Structure-Activity-Relationship and Mechanistic Insights for Anti-HIV Natural Products

Plant‐derived glucose transport inhibitors with potential antitumor activity

(2019) Pratik Shriwas et al.   PHYTOTHERAPY RESEARCH

Natural Products and HIV/AIDS

(2018) Daniele C. Cary et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

4-aryl/heteroaryl-4H-fused Pyrans as Anti-proliferative Agents: Design, Synthesis and Biological Evaluation

(2018) Dinesh Kumar et al.   Anti-Cancer Agents in Medicinal Chemistry

Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus

(2018) Bahare Salehi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-HIV activity of southern African plants: Current developments, phytochemistry and future research

(2018) Gerhard Prinsloo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Biologically active oligostilbenes from the stems of Vatica mangachapoi and chemotaxonomic significance

(2018) Shou-Yuan Wu et al.   NATURAL PRODUCT RESEARCH

Phytotherapeutics in cancer invasion and metastasis

(2018) Bahare Salehi et al.   PHYTOTHERAPY RESEARCH

Prenylated phloroglucinols from Hypericum scruglii, an endemic species of Sardinia (Italy), as new dual HIV-1 inhibitors effective on HIV-1 replication

(2018) Cinzia Sanna et al.   PLoS One

Identification of Novel HIV-1 Latency-Reversing Agents from a Library of Marine Natural Products

(2018) Khumoekae Richard et al.   Viruses-Basel

Natural product-derived compounds in HIV suppression, remission, and eradication strategies

(2018) Raymond J. Andersen et al.   ANTIVIRAL RESEARCH

Estrogenic terpenes and terpenoids: Pathways, functions and applications

(2017) Ryoiti Kiyama   EUROPEAN JOURNAL OF PHARMACOLOGY

An alternative strategy to western blot as a confirmatory diagnostic test for HIV infection

(2017) Xia Feng et al.   JOURNAL OF CLINICAL VIROLOGY

Naturally occurring Vpr inhibitors from medicinal plants of Myanmar

(2017) Nwet Nwet Win et al.   Journal of Natural Medicines

Anti-HIV Activity of Ocimum labiatum Extract and Isolated Pheophytin-a

(2017) Petrina Kapewangolo et al.   MOLECULES

Plants of the Genus Zingiber as a Source of Bioactive Phytochemicals: From Tradition to Pharmacy

(2017) Mehdi Sharifi-Rad et al.   MOLECULES

Uvaria angolensis as a promising source of inhibitors of HIV-1 RT-associated RNA-dependent DNA polymerase and RNase H functions

(2017) Alvine Ngoutane Mfopa et al.   NATURAL PRODUCT RESEARCH

Bioactive Triterpenoids from the Leaves and Twigs of Lithocarpus litseifolius and L. corneus

(2017) Yuan-Bin Cheng et al.   PLANTA MEDICA

Diversity of Secondary Metabolites from Some Medicinal Plants and Cultivated Lichen Mycobionts

(2017) Takao Tanahashi   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

The value of pyrans as anticancer scaffolds in medicinal chemistry

(2017) Dinesh Kumar et al.   RSC Advances

New Drugs in the Pipeline for the Treatment of HIV: a Review

(2017) Leigh Anne Hylton Gravatt et al.   Current Infectious Disease Reports

Naphthoflavones as Antiproliferative Agents: Design, Synthesis and Biological Evaluation

(2016) Dinesh Kumar et al.   Anti-Cancer Agents in Medicinal Chemistry

Isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their Vpr inhibitory activity

(2016) Nwet Nwet Win et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Secondary metabolites in plants: transport and self-tolerance mechanisms

(2016) Nobukazu Shitan   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

2,4-Diarylpyrano[3,2-c]chromen-5(4H)-ones as Antiproliferative Agents:

(2016) Dinesh Kumar et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Human Immunodeficiency Virus Diagnostic Testing: 30 Years of Evolution

