Therapeutics and delivery vehicles for local treatment of osteomyelitis

Adjuvant antibiotic‐loaded bone cement: Concerns with current use and research to make it work

(2020) Edward M. Schwarz et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Adjunct phage treatment enhances the effectiveness of low antibiotic concentration against Staphylococcus aureus biofilms in vitro

(2019) James Dickey et al.   PLoS One

Calcium Phosphate Spacers for the Local Delivery of Sitafloxacin and Rifampin to Treat Orthopedic Infections: Efficacy and Proof of Concept in a Mouse Model of Single-Stage Revision of Device-Associated Osteomyelitis

(2019) Ryan Trombetta et al.   Pharmaceutics

Successful treatment of antibiotic resistant poly-microbial bone infection with bacteriophages and antibiotics combination

(2019) Ran Nir-Paz et al.   CLINICAL INFECTIOUS DISEASES

Efficacy of novel nano-hydroxyapatite/polyurethane composite scaffolds with silver phosphate particles in chronic osteomyelitis

(2019) Dongli Zhang et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

2018 International Consensus Meeting on Musculoskeletal Infection: Research Priorities from the General Assembly Questions

(2019) Edward M. Schwarz et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Lysostaphin and BMP-2 co-delivery reduces S. aureus infection and regenerates critical-sized segmental bone defects

(2019) Christopher T. Johnson et al.   Science Advances

In vitro efficacy of gentamicin released from collagen sponge in eradication of bacterial biofilm preformed on hydroxyapatite surface

(2019) Beata Maczynska et al.   PLoS One

Chitosan-polycaprolactone blend sponges for management of chronic osteomyelitis: A preliminary characterization and in vitro evaluation

(2019) Vaishali Pawar et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Vancomycin-laden calcium phosphate-calcium sulfate composite allows bone formation in a rat infection model

(2019) K. Keely Boyle et al.   PLoS One

CRISPR-Cas9 modified bacteriophage for treatment of Staphylococcus aureus induced osteomyelitis and soft tissue infection

(2019) Leah H. Cobb et al.   PLoS One

Biological and antibacterial properties of the micro-nanostructured hydroxyapatite/chitosan coating on titanium

(2019) Baoe Li et al.   Scientific Reports

Local Delivery of Amikacin and Vancomycin from Chitosan Sponges Prevent Polymicrobial Implant-Associated Biofilm

(2018) Logan R Boles et al.   MILITARY MEDICINE

Ciprofloxacin and Rifampin Dual Antibiotic-Loaded Biopolymer Chitosan Sponge for Bacterial Inhibition

(2018) Carlos M Wells et al.   MILITARY MEDICINE

Hydrogel delivery of lysostaphin eliminates orthopedic implant infection byStaphylococcus aureusand supports fracture healing

(2018) Christopher T. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resistance Development to Bacteriophages Occurring during Bacteriophage Therapy

(2018) Frank Oechslin   Viruses-Basel

Designing Antibacterial Peptides with Enhanced Killing Kinetics

(2018) Faiza H. Waghu et al.   Frontiers in Microbiology

Treatment of osteomyelitis defects by a vancomycin-loaded gelatin/β-tricalcium phosphate composite scaffold

(2018) J. Zhou et al.   Bone & Joint Research

Magnetic Glycol Chitin-Based Hydrogel Nanocomposite for Combined Thermal and d-Amino-Acid-Assisted Biofilm Disruption

(2018) Eric C. Abenojar et al.   ACS Infectious Diseases

Targeting Virulence in Staphylococcus aureus by Chemical Inhibition of the Accessory Gene Regulator System In Vivo

(2018) Akram M. Salam et al.   mSphere

Inhaled bacteriophage-loaded polymeric microparticles ameliorate acute lung infections

(2018) Rachit Agarwal et al.   Nature Biomedical Engineering

Prolonged bacterial lag time results in small colony variants that represent a sub-population of persisters

