Thrombosis during pregnancy: Risks, prevention, and treatment for mother and fetus-harvesting the power of omic technology, biomarkers and in vitro or in vivo models to facilitate the treatment of thrombosis

Pravastatin for the Prevention of Preeclampsia in High-Risk Pregnant Women

(2016) Maged M. Costantine et al.   OBSTETRICS AND GYNECOLOGY

Angiogenic biomarkers in pregnancy: defining maternal and fetal health

(2015) Lene G. Rasmussen et al.   ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA

Unravelling the theories of pre-eclampsia: are the protective pathways the new paradigm?

(2015) Asif Ahmed et al.   BRITISH JOURNAL OF PHARMACOLOGY

PreImplantation Factor bolsters neuroprotection via modulating Protein Kinase A and Protein Kinase C signaling

(2015) M Mueller et al.   CELL DEATH AND DIFFERENTIATION

First-Trimester Uterine Artery Doppler Analysis in the Prediction of Later Pregnancy Complications

(2015) Su Lynn Khong et al.   DISEASE MARKERS

First-Trimester 3-Dimensional Power Doppler Placental Vascularization Indices From the Whole Placenta Versus the Placental Bed to Predict Preeclampsia

(2015) Karen E. Hannaford et al.   JOURNAL OF ULTRASOUND IN MEDICINE

Promising prognostic markers of Preeclampsia: New avenues in waiting

(2015) Anshul Jadli et al.   THROMBOSIS RESEARCH

Nitroso-Redox Balance and Mitochondrial Homeostasis Are Regulated by STOX1, a Pre-Eclampsia-Associated Gene

(2014) Ludivine Doridot et al.   ANTIOXIDANTS & REDOX SIGNALING

Preimplantation Factor (PIF) Promotes Human Trophoblast Invasion1

(2014) Hadia Moindjie et al.   BIOLOGY OF REPRODUCTION

Preeclampsia

(2014) Gary Stocks   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

Added Value of Angiogenic Factors for the Prediction of Early and Late Preeclampsia in the First Trimester of Pregnancy

(2014) Francesca Crovetto et al.   FETAL DIAGNOSIS AND THERAPY

Microsatellite Polymorphism in the Heme Oxygenase-1 Promoter Is Associated With Nonsevere and Late-Onset Preeclampsia

(2014) Tea Kaartokallio et al.   HYPERTENSION

Advances in the pathophysiology of pre-eclampsia and related podocyte injury

(2014) Iasmina M. Craici et al.   KIDNEY INTERNATIONAL

Recurring Complications in Second Pregnancy

(2014) Jacob Alexander Lykke et al.   OBSTETRICS AND GYNECOLOGY

IFPA Senior Award Lecture: Making sense of pre-eclampsia – Two placental causes of preeclampsia?

(2014) C.W. Redman et al.   PLACENTA

Insight into PreImplantation Factor (PIF*) Mechanism for Embryo Protection and Development: Target Oxidative Stress and Protein Misfolding (PDI and HSP) through Essential RIPK Binding Site

(2014) Eytan R. Barnea et al.   PLoS One

Placental Genome and Maternal-Placental Genetic Interactions: A Genome-Wide and Candidate Gene Association Study of Placental Abruption

(2014) Marie Denis et al.   PLoS One

PreImplantation factor promotes neuroprotection by targeting microRNA let-7

(2014) M. Mueller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-Term Risk to Develop Hypertension in Women With Former Preeclampsia

(2014) Chahinda Ghossein-Doha et al.   Reproductive Sciences

Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia

(2014) I. A. Buhimschi et al.   Science Translational Medicine

Clinical syndromes associated with acquired antithrombin deficiency via microvascular leakage and the related risk of thrombosis

(2014) Sara Ornaghi et al.   THROMBOSIS RESEARCH

New Developments in the Pathogenesis of Preeclampsia

(2013) Mihran V. Naljayan et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Heme Oxygenase Inhibition Increases Blood Pressure in Pregnant Rats

(2013) E. M. George et al.   AMERICAN JOURNAL OF HYPERTENSION

Long-term alterations in maternal plasma proteome after sFlt1–induced preeclampsia in mice

(2013) Egle Bytautiene et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Cardiovascular risk factors in women who had hypertensive disorders late in pregnancy: a cohort study

(2013) Wietske Hermes et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Future therapies for pre-eclampsia: beyond treading water

(2013) Christine Fenton et al.   AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY

Integrating multiple ‘omics’ analyses identifies serological protein biomarkers for preeclampsia

(2013) Linda Y Liu et al.   BMC Medicine

Pregnancy Characteristics and Women's Future Cardiovascular Health: An Underused Opportunity to Improve Women's Health?

