURNAL OF NUCLEAR MEDICINE

Frontotemporal dementia

(2015) Jee Bang et al.   LANCET

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Mutation analysis of C9orf72 in patients with corticobasal syndrome

(2015) Cassandra J. Anor et al.   NEUROBIOLOGY OF AGING

Neurofilament light chain: A prognostic biomarker in amyotrophic lateral sclerosis

(2015) C.-H. Lu et al.   NEUROLOGY

Invited review: Frontotemporal dementia caused bymicrotubule-associated protein taugene (MAPT) mutations: a chameleon for neuropathology and neuroimaging

(2015) Bernardino Ghetti et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Topiramate for Abnormal Eating Behaviour in Frontotemporal Dementia

(2014) Colin Singam et al.   BEHAVIOURAL NEUROLOGY

Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer‘s disease

(2014) Ludovic Collin et al.   BRAIN

Prion-like Properties of Tau Protein: The Importance of Extracellular Tau as a Therapeutic Target

(2014) Brandon B. Holmes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Frontotemporal Dementia and Pharmacologic Interventions

(2014) Edward D. Kaye et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles

(2014) D. L. Castillo-Carranza et al.   JOURNAL OF NEUROSCIENCE

Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial

(2014) Adam L Boxer et al.   LANCET NEUROLOGY

A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy

(2014) Eduardo Tolosa et al.   MOVEMENT DISORDERS

Tideglusib reduces progression of brain atrophy in progressive supranuclear palsy in a randomized trial

(2014) Günter U. Höglinger et al.   MOVEMENT DISORDERS

Results from a pilot study on amiodarone administration in monogenic frontotemporal dementia with granulin mutation

(2014) A. Alberici et al.   NEUROLOGICAL SCIENCES

Oxytocin for frontotemporal dementia: A randomized dose-finding study of safety and tolerability

(2014) E. C. Finger et al.   NEUROLOGY

Designing drug trials for Alzheimer’s disease: What we have learned from the release of the phase III antibody trials: A report from the EU/US/CTAD Task Force

(2013) Bruno Vellas et al.   Alzheimers & Dementia

Mental and Physical Activities Delay Cognitive Decline in Older Persons with Dementia

(2013) Sheung-Tak Cheng et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Cerebrospinal fluid neurofilament concentration reflects disease severity in frontotemporal degeneration

(2013) Carole S. Scherling et al.   ANNALS OF NEUROLOGY

Pilot study of pharmacological treatment for frontotemporal dementia: Risk of donepezil treatment for behavioral and psychological symptoms

(2013) Takemi Kimura et al.   Geriatrics & Gerontology International

Aripiprazole for Sexually Inappropriate Vocalizations in Frontotemporal Dementia

(2013) Roy R. Reeves et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

TDP-43 frontotemporal lobar degeneration and autoimmune disease

(2013) Z. A. Miller et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Donepezil-Induced Confusional State in a Patient With Autopsy-Proven Behavioral-Variant Frontotemporal Dementia

(2013) David B. Arciniegas et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

(2013) Timothy M Miller et al.   LANCET NEUROLOGY

Memantine in patients with frontotemporal lobar degeneration: a multicentre, randomised, double-blind, placebo-controlled trial

(2013) Adam L Boxer et al.   LANCET NEUROLOGY

Reduced CSF p-Tau181 to Tau ratio is a biomarker for FTLD-TDP

(2013) W. T. Hu et al.   NEUROLOGY

Criteria for the diagnosis of corticobasal degeneration

(2013) M. J. Armstrong et al.   NEUROLOGY

Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo

(2013) Kiran Yanamandra et al.   NEURON

Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS

(2013) Peter E.A. Ash et al.   NEURON

RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention

(2013) Christopher J. Donnelly et al.   NEURON

Tau Passive Immunotherapy in Mutant P301L Mice: Antibody Affinity versus Specificity

(2013) Cristina d’Abramo et al.   PLoS One

Efficacy and Safety of A Liposome-Based Vaccine against Protein Tau, Assessed in Tau.P301L Mice That Model Tauopathy

