Review
Biochemistry & Molecular Biology
Jelena Munjas, Miron Sopic, Aleksandra Stefanovic, Rok Kosir, Ana Ninic, Ivana Joksic, Tamara Antonic, Vesna Spasojevic-Kalimanovska, Ursula Prosenc Zmrzljak
Summary: Preeclampsia is a significant cause of maternal and neonatal morbidity and mortality worldwide, with abnormalities in lncRNAs and miRNAs in the placenta being associated with its pathophysiology. Currently, there is a lack of clinically available predictive biomarkers for Preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Wookyoung Jang, Jiwoo Kim, Seok Joon Mun, Sun Min Kim, Ki Wan Bong
Summary: Encapsulating dense magnetic nanoparticles in hydrogel microparticles simplifies the detection process and improves the efficiency and rapidity of miRNA detection.
Review
Medicine, General & Internal
Adrianna Kondracka, Ilona Jaszczuk, Dorota Koczkodaj, Bartosz Kondracki, Karolina Fraszczak, Anna Oniszczuk, Magda Rybak-Krzyszkowska, Jakub Staniczek, Agata Filip, Anna Kwasniewska
Summary: This study found that circulating C19MC microRNA can serve as an early marker of hypertension and preeclampsia in pregnant patients, based on a systematic review of existing literature.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Biomedical
Dana Al Sulaiman, Nidhi Juthani, Patrick S. Doyle
Summary: This study demonstrates the development and application of a method for quantitative and multiplex detection of EV-miRNA, which avoids the bias and losses associated with standard RNA extraction techniques. The method offers a large dynamic range, ease of multiplexing, and shows utility in clinical applications based on liquid biopsy tests.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Genetics & Heredity
Mariarita Brancaccio, Caterina Giachino, Assunta Maria Iazzetta, Antonio Cordone, Elena De Marino, Ornella Affinito, Maria Vivo, Viola Calabro, Alessandra Pollice, Tiziana Angrisano
Summary: By analyzing the miRNA expression profiles, we identified key miRNAs in preeclampsia and discovered some upregulated miRNAs, which could be used as new non-invasive biomarkers and therapeutic targets for personalized treatments.
Article
Peripheral Vascular Disease
Maged M. Costantine, Baha Sibai, Allan T. Bombard, Mark Sarno, Holly West, David M. Haas, Alan T. Tita, Michael J. Paidas, Erin A. S. Clark, Kim Boggess, Chad Grotegut, William Grobman, Emily J. Su, Irina Burd, George Saade, Martin R. Chavez, Michael J. Paglia, Audrey Merriam, Carlos Torres, Mounira Habli, Georges Macones, Tony Wen, James Bofill, Anna Palatnik, Rodney K. Edwards, Sina Haeri, Pankaj Oberoi, Amin Mazloom, Matthew Cooper, Steven Lockton, Gary D. Hankins
Summary: This study validates a novel multianalyte assay that is associated with the time to develop preeclampsia. The assay has moderate sensitivity and negative likelihood ratio but high negative predictive value when used as an aid to rule out preeclampsia within 7 days of enrollment.
Article
Biochemistry & Molecular Biology
Natalie K. K. Binder, Sally Beard, Natasha de Alwis, Bianca R. R. Fato, Tuong-Vi Nguyen, Tu'uhevaha J. Kaitu'u-Lino, Natalie J. J. Hannan
Summary: Preeclampsia is associated with increased risk of cardiovascular disease, possibly due to systemic organ and vascular damage or shared cardiovascular pathophysiology. Dysregulation of corin and ANP is common to both conditions. ANP, converted from pro-ANP by corin, is involved in blood pressure regulation. Although corin is mainly a cardiac enzyme, corin and pro-ANP are upregulated in the gravid uterus and dysregulated in preeclampsia. Limited information is available on the function of ANP in endothelial cells during preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Teresa M. MacDonald, Susan P. Walker, Natalie J. Hannan, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: Preeclampsia is a pregnancy-specific disease that has a significant impact on maternal and perinatal morbidity and mortality worldwide. Currently, there are limited options for predicting and diagnosing preeclampsia, and further research is needed to identify effective tests and biomarkers.
