Review
Pharmacology & Pharmacy
Chen-Chen Fu, Fa-Ying Xu, Yu-Chen Qian, Hoi-Lun Koo, Yi-Fan Duan, Geng-Min Weng, Tai-Ping Fan, Mo-Xian Chen, Fu-Yuan Zhu
Summary: Osmanthus fragrans, a flowering plant with a long history of cultivation in China, has not only edible and ornamental value, but also medicinal value. Its secondary metabolites, including flavonoids, terpenes, and phenolic acids, have antioxidant, anticancer, anti-inflammatory, and antibacterial activities, and can be used to treat various human diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Plant Sciences
Naoual El Menyiy, Fatima-Ezzahrae Guaouguaou, Aicha El Baaboua, Nasreddine El Omari, Douae Taha, Najoua Salhi, Mohammad Ali Shariati, Tarik Aanniz, Taoufiq Benali, Gokhan Zengin, Mohamed El-Shazly, Imane Chamkhi, Abdelhakim Bouyahya
Summary: Centaurium erythraea is an important medicinal plant used in traditional medicine to treat various diseases. It exhibits diverse biological properties and contains several classes of secondary metabolites, confirming the link between traditional medicinal use and scientific experiments. Further investigation using in vivo pharmacological assays, toxicological tests, and pharmacokinetic studies are recommended to validate its traditional use.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Natalya Vinogradova, Elena Vinogradova, Victor Chaplygin, Saglara Mandzhieva, Pradeep Kumar, Vishnu D. Rajput, Tatiana Minkina, Chandra Shekhar Seth, Marina Burachevskaya, Dionise Lysenko, Rupesh Kumar Singh
Summary: This article analyzes the impact of anthropogenically transformed environment on the content of pharmaceutically valuable biologically active compounds in medicinal plants. The study focuses on phenolic compounds such as flavonoids, anthocyanins, tannins, and phenolic acids. The discharge of transmissible forms of heavy metals, including cadmium, lead, and mercury, from factories has led to contamination of soil. This affects the activity of enzymes involved in the biosynthesis of phenolic compounds in medicinal plants, resulting in changes in their quantity.
Review
Plant Sciences
Benedicte Heral, Emilie Stierlin, Xavier Fernandez, Thomas Michel
Summary: The genus Lavandula naturally occurs in the Mediterranean basin and species like fine lavender and lavandin are cultivated for their essential oils. While volatile compounds in Lavandula have been well-studied, non-volatile secondary metabolites are less explored. The detailed list in this review reveals a total of 548 specialized metabolites in Lavandula species, providing a scientific foundation for future studies in chemical ecology and metabolomics.
PHYTOCHEMISTRY REVIEWS
(2021)
Review
Chemistry, Analytical
Aurora Antonio-Perez, Luis Fernando Duran-Armenta, Maria Guadalupe Perez-Loredo, Ana Laura Torres-Huerta
Summary: Green synthesis of copper nanoparticles can be achieved using plant extracts, which offers an environmentally friendly approach and improves the biocompatibility and functional properties of the synthesized nanoparticles. Traditional herbal compounds have a long history of medicinal use and can provide a dynamic reaction environment for nanoparticle synthesis.
Article
Biochemistry & Molecular Biology
Sylwia Bajkacz, Magdalena Ligor, Irena Baranowska, Boguslaw Buszewski
Summary: The study aimed to develop a method for isolating and determining polyphenols, particularly flavonoids in plants of the cabbage family, utilizing maceration, acid hydrolysis, and antioxidant capacity measurement. Thin-layer chromatography was found to be a suitable method for separating and determining chemopreventive phytochemicals in cabbage family plants.
Review
Biochemistry & Molecular Biology
Sayyedeh Fatemeh Askari, Razieh Avan, Zahra Tayarani-Najaran, Amirhossein Sahebkar, Samira Eghbali
Summary: Salvia is the largest genus of the Lamiaceae family, with over 900 species worldwide and about 60 species in Iran, 17 of which are endemic. Iranian Salvia species have a wide range of pharmacological activities, such as antidiabetic, antioxidant, antimicrobial, cytotoxic, and anti-inflammatory effects, and are traditionally used to treat various diseases.
