Article
Cardiac & Cardiovascular Systems
Jinsong Gao, Xianghua Huang, Wen Di, Xiaojing Dong, Wenli Gou, Hong Shi, Zilian Wang, Angela Dietl, Sonja Grill, Martin Hund
Summary: This study demonstrates that the sFlt-1/PlGF ratio cutoff of 38 has high predictive performance for short-term prediction of preeclampsia in Chinese women, helping to reduce unnecessary hospitalization for low-risk women.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jin Zhang, Wei Hua, Xinyuan Zhao, Fan Yang, Ting Guo, Jianhua Zhang, Xuerong Zheng, Wanqi Liang
Summary: This study confirmed the protective effects of paeoniflorin against preeclampsia-related endothelial damage by upregulating VEGFA to alleviate the injury caused by overexpression of sFlt-1 and sEng.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Lucia Perez-Roque, Elena Nunez-Gomez, Alicia Rodriguez-Barbero, Carmelo Bernabeu, Jose M. Lopez-Novoa, Miguel Pericacho
Summary: Preeclampsia is a pregnancy-specific disease characterized by hypertension, with its etiopathogenesis related to abnormal placentation and the release of soluble factors. High plasma levels of soluble endoglin (sEng) may serve as an early diagnostic and prognostic biomarker for the disease, impacting the pathophysiology of preeclampsia significantly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Antonella Iannaccone, Beatrix Reisch, Rainer Kimmig, Boerge Schmidt, Laven Mavarani, Marvin Darkwah Oppong, Bartosz Tyczynski, Mark Dzietko, Michael Jahn, Alexandra Gellhaus, Angela Koeninger
Summary: This study evaluated the feasibility of therapeutic plasma exchange (TPE) compared to standard-of-care treatment in delaying preterm delivery in early-onset preeclampsia (eoPE). The results showed that TPE could prolong the duration of pregnancy and reduce the levels of sFlt-1 and sEng in maternal serum without impairing neonatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Jessica R. Zolton, Lindsey A. Sjaarda, Sunni L. Mumford, Elizabeth A. DeVilbiss, Keewan Kim, Kerry S. Flannagan, Jeannie G. Radoc, Neil J. Perkins, Robert M. Silver, Jean Wactawski-Wende, Micah J. Hill, Alan H. DeCherney, Enrique F. Schisterman
Summary: Circulating VEGF and sFLT-1 did not vary significantly across the menstrual cycle in normal ovulating women, and may not be useful as peripheral biomarkers of endometrial changes during the menstrual cycle. Plasma may be the preferred medium for measuring circulating VEGF in reproductive-age women, regardless of menstrual cycle phase.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Samuel Parry, Benjamin A. Carper, William A. Grobman, Ronald J. Wapner, Judith H. Chung, David M. Haas, Brian Mercer, Robert M. Silver, Hyagriv N. Simhan, George R. Saade, Uma M. Reddy, Corette B. Parker
Summary: The study aimed to investigate placental physiology and identify novel biomarkers related to adverse pregnancy outcomes. The findings indicate that certain analytes in maternal serum during early pregnancy are associated with adverse pregnancy outcomes, but the test characteristics of these analytes do not support their use as clinical biomarkers for predicting adverse pregnancy outcomes, either alone or in combination with maternal clinical characteristics.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Environmental Sciences
Karen Hettfleisch, Mariana Azevedo Carvalho, Mara Sandra Hoshida, Luciana Duzolina Manfre Pastro, Silvia Regina Dias Medici Saldiva, Sandra Elisabete Vieira, Rossana Pulcineli Vieira Francisco, Paulo Hilario Nascimento Saldiva, Lisandra Stein Bernardes
Summary: This study found that the air pollutant NO2 is positively correlated with the sFlt1/PLGF ratio and negatively correlated with PLGF concentration in pregnant women's blood. This suggests that increased levels of NO2 may lead to an antiangiogenic state, affecting pregnancy outcomes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Obstetrics & Gynecology
Ele Hanson, Kristiina Rull, Kaspar Ratnik, Pille Vaas, Pille Teesalu, Maris Laan
Summary: The study aimed to evaluate the value of screening for maternal serum sFlt-1/PlGF ratio in predicting the development of preeclampsia during the third trimester. The results showed that testing sFlt-1/PlGF ratio between 180-259 gestational days could detect approximately half of subsequent preeclampsia cases, with the highest detection rate observed at 225-238 gestational days.