Review
Obstetrics & Gynecology
Sean Lim, Wentao Li, Jessica Kemper, Andrew Nguyen, Ben Willem Mol, Maya Reddy
Summary: The study systematically reviewed the performance of sFlt-1, PlGF, and the sFlt-1/PlGF ratio in predicting adverse outcomes in women with preeclampsia. PlGF and the sFlt-1/PlGF ratio showed prognostic promise for adverse outcomes in preeclampsia, but study heterogeneity limits their clinical utility.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Sunitha Suresh, Easha Patel, Ariel Mueller, Jessica Morgan, Whitney Lynn Lewandowski, Stefan Verlohren, Peter von Dadelszen, Laura A. Magee, Sarosh Rana
Summary: Hypertension complicates a significant percentage of pregnancies and is a leading cause of maternal and perinatal morbidity and mortality. This study aimed to evaluate the prognostic value of the soluble fms-like tyrosine kinase-1/placental growth factor ratio in women with suspected preeclampsia who have already met the diagnostic criteria. The findings suggest that this ratio is associated with an increased risk of developing preeclampsia with severe features.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Multidisciplinary Sciences
Clara Odilia Sailer, Julie Refardt, Claudine Angela Blum, Ingeborg Schnyder, Jose Alberto Molina-Tijeras, Wiebke Fenske, Mirjam Christ-Crain
Summary: The study aimed to compare three commercially available copeptin assays for the differential diagnosis of the polyuria-polydipsia syndrome. Results showed that the KRYPTOR and LIA had high diagnostic accuracy, while the ELISA performed poorly. Additional validation studies are needed before using other assays.
SCIENTIFIC REPORTS
(2021)
Review
Endocrinology & Metabolism
Jingqi Qi, Bingbing Wu, Xiuying Chen, Wei Wei, Xudong Yao
Summary: This review discusses the current developments in biochemical prediction of pre-eclampsia and the interventions to improve disease progression, aiming to provide references for clinical diagnoses and treatments.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Cell Biology
Chidambra D. Halari, Pinki Nandi, Jasmin Sidhu, Maria Sbirnac, Michael Zheng, Peeyush K. Lala
Summary: Decorin is a proteoglycan produced by chorionic villus mesenchymal cells and decidual cells during human pregnancy, and it has been shown to restrain trophoblast functions and serve as a predictive biomarker for preeclampsia. MiRNAs are involved in the pathogenesis of preeclampsia and some of them are dysregulated in placentas of preeclampsia patients. In this study, miR-512-3p was found to be induced by Decorin and upregulated in preeclampsia placentas. Functional assays revealed that miR-512-3p compromised trophoblast functions. Furthermore, the elevation of PPP3R1, a known target of miR-512-3p, was paradoxically observed in miR-512-3p-overexpressing trophoblast and preeclampsia-associated placentas.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Ningxia Sun, Shiting Qin, Lu Zhang, Shiguo Liu
Summary: Preeclampsia (PE) is a disease occurring during pregnancy with unclear pathogenesis, posing serious risks to maternal and infant safety. Current treatments are limited, with termination of pregnancy being the only way to eliminate clinical symptoms. Noncoding RNAs play important roles in the pathogenesis of PE and may serve as biomarkers for its diagnosis.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alberto Palazzuoli, Francesco Tramonte, Matteo Beltrami
Summary: HFpEF is a poorly characterized syndrome with diverse patient profiles, various risk factors, and multiple pathophysiological pathways. Recent laboratory and metabolomic findings have revealed specific cellular and molecular mechanisms' dysregulation, allowing for early identification and new diagnostic approaches. Integrating clinical imaging, laboratory findings, and biomarkers' signature partnership can provide a precision medicine approach for prognosis and therapy.
Article
Hematology
Avani Shah, Parizad Patel, Keyur Patel, Binal Patel, Keyuri Jariwala, Preeti Sharma, Kanchan Mishra, Kanjaksha Ghosh
TRANSFUSION AND APHERESIS SCIENCE
(2020)
Letter
Rheumatology
Kanjaksha Ghosh
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Medicine, Research & Experimental
Salam Alkindi, Said S. Almufargi, Anil Pathare
EXPERIMENTAL BIOLOGY AND MEDICINE
(2020)
Article
Multidisciplinary Sciences
Salam Alkindi, Ikhlas Al-Busaidi, Bushra Al-Salami, Samir Raniga, Anil Pathare, Samir K. Ballas
SCIENTIFIC REPORTS
(2020)
Article
Hematology
Avani Shah, Parizad Patel, Keyuri Jariwala, Farzin Qureshi, Kanchan Mishra, Sumit Bharadva, Kanjaksha Ghosh
Summary: There is a lack of data on the prevalence of rare blood group antigens among the blood donor population in South Gujarat due to the unavailability and high cost of antisera. This study used a PCR-based method to detect the presence of In-a and In-b antigens in regular voluntary blood donors. The frequency of In a antigen was found to be higher than Caucasians, lower than Iranians and Arabs, and comparable to Indians in Mumbai. This PCR-based method could be extremely helpful in creating a rare donor registry and screening blood donors on a large scale in the absence of antisera, particularly for low-frequency alleles like In-a.
