Relevance of immune cell and tumor microenvironment imaging in the new era of immunotherapy

Mechanisms of checkpoint inhibition‐induced adverse events

(2020) P. Urwyler et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Human Anti-tumor Immunity: Insights from Immunotherapy Clinical Trials

(2020) Jackson G. Egen et al.   IMMUNITY

B cells are associated with survival and immunotherapy response in sarcoma

(2020) Florent Petitprez et al.   NATURE

Tertiary lymphoid structures improve immunotherapy and survival in melanoma

(2020) Rita Cabrita et al.   NATURE

B cells and tertiary lymphoid structures promote immunotherapy response

(2020) Beth A. Helmink et al.   NATURE

Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis

(2020) Yaqing Zhang et al.   Cancer Discovery

Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology

(2019) Neel I. Nissen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

3D models in the new era of immune oncology: focus on T cells, CAF and ECM

(2019) Francesca Di Modugno et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Therapeutic challenges and current immunomodulatory strategies in targeting the immunosuppressive pancreatic tumor microenvironment

(2019) Chin-King Looi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cancer stemness, intratumoral heterogeneity, and immune response across cancers

(2019) Alex Miranda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Tumor-Associated Macrophages in Cancer

(2019) Paulina Pathria et al.   TRENDS IN IMMUNOLOGY

Trial watch: dendritic cell vaccination for cancer immunotherapy

(2019) Jenny Sprooten et al.   OncoImmunology

Immunometabolic Checkpoints of Treg Dynamics: Adaptation to Microenvironmental Opportunities and Challenges

(2019) Ilenia Pacella et al.   Frontiers in Immunology

Neutrophil Heterogeneity in Cancer: From Biology to Therapies

(2019) Pacôme Lecot et al.   Frontiers in Immunology

18F-AzaFol for Detection of Folate Receptor-β Positive Macrophages in Experimental Interstitial Lung Disease—A Proof-of-Concept Study

(2019) Janine Schniering et al.   Frontiers in Immunology

Oncolytic Viruses for Cancer Therapy: Barriers and Recent Advances

(2019) Meijun Zheng et al.   Molecular Therapy-Oncolytics

Use of Immune Checkpoint Inhibitors in the Treatment of Patients With Cancer and Preexisting Autoimmune Disease

(2018) Noha Abdel-Wahab et al.   ANNALS OF INTERNAL MEDICINE

Plasticity of myeloid-derived suppressor cells in cancer

(2018) Evgenii Tcyganov et al.   CURRENT OPINION IN IMMUNOLOGY

NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis

(2018) Ariella Glasner et al.   IMMUNITY

Cancer immunotherapy beyond immune checkpoint inhibitors

(2018) Julian A. Marin-Acevedo et al.   Journal of Hematology & Oncology

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Combining chemotherapy with PD-1 blockade in NSCLC

(2018) Matthen Mathew et al.   PHARMACOLOGY & THERAPEUTICS

Immuno-PET imaging of tumor-infiltrating lymphocytes using zirconium-89 radiolabeled anti-CD3 antibody in immune-competent mice bearing syngeneic tumors

(2018) Denis R. Beckford Vera et al.   PLoS One

Non-invasive visualization of tumor infiltrating lymphocytes in patients with metastatic melanoma undergoing immune checkpoint inhibitor therapy: a pilot study

(2018) Svetomir N. Markovic et al.   Oncotarget

The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy

(2018) Lilla Hornyák et al.   Frontiers in Immunology

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

(2018) Peng Jiang et al.   NATURE MEDICINE

Immunomodulation of Tumor Vessels: It Takes Two to Tango

(2018) Anna Johansson-Percival et al.   TRENDS IN IMMUNOLOGY

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

(2018) Spencer C. Wei et al.   Cancer Discovery

Optical Imaging of Cellular Immunotherapy against Prostate Cancer

(2018) Sidhartha Tavri et al.   Molecular Imaging

Deciphering cancer fibroblasts

(2018) Giulia Biffi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

89Zr-labeled nivolumab for imaging of T-cell infiltration in a humanized murine model of lung cancer