JOURNAL OF PERINATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Anne Dathan-Stumpf, Victoria Czarnowsky, Vicky Hein, Theresa Andraczek, Holger Stepan
Summary: This real-world data analysis found a correlation between the soluble fms-like tyrosine kinase-1 to placental growth factor ratio and the severity of preeclampsia and placental dysfunction, providing a useful tool for stratifying patients' outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Cell Biology
Georgia Margioula-Siarkou, Chrysoula Margioula-Siarkou, Stamatios Petousis, Kosmas Margaritis, Eleftherios Vavoulidis, Giuseppe Gullo, Maria Alexandratou, Konstantinos Dinas, Alexandros Sotiriadis, Georgios Mavromatidis
Summary: Preeclampsia, a leading cause of maternal and fetal morbidity and mortality, involves dysfunction of the placenta leading to imbalance of angiogenic and anti-angiogenic factors. Endoglin and soluble endoglin play significant roles in the pathophysiology of preeclampsia by interfering with signaling pathways that regulate angiogenesis and endothelial function. Further research is needed to explore the potential prognostic, diagnostic, and therapeutic implications of these molecules in clinical management of preeclampsia.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Medicine, General & Internal
Thanaphan Thitivichienlert, Chadakarn Phaloprakarn, Thananda Trakarnvanich
Summary: Preeclampsia can lead to renal function impairment, but the currently available biomarkers do not provide predictive value for long-term renal function, blood pressure, and urine albumin/creatinine ratio in patients with preeclampsia.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Obstetrics & Gynecology
Kazuya Mimura, Takuji Tomimatsu, Masayuki Endo, Tadashi Kimura
Summary: In early pregnancy, the sFlt-1/PlGF ratio may be used to differentiate between exacerbation of systemic lupus erythematosus and preeclampsia.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Medicine, Research & Experimental
Abhineet M. Sharma, Robert Birkett, Erika T. Lin, Linda M. Ernst, William A. Grobman, Suchitra Swaminathan, Hiam Abdala-Valencia, Alexander Misharin, Elizabeth T. Bartom, Karen K. Mestan
Summary: Placental lesions are associated with unique changes in gene expression in fetal monocytes and monocyte subsets. Fetal monocytes exposed to acute placental inflammation upregulate biological processes related to monocyte activation, monocyte chemotaxis, and platelet function, while monocytes exposed to maternal vascular malperfusion lesions downregulate these processes. Intermediate monocytes might be a source of mitogens implicated in different outcomes related to prematurity.
Article
Biochemistry & Molecular Biology
Madalina Nicoleta Nan, Alvaro Garcia-Osuna, Josefina Mora, Cristina Trilla, Assumpta Antonijuan, Vanesa Orantes, Monica Cruz-Lemini, Francisco Blanco-Vaca, Elisa Llurba
Summary: Algorithms for first-trimester prediction of pre-eclampsia lack sensitivity for predicting late-onset pre-eclampsia and other placental complications. This study aimed to assess the screening performance of biomarkers in the prediction of adverse obstetric outcomes related to placental insufficiency. PlGF, sFlt-1, NT-proBNP, and uric acid measurements combined with maternal factors improved the prediction of complications.
Review
Peripheral Vascular Disease
Juilee S. Deshpande, Deepali P. Sundrani, Akriti S. Sahay, Sanjay A. Gupte, Sadhana R. Joshi
Summary: Preeclampsia is a dangerous disorder for pregnant women and neonates that requires specific and reliable biomarkers for early prediction. The imbalance of angiogenic factors contributes to the pathophysiology. Applying a multivariable model from the start of pregnancy throughout gestation is essential for early and specific prediction of preeclampsia.