(2013) Janet W. Rich-Edwards et al.   EPIDEMIOLOGIC REVIEWS

Genetic variants in pre-eclampsia: a meta-analysis

(2013) A.J. Buurma et al.   HUMAN REPRODUCTION UPDATE

Preeclampsia-Like Symptoms Induced in Mice by Fetoplacental Expression of STOX1 Are Reversed by Aspirin Treatment

(2013) Ludivine Doridot et al.   HYPERTENSION

Redefining Preeclampsia Using Placenta-Derived Biomarkers

(2013) Anne Cathrine Staff et al.   HYPERTENSION

Gestational Hypoxia Induces Preeclampsia-Like Symptoms via Heightened Endothelin-1 Signaling in Pregnant Rats

(2013) Jianjun Zhou et al.   HYPERTENSION

Genome-wide methylation profiling demonstrates hypermethylation in maternal leukocyte DNA in preeclamptic compared to normotensive pregnancies

(2013) Wendy M. White et al.   HYPERTENSION IN PREGNANCY

The effect of maternal pravastatin therapy on adverse sensorimotor outcomes of the offspring in a murine model of preeclampsia

(2013) Alissa R. Carver et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Widespread DNA hypomethylation at gene enhancer regions in placentas associated with early-onset pre-eclampsia

(2013) J. D. Blair et al.   MOLECULAR HUMAN REPRODUCTION

Fetomaternal immune cross-talk and its consequences for maternal and offspring's health

(2013) Petra C Arck et al.   NATURE MEDICINE

Cardiovascular Disease Risk Factors in Women With a History of Early-Onset Preeclampsia

(2013) Bas B. van Rijn et al.   OBSTETRICS AND GYNECOLOGY

MicroRNA expression profiles in placenta with severe preeclampsia using a PNA-based microarray

(2013) S.-Y. Choi et al.   PLACENTA

Measurement of placental bed vascularization in the first trimester, using 3D-power-Doppler, for the detection of pregnancies at-risk for fetal and maternal complications

(2013) E. Hafner et al.   PLACENTA

IFPA Meeting 2013 Workshop Report II: Use of ‘omics’ in understanding placental development, bioinformatics tools for gene expression analysis, planning and coordination of a placenta research network, placental imaging, evolutionary approaches to understanding pre-eclampsia

(2013) W.E. Ackerman et al.   PLACENTA

PreImplantation factor (PIF) detection in maternal circulation in early pregnancy correlates with live birth (bovine model)

(2013) Sivakumar Ramu et al.   Reproductive Biology and Endocrinology

Effects of Pravastatin on Angiogenic and Placental Hypoxic Imbalance in a Mouse Model of Preeclampsia

(2013) Antonio F. Saad et al.   Reproductive Sciences

Vascular associated gene variants in patients with preeclampsia: results from the Danish National Birth Cohort

(2012) JACOB A. LYKKE et al.   ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA

Fetal growth and later maternal death, cardiovascular disease and diabetes

(2012) JACOB A. LYKKE et al.   ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA

A deficiency in haem oxygenase-1 induces foetal growth restriction by placental vasculature defects

(2012) Ronald J Wong et al.   ACTA PAEDIATRICA

PreImplantation Factor (PIF) orchestrates systemic antiinflammatory response by immune cells: effect on peripheral blood mononuclear cells

(2012) Eytan R. Barnea et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Molecular genetics of preeclampsia and HELLP syndrome — A review

(2012) Jiska Jebbink et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Associations of Pregnancy Complications With Calculated Cardiovascular Disease Risk and Cardiovascular Risk Factors in Middle Age

(2012) Abigail Fraser et al.   CIRCULATION

Endothelin as a final common pathway in the pathophysiology of preeclampsia

(2012) Eric M. George et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Statins and Pregnancy

(2012) Edouard Lecarpentier et al.   DRUGS

Functional ‘-omics’ in intrauterine growth restriction: novel insights into child development

(2012) Santo Davide Ferrara et al.   Expert Review of Proteomics

Combined Screening for Preeclampsia and Small for Gestational Age at 11–13 Weeks

(2012) Leona C.Y. Poon et al.   FETAL DIAGNOSIS AND THERAPY

eNOS Deficiency Acts through Endothelin to Aggravate sFlt-1-Induced Pre-Eclampsia-Like Phenotype

(2012) F. Li et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Thrombophilias and adverse pregnancy outcomes: results from the Danish National Birth Cohort

(2012) J. A. LYKKE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Intrauterine environment and multiple sclerosis: a population- based case-control study