(2017) Christopher G. England et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

A new insight in chimeric antigen receptor-engineered T cells for cancer immunotherapy

(2017) Erhao Zhang et al.   Journal of Hematology & Oncology

Intracavitary Bacillus Calmette-Guerin in the Treatment of Superficial Bladder Tumors

(2017) A. Morales et al.   JOURNAL OF UROLOGY

Nivolumab plus ipilimumab as first-line treatment for advanced non-small-cell lung cancer (CheckMate 012): results of an open-label, phase 1, multicohort study

(2017) Matthew D Hellmann et al.   LANCET ONCOLOGY

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

The immune contexture in cancer prognosis and treatment

(2017) Wolf H. Fridman et al.   Nature Reviews Clinical Oncology

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Review of cancer treatment with immune checkpoint inhibitors

(2017) Christiane Thallinger et al.   WIENER KLINISCHE WOCHENSCHRIFT

Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers

(2017) Oliver M.T. Pearce et al.   Cancer Discovery

The integrative clinical impact of tumor-infiltrating T lymphocytes and NK cells in relation to B lymphocyte and plasma cell density in esophageal and gastric adenocarcinoma

(2017) Maria C. Svensson et al.   Oncotarget

Cancer Immunotherapy: Historical Perspective of a Clinical Revolution and Emerging Preclinical Animal Models

(2017) William K. Decker et al.   Frontiers in Immunology

Natural Killer Cell Response to Chemotherapy-Stressed Cancer Cells: Role in Tumor Immunosurveillance

(2017) Alessandra Zingoni et al.   Frontiers in Immunology

A novel immunohistochemical score to predict early mortality in acute myeloid leukemia patients based on indoleamine 2,3 dioxygenase expression

(2017) Abhishek Mangaonkar et al.   Scientific Reports

Baseline neutrophils and derived neutrophil-to-lymphocyte ratio: prognostic relevance in metastatic melanoma patients receiving ipilimumab

(2016) P. F. Ferrucci et al.   ANNALS OF ONCOLOGY

Baseline Peripheral Blood Biomarkers Associated with Clinical Outcome of Advanced Melanoma Patients Treated with Ipilimumab

(2016) A. Martens et al.   CLINICAL CANCER RESEARCH

Clinical Significance of Circulating CD33+CD11b+HLA-DR- Myeloid Cells in Patients with Stage IV Melanoma Treated with Ipilimumab

(2016) M. Sade-Feldman et al.   CLINICAL CANCER RESEARCH

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

(2016) Philippe Gascard et al.   GENES & DEVELOPMENT

Molecular Imaging of Immunotherapy Targets in Cancer

(2016) E. B. Ehlerding et al.   JOURNAL OF NUCLEAR MEDICINE

IL-6 Secreted from Cancer-Associated Fibroblasts Mediates Chemoresistance in NSCLC by Increasing Epithelial-Mesenchymal Transition Signaling

(2016) Yasushi Shintani et al.   Journal of Thoracic Oncology

Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

(2016) J. Park et al.   Science Translational Medicine

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

Mesenchymal Transition of High-Grade Breast Carcinomas Depends on Extracellular Matrix Control of Myeloid Suppressor Cell Activity

(2016) Sabina Sangaletti et al.   Cell Reports

Timing of CSF-1/CSF-1R signaling blockade is critical to improving responses to CTLA-4 based immunotherapy

(2016) Rikke B. Holmgaard et al.   OncoImmunology

Expansion of tumor-infiltrating lymphocytes (TIL) from human pancreatic tumors

(2016) MacLean Hall et al.   Journal for ImmunoTherapy of Cancer

Into the clinic: Talimogene laherparepvec (T-VEC), a first-in-class intratumoral oncolytic viral therapy

(2016) Hasan Rehman et al.   Journal for ImmunoTherapy of Cancer

Expression of programmed death ligand-1 on tumor cells varies pre and post chemotherapy in non-small cell lung cancer

