Identification of Novel HIV-1 Latency-Reversing Agents from a Library of Marine Natural Products

Natural Products and HIV/AIDS

(2018) Daniele C. Cary et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Novel Latency Reversal Agents for HIV-1 Cure

(2018) Adam M. Spivak et al.   Annual Review of Medicine

Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A

(2018) Ian Tietjen et al.   ANTIVIRAL RESEARCH

The Croton megalobotrys Müll Arg. traditional medicine in HIV/AIDS management: Documentation of patient use, in vitro activation of latent HIV-1 provirus, and isolation of active phorbol esters

(2018) Ian Tietjen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Synergistic reactivation of latent HIV-1 provirus by PKA activator dibutyryl-cAMP in combination with an HDAC inhibitor

(2017) Hoyong Lim et al.   VIRUS RESEARCH

Molecular mechanisms of HIV latency

(2016) Daniele C. Cary et al.   JOURNAL OF CLINICAL INVESTIGATION

Sesterterpenoids Isolated from the Sponge Phorbas sp. Activate Latent HIV-1 Provirus Expression

(2016) Meng Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Shocking HIV out of hiding

(2016) Thomas A. Rasmussen et al.   Current Opinion in HIV and AIDS

HIV-1 Vpr reactivates latent HIV-1 provirus by inducing depletion of class I HDACs on chromatin

(2016) Bizhan Romani et al.   Scientific Reports

Ex vivo analysis identifies effective HIV-1 latency–reversing drug combinations

(2015) Gregory M. Laird et al.   JOURNAL OF CLINICAL INVESTIGATION

Synergistic Activation of Latent HIV-1 Expression by Novel Histone Deacetylase Inhibitors and Bryostatin-1

(2015) Marta Martínez-Bonet et al.   Scientific Reports

An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression

(2015) Gilles Darcis et al.   PLoS Pathogens

Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation

(2015) Guochun Jiang et al.   PLoS Pathogens

Discovery of a Small Molecule Agonist of Phosphatidylinositol 3-Kinase p110α That Reactivates Latent HIV-1

(2014) Geneviève Doyon et al.   PLoS One

Emerging strategies to deplete the HIV reservoir

(2013) Nancie M. Archin et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Unique characteristics of histone deacetylase inhibitors in reactivation of latent HIV-1 in Bcl-2-transduced primary resting CD4+ T cells

(2013) Liang Shan et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Sesterterpenoids Isolated from a Northeastern Pacific Phorbas sp.

(2013) Julie Daoust et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo

(2013) E. J. Beans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients

(2013) Celsa A. Spina et al.   PLoS Pathogens

Defining the Mechanism of Action and Enzymatic Selectivity of Psammaplin A against Its Epigenetic Targets

(2012) Matthias G. J. Baud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Halicloic Acids A and B Isolated from the Marine Sponge Haliclona sp. Collected in the Philippines Inhibit Indoleamine 2,3-Dioxygenase

(2012) David E. Williams et al.   JOURNAL OF NATURAL PRODUCTS

Combination of Biological Screening in a Cellular Model of Viral Latency and Virtual Screening Identifies Novel Compounds That Reactivate HIV-1

(2012) E. Gallastegui et al.   JOURNAL OF VIROLOGY

Shock and kill

(2012) Steven G. Deeks   NATURE

Nahuoic Acid A Produced by a Streptomyces sp. Isolated From a Marine Sediment Is a Selective SAM-Competitive Inhibitor of the Histone Methyltransferase SETD8

(2012) David E. Williams et al.   ORGANIC LETTERS

High-throughput Screening Uncovers a Compound That Activates Latent HIV-1 and Acts Cooperatively with a Histone Deacetylase (HDAC) Inhibitor

(2011) Sofiya Micheva-Viteva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Turnagainolides A and B, Cyclic Depsipeptides Produced in Culture by aBacillussp.: Isolation, Structure Elucidation, and Synthesis

(2011) Dehai Li et al.   JOURNAL OF NATURAL PRODUCTS

Padanamides A and B, Highly Modified Linear Tetrapeptides Produced in Culture by aStreptomycessp. Isolated from a Marine Sediment

(2011) David. E. Williams et al.   ORGANIC LETTERS

Bryostatin-1 Synergizes with Histone Deacetylase Inhibitors to Reactivate HIV-1 from Latency

(2010) Moises Perez et al.   CURRENT HIV RESEARCH

Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation

(2009) Hung-Chih Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Synergistic Activation of HIV-1 Expression by Deacetylase Inhibitors and Prostratin: Implications for Treatment of Latent Infection

(2009) Sophie Reuse et al.   PLoS One