(2016) Thomas S. Alexander   Clinical and Vaccine Immunology

A Comprehensive Review of N-Heterocycles as Cytotoxic Agents

(2016) Dinesh Kumar et al.   CURRENT MEDICINAL CHEMISTRY

Ethnobotanical Study of Plants Used in the Management of HIV/AIDS-Related Diseases in Livingstone, Southern Province, Zambia

(2016) Kazhila C. Chinsembu   Evidence-based Complementary and Alternative Medicine

Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults

(2016) Huldrych F. Günthard et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Ximenia caffra Sond. (Ximeniaceae) in sub-Saharan Africa: A synthesis and review of its medicinal potential

(2016) Alfred Maroyi   JOURNAL OF ETHNOPHARMACOLOGY

Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity

(2016) Cheng Jiang et al.   JOURNAL OF NATURAL PRODUCTS

Inhibition of CYP2B6 by Medicinal Plant Extracts: Implication for Use of Efavirenz and Nevirapine-Based Highly Active Anti-Retroviral Therapy (HAART) in Resource-Limited Settings

(2016) Nicholas Thomford et al.   MOLECULES

Anti-HIV-1 integrase compounds fromDioscorea bulbiferaand molecular docking study

(2016) Prapaporn Chaniad et al.   PHARMACEUTICAL BIOLOGY

Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication

(2016) Francesca Esposito et al.   PHYTOMEDICINE

A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation

(2016) Bridgette Janine Connell et al.   PLoS One

Latency reversal and viral clearance to cure HIV-1

(2016) D. M. Margolis et al.   SCIENCE

Sceletium tortuosum demonstrates in vitro anti-HIV and free radical scavenging activity

(2016) P. Kapewangolo et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Alkaloids from Croton echinocarpus Baill.: Anti-HIV potential

(2016) N. Ravanelli et al.   SOUTH AFRICAN JOURNAL OF BOTANY

The Life-Cycle of the HIV-1 Gag–RNA Complex

(2016) Elodie Mailler et al.   Viruses-Basel

Natural Products as Anti-HIV Agents and Role in HIV-Associated Neurocognitive Disorders (HAND): A Brief Overview

(2016) Kesava Rao V. Kurapati et al.   Frontiers in Microbiology

Anti-HIV-1 protease activities of crude extracts of some Garcinia species growing in Tanzania

(2016) J Magadula Joseph et al.   AFRICAN JOURNAL OF BIOTECHNOLOGY

Field accuracy of fourth-generation rapid diagnostic tests for acute HIV-1

(2015) Joseph M. Lewis et al.   AIDS

Engineering of Secondary Metabolism

(2015) Sarah E. O'Connor   Annual Review of Genetics

4,6-diaryl Pyrimidones as Constrained Chalcone Analogues: Design, Synthesis and Evaluation as Antiproliferative Agents

(2015) Dinesh Kumar et al.   Anti-Cancer Agents in Medicinal Chemistry

HIV integrase inhibitors: a new era in the treatment of HIV

(2015) Jose Luis Blanco et al.   EXPERT OPINION ON PHARMACOTHERAPY

Stelleralides D–J and Anti-HIV Daphnane Diterpenes from Stellera chamaejasme

(2015) Min Yan et al.   JOURNAL OF NATURAL PRODUCTS

A new butenolide cinnamate and other biological active chemical constituents fromPolygonum glabrum

(2015) Madhukar S. Said et al.   NATURAL PRODUCT RESEARCH

HIV-1 assembly, release and maturation

(2015) Eric O. Freed   NATURE REVIEWS MICROBIOLOGY

Anti-HIV-1 integrase activity and molecular docking of compounds fromAlbizia procerabark

(2015) Pattarapan Panthong et al.   PHARMACEUTICAL BIOLOGY

Derivation of Cinnamon Blocks Leukocyte Attachment by Interacting with Sialosides

