Prenylated phloroglucinols from Hypericum scruglii, an endemic species of Sardinia (Italy), as new dual HIV-1 inhibitors effective on HIV-1 replication

Evaluation of chemical composition, antioxidant and anti-acetylcholinesterase activities of Hypericum neurocalycinum and Hypericum malatyanum

(2018) E. Eroglu Ozkan et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Phytochemical profile and α-glucosidase inhibitory activity of Sardinian Hypericum scruglii and Hypericum hircinum

(2017) Manuela Mandrone et al.   FITOTERAPIA

Through scaffold modification to 3,5-diaryl-4,5-dihydroisoxazoles: new potent and selective inhibitors of monoamine oxidase B

(2017) Rita Meleddu et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

The Role of HIV-1 Drug-Resistant Minority Variants in Treatment Failure

(2017) Natalia Stella-Ascariz et al.   JOURNAL OF INFECTIOUS DISEASES

Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity

(2017) Sanjeev Kumar V. Vernekar et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vitro anti-herpes simplex virus-2 activity of Salvia desoleana Atzei & V. Picci essential oil

(2017) Valeria Cagno et al.   PLoS One

Chelation Motifs Affecting Metal-dependent Viral Enzymes: N′-acylhydrazone Ligands as Dual Target Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain

(2017) Mauro Carcelli et al.   Frontiers in Microbiology

Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and RDDP functions

(2017) Angela Corona et al.   Pathogens and Disease

Multi-target activity of Hemidesmus indicus decoction against innovative HIV-1 drug targets and characterization of Lupeol mode of action

(2017) Francesca Esposito et al.   Pathogens and Disease

The modification of natural products for medical use

(2017) Zongru Guo   Acta Pharmaceutica Sinica B

New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H

(2016) Angela Corona et al.   ANTIVIRAL RESEARCH

An analysis of FDA-approved drugs: natural products and their derivatives

(2016) Eric Patridge et al.   DRUG DISCOVERY TODAY

Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors

(2016) Anna Schneider et al.   NUCLEIC ACIDS RESEARCH

Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication

(2016) Francesca Esposito et al.   PHYTOMEDICINE

Secondary metabolites of Hypericum species from the Drosanthe and Olympia sections

(2016) C. Cirak et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6

(2016) Angela Corona et al.   PLoS One

Isolation and anticancer, anthelminthic, and antiviral (HIV) activity of acylphloroglucinols, and regioselective synthesis of empetrifranzinans from Hypericum roeperianum

(2015) Serge Alain Tanemossu Fobofou et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Investigation on the sucrose binding pocket of HIV-1 Integrase by molecular dynamics and synergy experiments

(2015) Cristina Tintori et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Kuwanon-L as a New Allosteric HIV-1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation

(2015) Francesca Esposito et al.   CHEMBIOCHEM

Phytochemical analysis and in vitro biological activity of three Hypericum species from the Canary Islands (Hypericum reflexum, Hypericum canariense and Hypericum grandifolium)

(2015) Christian Zorzetto et al.   FITOTERAPIA

Antioxidant and anti-collagenase activity of Hypericum hircinum L.

(2015) Manuela Mandrone et al.   INDUSTRIAL CROPS AND PRODUCTS

Chemical composition and biological activity of Tanacetum audibertii (Req.) DC. (Asteraceae), an endemic species of Sardinia Island, Italy

(2015) Andrea Maxia et al.   INDUSTRIAL CROPS AND PRODUCTS

Structure–Activity Relationship of Pyrrolyl Diketo Acid Derivatives as Dual Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain

(2015) Giuliana Cuzzucoli Crucitti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends

(2015) Peng Zhan et al.   JOURNAL OF MEDICINAL CHEMISTRY

From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors

(2015) Lijia Xu et al.   JOURNAL OF MICROBIOLOGY

Chemical composition and biological activity of the essential oil from Helichrysum microphyllum Cambess. ssp. tyrrhenicum Bacch., Brullo e Giusso growing in La Maddalena Archipelago, Sardinia.

(2015) Luigi Ornano et al.   Journal of Oleo Science

Essential oil composition and biological activity fromArtemisia caerulescenssubsp.densiflora(Viv.) Gamisans ex Kerguélen & Lambinon (Asteraceae), an endemic species in the habitat of La Maddalena Archipelago

(2015) Luigi Ornano et al.   NATURAL PRODUCT RESEARCH

Phytochemical analysis of non-volatile fraction ofArtemisia caerulescenssubsp.densiflora(Viv.) (Asteraceae), an endemic species of La Maddalena Archipelago (Sardinia – Italy)

(2015) Luigi Ornano et al.   NATURAL PRODUCT RESEARCH

A new glucosidic phthalide fromHelichrysum microphyllumsubsp.tyrrhenicumfrom La Maddalena Island (Sardinia, Italy)

(2015) Alessandro Venditti et al.   NATURAL PRODUCT RESEARCH

Filiferol, a chalconoid analogue from Washingtonia filifera possibly involved in the defence against the Red Palm Weevil Rhynchophorus ferrugineus Olivier

(2015) Benedetta Cangelosi et al.   PHYTOCHEMISTRY

Identification of Highly Conserved Residues Involved in Inhibition of HIV-1 RNase H Function by Diketo Acid Derivatives

(2014) Angela Corona et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

2-Aminothiazolones as Anti-HIV Agents That Act as gp120-CD4 Inhibitors

(2014) Marika Tiberi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of Foamy Virus Reverse Transcriptase by Human Immunodeficiency Virus Type 1 RNase H Inhibitors

(2014) Angela Corona et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Can the ever-promising target HIV reverse transcriptase-associated RNase H become a success story for drug development?

