Imaging macrophages with nanoparticles

A targeted approach to cancer imaging and therapy

(2014) Chun Li   NATURE MATERIALS

Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal

(2013) Leo M. Carlin et al.   CELL

Polymeric Nanoparticle PET/MR Imaging Allows Macrophage Detection in Atherosclerotic Plaques

(2013) Maulik D. Majmudar et al.   CIRCULATION RESEARCH

Angiotensin II Drives the Production of Tumor-Promoting Macrophages

(2013) Virna Cortez-Retamozo et al.   IMMUNITY

Leukocyte Behavior in Atherosclerosis, Myocardial Infarction, and Heart Failure

(2013) F. K. Swirski et al.   SCIENCE

A novel probe for the non-invasive detection of tumor-associated inflammation

(2013) Anthony Balducci et al.   OncoImmunology

Synthesis and In Vivo Pharmacokinetic Evaluation of Degradable Shell Cross-Linked Polymer Nanoparticles with Poly(carboxybetaine) versus Poly(ethylene glycol) Surface-Grafted Coatings

(2012) Ang Li et al.   ACS Nano

64Cu Core-Labeled Nanoparticles with High Specific Activity via Metal-Free Click Chemistry

(2012) Dexing Zeng et al.   ACS Nano

The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

(2012) Hiroshi Maeda et al.   ADVANCED DRUG DELIVERY REVIEWS

Intrinsically Copper-64-Labeled Organic Nanoparticles as Radiotracers

(2012) Tracy W. Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cationic Nanoparticles Have Superior Transvascular Flux into Solid Tumors: Insights from a Mathematical Model

(2012) Triantafyllos Stylianopoulos et al.   ANNALS OF BIOMEDICAL ENGINEERING

A Leukocyte-Mimetic Magnetic Resonance Imaging Contrast Agent Homes Rapidly to Activated Endothelium and Tracks With Atherosclerotic Lesion Macrophage Content

(2012) Martina A. McAteer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role and function of macrophages in the metabolic syndrome

(2012) Prerna Bhargava et al.   BIOCHEMICAL JOURNAL

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Biological applications of magnetic nanoparticles

(2012) Miriam Colombo et al.   CHEMICAL SOCIETY REVIEWS

Noninvasive Assessment of Myocardial Inflammation by Cardiovascular Magnetic Resonance in a Rat Model of Experimental Autoimmune Myocarditis

(2012) Hyeyoung Moon et al.   CIRCULATION

Molecular Imaging of Aortic Aneurysms

(2012) Denis B. Buxton   Circulation-Cardiovascular Imaging

Ultrasmall Superparamagnetic Particles of Iron Oxide in Patients With Acute Myocardial Infarction

(2012) Shirjel R. Alam et al.   Circulation-Cardiovascular Imaging

Imaging of myocardial infarction using ultrasmall superparamagnetic iron oxide nanoparticles: a human study using a multi-parametric cardiovascular magnetic resonance imaging approach

(2012) Ali Yilmaz et al.   EUROPEAN HEART JOURNAL

Clinically-translated silica nanoparticles as dual-modality cancer-targeted probes for image-guided surgery and interventions

(2012) Michelle S. Bradbury et al.   Integrative Biology

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

(2012) Wahajuddin et al.   International Journal of Nanomedicine

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis

(2012) Florian Leuschner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Surface Coatings Shape the Protein Corona of SPIONs with Relevance to Their Application in Vivo

(2012) Angéla Jedlovszky-Hajdú et al.   LANGMUIR

Modeling Biological Activities of Nanoparticles

(2012) V. Chandana Epa et al.   NANO LETTERS

Myocardial infarction accelerates atherosclerosis

(2012) Partha Dutta et al.   NATURE

Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging

(2012) Wenxian Fu et al.   NATURE IMMUNOLOGY

Self-assembling nanocomplexes by combining ferumoxytol, heparin and protamine for cell tracking by magnetic resonance imaging

(2012) Mya S Thu et al.   NATURE MEDICINE

M13-templated magnetic nanoparticles for targeted in vivo imaging of prostate cancer

(2012) Debadyuti Ghosh et al.   Nature Nanotechnology

Origins of tumor-associated macrophages and neutrophils

(2012) V. Cortez-Retamozo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic upconverting nanoparticles enable in vivo multiphoton microscopy with low-power continuous wave sources

