Intranasal MMI-0100 Attenuates Aβ1−42- and LPS-Induced Neuroinflammation and Memory Impairments via the MK2 Signaling Pathway

Fluoxetine and Vortioxetine Reverse Depressive-Like Phenotype and Memory Deficits Induced by Aβ1-42 Oligomers in Mice: A Key Role of Transforming Growth Factor-β1

(2019) Sebastiano Alfio Torrisi et al.   Frontiers in Pharmacology

The role of Cortistatin-14 in the gastrointestinal motility in mice

(2018) JinHong Jiang et al.   Pharmacological Reports

The potential of solanezumab and gantenerumab to prevent Alzheimer’s disease in people with inherited mutations that cause its early onset

(2017) Francesco Panza et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Inhibitory effect of punicalagin on lipopolysaccharide-induced neuroinflammation, oxidative stress and memory impairment via inhibition of nuclear factor-kappaB

(2017) Young Eun Kim et al.   NEUROPHARMACOLOGY

Involvement of GluN2B subunit containing N-methyl- d -aspartate (NMDA) receptors in mediating the acute and chronic synaptotoxic effects of oligomeric amyloid-beta (Aβ) in murine models of Alzheimer's disease (AD)

(2017) Gerhard Rammes et al.   NEUROPHARMACOLOGY

Biological functions and role of mitogen-activated protein kinase activated protein kinase 2 (MK2) in inflammatory diseases

(2017) Rakesh Kumar Singh et al.   Pharmacological Reports

The role of the hippocampus in approach-avoidance conflict decision-making: Evidence from rodent and human studies

(2016) Rutsuko Ito et al.   BEHAVIOURAL BRAIN RESEARCH

Mechanism of Enhanced Cellular Uptake and Cytosolic Retention of MK2 Inhibitory Peptide Nano-polyplexes

(2016) Kameron V. Kilchrist et al.   Cellular and Molecular Bioengineering

Endomorphin-1 attenuates Aβ42 induced impairment of novel object and object location recognition tasks in mice

(2015) Rui-san Zhang et al.   BRAIN RESEARCH

Phoenixin-14 enhances memory and mitigates memory impairment induced by Aβ1-42 and scopolamine in mice

(2015) J.H. Jiang et al.   BRAIN RESEARCH

Direct nose-to-brain delivery of lamotrigine following intranasal administration to mice

(2015) Ana Serralheiro et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Lycopene abrogates Aβ(1–42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer’s disease

(2015) Anand Kamal Sachdeva et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Nose-to-Brain Delivery: Investigation of the Transport of Nanoparticles with Different Surface Characteristics and Sizes in Excised Porcine Olfactory Epithelium

(2015) Alpesh Mistry et al.   MOLECULAR PHARMACEUTICS

Toxicology Studies for Inhaled and Nasal Delivery

(2015) R. K. Wolff   MOLECULAR PHARMACEUTICS

Kisspeptin-13 enhances memory and mitigates memory impairment induced by Aβ1–42 in mice novel object and object location recognition tasks

(2015) J.H. Jiang et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

p38 MAPK inhibitors: a patent review (2012 – 2013)

(2014) Stefanie Bühler et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The role of the hippocampus in flexible cognition and social behavior

(2014) Rachael D. Rubin et al.   Frontiers in Human Neuroscience

The improved blood–brain barrier permeability of endomorphin-1 using the cell-penetrating peptide synB3 with three different linkages

(2014) Hui Liu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

MMI-0100 inhibits cardiac fibrosis in myocardial infarction by direct actions on cardiomyocytes and fibroblasts via MK2 inhibition

(2014) Lei Xu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial

(2014) L Kristin Newby et al.   LANCET

Strategies To Deliver Peptide Drugs to the Brain

(2014) Aikaterini Lalatsa et al.   MOLECULAR PHARMACEUTICS

Aβ–fibrinogen interaction inhibitor improves cognition in AD

(2014) Alexandra Flemming   NATURE REVIEWS DRUG DISCOVERY

Insights into direct nose to brain delivery: current status and future perspective

(2013) Deepti Mittal et al.   DRUG DELIVERY

Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease

(2013) Zhiyou Cai et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Alzheimer disease therapy—moving from amyloid-β to tau

(2013) Ezio Giacobini et al.   Nature Reviews Neurology

Neuropeptide S enhances memory and mitigates memory impairment induced by MK801, scopolamine or Aβ1–42 in mice novel object and object location recognition tasks

(2013) Ren-Wen Han et al.   NEUROPHARMACOLOGY

Therapeutics of Alzheimer's disease: Past, present and future

(2013) R. Anand et al.   NEUROPHARMACOLOGY

Apigenin attenuates copper-mediated β-amyloid neurotoxicity through antioxidation, mitochondrion protection and MAPK signal inactivation in an AD cell model

(2012) Le Zhao et al.   BRAIN RESEARCH

Cell-penetrating peptides can confer biological function: Regulation of inflammatory cytokines in human monocytes by MK2 inhibitor peptides

(2011) Jamie L. Brugnano et al.   JOURNAL OF CONTROLLED RELEASE

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

(2011) Adam D Bachstetter et al.   Journal of Neuroinflammation

Peptide Inhibitors of MK2 Show Promise for Inhibition of Abdominal Adhesions

(2011) Brian C. Ward et al.   JOURNAL OF SURGICAL RESEARCH

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

MK2 Signaling: Lessons on Tissue Specificity in Modulation of Inflammation

(2010) Nanna Fyhrquist et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

Facilitation of central imidazoline I1-site/extracellular signal-regulated kinase/p38 mitogen-activated protein kinase signalling mediates the hypotensive effect of ethanol in rats with acute renal failure

(2009) Mahmoud M El-Mas et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting p38 MAPK pathway for the treatment of Alzheimer's disease

(2009) Lenka Munoz et al.   NEUROPHARMACOLOGY