(2014) Angela Corona et al.   Future Virology

An inventory of vascular plants endemic to Italy

(2014) LORENZO PERUZZI et al.   Phytotaxa

Molecular basis of human immunodeficiency virus type 1 drug resistance: Overview and recent developments

(2013) Luis Menéndez-Arias   ANTIVIRAL RESEARCH

Natural products: A continuing source of novel drug leads

(2013) Gordon M. Cragg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Molecular Aspects of the RT/drug Interactions. Perspective of Dual Inhibitors

(2013) Simona Distinto et al.   CURRENT PHARMACEUTICAL DESIGN

Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase

(2013) Angela Corona et al.   Future Medicinal Chemistry

Carbamoyl Pyridone HIV-1 Integrase Inhibitors. 2. Bi- and Tricyclic Derivatives Result in Superior Antiviral and Pharmacokinetic Profiles

(2013) Takashi Kawasuji et al.   JOURNAL OF MEDICINAL CHEMISTRY

6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic Acids as Dual Inhibitors of Recombinant HIV-1 Integrase and Ribonuclease H, Synthesized by a Parallel Synthesis Approach

(2013) Roberta Costi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metabolite profiling and fingerprinting of Hypericum species: a comparison of MS and NMR metabolomics

(2013) Andrea Porzel et al.   Metabolomics

Changes in the contents of main secondary metabolites in two TurkishHypericumspecies during plant development

(2013) Cuneyt Cirak et al.   PHARMACEUTICAL BIOLOGY

Chemical composition of Hypericum species from the Taeniocarpium and Drosanthe sections

(2013) Necdet Camas et al.   PLANT SYSTEMATICS AND EVOLUTION

Hypericum hircinumL. components as new single-molecule inhibitors of both HIV-1 reverse transcriptase-associated DNA polymerase and ribonuclease H activities

(2013) Francesca Esposito et al.   Pathogens and Disease

Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

(2012) Jacques J. Kessl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective effect ofHypericum hircinumon doxorubicin-induced cardiotoxicity in rats

(2012) Sudeep Shah et al.   NATURAL PRODUCT RESEARCH

Natural products: An evolving role in future drug discovery

(2011) Bhuwan B. Mishra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cross-resistance Profile of the Novel Integrase Inhibitor Dolutegravir (S/GSK1349572) Using Clonal Viral Variants Selected in Patients Failing Raltegravir

(2011) Filippo Canducci et al.   JOURNAL OF INFECTIOUS DISEASES

Biomimetic synthesis and anti-HIV activity of dimeric phloroglucinols

(2010) Siddheshwar K. Chauthe et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Active site binding modes of dimeric phloroglucinols for HIV-1 reverse transcriptase, protease and integrase

(2010) Pawan Gupta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pharmacological studies in an herbal drug combination of St. John's Wort (Hypericum perforatum) and passion flower (Passiflora incarnata): In vitro and in vivo evidence of synergy between Hypericum and Passiflora in antidepressant pharmacological models

(2010) Bernd L. Fiebich et al.   FITOTERAPIA

Genotypic/phenotypic patterns of HIV-1 integrase resistance to raltegravir

(2010) Filippo Canducci et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Hypericum scruglii sp. nov. (Guttiferae) from Sardinia

(2010) Gianluigi Bacchetta et al.   NORDIC JOURNAL OF BOTANY

Raltegravir: The First HIV Type 1 Integrase Inhibitor

(2009) Charles Hicks et al.   CLINICAL INFECTIOUS DISEASES

Computational Analysis of Human Immunodeficiency Virus (HIV) Type-1 Reverse Transcriptase Crystallographic Models Based on Significant Conserved Residues Found in Highly Active Antiretroviral Therapy (HAART)-Treated Patients (Supplementary Material)

(2009) Stefano Alcaro et al.   CURRENT MEDICINAL CHEMISTRY

Inhibition of HIV-1 Ribonuclease H Activity by Novel Frangula-Emodine Derivatives

(2009) Kharlamova Tatyana et al.   Medicinal Chemistry

Hypericumin infection: Identification of anti-viral and anti-inflammatory constituents

(2009) Diane F. Birt et al.   PHARMACEUTICAL BIOLOGY

HIV-1-Inhibiting Activity of the Essential Oil ofRidolfia segetumandOenanthe crocata

(2009) Carlo Bicchi et al.   PLANTA MEDICA

Phenolic constituents of 17 Hypericum species from Turkey

(2008) Andrija Smelcerovic et al.   BIOCHEMICAL SYSTEMATICS AND ECOLOGY

Anti-HIV-1 activity of phloroglucinol derivative, 6,6′-bieckol, from Ecklonia cava

(2008) Murat Artan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Characterizing the Metabolic Fingerprint and Anti-inflammatory Activity ofHypericum gentianoides

(2008) Matthew L. Hillwig et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

(2008) Vincenzo Summa et al.   JOURNAL OF MEDICINAL CHEMISTRY

A natural history of botanical therapeutics

(2008) Barbara Schmidt et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Anti-inflammatory phloroglucinol derivatives from Hypericum empetrifolium

(2008) Sara L. Crockett et al.   Phytochemistry Letters

Plant-Derived Leading Compounds for Chemotherapy of Human Immunodefiency Virus (HIV) Infection – An Update (1998 – 2007)

(2008) Paul Cos et al.   PLANTA MEDICA