(2012) T. V. Esipova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monocyte and/or Macrophage Infiltration of Heart after Myocardial Infarction: MR Imaging by Using T1-shortening Liposomes

(2012) Nivedita K. Naresh et al.   RADIOLOGY

Assessment of Disease Activity in Multiple Sclerosis Phenotypes with Combined Gadolinium- and Superparamagnetic Iron Oxide–enhanced MR Imaging

(2012) Thomas Tourdias et al.   RADIOLOGY

Science to Practice: Can Macrophage Infiltration Serve as a Surrogate Marker for Stem Cell Viability?

(2012) Jeff W. M. Bulte   RADIOLOGY

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities

(2012) Z. Cheng et al.   SCIENCE

Applications and Potential Toxicity of Magnetic Iron Oxide Nanoparticles

(2012) Gang Liu et al.   Small

Early Change in Ferumoxytol-Enhanced Magnetic Resonance Imaging Signal Suggests Unstable Human Cerebral Aneurysm

(2012) David Hasan et al.   STROKE

Uptake and Intracellular Fate of Fluorescent-Magnetic Glyco-nanoparticles

(2012) Juan Gallo et al.   Advanced Healthcare Materials

MR imaging of tumor-associated macrophages

(2012) Heike Daldrup-Link et al.   OncoImmunology

Dextran-Coated Iron Oxide Nanoparticles: A Versatile Platform for Targeted Molecular Imaging, Molecular Diagnostics, and Therapy

(2011) Carlos Tassa et al.   ACCOUNTS OF CHEMICAL RESEARCH

Multicore Assemblies Potentiate Magnetic Properties of Biomagnetic Nanoparticles

(2011) Tae-Jong Yoon et al.   ADVANCED MATERIALS

Highly Magnetic Core-Shell Nanoparticles with a Unique Magnetization Mechanism

(2011) Tae-Jong Yoon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting of nanoparticles in cancer

(2011) Meghna Talekar et al.   ANTI-CANCER DRUGS

Detection of Macrophages in Aortic Aneurysms by Nanoparticle Positron Emission Tomography–Computed Tomography

(2011) Matthias Nahrendorf et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

89Zr-Labeled Dextran Nanoparticles Allow in Vivo Macrophage Imaging

(2011) Edmund J. Keliher et al.   BIOCONJUGATE CHEMISTRY

Intravital Imaging

(2011) Mikael J. Pittet et al.   CELL

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Abdominal Aortic Aneurysm Growth Predicted by Uptake of Ultrasmall Superparamagnetic Particles of Iron Oxide

(2011) Jennifer M.J. Richards et al.   Circulation-Cardiovascular Imaging

MRI of Tumor-Associated Macrophages with Clinically Applicable Iron Oxide Nanoparticles

(2011) H. E. Daldrup-Link et al.   CLINICAL CANCER RESEARCH

Bone Marrow Mesenchymal Stem and Progenitor Cells Induce Monocyte Emigration in Response to Circulating Toll-like Receptor Ligands

(2011) Chao Shi et al.   IMMUNITY

Macropinocytosis: an endocytic pathway for internalising large gulps

(2011) Jet Phey Lim et al.   IMMUNOLOGY AND CELL BIOLOGY

Large-Scale Synthesis of Bioinert Tantalum Oxide Nanoparticles for X-ray Computed Tomography Imaging and Bimodal Image-Guided Sentinel Lymph Node Mapping

(2011) Myoung Hwan Oh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phosphonate-Anchored Monolayers for Antibody Binding to Magnetic Nanoparticles

(2011) Helly Benbenishty-Shamir et al.   LANGMUIR

19F MRI detection of acute allograft rejection with in vivo perfluorocarbon labeling of immune cells

(2011) T. Kevin Hitchens et al.   MAGNETIC RESONANCE IN MEDICINE

Compact Zwitterion-Coated Iron Oxide Nanoparticles for Biological Applications

(2011) He Wei et al.   NANO LETTERS

Imaging of size-dependent uptake and identification of novel pathways in mouse Peyer's patches using fluorescent organosilica particles

