Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling

Biodiversity of small molecules – a new perspective in screening set selection

(2013) Paula M. Petrone et al.   DRUG DISCOVERY TODAY

Multiplex Cytological Profiling Assay to Measure Diverse Cellular States

(2013) Sigrun M. Gustafsdottir et al.   PLoS One

Exploring Chemical Space for Drug Discovery Using the Chemical Universe Database

(2012) Jean-Louis Reymond et al.   ACS Chemical Neuroscience

Biology-Oriented Synthesis

(2011) Stefan Wetzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Impact of high-throughput screening in biomedical research

(2011) Ricardo Macarron et al.   NATURE REVIEWS DRUG DISCOVERY

Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections

(2011) P. A. Clemons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extended-Connectivity Fingerprints

(2010) David Rogers et al.   Journal of Chemical Information and Modeling

Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles

(2010) P. A. Clemons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connecting synthetic chemistry decisions to cell and genome biology using small-molecule phenotypic profiling

(2009) Bridget K Wagner et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Using Biological Performance Similarity To Inform Disaccharide Library Design

(2009) Tetsuya Tanikawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds

(2009) Yan Feng et al.   NATURE REVIEWS DRUG DISCOVERY