HYPERTENSION RESEARCH
(2021)
Article
Obstetrics & Gynecology
Nuria Banos, Xavier P. Burgos-Artizzu, Brenda Valenzuela-Alcaraz, David Coronado-Gutierrez, Alvaro Perez-Moreno, Julia Ponce, Eduard Gratacos, Montse Palacio
Summary: This study evaluated the reproducibility of ultrasound cervical length (CL) measurement in the second trimester and found moderate agreement among intra- and inter-observers. However, wide disagreements were observed when using specific cutoffs to classify patients, highlighting the importance of training and quality assessments when considering the universal application of CL measurement for screening.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Immunology
Iolanda Jordan, Mariona Fernandez de Sevilla, Victoria Fumado, Quique Bassat, Elisenda Bonet-Carne, Claudia Fortuny, Aleix Garcia-Miquel, Cristina Jou, Cristina Adroher, Maria Mele Casas, Monica Girona-Alarcon, Maria Hernandez Garcia, Gemma Pons Tomas, Sara Ajanovic, Sara Arias, Nuria Balanza, Barbara Baro, Pere Millat-Martinez, Rosauro Varo, Sergio Alonso, Enric Alvarez-Lacalle, Daniel Lopez, Joana Claverol, Marta Cubells, Pedro Brotons, Anna Codina, Daniel Cuadras, Patricia Bruijning-Verhagen, Saul Faust, Alasdair Munro, Carmen Munoz-Almagro, Marti Catala, Clara Prats, Juan Jose Garcia-Garcia, Eduard Gratacos
Summary: The transmission rate of SARS-CoV-2 infection among children and adult staff in summer schools in Barcelona was lower than the general population, indicating that schools under strict preventive measures are unlikely to be significant sources of transmission.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Acoustics
M. Perez-Cruz, O. Gomez, M. Gibert, N. Masoller, E. Marimon, D. Lip-Sosa, M. Bennasar, E. Bonet-Carne, M. D. Gomez-Roig, J. M. Martinez-Crespo, E. Gratacos, E. Eixarch
Summary: The study aimed to evaluate corpus callosum size in fetuses with isolated major congenital heart defects using neurosonography. Findings revealed that fetuses with major CHD had a smaller corpus callosum compared to controls, particularly in the subgroup with expected poorer brain oxygen supply. This suggests sonographic corpus callosum size could serve as a clinically feasible marker of abnormal white matter development in congenital heart defects.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Genetics & Heredity
Rebecca N. Spencer, Kurt Hecher, Gill Norman, Karel Marsal, Jan Deprest, Alan Flake, Francesc Figueras, Christoph Lees, Steve Thornton, Kathleen Beach, Marcy Powell, Fatima Crispi, Anke Diemert, Neil Marlow, Donald M. Peebles, Magnus Westgren, Helena Gardiner, Eduard Gratacos, Jana Brodszki, Albert Batista, Helen Turier, Mehali Patel, Beverley Power, James Power, Gillian Yaz, Anna L. David
Summary: This study aimed to improve safety monitoring for developing pregnancy drugs, devices, and interventions by creating AE terminology. An international multidisciplinary group filled gaps in definitions and severity grading through a modified Delphi process, allowing systematic consistent AE assessment in pregnancy trials.
PRENATAL DIAGNOSIS
(2022)
Article
Acoustics
M. L. Boutet, E. Eixarch, P. Ahumada-Droguett, A. Nakaki, F. Crovetto, M. S. Civico, A. Borras, D. Manau, E. Gratacos, F. Crispi, G. Casals
Summary: The study found that fetuses conceived by assisted reproductive technology (ART) exhibit a distinct pattern of cortical development, with more pronounced changes in brain reorganization in those conceived following fresh embryo transfer. Infants conceived by ART also showed suboptimal neurodevelopment compared to spontaneously conceived infants, especially in the fresh embryo transfer group.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Gabriel Bernardino, Alvaro Sepulveda-Martinez, Merida Rodriguez-Lopez, Susanna Prat-Gonzalez, Carolina Pajuelo, Rosario J. Perea, Maria T. Caralt, Francesca Crovetto, Miguel A. Gonzalez Ballester, Marta Sitges, Bart Bijnens, Fatima Crispi
Summary: Being born small for gestational age (SGA) is associated with increased risk of cardiovascular mortality and lower exercise tolerance. This study aimed to assess the impact of central obesity on cardiac remodeling and dysfunction in young adults born SGA.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Chemistry, Multidisciplinary
Andrea Urru, Ayako Nakaki, Oualid Benkarim, Francesca Crovetto, Laura Segales, Valentin Comte, Nadine Hahner, Elisenda Eixarch, Eduard Gratacos, Fatima Crispi, Gemma Piella, Miguel A. Gonzalez Ballester
Summary: In this study, a new pipeline for fetal and neonatal segmentation has been developed, along with the creation of two new fetal atlases. The results show that the use of the new templates and segmentation strategy leads to accurate results, outperforming a reference pipeline in early and late-onset fetal brain segmentation.