(2011) Aziz Awaad et al.   Nanomedicine-Nanotechnology Biology and Medicine

Engineered nanoparticles for biomolecular imaging

(2011) Morteza Mahmoudi et al.   Nanoscale

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Therapeutic siRNA silencing in inflammatory monocytes in mice

(2011) Florian Leuschner et al.   NATURE BIOTECHNOLOGY

Synthesis of magnetic resonance–, X-ray– and ultrasound-visible alginate microcapsules for immunoisolation and noninvasive imaging of cellular therapeutics

(2011) Brad P Barnett et al.   Nature Protocols

Perspectives and opportunities for nanomedicine in the management of atherosclerosis

(2011) Mark E. Lobatto et al.   NATURE REVIEWS DRUG DISCOVERY

MRI signature in a novel mouse model of genetically induced adult oligodendrocyte cell death

(2011) Thomas Mueggler et al.   NEUROIMAGE

Scaling rules for diffusive drug delivery in tumor and normal tissues

(2011) James W. Baish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

The uptake and intracellular fate of a series of different surface coated quantum dots in vitro

(2011) Martin J.D. Clift et al.   TOXICOLOGY

Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies

(2011) Vikash P. Chauhan et al.   Annual Review of Chemical and Biomolecular Engineering

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

(2011) David G. DeNardo et al.   Cancer Discovery

Quantitative Nanostructure−Activity Relationship Modeling

(2010) Denis Fourches et al.   ACS Nano

Microglial Response to Gold Nanoparticles

(2010) Eliza Hutter et al.   ACS Nano

A Nanoparticle Size Series for In Vivo Fluorescence Imaging

(2010) Zoran Popović et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis

(2010) Dimitrios Karussis et al.   ARCHIVES OF NEUROLOGY

The biological properties of iron oxide core high-density lipoprotein in experimental atherosclerosis

(2010) Torjus Skajaa et al.   BIOMATERIALS

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Monocytes: Protagonists of Infarct Inflammation and Repair After Myocardial Infarction

(2010) Matthias Nahrendorf et al.   CIRCULATION

Detection of lymph nodes in pelvic malignancies with computed tomography and magnetic resonance imaging

(2010) Anuradha Saokar et al.   CLINICAL IMAGING

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

New approaches to neuroimaging of central nervous system inflammation

(2010) Guido Stoll et al.   CURRENT OPINION IN NEUROLOGY

Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors

(2010) Jérôme Cros et al.   IMMUNITY

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients

(2010) Jason L. Gaglia et al.   JOURNAL OF CLINICAL INVESTIGATION

Superparamagnetic nanoclusters coated with oleic acid bilayers for stabilization of emulsions of water and oil at low concentration

(2010) Davis R. Ingram et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Targeted Iron Oxide Particles for In Vivo Magnetic Resonance Detection of Atherosclerotic Lesions With Antibodies Directed to Oxidation-Specific Epitopes

(2010) Karen C. Briley-Saebo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Iodinated NanoClusters as an Inhaled Computed Tomography Contrast Agent for Lung Visualization

(2010) Kristin L. Aillon et al.   MOLECULAR PHARMACEUTICS

Quantum Dot and Cy5.5 Labeled Nanoparticles to Investigate Lipoprotein Biointeractions via Förster Resonance Energy Transfer

(2010) Torjus Skajaa et al.   NANO LETTERS

An index for characterization of nanomaterials in biological systems

(2010) Xin-Rui Xia et al.   Nature Nanotechnology

Lymphotropic nanoparticle enhanced MRI for the staging of genitourinary tumors

(2010) Samdeep K. Mouli et al.   Nature Reviews Urology

Tumor-Associated Macrophages and Survival in Classic Hodgkin's Lymphoma

(2010) Christian Steidl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Uniform Silica Coated Fluorescent Nanoparticles: Synthetic Method, Improved Light Stability and Application to Visualize Lymph Network Tracer

(2010) Liman Cong et al.   PLoS One

Hybrid PET-optical imaging using targeted probes

(2010) Matthias Nahrendorf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atherosclerotic Plaque Composition: Analysis with Multicolor CT and Targeted Gold Nanoparticles

(2010) David P. Cormode et al.   RADIOLOGY

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Magnetic nanoparticles for biomedical NMR-based diagnostics