(2015) Wei-Ling Lin et al.   PLoS One

Mechanism of Anti-HIV Activity of Ribosome Inactivating Protein, Saporin

(2015) Santosh Yadav et al.   PROTEIN AND PEPTIDE LETTERS

Retroviral proteases and their roles in virion maturation

(2015) Jan Konvalinka et al.   VIROLOGY

The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription

(2015) Xin Deng et al.   Virology Journal

Curcumin and its analogues: a potential natural compound against HIV infection and AIDS

(2015) Sahdeo Prasad et al.   Food & Function

In vitro antiplasmodial and HIV-1 neutralization activities of root and leaf extracts from Berberis holstii

(2015) Kennedy J. Ngwira et al.   Journal of Herbal Medicine

HIV infection

(2015) Steven G. Deeks et al.   Nature Reviews Disease Primers

Screening of the Pan-African Natural Product Library Identifies Ixoratannin A-2 and Boldine as Novel HIV-1 Inhibitors

(2015) Ian Tietjen et al.   PLoS One

Anticancer Hybrids- A Patent Survey

(2015) Kunal Nepali et al.   Recent Patents on Anti-Cancer Drug Discovery

Phytoconstituents of Jatropha curcas L. Leaves and their Immunomodulatory Activity on Humoral and Cell-Mediated Immune Response in Chicks

(2015) Howaida I. Abd-Alla et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

In vitro anti-HIV and immunomodulatory potentials of Azadirachta indica (Meliaceae) leaf extract

(2014) M. Awah   African Journal of Pharmacy and Pharmacology

Cepharanthine inhibited HIV-1 cell–cell transmission and cell-free infection via modification of cell membrane fluidity

(2014) Kouki Matsuda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Alepidea amatymbicaEckl. & Zeyh.: A Review of Its Traditional Uses, Phytochemistry, Pharmacology, and Toxicology

(2014) O. A. Wintola et al.   Evidence-based Complementary and Alternative Medicine

Targeting strategies for delivery of anti-HIV drugs

(2014) Lakshmi Narashimhan Ramana et al.   JOURNAL OF CONTROLLED RELEASE

Uralsaponins M–Y, Antiviral Triterpenoid Saponins from the Roots of Glycyrrhiza uralensis

(2014) Wei Song et al.   JOURNAL OF NATURAL PRODUCTS

Sparstolonin B suppresses lipopolysaccharide-induced inflammation in human umbilical vein endothelial cells

(2013) Qiaoli Liang et al.   ARCHIVES OF PHARMACAL RESEARCH

Experimental and Clinical Pharmacology ofAndrographis paniculataand Its Major Bioactive Phytoconstituent Andrographolide

(2013) Thanasekaran Jayakumar et al.   Evidence-based Complementary and Alternative Medicine

Terpenoids and their anti-HIV-1 activities from Excoecaria acerifolia

(2013) Sheng-Zhuo Huang et al.   FITOTERAPIA

Inhibition of HIV-1 enzymes, antioxidant and anti-inflammatory activities of Plectranthus barbatus

(2013) Petrina Kapewangolo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Bioactive natural products derived from the Central African flora against neglected tropical diseases and HIV

(2013) Denis Zofou et al.   NATURAL PRODUCT REPORTS

Inhibition of HIV-1 Replication by Balsamin, a Ribosome Inactivating Protein of Momordica balsamina

(2013) Inderdeep Kaur et al.   PLoS One

Identification of compounds from the plant species Alepidea amatymbica active against HIV

(2013) S. Louvel et al.   SOUTH AFRICAN JOURNAL OF BOTANY

An ethnobotanical survey of indigenous knowledge on medicinal plants used by the traditional healers of the Lwamondo area, Limpopo province, South Africa