(2012) Beth A Mueller et al.   Multiple Sclerosis Journal

Identification of Differential Gene Expression Profiles in Placentas from Preeclamptic Pregnancies Versus Normal Pregnancies by DNA Microarrays

(2012) Tao Meng et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Genome-Wide Association Scan Identifies a Risk Locus for Preeclampsia on 2q14, Near the Inhibin, Beta B Gene

(2012) Matthew P. Johnson et al.   PLoS One

Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface

(2012) B. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PreImplantation Factor (PIF) promoting role in embryo implantation: increases endometrial Integrin-α2β3, amphiregulin and epiregulin while reducing betacellulin expression via MAPK in decidua

(2012) Eytan R Barnea et al.   Reproductive Biology and Endocrinology

Preimplantation factor inhibits circulating natural killer cell cytotoxicity and reduces CD69 expression: implications for recurrent pregnancy loss therapy

(2012) Roumen G. Roussev et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Endothelin type A receptor antagonist attenuates placental ischemia–induced hypertension and uterine vascular resistance

(2011) Kiran B. Tam Tam et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Cord blood metabolomic profiling in intrauterine growth restriction

(2011) Donata Favretto et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Birth Characteristics and Subsequent Risks of Maternal Cardiovascular Disease

(2011) Anna-Karin Edstedt Bonamy et al.   CIRCULATION

Pilot Study of Extracorporeal Removal of Soluble Fms-Like Tyrosine Kinase 1 in Preeclampsia

(2011) Ravi Thadhani et al.   CIRCULATION

Metabolomics in neonatology and pediatrics

(2011) V. Fanos et al.   CLINICAL BIOCHEMISTRY

Natural coagulation inhibitors and active protein c resistance in preeclampsia

(2011) Cengiz Demir et al.   Clinics

Tumor necrosis factor α induces a model of preeclampsia in pregnant baboons (Papio hamadryas)

(2011) Neroli S. Sunderland et al.   CYTOKINE

A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia

(2011) N. M. Hunkapiller et al.   DEVELOPMENT

Changes in amniotic fluid and umbilical cord serum proteomic profiles of foetuses with intrauterine growth retardation

(2011) Daniela Cecconi et al.   ELECTROPHORESIS

Notch1 mediates uterine stromal differentiation and is critical for complete decidualization in the mouse

(2011) Yalda Afshar et al.   FASEB JOURNAL

Induction of Heme Oxygenase 1 Attenuates Placental Ischemia–Induced Hypertension

(2011) Eric M. George et al.   HYPERTENSION

The relationship between circulating endothelin-1, soluble fms-like tyrosine kinase-1 and soluble endoglin in preeclampsia

(2011) P K Aggarwal et al.   JOURNAL OF HUMAN HYPERTENSION

Drug development in preeclampsia: a ‘no go’ area?

(2011) Thomas R. Everett et al.   Journal of Maternal-Fetal & Neonatal Medicine

miRNA expression profiling in formalin-fixed and paraffin-embedded placental tissue samples from pregnancies with severe preeclampsia

(2011) Frank Noack et al.   JOURNAL OF PERINATAL MEDICINE

PreImplantation Factor (PIF) correlates with early mammalian embryo development-bovine and murine models

(2011) Christopher W Stamatkin et al.   Reproductive Biology and Endocrinology

Preimplantation factor negates embryo toxicity and promotes embryo development in culture

(2011) Christopher W. Stamatkin et al.   REPRODUCTIVE BIOMEDICINE ONLINE

New insights into the etiology of preeclampsia: identification of key elusive factors for the vascular complications

(2011) Asif Ahmed   THROMBOSIS RESEARCH

Preimplantation factor promotes first trimester trophoblast invasion

(2010) Christina M. Duzyj et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

A genomic and proteomic investigation of the impact of preimplantation factor on human decidual cells

(2010) Michael J. Paidas et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Early or Recurrent Preterm Birth and Maternal Cardiovascular Disease Risk

(2010) Janet M. Catov et al.   ANNALS OF EPIDEMIOLOGY

Preterm delivery and risk of subsequent cardiovascular morbidity and type-II diabetes in the mother

(2010) JA Lykke et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Soluble FLT1 sensitizes endothelial cells to inflammatory cytokines by antagonizing VEGF receptor-mediated signalling

(2010) T. Cindrova-Davies et al.   CARDIOVASCULAR RESEARCH

Hypertension in Pregnancy and Later Cardiovascular Risk

(2010) Pål R. Romundstad et al.   CIRCULATION

Angiotensin Receptor Agonistic Autoantibody–Mediated Tumor Necrosis Factor-α Induction Contributes to Increased Soluble Endoglin Production in Preeclampsia

