RUNX2 expression in thyroid and breast cancer requires the cooperation of three non-redundant enhancers under the control of BRD4 and c-JUN

CBX4 Suppresses Metastasis via Recruitment of HDAC3 to the Runx2 Promoter in Colorectal Carcinoma

(2016) Xin Wang et al.   CANCER RESEARCH

The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome

(2016) Cailyn H. Spurrell et al.   CELL

Ever-Changing Landscapes: Transcriptional Enhancers in Development and Evolution

(2016) Hannah K. Long et al.   CELL

Nucleotide excision repair is impaired by binding of transcription factors to DNA

(2016) Radhakrishnan Sabarinathan et al.   NATURE

Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer

(2016) Shaokun Shu et al.   NATURE

Hierarchy within the mammary STAT5-driven Wap super-enhancer

(2016) Ha Youn Shin et al.   NATURE GENETICS

Genetic dissection of the α-globin super-enhancer in vivo

(2016) Deborah Hay et al.   NATURE GENETICS

BRD4 localization to lineage-specific enhancers is associated with a distinct transcription factor repertoire

(2016) Zeynab Najafova et al.   NUCLEIC ACIDS RESEARCH

Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy

(2016) M Gugnoni et al.   ONCOGENE

Histone Deacetylase Inhibitors Repress Tumoral Expression of the Proinvasive Factor RUNX2

(2015) V. Sancisi et al.   CANCER RESEARCH

Architectural and Functional Commonalities between Enhancers and Promoters

(2015) Tae-Kyung Kim et al.   CELL

BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia

(2015) Jae-Seok Roe et al.   MOLECULAR CELL

Convergence of Developmental and Oncogenic Signaling Pathways at Transcriptional Super-Enhancers

(2015) Denes Hnisz et al.   MOLECULAR CELL

Ligand-dependent genomic function of glucocorticoid receptor in triple-negative breast cancer

(2015) Zhong Chen et al.   Nature Communications

Induction of USP17 by combining BET and HDAC inhibitors in breast cancer cells

(2015) Gabor Borbely et al.   Oncotarget

Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast Cancer

(2015) Ying Su et al.   Cell Reports

Resistance to everolimus driven by epigenetic regulation of MYC in ER+ breast cancers

(2015) Teeru Bihani et al.   Oncotarget

The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition

(2014) Junwei Shi et al.   MOLECULAR CELL

BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones

(2014) Tomohiko Kanno et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The bone-specific Runx2-P1 promoter displays conserved three-dimensional chromatin structure with the syntenic Supt3h promoter

(2014) A. Rasim Barutcu et al.   NUCLEIC ACIDS RESEARCH

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphoma

(2014) Joydeep Bhadury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opposing TNF-α/IL-1β- and BMP-2-activated MAPK signaling pathways converge on Runx2 to regulate BMP-2-induced osteoblastic differentiation

(2014) R-L Huang et al.   Cell Death & Disease

Bromodomain Protein BRD4 Is Required for Estrogen Receptor-Dependent Enhancer Activation and Gene Transcription

(2014) Sankari Nagarajan et al.   Cell Reports

Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma

(2013) Bjoern Chapuy et al.   CANCER CELL

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

(2013) Warren A. Whyte et al.   CELL

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

Estrogen Receptor α (ERα) and Estrogen Related Receptor α (ERRα) are both transcriptional regulators of the Runx2-I isoform

(2013) Martial Kammerer et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Enhancers: five essential questions

(2013) Len A. Pennacchio et al.   NATURE REVIEWS GENETICS

HDAC inhibitors induce transcriptional repression of high copy number genes in breast cancer through elongation blockade

(2013) Y J Kim et al.   ONCOGENE

Cadherin 6 Is a New RUNX2 Target in TGF-β Signalling Pathway

(2013) Valentina Sancisi et al.   PLoS One

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

(2013) Tim Wang et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Clinical significance of RUNX2 expression in patients with nonsmall cell lung cancer: a 5-year follow-up study

(2013) Hong Li et al.   TUMOR BIOLOGY

Extensive Promoter-Centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation

(2012) Guoliang Li et al.   CELL

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

(2012) Panagis Filippakopoulos et al.   CELL

Runt-related transcription factor 2 in human colon carcinoma: A potent prognostic factor associated with estrogen receptor

(2012) Tomohiko Sase et al.   INTERNATIONAL JOURNAL OF CANCER

RUNX2 in mammary gland development and breast cancer

(2012) Nicola Ferrari et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Runx2 Isoform I Controls a Panel of Proinvasive Genes Driving Aggressiveness of Papillary Thyroid Carcinomas

(2012) Valentina Sancisi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Analysis of long-range chromatin interactions using Chromosome Conformation Capture

(2012) Natalia Naumova et al.   METHODS

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Transcription factors: from enhancer binding to developmental control

(2012) François Spitz et al.   NATURE REVIEWS GENETICS

Complex interactions between cis-regulatory modules in native conformation are critical for Drosophila snail expression

(2011) L. Dunipace et al.   DEVELOPMENT

Ugonin K promotes osteoblastic differentiation and mineralization by activation of p38 MAPK- and ERK-mediated expression of Runx2 and osterix

(2011) Chia-Hsin Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

HDAC Inhibition Decreases the Expression of EGFR in Colorectal Cancer Cells

(2011) Chia-Wei Chou et al.   PLoS One

Multiple enhancers ensure precision of gap gene-expression patterns in the Drosophila embryo

(2011) M. W. Perry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shadow Enhancers Foster Robustness of Drosophila Gastrulation

(2010) Michael W. Perry et al.   CURRENT BIOLOGY

Runx2 Deficiency in Mice Causes Decreased Thyroglobulin Expression and Hypothyroidism

(2010) Toyoshi Endo et al.   MOLECULAR ENDOCRINOLOGY

Ectopic Runx2 Expression in Mammary Epithelial Cells Disrupts Formation of Normal Acini Structure: Implications for Breast Cancer Progression

(2009) J. Pratap et al.   CANCER RESEARCH

Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions

(2009) J Akech et al.   ONCOGENE

Pharmacologic suppression of MITF expression via HDAC inhibitors in the melanocyte lineage

(2008) Satoru Yokoyama et al.   Pigment Cell & Melanoma Research