TRANSFUSION AND APHERESIS SCIENCE
(2022)
Article
Medicine, General & Internal
Naglaa Fawaz, Ismail Beshlawi, Alauldeen Alqasim, Mathew Zachariah, Roberta Russo, Immacolata Andolfo, Antonella Gambale, Anil Pathare, Achille Iolascon
Summary: We report a case of transfusion-dependent chronic anemia in a child, with clinical and laboratory features suggestive of a chronic nonspherocytic hemolytic anemia and bone marrow features suggestive of congenital dyserythropoietic anemia. However, DNA studies revealed a novel mutation in the PKLR gene responsible for pyruvate kinase deficiency as the underlying condition. Molecular investigations using targeted next-generation sequencing identified the patient as homozygous for a novel missense mutation, while both parents were heterozygous for the same mutation.
CLINICAL CASE REPORTS
(2022)
Review
Hematology
Kanjaksha Ghosh, Kinjalka Ghosh
Summary: Monoclonal antibodies are increasingly used in hematology practice, either alone or in combination with other therapies, to improve outcomes in various hematological conditions. These antibodies have a wide range of applications in malignant and benign hematological diseases, as well as in different phases of stem cell transplantation. Advancements in protein engineering are rapidly improving the function of antibodies.
EXPERT REVIEW OF HEMATOLOGY
(2022)
Review
Medicine, Research & Experimental
Kanjaksha Ghosh, Durjoy K. Shome, Bipin Kulkarni, Malay K. Ghosh, Kinjalka Ghosh
Summary: Bone marrow fibrosis is a significant structural change in the marrow that is not well understood in terms of its causes. This review consolidates the current understanding of marrow fibrosis, highlighting the complex interactions between growth factors, cytokines, chemokines, and hormones. The involvement of various cells, molecules, and genetic/epigenetic changes in the fibrosis process is also discussed.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Suryyani Deb, Mohammad Azharuddin, Sofia Ramstrom, Kanjaksha Ghosh, Santiswarup Singha, Thobias Romu, Hirak Kumar Patra
Summary: Arterial thrombosis is caused by platelet-mediated thrombus formation in blood vessels, leading to severe cardiovascular diseases. To better predict and treat arterial thrombosis, we have developed a nanoparticle platform that can simultaneously monitor and restrict thrombus growth. The platform works by inhibiting receptors on platelets and visualizing the thrombus status through magnetic resonance imaging.
BIOENGINEERING-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Prashant P. Warang, Nikhil S. Shinde, Vinod D. Umare, Prajyot Deshmukh, Kanjaksha Ghosh, Manisha R. Madkaikar, Roshan B. Colah, Malay B. Mukherjee
Summary: This study evaluated the effects of fermented papaya preparation (FPP) on sickle cell patients, finding that it has the potential to reduce oxidative stress and protect red blood cell morphology. The analysis also revealed the presence of essential amino acids and vitamin D3 and derivatives in FPP.
Article
Biochemistry & Molecular Biology
Vinod Umare, Vandana Pradhan, Sneha Dadheech, Anjali Rajadhyaksha, Kanjaksha Ghosh, Anita Nadkarni
Article
Pathology
Sandhya Tamgadge, Treville Pereira, Sandeep Kale, Subraj Shetty, Avinash Tamgadge
INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY
(2020)
Article
Dermatology
Treville Pereira, J. Aswathy, Subraj Shetty, Avinash Tamgadge, Sandhya Tamgadge, Swati Gotmare
INDIAN DERMATOLOGY ONLINE JOURNAL
(2019)
Review
Oncology
Subraj J. Shetty, Treville Pereira, Rajiv S. Desai
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2019)
Article
Gastroenterology & Hepatology
Kanchan K. Mishra, Shashikant Srivastava, Archana Aayyagari, Kanjaksha Ghosh
INDIAN JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)
