Houttuynia cordata Thunb. and its bioactive compound 2-undecanone significantly suppress benzo(a)pyrene-induced lung tumorigenesis by activating the Nrf2-HO-1/NQO-1 signaling pathway

Camptosorus sibiricus rupr aqueous extract prevents lung tumorigenesis via dual effects against ROS and DNA damage

(2018) Shugui He et al.   JOURNAL OF ETHNOPHARMACOLOGY

Therapeutic potentials of Houttuynia cordata Thunb. against inflammation and oxidative stress: A review

(2018) Khanchuila Shingnaisui et al.   JOURNAL OF ETHNOPHARMACOLOGY

Roflumilast treatment inhibits lung carcinogenesis in benzo(a)pyrene-induced murine lung cancer model

(2017) Chang Dong Yeo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Polyphenol inhibition of benzo[a]pyrene-induced oxidative stress and neoplastic transformation in an in vitro model of carcinogenesis

(2017) Kosar Omidian et al.   FOOD AND CHEMICAL TOXICOLOGY

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

(2017) Paul M Ridker et al.   LANCET

Linking the generation of DNA adducts to lung cancer

(2017) Marcello Ceppi et al.   TOXICOLOGY

Biological interaction of cigarette smoking on the association between genetic polymorphisms involved in inflammation and the risk of lung cancer: A case-control study in Japan

(2017) Yuzo Yamamoto et al.   Oncology Letters

MicroRNAs in lung cancer

(2017) Diana Castro et al.   Oncotarget

Lung Cancer Screening: Advantages, Controversies, and Applications

(2017) Prema Nanavaty et al.   Cancer Control

Inflammasome-dependent IL-1β release depends upon membrane permeabilisation

(2016) F Martín-Sánchez et al.   CELL DEATH AND DIFFERENTIATION

Modulatory effects of catechin hydrate against genotoxicity, oxidative stress, inflammation and apoptosis induced by benzo(a)pyrene in mice

(2016) Ayaz Shahid et al.   FOOD AND CHEMICAL TOXICOLOGY

The International Epidemiology of Lung Cancer: Latest Trends, Disparities, and Tumor Characteristics

(2016) Ting-Yuan David Cheng et al.   Journal of Thoracic Oncology

Benzo(a)pyrene Induced p53 Mediated Male Germ Cell Apoptosis: Synergistic Protective Effects of Curcumin and Resveratrol

(2016) Bhaswati Banerjee et al.   Frontiers in Pharmacology

The Nrf2-ARE pathway is associated with Schisandrin b attenuating benzo(a)pyrene-Induced HTR cells damagesin vitro

(2015) Qulong Dong et al.   ENVIRONMENTAL TOXICOLOGY

Houttuynia cordata Thunb. polysaccharides ameliorates lipopolysaccharide-induced acute lung injury in mice

(2015) Yan-Yan Xu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Benzo(a)pyrene induced lung cancer: Role of dietary phytochemicals in chemoprevention

(2015) Eshvendar Reddy Kasala et al.   Pharmacological Reports

A Comparative Study of Sodium Houttuyfonate and 2-Undecanone for Their in Vitro and in Vivo Anti-Inflammatory Activities and Stabilities

(2014) Jing Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Curcumin and Vitamin E Protect against Adverse Effects of Benzo[a]pyrene in Lung Epithelial Cells

(2014) Wenbin Zhu et al.   PLoS One

Baicalein Abrogates Reactive Oxygen Species (ROS)-mediated Mitochondrial Dysfunction during Experimental Pulmonary CarcinogenesisIn Vivo

(2013) Chandrashekar Naveenkumar et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Chemoprevention of Lung Cancer

(2013) Eva Szabo et al.   CHEST

A critical role for interleukin-1β in the progression of autoimmune diseases

(2013) Ruijuan Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

DNA Damage in Inflammation-Related Carcinogenesis and Cancer Stem Cells

(2013) Shiho Ohnishi et al.   Oxidative Medicine and Cellular Longevity

Pulmonary Oxidative Stress, Inflammation and Cancer: Respirable Particulate Matter, Fibrous Dusts and Ozone as Major Causes of Lung Carcinogenesis through Reactive Oxygen Species Mechanisms

(2013) Athanasios Valavanidis et al.   International Journal of Environmental Research and Public Health

Houttuyniae Herba protects rat primary cortical cells from Aβ25–35-induced neurotoxicity via regulation of calcium influx and mitochondria-mediated apoptosis

(2012) H Park et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Cancer-Related Inflammation

(2012) Juliana Candido et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Nrf2: control of sensitivity to carcinogens

(2011) Stephen L. Slocum et al.   ARCHIVES OF TOXICOLOGY

Sustained Systemic Delivery of Green Tea Polyphenols by Polymeric Implants Significantly Diminishes Benzo[a]pyrene-Induced DNA Adducts

(2011) Pengxiao Cao et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Carcinogenic activity of benzo[a]pyrene in a 2 year oral study in Wistar rats

(2011) P.W. Wester et al.   FOOD AND CHEMICAL TOXICOLOGY

Caffeic acid and quercitrin purified fromHouttuynia cordatainhibit DNA topoisomerase I activity

(2010) Seok-Young Jang† et al.   NATURAL PRODUCT RESEARCH

Chronic inflammation, chronic obstructive pulmonary disease, and lung cancer

(2009) Gina Lee et al.   CURRENT OPINION IN PULMONARY MEDICINE

COPD prevalence is increased in lung cancer, independent of age, sex and smoking history

(2009) R. P. Young et al.   EUROPEAN RESPIRATORY JOURNAL

Benzo(a)pyrene-induced genotoxicity: Attenuation by farnesol in a mouse model

(2008) Tamanna Jahangir et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Dibenzoylmethane Activates Nrf2-Dependent Detoxification Pathway and Inhibits Benzo(a)pyrene Induced DNA Adducts in Lungs

(2008) R. Thimmulappa et al.   Medicinal Chemistry

DNA Damage Responses: Mechanisms and Roles in Human Disease: 2007 G.H.A. Clowes Memorial Award Lecture

(2008) M. B. Kastan   MOLECULAR CANCER RESEARCH

Cancer is a Preventable Disease that Requires Major Lifestyle Changes

(2008) Preetha Anand et al.   PHARMACEUTICAL RESEARCH