(2018) Clément Vulin et al.   Nature Communications

Bacteriophage Therapy: Clinical Trials and Regulatory Hurdles

(2018) Lucy L. Furfaro et al.   Frontiers in Cellular and Infection Microbiology

Synergistic effect of vancomycin and l-homocarnosine alleviates Staphylococcus aureus-induced osteomyelitis in rats

(2018) Panyu Zhou et al.   BIOMEDICINE & PHARMACOTHERAPY

In vivo efficiency of antimicrobial inorganic bone grafts in osteomyelitis treatments

(2018) G. Mestres et al.   Materials Science & Engineering C-Materials for Biological Applications

Testing the efficacy of antimicrobial peptides in the topical treatment of induced osteomyelitis in rats

(2017) Pavel Melicherčík et al.   FOLIA MICROBIOLOGICA

Silver nanoparticle deposited implants to treat osteomyelitis

(2017) Samit Kumar Nandi et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Testing of a bioactive, moldable bone graft substitute in an infected, critically sized segmental defect model

(2017) Matt E. Brown et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Evidence of Staphylococcus Aureus Deformation, Proliferation, and Migration in Canaliculi of Live Cortical Bone in Murine Models of Osteomyelitis

(2017) Karen L de Mesy Bentley et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Thermally triggered release of the bacteriophage endolysin CHAPK and the bacteriocin lysostaphin for the control of methicillin resistant Staphylococcus aureus (MRSA)

(2017) Hollie Hathaway et al.   JOURNAL OF CONTROLLED RELEASE

Controlled and Localized Nitric Oxide Precursor Delivery From Chitosan Gels to Staphylococcus aureus Biofilms

(2017) Sayeed Hasan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Antibiotic loaded microspheres as antimicrobial delivery systems for medical applications

(2017) J. Szczeblinska et al.   Materials Science & Engineering C-Materials for Biological Applications

Carboxylated chitosan/silver-hydroxyapatite hybrid microspheres with improved antibacterial activity and cytocompatibility

(2017) Juan Shen et al.   Materials Science & Engineering C-Materials for Biological Applications

Natural polymeric microspheres for modulated drug delivery

(2017) Costantino Del Gaudio et al.   Materials Science & Engineering C-Materials for Biological Applications

Antibacterial silk fibroin/nanohydroxyapatite hydrogels with silver and gold nanoparticles for bone regeneration

(2017) Marta Ribeiro et al.   Nanomedicine-Nanotechnology Biology and Medicine

The mechanism of human β-defensin 3 in MRSA-induced infection of implant drug-resistant bacteria biofilm in the mouse tibial bone marrow

(2017) Chen Zhu et al.   Experimental and Therapeutic Medicine

Amino-functionalized poloxamer 407 with both mucoadhesive and thermosensitive properties: preparation, characterization and application in a vaginal drug delivery system

(2017) Liqian Ci et al.   Acta Pharmaceutica Sinica B

Repurposing the Nonsteroidal Anti-inflammatory Drug Diflunisal as an Osteoprotective, Antivirulence Therapy for Staphylococcus aureus Osteomyelitis

(2016) Andrew S. Hendrix et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biodegradable Mg-Cu alloy implants with antibacterial activity for the treatment of osteomyelitis: In vitro and in vivo evaluations

(2016) Yang Li et al.   BIOMATERIALS

A new model of implant-related osteomyelitis in the metaphysis of rat tibiae

(2016) Norbert Harrasser et al.   BMC MUSCULOSKELETAL DISORDERS

Synergistic antimicrobial activity of bacteriophages and antibiotics against Staphylococcus aureus

(2016) Ara Jo et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Phage therapy of staphylococcal chronic osteomyelitis in experimental animal model

(2016) Gopal Nath et al.   INDIAN JOURNAL OF MEDICAL RESEARCH

Development of nanoantibiotic delivery system using cockle shell-derived aragonite nanoparticles for treatment of osteomyelitis

(2016) Lamin Saidykhan et al.   International Journal of Nanomedicine

A therapeutic delivery system for chronic osteomyelitis via a multi-drug implant based on three-dimensional printing technology