Article
Plant Sciences
Magdalena Simlat, Agata Ptak, Tomasz Wojtowicz, Agnieszka Szewczyk
Summary: This study investigated the content of phenolic acids and flavonoids in stevia leaves as affected by treatment with melatonin and germination in NaCl conditions. The results showed that phenolic acids were more abundant than flavonoids in stevia leaves. Treatment with melatonin increased the content of both phenolic acids and flavonoids, and 500μM melatonin under salinity conditions had the most favorable effect on the synthesis of phenolic acids. The content of phenolic compounds also varied depending on the age of the leaves.
Article
Food Science & Technology
Fachun Wan, Chengfeng Feng, Kaiyun Luo, Wenyu Cui, Zhihui Xia, Anwei Cheng
Summary: This review provides a comprehensive summary of the application of steam explosion (SE) in food pretreatment and its effects on phenolic compounds. SE can increase the release of phenolics and enhance their antioxidant activity. Different forms of phenolics exist in the plant matrix, including free and bound forms. The temperature/pressure and residence time during SE processing are the main factors affecting phenolic extraction and conversion. SE can break down glycosidic and ester bonds, increasing the content of carboxyl and phenolic hydroxyl groups.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rui Yang, Yanmei Dong, Fei Gao, Jingyi Li, Zora Dajic Stevanovic, Hui Li, Lei Shi
Summary: This paper assessed the bioactive compounds and antioxidant capacity of four traditionally used thyme species. The study found a positive correlation between the content of total polyphenols and total flavonoids, and their antioxidant activity. Flavonoids were identified as the key contributors to the high antioxidant capacity of thyme species.
Article
Plant Sciences
Kamil Foss, Katarzyna E. Przybylowicz, Tomasz Sawicki
Summary: Herbs are rich in phenolic compounds, which have beneficial effects on human health. Each herb has its own composition of phenolic compounds and antioxidant properties.
PLANT FOODS FOR HUMAN NUTRITION
(2022)
Article
Food Science & Technology
Agnieszka Micek, Justyna Godos, Achille Cernigliaro, Raffaele Ivan Cincione, Silvio Buscemi, Massimo Libra, Fabio Galvano, Giuseppe Grosso
Summary: The intake of polyphenol-rich beverages is associated with metabolic status, with individuals consuming more of these beverages less likely to have hypertension, type 2 diabetes, and dyslipidemia, particularly with a significant association with hypertension. Current scientific evidence suggests that such beverages may have a positive impact on cardio-metabolic risk factors.
Review
Plant Sciences
Xu Lu, Lijin Huang, Henrik Scheller, Jay D. Keasling
Summary: Terpenoid glycosides derived from medicinal plants have shown significant curative effects in the treatment of various diseases. UDP-dependent glycosyltransferases in plants play a crucial role in the biosynthesis of bioactive glycosides. In this review, the characteristics, evolution, and recent advances in terpenoid UDP-glycosyltransferases (UGTs) in medicinal plants over the past 20 years are summarized, providing a reference for the study of glycosylation and biosynthetic pathways of medicinal terpenoids in plants.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Agronomy
Renata Nurzynska-Wierdak, Andrzej Salata, Magdalena Kniaziewicz
Summary: This research evaluated the morphological and chemical properties of tansy plants growing in various natural habitats, including the content and composition of essential oil, flavonoids, phenolic acids, and antioxidant activity levels. The variability in the chemical composition of tansy was found to be influenced by environmental and genetic factors.