(2016) Jin Sheng et al.   Scientific Reports

Hematological Effects, Serum, and Pulmonary Cytokine Profiles in a Melanoma Mouse Model Treated with GK1

(2015) Armando Pérez-Torres et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy

(2015) R. Tavare et al.   CANCER RESEARCH

Nutrient Competition: A New Axis of Tumor Immunosuppression

(2015) Madhusudhanan Sukumar et al.   CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

CCR 20th Anniversary Commentary: Autologous T Cells--The Ultimate Personalized Drug for the Immunotherapy of Human Cancer

(2015) S. A. Rosenberg   CLINICAL CANCER RESEARCH

Myeloid Cells and Related Chronic Inflammatory Factors as Novel Predictive Markers in Melanoma Treatment with Ipilimumab

(2015) C. Gebhardt et al.   CLINICAL CANCER RESEARCH

Immunotherapy Approaches in Cancer Treatment

(2015) Pavel Klener et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Non-invasive tracking of CD4+ T cells with a paramagnetic and fluorescent nanoparticle in brain ischemia

(2015) Wei-Na Jin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

In Vivo Imaging of Natural Killer Cell Trafficking in Tumors

(2015) F. Galli et al.   JOURNAL OF NUCLEAR MEDICINE

PET Imaging of Tumor-Associated Macrophages with 89Zr-Labeled High-Density Lipoprotein Nanoparticles

(2015) C. Perez-Medina et al.   JOURNAL OF NUCLEAR MEDICINE

Immuno-PET of Murine T Cell Reconstitution Postadoptive Stem Cell Transplantation Using Anti-CD4 and Anti-CD8 Cys-Diabodies

(2015) R. Tavare et al.   JOURNAL OF NUCLEAR MEDICINE

Distinct Functions of Neutrophil in Cancer and Its Regulation

(2015) Zvi Granot et al.   MEDIATORS OF INFLAMMATION

Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy

(2015) Shabnam Shalapour et al.   NATURE

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

(2015) Adrienne H Long et al.   NATURE MEDICINE

The Predicted Impact of Ipilimumab Usage on Survival in Previously Treated Advanced or Metastatic Melanoma in the UK

(2015) James Larkin et al.   PLoS One

64Cu antibody-targeting of the T-cell receptor and subsequent internalization enables in vivo tracking of lymphocytes by PET

(2015) Christoph M. Griessinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell exclusion, immune privilege, and the tumor microenvironment

(2015) J. A. Joyce et al.   SCIENCE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Harnessing nanoparticles for immune modulation

(2015) Daniel R. Getts et al.   TRENDS IN IMMUNOLOGY

New approaches for cancer immunotherapy

(2015) Ayfer Karlitepe et al.   TUMOR BIOLOGY

Novel 89Zr cell labeling approach for PET-based cell trafficking studies

(2015) Aditya Bansal et al.   EJNMMI Research

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Cytokine Networks That Mediate Epithelial Cell-Macrophage Crosstalk in the Mammary Gland: Implications for Development and Cancer

(2014) Xuan Sun et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Imaging macrophages with nanoparticles

(2014) Ralph Weissleder et al.   NATURE MATERIALS

Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

(2014) Antonella Sistigu et al.   NATURE MEDICINE

Radiolabeling Strategies for Radionuclide Imaging of Stem Cells

(2014) Esther Wolfs et al.   Stem Cell Reviews and Reports

Dendritic Cell Therapy in an Allogeneic-Hematopoietic Cell Transplantation Setting: An Effective Strategy toward Better Disease Control?