(2016) Weigang Wu et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

A novel, multi-barrier, drug eluting calcium sulfate/biphasic calcium phosphate biodegradable composite bone cement for treatment of experimental MRSA osteomyelitis in rabbit model

(2016) Surajit Mistry et al.   JOURNAL OF CONTROLLED RELEASE

Polymicrobial Biofilm Inhibition Effects of Acetate-Buffered Chitosan Sponge Delivery Device

(2016) Jessica Amber Jennings et al.   MACROMOLECULAR BIOSCIENCE

An experimental design approach to the preparation of pegylated polylactide-co-glicolide gentamicin loaded microparticles for local antibiotic delivery

(2016) Rossella Dorati et al.   Materials Science & Engineering C-Materials for Biological Applications

Surgical Debridement Is Superior to Sole Antibiotic Therapy in a Novel Murine Posttraumatic Osteomyelitis Model

(2016) Johannes Maximilian Wagner et al.   PLoS One

An Injectable In-Situ Conducting Thermosensitive Gel for Controlled Delivery of Vancomycin in Osteomyelitis Treatment and Bone Regeneration

(2016) R. S. L. Aparna et al.   Science of Advanced Materials

An effective treatment of experimental osteomyelitis using the antimicrobial titanium/silver-containing nHP66 (nano-hydroxyapatite/polyamide-66) nanoscaffold biomaterials

(2016) Minpeng Lu et al.   Scientific Reports

A combination of silver nanoparticles and visible blue light enhances the antibacterial efficacy of ineffective antibiotics against methicillin-resistant Staphylococcus aureus (MRSA)

(2016) Fatma Elzahraa Akram et al.   Annals of Clinical Microbiology and Antimicrobials

The Quorum Sensing Inhibitor Hamamelitannin Increases Antibiotic Susceptibility of Staphylococcus aureus Biofilms by Affecting Peptidoglycan Biosynthesis and eDNA Release

(2016) Gilles Brackman et al.   Scientific Reports

Poly(N-isopropylacrylamide-co-allylamine) (PNIPAM-co-ALA) nanospheres for the thermally triggered release of Bacteriophage K

(2015) Hollie Hathaway et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Staphylococcus aureus Adapts to Oxidative Stress by Producing H2O2-Resistant Small-Colony Variants via the SOS Response

(2015) Kimberley L. Painter et al.   INFECTION AND IMMUNITY

Staphylococcus aureusdevelops increased resistance to antibiotics by forming dynamic small colony variants during chronic osteomyelitis

(2015) L. Tuchscherr et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Local Delivery of the Cationic Steroid Antibiotic CSA-90 Enables Osseous Union in a Rat Open Fracture Model of Staphylococcus aureus Infection

(2015) Aaron Schindeler et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Injectable gellan gum-based nanoparticles-loaded system for the local delivery of vancomycin in osteomyelitis treatment

(2015) Urszula Posadowska et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Preparation and characterization of dry powder bacteriophage K for intestinal delivery through oral administration

(2015) Zhenxing Tang et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

APD3: the antimicrobial peptide database as a tool for research and education

(2015) Guangshun Wang et al.   NUCLEIC ACIDS RESEARCH

Cell shape dynamics during the staphylococcal cell cycle

(2015) João M. Monteiro et al.   Nature Communications

Oxidized alginate hydrogels for bone morphogenetic protein-2 delivery in long bone defects

(2014) Lauren B. Priddy et al.   Acta Biomaterialia

d-Amino Acids Enhance the Activity of Antimicrobials against Biofilms of Clinical Wound Isolates of Staphylococcus aureus and Pseudomonas aeruginosa

(2014) Carlos J. Sanchez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Triggered Release of Bacteriophage K from Agarose/Hyaluronan Hydrogel Matrixes by Staphylococcus aureus Virulence Factors

(2014) Jessica E. Bean et al.   CHEMISTRY OF MATERIALS

Local Gentamicin Delivery From Resorbable Viscous Hydrogels Is Therapeutically Effective

(2014) Derek Overstreet et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Chitosan coating to enhance the therapeutic efficacy of calcium sulfate-based antibiotic therapy in the treatment of chronic osteomyelitis