Article
Food Science & Technology
Tatiane Luiza C. Oldoni, Nathalie Merlin, Thariane Carvalho Bicas, Anaclara Prasniewski, Solange Teresinha Carpes, Jociani Ascari, Severino Matias de Alencar, Adna Prado Massarioli, Margarete Dulce Bagatini, Rafael Morales, Gustavo Thome
Summary: For the first time, the antihyperglycemic activity of Moringa oleifera leaves cultivated in Brazil was studied using a bioguided approach, leading to the isolation of phenolic compounds with high antioxidant activity. The ethyl acetate fraction showed significant antioxidant potential and protected the liver and kidney of diabetic rats.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Garland Kgosi More, Stephen Meddows-Taylor, Gerhard Prinsloo
Summary: This study aimed to determine biochemical variations in five Vachellia species and correlate their metabolite profiles to antioxidant activity. V. karroo, V. kosiensis, and V. xanthophloea demonstrated the highest radical scavenging activity among the tested species. Through advanced analytical techniques, various metabolites responsible for the observed antioxidant activity were identified, providing insights into the potential free radical scavenging activities of Vachellia species.
Article
Plant Sciences
J. Malele, R. Kleynhans, G. Prinsloo, B. Matsiliza-Mlathi
Summary: Greyia radlkoferi leaf extracts are proven to treat skin hyperpigmentation effectively without side effects. Seed propagation is easy, but obtaining uniform and quality plant material is challenging. Basal and median cuttings, especially in winter, show better survival and rooting rates, with no impact of donor plant age on rooting success.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Multidisciplinary Sciences
Olusola Bodede, Mamokoena Kuali, Gerhard Prinsloo, Roshila Moodley, Roshini Govinden
Summary: In this study, a C-16-terpene dilactone compound was isolated from the fungal endophytes of Kigelia africana, showing antibacterial potential against Pseudomonas aeruginosa. The bioactive fungal isolate was identified as Neofusicoccum luteum based on genomic DNA sequencing.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Caradee Y. Wright, Thandi Kapwata, Nada Abdelatif, Chiara Batini, Bianca Wernecke, Zamantimande Kunene, Danielle A. Millar, Angela Mathee, Renee Street, Rikesh Panchal, Anna Hansell, Rebecca Cordell, Joshua Vande Hey
Summary: During COVID-19 lockdown in South Africa, households may have increased their exposure to household air pollution (HAP). Some households reduced their electricity usage or switched to dirty fuels. Presence of environmental tobacco smoke, a source of HAP-associated respiratory illnesses, was reported in one third of households. Majority of households reported increased cooking, cleaning, and indoor time, potentially increasing their exposure to HAP.
ANNALS OF GLOBAL HEALTH
(2022)
Article
Immunology
Olubukola Titilope Oyebode, John Oludele Olanlokun, Olamilekan Salami, Ifeanyi Obi, Olusola Bodede, Gerhard Prinsloo, Olufunso Olabode Olorunsogo
Summary: The study compared the efficacy of terpene-rich fractions of F. mucoso root bark on LPS-induced inflammation and mitochondrial health, finding that TRDF was more effective in reducing cytokine levels and improving liver mitochondrial permeability transition compared to TREF. These results suggest that TRDF is a promising anti-inflammatory compound for LPS-induced acute systemic inflammation.
INFLAMMOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Garland Kgosi More, Jacques Vervoort, Paul Anton Steenkamp, Gerhard Prinsloo
Summary: This study investigates twenty medicinal plants with previously established anti-viral activity against a wild-type RVFV using bio-chemometric and analytical techniques. The aim is to identify common compounds in the plants that contribute to the anti-viral effect. Proton nuclear magnetic resonance (H-1 NMR) spectroscopy and multivariate data analysis (MVDA) were used to characterize metabolite profiles. The study identifies potential metabolites, such as trigonelline and vanillic acid, as well as the presence of hydroxylated fatty acids, which have not been previously reported in all tested plants with high anti-RVFV activity. These findings provide insight into the metabolomic profile of anti-RVFV plant extracts and suggest potential targets for the development of antiviral therapeutic agents.
Article
Biochemistry & Molecular Biology
Olusola Bodede, Garland K. More, Roshila Moodley, Paul Steenkamp, Himansu Baijnath, Vinesh Maharaj, Gerhard Prinsloo
Summary: This study presents the first report on the phytochemical investigation of Harpephyllum caffrum Bernh. gum exudate, and identifies a known compound and three new compounds from the gum. The ethanolic extract of the gum is found to be a potent tyrosinase inhibitor, suggesting its potential application in cosmetics.