(2013) Clara Theunis et al.   PLoS One

Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration

(2013) C. Lagier-Tourenne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Managing abnormal eating behaviours in frontotemporal lobar degeneration patients with topiramate

(2013) Shunichiro SHINAGAWA et al.   Psychogeriatrics

The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: The next therapeutic frontier)

(2012) Adam L. Boxer et al.   Alzheimers & Dementia

Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations

(2012) J. S. Snowden et al.   BRAIN

RNA-binding proteins in microsatellite expansion disorders: Mediators of RNA toxicity

(2012) Gloria V. Echeverria et al.   BRAIN RESEARCH

Treatment of Indiscriminate, Inappropriate Sexual Behavior in Frontotemporal Dementia With Carbamazepine

(2012) Connie E. Poetter et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Treatment implications of C9ORF72

(2012) Sharon J Sha et al.   Alzheimers Research & Therapy

Serotonergic Function and Treatment of Behavioral and Psychological Symptoms of Frontotemporal Dementia

(2011) Nathan Herrmann et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Clinicopathological correlations in corticobasal degeneration

(2011) Suzee E. Lee et al.   ANNALS OF NEUROLOGY

Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia

(2011) Katya Rascovsky et al.   BRAIN

Suberoylanilide Hydroxamic Acid (Vorinostat) Up-regulates Progranulin Transcription

(2011) Basar Cenik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Passive Immunization with Anti-Tau Antibodies in Two Transgenic Models

(2011) Xiyun Chai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain

(2011) Allal Boutajangout et al.   JOURNAL OF NEUROCHEMISTRY

Reversal of abnormal eating and drinking behaviour in a frontotemporal lobar degeneration patient using low-dose topiramate: Table 1

(2011) Peter J Nestor   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase

(2011) A. Capell et al.   JOURNAL OF NEUROSCIENCE

Classification of primary progressive aphasia and its variants

(2011) M. L. Gorno-Tempini et al.   NEUROLOGY

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Rates of brain atrophy and clinical decline over 6 and 12-month intervals in PSP: Determining sample size for treatment trials

(2011) Jennifer L. Whitwell et al.   PARKINSONISM & RELATED DISORDERS

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Rivastigmine for the treatment of dementia in patients with progressive supranuclear palsy: Clinical observations as a basis for power calculations and safety analysis

(2010) Iuga Liepelt et al.   Alzheimers & Dementia

Does corticobasal degeneration exist? A clinicopathological re-evaluation

(2010) H. Ling et al.   BRAIN

Clinical, neuroimaging and neuropathological features of a new chromosome 9p-linked FTD-ALS family

(2010) A. L. Boxer et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

An Open-label Study of Memantine Treatment in 3 Subtypes of Frontotemporal Lobar Degeneration

(2009) Adam L. Boxer et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Serum biomarker for progranulin-associated frontotemporal lobar degeneration

(2009) Kristel Sleegers et al.   ANNALS OF NEUROLOGY

Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members

(2009) N. Finch et al.   BRAIN

Stimulant Treatment of Frontotemporal Dementia in 8 Patients

(2009) Edward D. Huey et al.   JOURNAL OF CLINICAL PSYCHIATRY

Behavioural abnormalities associated with rapid deterioration of language functions in semantic dementia respond to sertraline

(2009) C I Prodan et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Development of methodology for conducting clinical trials in frontotemporal lobar degeneration

(2008) D. S. Knopman et al.   BRAIN

Topiramate may Modulate Alcohol Abuse But not Other Compulsive Behaviors in Frontotemporal Dementia

(2008) Marcelo Cruz et al.   Cognitive and Behavioral Neurology

Galantamine in Frontotemporal Dementia and Primary Progressive Aphasia

(2008) A. Kertesz et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Mutations in progranulin (GRN) within the spectrum of clinical and pathological phenotypes of frontotemporal dementia

(2008) John C van Swieten et al.   LANCET NEUROLOGY

Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration

(2008) R. Ghidoni et al.   NEUROLOGY