(2014) Karen E Beenken et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Characterization of local delivery with amphotericin B and vancomycin from modified chitosan sponges and functional biofilm prevention evaluation

(2014) Ashley Cox Parker et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The Potential Role of Increasing the Release of Mouse β- Defensin-14 in the Treatment of Osteomyelitis in Mice: A Primary Study

(2014) Chen Zhu et al.   PLoS One

A Novel Injectable Borate Bioactive Glass Cement as an Antibiotic Delivery Vehicle for Treating Osteomyelitis

(2014) Hao Ding et al.   PLoS One

Bacteriophage Mediated Killing of Staphylococcus aureus In Vitro on Orthopaedic K Wires in Presence of Linezolid Prevents Implant Colonization

(2014) Sandeep Kaur et al.   PLoS One

Lysostaphin-Coated Titan-Implants Preventing Localized Osteitis by Staphylococcus aureus in a Mouse Model

(2014) Ceylan D. Windolf et al.   PLoS One

Phage Neutralization by Sera of Patients Receiving Phage Therapy

(2014) Marzanna Łusiak-Szelachowska et al.   VIRAL IMMUNOLOGY

Selective Chemical Inhibition of agr Quorum Sensing in Staphylococcus aureus Promotes Host Defense with Minimal Impact on Resistance

(2014) Erin K. Sully et al.   PLoS Pathogens

Staphylococcus aureus small colony variants show common metabolic features in central metabolism irrespective of the underlying auxotrophism

(2014) André Kriegeskorte et al.   Frontiers in Cellular and Infection Microbiology

The Changing Epidemiology of Methicillin-Resistant Staphylococcus aureus in the United States: A National Observational Study

(2013) Eili Y. Klein et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Effects of local delivery of d-amino acids from biofilm-dispersive scaffolds on infection in contaminated rat segmental defects

(2013) Carlos J. Sanchez et al.   BIOMATERIALS

Structural and functional stabilization of phage particles in carbohydrate matrices for bacterial biosensing

(2013) Victor M. Balcão et al.   ENZYME AND MICROBIAL TECHNOLOGY

Chimeric Ply187 endolysin killsStaphylococcus aureusmore effectively than the parental enzyme

(2013) Jinzhe Mao et al.   FEMS MICROBIOLOGY LETTERS

Biofilm Matrix Exoproteins Induce a Protective Immune Response against Staphylococcus aureus Biofilm Infection

(2013) Carmen Gil et al.   INFECTION AND IMMUNITY

Efficacy of antibacterial-loaded coating in an in vivo model of acutely highly contaminated implant

(2013) Gianluca Giavaresi et al.   INTERNATIONAL ORTHOPAEDICS

Bacteriophage Therapy in Implant-Related Infections

(2013) Cengiz Yilmaz et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Long Bone Osteomyelitis in Adults: Fundamental Concepts and Current Techniques

(2013) Julia Sanders et al.   ORTHOPEDICS

National Burden of Invasive Methicillin-ResistantStaphylococcus aureusInfections, United States, 2011

(2013) Raymund Dantes   JAMA Internal Medicine

Economic Burden of Periprosthetic Joint Infection in the United States

(2012) Steven M. Kurtz et al.   JOURNAL OF ARTHROPLASTY

Highly stable, protein capped gold nanoparticles as effective drug delivery vehicles for amino-glycosidic antibiotics

(2012) Lori Rastogi et al.   Materials Science & Engineering C-Materials for Biological Applications

Novel Chimerical Endolysins with Broad Antimicrobial Activity Against Methicillin-Resistant Staphylococcus aureus

(2012) Sofia Fernandes et al.   Microbial Drug Resistance

Bacteriophages and their Implications on Future Biotechnology: A Review

(2012) Irshad UL Haq et al.   Virology Journal

Quorum Sensing Inhibitors Increase the Susceptibility of Bacterial Biofilms to Antibiotics In Vitro and In Vivo

(2011) Gilles Brackman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization of inducedStaphylococcus aureusbacteriophage SAP-26 and its anti-biofilm activity with rifampicin

