Journal
JOURNAL OF NATURAL PRODUCTS
Volume 79, Issue 3, Pages 578-583Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b01012
Keywords
-
Funding
- National High-Tech R&D Program of China (863 Program) [2012AA020307]
- Guangdong Innovative Research Team Program [2009010058]
- National Natural Science Foundation of China [81173470]
- National Institute of Allergy and Infectious Diseases (NIAID) Grant [AI33066]
Ask authors/readers for more resources
Seven new carolignans, including two pairs of enantiomers (+/-)-erythro-7'-methylcarolignan E (1a/1b) and (+/-)-threo-7'-methylcarolignan E (2a/2b), (+)-threo-carolignan E (3a), (+)-elythro-carolignan E (4a), and (-)-erythrocarolignan Z (5), together with four known lignans (3b, 4b, 6, and 7) and six polyphenols (8-13) were isolated from the aerial parts of Euphorbia sikkimensis. The structures of the new compounds were elucidated by spectroscopic analysis, and their absolute configurations were determined by electronic circular dichroism calculations. Seven of the isolates were examined for anti-HIV effects, and compounds 1a and 1b showed moderate anti-HIV activity with EC50 values of 6.3 and 5.3 mu M.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available