(2010) Cissy Chenyi Zhou et al.   CIRCULATION

Preeclampsia and Cardiovascular Disease Death

(2010) Morgana L. Mongraw-Chaffin et al.   HYPERTENSION

Robust Early Pregnancy Prediction of Later Preeclampsia Using Metabolomic Biomarkers

(2010) Louise C. Kenny et al.   HYPERTENSION

Preeclampsia and future maternal health

(2010) David M Carty et al.   JOURNAL OF HYPERTENSION

Mortality of mothers from cardiovascular and non-cardiovascular causes following pregnancy complications in first delivery

(2010) Jacob A. Lykke et al.   PAEDIATRIC AND PERINATAL EPIDEMIOLOGY

Distribution of Notch family proteins in intrauterine growth restriction and hypertension complicated human term placentas

(2009) Zeliha Sahin et al.   ACTA HISTOCHEMICA

Toll-Like Receptor 3 Activation During Pregnancy Elicits Preeclampsia-Like Symptoms in Rats

(2009) J. H. Tinsley et al.   AMERICAN JOURNAL OF HYPERTENSION

The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity

(2009) Stacey Beck et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Atrial natriuretic peptide (ANP) in preeclampsia-like syndrome in a rat model

(2009) F. Casper et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Hypertensive Pregnancy Disorders and Subsequent Cardiovascular Morbidity and Type 2 Diabetes Mellitus in the Mother

(2009) Jacob A. Lykke et al.   HYPERTENSION

First-Trimester Prediction of Hypertensive Disorders in Pregnancy

(2009) Leona C.Y. Poon et al.   HYPERTENSION

Hypertension in Response to Autoantibodies to the Angiotensin II Type I Receptor (AT1-AA) in Pregnant Rats

(2009) Babbette LaMarca et al.   HYPERTENSION

Recombinant Vascular Endothelial Growth Factor 121 Infusion Lowers Blood Pressure and Improves Renal Function in Rats With PlacentalIschemia-Induced Hypertension

(2009) Jeffrey S. Gilbert et al.   HYPERTENSION

Role of Endothelin in Mediating Soluble fms-Like Tyrosine Kinase 1–Induced Hypertension in Pregnant Rats

(2009) Sydney R. Murphy et al.   HYPERTENSION

Reduction of circulating soluble Flt-1 alleviates preeclampsia-like symptoms in a mouse model

(2009) Astrid Bergmann et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial

(2009) Paul M Ridker et al.   LANCET

Pulmonary embolism in pregnancy

(2009) Ghada Bourjeily et al.   LANCET

Early-Onset Preeclampsia and the Prevalence of Postpartum Metabolic Syndrome

(2009) Eva Stekkinger et al.   OBSTETRICS AND GYNECOLOGY

Hypertensive Disorders in Pregnancy and Subsequently Measured Cardiovascular Risk Factors

(2009) Elisabeth B. Magnussen et al.   OBSTETRICS AND GYNECOLOGY

Gabor Than Award Lecture 2008: Pre-eclampsia – From Placental Oxidative Stress to Maternal Endothelial Dysfunction

(2009) T. Cindrova-Davies   PLACENTA

Placental Stress and Pre-eclampsia: A Revised View

(2009) C.W.G. Redman et al.   PLACENTA

Inhibitors of Heme Oxygenase Reduce Invasion of Human Primary Cytotrophoblast Cells In vitro

(2009) D. McCaig et al.   PLACENTA

Rheological and Physiological Consequences of Conversion of the Maternal Spiral Arteries for Uteroplacental Blood Flow during Human Pregnancy

(2009) G.J. Burton et al.   PLACENTA

Cellular mRNA expressions of anti-oxidant factors in the blood of preeclamptic women

(2009) Masamitsu Nakamura et al.   PRENATAL DIAGNOSIS

Cardiovascular sequelae of preeclampsia/eclampsia: A systematic review and meta-analyses

(2008) Sarah D. McDonald et al.   AMERICAN HEART JOURNAL

Proteomic profiling of urine identifies specific fragments of SERPINA1 and albumin as biomarkers of preeclampsia

(2008) Irina A. Buhimschi et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Heme Oxygenase-1 and Carbon Monoxide in Vascular Pathobiology

(2008) Jozef Dulak et al.   CIRCULATION

Hypertension in Response to Chronic Reductions in Uterine Perfusion in Pregnant Rats

(2008) Babbette LaMarca et al.   HYPERTENSION

Antithrombin plasma levels decrease is associated with preeclampsia worsening

(2008) M. MARIETTA et al.   International Journal of Laboratory Hematology

Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice

(2008) Cissy C Zhou et al.   NATURE MEDICINE