(2011) Marzia Rahman et al.   BIOFOULING

Hydrophobic polycationic coatings that inhibit biofilms and support bone healing during infection

(2011) Thomas P. Schaer et al.   BIOMATERIALS

Keratin hydrogels support the sustained release of bioactive ciprofloxacin

(2011) Justin M. Saul et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Antibacterial effect of 317L stainless steel contained copper in prevention of implant-related infection in vitro and in vivo

(2011) Hongwei Chai et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Antibacterial and anti-adhesive zeolite coatings on titanium alloy surface

(2011) Jincheng Wang et al.   MICROPOROUS AND MESOPOROUS MATERIALS

Designing antimicrobial peptides: form follows function

(2011) Christopher D. Fjell et al.   NATURE REVIEWS DRUG DISCOVERY

Highly Selective End-Tagged Antimicrobial Peptides Derived from PRELP

(2011) Martin Malmsten et al.   PLoS One

A play in four acts: Staphylococcus aureus abscess formation

(2011) Alice G. Cheng et al.   TRENDS IN MICROBIOLOGY

Novel antimicrobial peptides from the venom of the eusocial bee Halictus sexcinctus (Hymenoptera: Halictidae) and their analogs

(2010) Lenka Monincová et al.   AMINO ACIDS

Treatment with Linezolid or Vancomycin in Combination with Rifampin Is Effective in an Animal Model of Methicillin-ResistantStaphylococcus aureusForeign Body Osteomyelitis

(2010) Paschalis Vergidis et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Teicoplanin-loaded borate bioactive glass implants for treating chronic bone infection in a rabbit tibia osteomyelitis model

(2010) Xin Zhang et al.   BIOMATERIALS

Treatment of osteomyelitis with teicoplanin-encapsulated biodegradable thermosensitive hydrogel nanoparticles

(2010) Kuo-Ti Peng et al.   BIOMATERIALS

The effectiveness of the controlled release of gentamicin from polyelectrolyte multilayers in the treatment of Staphylococcus aureus infection in a rabbit bone model

(2010) Joshua S. Moskowitz et al.   BIOMATERIALS

Enhanced alginate microspheres as means of oral delivery of bacteriophage for reducing Staphylococcus aureus intestinal carriage

(2010) Yongsheng Ma et al.   FOOD HYDROCOLLOIDS

Sustained release of vancomycin from polyurethane scaffolds inhibits infection of bone wounds in a rat femoral segmental defect model

(2010) Bing Li et al.   JOURNAL OF CONTROLLED RELEASE

To protect peptide pharmaceuticals against peptidases

(2010) R. Rink et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Lasioglossins: Three Novel Antimicrobial Peptides from the Venom of the Eusocial BeeLasioglossum laticeps(Hymenoptera: Halictidae)

(2009) Václav Čeřovský et al.   CHEMBIOCHEM

The Effects of Farnesol on Staphylococcus aureus Biofilms and Osteoblasts

(2009) Aasis Unnanuntana et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense

(2009) Yuping Lai et al.   TRENDS IN IMMUNOLOGY

Topical versus Systemic Antimicrobial Therapy for Treating Mildly Infected Diabetic Foot Ulcers: A Randomized, Controlled, Double‐Blinded, Multicenter Trial of Pexiganan Cream

(2008) Benjamin A. Lipsky et al.   CLINICAL INFECTIOUS DISEASES

The phage K lytic enzyme LysK and lysostaphin act synergistically to kill MRSA

(2008) Stephen C. Becker et al.   FEMS MICROBIOLOGY LETTERS

The evolution of Staphylococcus aureus

(2008) Ruud H. Deurenberg et al.   INFECTION GENETICS AND EVOLUTION

Phage therapy experience at the Eliava Institute

(2008) M. Kutateladze et al.   MEDECINE ET MALADIES INFECTIEUSES

Bottom-Up Assembly of Hydrogels from Bacteriophage and Au Nanoparticles: The Effect of Cis- and Trans-Acting Factors

(2008) Glauco R. Souza et al.   PLoS One