Representing high throughput expression profiles via perturbation barcodes reveals compound targets

Using transcriptomics to guide lead optimization in drug discovery projects: Lessons learned from the QSTAR project

(2015) Bie Verbist et al.   DRUG DISCOVERY TODAY

Toxicity Mechanisms Identification via Gene Set Enrichment Analysis of Time-Series Toxicogenomics Data: Impact of Time and Concentration

(2015) Ce Gao et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Compound signature detection on LINCS L1000 big data

(2015) Chenglin Liu et al.   Molecular BioSystems

Building Predictive Models inRUsing thecaretPackage

(2015) Max Kuhn   Journal of Statistical Software

Multimodal Similarity-Preserving Hashing

(2014) Jonathan Masci et al.   IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE

LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures

(2014) Qiaonan Duan et al.   NUCLEIC ACIDS RESEARCH

Target identification and mechanism of action in chemical biology and drug discovery

(2013) Monica Schenone et al.   Nature Chemical Biology

Robustness and Compensation of Information Transmission of Signaling Pathways

(2013) S. Uda et al.   SCIENCE

Rethinking Molecular Similarity: Comparing Compounds on the Basis of Biological Activity

(2012) Paula M. Petrone et al.   ACS Chemical Biology

Deep Neural Networks for Acoustic Modeling in Speech Recognition: The Shared Views of Four Research Groups

(2012) Geoffrey Hinton et al.   IEEE SIGNAL PROCESSING MAGAZINE

Exploring Activity Cliffs in Medicinal Chemistry

(2012) Dagmar Stumpfe et al.   JOURNAL OF MEDICINAL CHEMISTRY

ChEMBL: a large-scale bioactivity database for drug discovery

(2011) A. Gaulton et al.   NUCLEIC ACIDS RESEARCH

Tackling the widespread and critical impact of batch effects in high-throughput data

(2010) Jeffrey T. Leek et al.   NATURE REVIEWS GENETICS

Discovery of drug mode of action and drug repositioning from transcriptional responses

(2010) F. Iorio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Semantic hashing

(2008) Ruslan Salakhutdinov et al.   INTERNATIONAL JOURNAL OF APPROXIMATE REASONING