(2013) S.T. Mahwasane et al.   SOUTH AFRICAN JOURNAL OF BOTANY

CCR5 as a Natural and Modulated Target for Inhibition of HIV

(2013) Bryan Burke et al.   Viruses-Basel

HIV-1 Assembly, Budding, and Maturation

(2013) W. I. Sundquist et al.   Cold Spring Harbor Perspectives in Medicine

Ameliorative potential of Butea monosperma on chronic constriction injury of sciatic nerve induced neuropathic pain in rats

(2012) Venkata R.K. Thiagarajan et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

In search of a treatment for HIV – current therapies and the role of non-nucleoside reverse transcriptase inhibitors (NNRTIs)

(2012) Chevonne Reynolds et al.   CHEMICAL SOCIETY REVIEWS

Olean-18-ene triterpenoids from Celastraceae species inhibit HIV replication targeting NF-kB and Sp1 dependent transcription

(2012) Alex A. Osorio et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-HIV activity of semisynthetic derivatives of andrographolide and computational study of HIV-1 gp120 protein binding

(2012) Mayur M. Uttekar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzophenone glycosides and epicatechin derivatives from Malania oleifera

(2012) Xing-De Wu et al.   FITOTERAPIA

Ethnopharmacology in overdrive: The remarkable anti-HIV activity of Artemisia annua

(2012) Andrea Lubbe et al.   JOURNAL OF ETHNOPHARMACOLOGY

The structural biology of HIV-1: mechanistic and therapeutic insights

(2012) Alan Engelman et al.   NATURE REVIEWS MICROBIOLOGY

Virus-inhibitory peptide

(2011) Miguel E. Quiñones-Mateu et al.   AIDS

Pathogenic Mechanisms of HIV Disease

(2011) Susan Moir et al.   Annual Review of Pathology-Mechanisms of Disease

The Role of Conserved Glu Residue on Cyclotide Stability and Activity: A Structural and Functional Study of Kalata B12, a Naturally Occurring Glu to Asp Mutant

(2011) Conan K. L. Wang et al.   BIOCHEMISTRY

Flavonoids from Daphne aurantiaca and Their Inhibitory Activities against Nitric Oxide Production

(2011) Shuang Liang et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Antidiabetic Activity ofGnidia glaucaandDioscorea bulbifera: Potent Amylase and Glucosidase Inhibitors

(2011) Sougata Ghosh et al.   Evidence-based Complementary and Alternative Medicine

Antitumor activity of Dioscorea bulbifera L. rhizome in vivo

(2011) Jun-Ming Wang et al.   FITOTERAPIA

Antimycobacterials from natural sources: ancient times, antibiotic era and novel scaffolds

(2011) Juan et al.   Frontiers in Bioscience-Landmark

Anti-HIV activity of Indian medicinal plants

(2011) Sudeep Sabde et al.   Journal of Natural Medicines

Library-Based Discovery and Characterization of Daphnane Diterpenes as Potent and Selective HIV Inhibitors in Daphne gnidium

(2011) Vincent Vidal et al.   JOURNAL OF NATURAL PRODUCTS

Lathyrane Diterpenoids from the Roots ofEuphorbia micractinaand Their Biological Activities

(2011) Ye Tian et al.   JOURNAL OF NATURAL PRODUCTS

Prevention of HIV-1 Infection with Early Antiretroviral Therapy

(2011) Myron S. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

An evaluation of the RNase H inhibitory effects of Vietnamese medicinal plant extracts and natural compounds

(2011) Bui Huu Tai et al.   PHARMACEUTICAL BIOLOGY

Inhibition of HIV-1 infection by aqueous extracts of Prunella vulgaris L.