Letter
Medicine, General & Internal
Stefania Triunfo, Roberta Mayer, Michelangela Danza, Antonio Lanzone
Article
Nutrition & Dietetics
Irene Casas, Ayako Nakaki, Rosalia Pascal, Sara Castro-Barquero, Lina Youssef, Mariona Genero, Leticia Benitez, Marta Larroya, Maria Laura Boutet, Giulia Casu, Alex Gomez-Gomez, Oscar J. Pozo, Ivette Morilla, Anabel Martinez-aran, Eduard Vieta, Maria Dolores Gomez-Roig, Rosa Casas, Ramon Estruch, Eduard Gratacos, Fatima Crispi, Francesca Crovetto
Summary: A study investigated the effects of a Mediterranean diet intervention on stress, well-being, and sleep quality in pregnant women. The results showed that pregnant women who followed a Mediterranean diet had reduced stress and anxiety, and improved sleep quality.
Article
Obstetrics & Gynecology
Anna Peguero, Lorena Fernandez-Blanco, Edurne Mazarico, Leticia Benitez, Alba Gonzalez, David Boada, Cristina Borras, Lina Youssef, Fatima Crispi, Sandra Hernandez, Francesc Figueras
Summary: This study aims to assess the predictive value of Doppler ultrasound, angiogenic factors, and multi-parametric risk-score models for adverse neonatal outcomes in patients with early-onset severe preeclampsia. The placental growth factor (PlGF) showed the best discrimination between neonatal outcomes among angiogenic factors. The combination of maternal risk scoring (PREP-L score) with advanced Doppler or PlGF levels performs well in predicting adverse neonatal outcome.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2023)
Article
Medicine, General & Internal
Julia Ponce, Teresa Cobo, Clara Murillo, Anna Gonce, Nadia Dominguez, Francesca Crovetto, Laura Guirado, Montse Palacio, Mar Bennasar
Summary: Preterm prelabour rupture of membranes (PPROMs) before viability carries significant perinatal mortality and morbidity. Clinical management and prenatal counselling are a challenge, especially in twin pregnancies, due to scarce evidence on how previable PPROM affects this population. This study aimed to describe pregnancy outcomes of twin pregnancies complicated with previable PPROM and evaluate potential prognostic factors that may predict perinatal mortality. The overall survival rate of twin pregnancies complicated with previable PPROM is poor but similar to singletons. No prognostic factors, apart from achieving periviability, were identified as individual predictors of perinatal mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Elisenda Eixarch, Miriam Illa, Raquel Fucho, Kambiz Rezaei, Ameth Hawkins-Villarreal, Sara Bobillo-Perez, Paula C. Randanne, Miguel Moran, Marina Chorda, Sergio Sanchez-Martinez, Yolanda J. D. de Roo-Puente, Maria del Mar Velilla, Ruth del Rio, Marc Gallego, Daniel Sanin-Ramirez, Victor Narvaez, Fatima Crispi, Elisenda Bonet-Carne, Eduard Gratacos
Summary: This study describes the development of an artificial placenta (AP) system in sheep, facing challenges and bottlenecks but ultimately achieving survival up to one week. A total of 28 fetal sheep were transferred to the AP system, with progressively increased survival goals. Results showed improved success rates over the course of the study, but common issues still hindered the system in the first two groups. The study concludes that developing a reproducible AP system requires significant time, effort, and a highly multidisciplinary team.
Article
Obstetrics & Gynecology
M. L. Boutet, G. Casals, B. Valenzuela-Alcaraz, L. Garcia-Otero, F. Crovetto, A. Borras, M. S. Civico, D. Manau, E. Gratacos, F. Crispi
Summary: A study comparing fetuses conceived spontaneously and through IVF found that subfertile couples' fetuses did not show signs of cardiac remodeling, unlike those conceived through IVF. Fetuses from subfertile couples showed similar cardiac structure and function to those from fertile couples.
HUMAN REPRODUCTION
(2023)
Article
Computer Science, Information Systems
Freddy L. Bueno-Palomeque, Konstantinos A. Mountris, Nuria Ortigosa, Raquel Bailon, Bart Bijnens, Fatima Crispi, Esther Pueyo, Ana Minchole, Pablo Laguna
Summary: Changes in cardiovascular anatomy and function induced by intrauterine growth restriction (IUGR) have long-term impacts and may increase the predisposition to heart disease in adulthood. This study investigated the relationship between morphological remodeling and angular variation of QRS and T-wave dominant vectors in IUGR using computational models. The results suggest that IUGR-induced morphological remodeling could contribute to the observed angle changes in IUGR patients.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)