Article
Agronomy
Elmien Coetser, Elsa S. du Toit, Gerhard Prinsloo
Summary: This study tested the effect of temporary immersion system (TIS) bioreactors on the mass micropropagation of Moringa oleifera. The results showed that TIS bioreactors were effective in increasing both the amount and length of shoots produced, indicating the potential application of TIS bioreactors for Moringa oleifera propagation.
Article
Biochemistry & Molecular Biology
Wilson Bamise Adeosun, Garland K. More, Paul Steenkamp, Gerhard Prinsloo
Summary: This study aimed to determine the impact of seasonal variation and locality on the antiviral properties of Helichrysum aureonitens. The metabolic profile variations of chlorogenic acid derivatives were analyzed using UPLC-qTOF-MS. The extracts of the plants were evaluated for anti-HSV activity, and the most abundant compound was found to be dicaffeoylquinic acid (DCQA), which showed significant antiviral activity against HSV.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wilson Bamise Adeosun, Olusola Bodede, Gerhard Prinsloo
Summary: This study investigated the effect of seasonal variation and geographical location on the antibacterial and antifungal activities of Helichrysum aureonitens. The results showed that plant materials collected from different locations and seasons exhibited varying activities. Additionally, extracts from plants harvested in wetter regions had higher antifungal activity.
Article
Plant Sciences
Motiki M. Mofokeng, Gerhard Prinsloo, Hintsa T. Araya, Stephen O. Amoo, Christian P. du Plooy, Phatu W. Mashela
Summary: Soaking Hypoxis hemerocallidea corms can improve the propagation and development of buds. Through NMR analysis, inhibitory chemical compounds were identified, which may leach out of the corms during the first rain under natural conditions and release bud dormancy.
Article
Biochemistry & Molecular Biology
Ljubica Zupunski, Renee Street, Evgenia Ostroumova, Frank Winde, Susanne Sachs, Gerhard Geipel, Vusumuzi Nkosi, Liacine Bouaoun, Tanya Haman, Joachim Schuz, Angela Mathee
Summary: This study investigated the uranium concentration in hair samples of residents in the Northeast-Soweto area of Johannesburg, South Africa, and found no significant association between the distance from the mine tailings and uranium concentration. However, overall concentrations were higher than in general population samples from other parts of the world. Children had significantly higher uranium concentrations compared to adults. These findings are important for improving mining waste policies and implementing health monitoring and protective measures in at-risk populations.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Review
Food Science & Technology
Lufuno Ethel Nemadodzi, Gudani Millicent Managa, Gerhard Prinsloo
Summary: The Gonimbrasia belina and Cirina forda caterpillars are widely consumed in southern Africa and have evolved from being part of the diet to playing a vital role in income generation. These caterpillars are rich in nutrients and have the potential to provide nutrient-dense complementary foods. However, limited information is available regarding the trees that serve as hosts for these caterpillars.
Article
Microbiology
Lufuno Ethel Nemadodzi, Gerhard Prinsloo
Summary: This study investigated the possible symbiotic relationship between Burkea africana trees and C. forda caterpillars in harsh natural conditions and low-nutrient soils. The findings revealed that C. forda caterpillars not only serve as a source of feed for B. africana trees, but also inoculate the soil with the fungus A. nomius, which suggests a symbiotic and/or synergistic relationship between the two.
Article
Ergonomics
Busisiwe Shezi, Angela Mathee, Laura Alfers, Richard Dobson, Patrick Ndlovu, Tarylee Reddy, Renee A. Street
Summary: This study describes the respiratory outcomes associated with processing plant products among informal traditional medicine traders, highlighting the need for targeted workplace interventions.
INTERNATIONAL JOURNAL OF OCCUPATIONAL SAFETY AND ERGONOMICS
(2022)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)