(2014) Maud Plantinga et al.   Frontiers in Immunology

Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression

(2013) Inbal Mishalian et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cancer immunotherapies, their safety and toxicity

(2013) Gheath Alatrash et al.   Expert Opinion On Drug Safety

Dendritic-Cell-Based Therapeutic Cancer Vaccines

(2013) Karolina Palucka et al.   IMMUNITY

Reciprocal Relationship between Myeloid-Derived Suppressor Cells and T Cells

(2013) S. Nagaraj et al.   JOURNAL OF IMMUNOLOGY

Oncolytic viruses as therapeutic cancer vaccines

(2013) David L Bartlett et al.   Molecular Cancer

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Labeling cells for in vivo tracking using 19F MRI

(2012) Mangala Srinivas et al.   BIOMATERIALS

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Nanobody-Based Targeting of the Macrophage Mannose Receptor for EffectiveIn VivoImaging of Tumor-Associated Macrophages

(2012) Kiavash Movahedi et al.   CANCER RESEARCH

CD20+ Tumor-Infiltrating Lymphocytes Have an Atypical CD27- Memory Phenotype and Together with CD8+ T Cells Promote Favorable Prognosis in Ovarian Cancer

(2012) J. S. Nielsen et al.   CLINICAL CANCER RESEARCH

Fibroblast Activation Protein in Remodeling Tissues

(2012) M. Jacob et al.   CURRENT MOLECULAR MEDICINE

89Zr-Labeled Dextran Nanoparticles Allow in Vivo Macrophage Imaging

(2011) Edmund J. Keliher et al.   BIOCONJUGATE CHEMISTRY

Benefits of Hybrid SPECT/CT for 111In-Oxine- and Tc-99m-Hexamethylpropylene Amine Oxime-Labeled Leukocyte Imaging

(2011) Mehdi Djekidel et al.   CLINICAL NUCLEAR MEDICINE

Differential Expression of the 18 kDa Translocator Protein (TSPO) by Neoplastic and Inflammatory Cells in Mouse Tumors of Breast Cancer

(2011) Jinzi Zheng et al.   MOLECULAR PHARMACEUTICS

Cell transfer immunotherapy for metastatic solid cancer—what clinicians need to know

(2011) Steven A. Rosenberg   Nature Reviews Clinical Oncology

gp100 Peptide Vaccine and Interleukin-2 in Patients with Advanced Melanoma

(2011) Douglas J. Schwartzentruber et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chimeric Antigen Receptor-Engineered T Cells for Immunotherapy of Cancer

(2010) Marc Cartellieri et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

B Cells Are Required for Optimal CD4+ and CD8+ T Cell Tumor Immunity: Therapeutic B Cell Depletion Enhances B16 Melanoma Growth in Mice

(2010) D. J. DiLillo et al.   JOURNAL OF IMMUNOLOGY

Impact of Indium-111 Oxine Labelling on Viability of Human Mesenchymal Stem Cells In Vitro, and 3D Cell-Tracking Using SPECT/CT In Vivo

(2010) Franz Josef Gildehaus et al.   MOLECULAR IMAGING AND BIOLOGY

B-cell-derived lymphotoxin promotes castration-resistant prostate cancer

(2010) Massimo Ammirante et al.   NATURE

Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein- 

(2010) M. Kraman et al.   SCIENCE

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1

(2009) Dong-Ming Kuang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In vitro human leukocyte labeling with 64Cu: an intraindividual comparison with 111In-oxine and 18F-FDG

(2009) Kuldeep K. Bhargava et al.   NUCLEAR MEDICINE AND BIOLOGY

Prognostic Effect of Epithelial and Stromal Lymphocyte Infiltration in Non-Small Cell Lung Cancer

(2008) K. I. Al-Shibli et al.   CLINICAL CANCER RESEARCH

CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer

(2008) Yoshiki Mizukami et al.   INTERNATIONAL JOURNAL OF CANCER

Self-delivering Nanoemulsions for Dual Fluorine-19 MRI and Fluorescence Detection

(2008) Jelena M. Janjic et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients

(2008) F. S. Hodi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology

A comparative study of the cellular immune response in patients with stage IB cervical squamous cell carcinoma. Low numbers of several immune cell subtypes are strongly associated with relapse of disease within 5 years

(2007) Bettina S. Nedergaard et al.   GYNECOLOGIC ONCOLOGY