(2011) ChoonSeok Oh et al.   Virology Journal

Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata

(2010) Tao Feng et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Cinnamon and Health

(2010) Joerg Gruenwald et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Analgesic and Anti-Inflammatory Properties of Extracts from the Bulbils ofDioscorea bulbiferaL. varsativa(Dioscoreaceae) in Mice and Rats

(2010) M. Mbiantcha et al.   Evidence-based Complementary and Alternative Medicine

Isolation, Sequencing, and Structure−Activity Relationships of Cyclotides

(2010) David C. Ireland et al.   JOURNAL OF NATURAL PRODUCTS

Recent advances in anti-HIV natural products

(2010) Inder Pal Singh et al.   NATURAL PRODUCT REPORTS

Anti-HIV activity of natural triterpenoids and hemisynthetic derivatives 2004–2009

(2010) Bruce K. Cassels et al.   PHYTOCHEMISTRY REVIEWS

Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian)

(2010) Wen-Wan Chao et al.   Chinese Medicine

The anti-viral protein of trichosanthin penetrates into human immunodeficiency virus type 1

(2009) W. Zhao et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Chebulagic acid (CA) attenuates LPS-induced inflammation by suppressing NF-κB and MAPK activation in RAW 264.7 macrophages

(2009) D. Bharat Reddy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ribosome Inactivating Proteins (RIPs) from Momordica charantia for Anti Viral Therapy

(2009) M. Puri et al.   CURRENT MOLECULAR MEDICINE

Andrographolide: A New Plant-Derived Antineoplastic Entity on Horizon

(2009) Astha Varma et al.   Evidence-based Complementary and Alternative Medicine

Antibacterial, antifungal, and antiviral activities of some flavonoids

(2009) Didem Deliorman Orhan et al.   MICROBIOLOGICAL RESEARCH

Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents

(2009) Reen-Yen Kuo et al.   NATURAL PRODUCT REPORTS

Highly Functionalized Daphnane Diterpenoids fromTrigonostemon thyrsoideum

(2009) Ling Zhang et al.   ORGANIC LETTERS

Hypericumin infection: Identification of anti-viral and anti-inflammatory constituents

(2009) Diane F. Birt et al.   PHARMACEUTICAL BIOLOGY

Antifungal constituents isolated from the seeds of Aegle marmelos

(2009) Bhuwan B. Mishra et al.   PHYTOCHEMISTRY

Anti-HIV‐1 and Anti-Inflammatory Lupanes from the Leaves, Twigs, and Resin ofGarcinia hanburyi

(2009) Vichai Reutrakul et al.   PLANTA MEDICA

Immune-suppressive activity of punicalagin via inhibition of NFAT activation

(2008) Sang-Ik Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dichapetalin-Type Triterpenoids and Lignans from the Aerial Parts ofPhyllanthus acutissima

(2008) Patoomratana Tuchinda et al.   JOURNAL OF NATURAL PRODUCTS

Periglaucines A−D, Anti-HBV and -HIV-1 Alkaloids fromPericampylus glaucus

(2008) Meng-Hong Yan et al.   JOURNAL OF NATURAL PRODUCTS

Lupane-Type Triterpenoids fromMicrotropis fokienensisandPerrottetia arisanensisand the Apoptotic Effect of 28-Hydroxy-3-oxo-lup-20(29)-en-30-al

(2008) I-Hsiao Chen et al.   JOURNAL OF NATURAL PRODUCTS

Bioactive compounds fromLippia javanicaandHoslundia opposita

(2008) Silva F. Mujovo et al.   NATURAL PRODUCT RESEARCH

Anti-HIV-1 protease triterpenoids from Stauntonia obovatifoliola Hayata subsp. intermedia

(2008) Ying Wei et al.   PHYTOCHEMISTRY

Anti-HIV protease triterpenoids from the acid hydrolysate of Panax ginseng

(2008) Ying Wei et al.   Phytochemistry Letters

Plant-Derived Leading Compounds for Chemotherapy of Human Immunodefiency Virus (HIV) Infection – An Update (1998 – 2007)

(2008) Paul Cos et al.   PLANTA MEDICA

Octanorcucurbitane and Cucurbitane Triterpenoids from the Tubers ofHemsleya endecaphyllawith HIV-1 Inhibitory Activity

(2007) Jian-Chao Chen et al.   JOURNAL OF NATURAL PRODUCTS