(2010) Huilin Shao et al.   Beilstein Journal of Nanotechnology

In Vivo MRI Cell Tracking: Clinical Studies

(2009) Jeff W. M. Bulte   AMERICAN JOURNAL OF ROENTGENOLOGY

Hybrid In Vivo FMT-CT Imaging of Protease Activity in Atherosclerosis With Customized Nanosensors

(2009) Matthias Nahrendorf et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Multi-slice computed tomography with N1177 identifies ruptured atherosclerotic plaques in rabbits

(2009) Jozef Leo Herck et al.   BASIC RESEARCH IN CARDIOLOGY

18F Labeled Nanoparticles forin VivoPET-CT Imaging

(2009) Neal K. Devaraj et al.   BIOCONJUGATE CHEMISTRY

Binding Affinity and Kinetic Analysis of Targeted Small Molecule-Modified Nanoparticles

(2009) Carlos Tassa et al.   BIOCONJUGATE CHEMISTRY

Molecular Imaging of Innate Immune Cell Function in Transplant Rejection

(2009) Thomas Christen et al.   CIRCULATION

In vivo labelling of resting monocytes in the reticuloendothelial system with fluorescent iron oxide nanoparticles prior to injury reveals that they are mobilized to infarcted myocardium

(2009) Karin Montet-Abou et al.   EUROPEAN HEART JOURNAL

Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries

(2009) Kimberly A. Kelly et al.   Integrative Biology

Safety and Tolerability of Ultrasmall Superparamagnetic Iron Oxide Contrast Agent

(2009) Hamm Bernd et al.   INVESTIGATIVE RADIOLOGY

Quantification of Inflammation Within Rabbit Atherosclerotic Plaques Using the Macrophage-Specific CT Contrast Agent N1177: A Comparison with 18F-FDG PET/CT and Histology

(2009) F. Hyafil et al.   JOURNAL OF NUCLEAR MEDICINE

The Advantages of Nanoparticles for PET

(2009) M. J. Welch et al.   JOURNAL OF NUCLEAR MEDICINE

Impact of Heterogeneity of Human Peripheral Blood Monocyte Subsets on Myocardial Salvage in Patients With Primary Acute Myocardial Infarction

(2009) Hiroto Tsujioka et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The ATHEROMA (Atorvastatin Therapy: Effects on Reduction of Macrophage Activity) Study

(2009) Tjun Y. Tang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Combinatorial libraries of peptide dendrimers: design, synthesis, on-bead high-throughput screening, bead decoding and characterization

(2009) Noélie Maillard et al.   Nature Protocols

Prostate Cancer: Detection of Lymph Node Metastases Outside the Routine Surgical Area with Ferumoxtran-10–enhanced MR Imaging

(2009) Roel A. M. Heesakkers et al.   RADIOLOGY

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

(2009) F. K. Swirski et al.   SCIENCE

Noninvasive Evaluation of Cardiac Allograft Rejection by Cellular and Functional Cardiac Magnetic Resonance

(2009) Yijen L. Wu et al.   JACC-Cardiovascular Imaging

Macrophage-Specific Lipid-Based Nanoparticles Improve Cardiac Magnetic Resonance Detection and Characterization of Human Atherosclerosis

(2009) Michael J. Lipinski et al.   JACC-Cardiovascular Imaging

Synthesis of64Cu-Labeled Magnetic Nanoparticles for Multimodal Imaging

(2008) Benjamin R. Jarrett et al.   BIOCONJUGATE CHEMISTRY

Synthesis and Characterization of Core–Shell Star Copolymers for In Vivo PET Imaging Applications

(2008) Ken-ichi Fukukawa et al.   BIOMACROMOLECULES

In Vivo Monitoring of Inflammation After Cardiac and Cerebral Ischemia by Fluorine Magnetic Resonance Imaging

(2008) Ulrich Flögel et al.   CIRCULATION

Nanocrystal Core High-Density Lipoproteins: A Multimodality Contrast Agent Platform

(2008) David P. Cormode et al.   NANO LETTERS

Imaging in the era of molecular oncology

(2008) Ralph Weissleder et al.   NATURE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

(2008) Akin Akinc et al.   NATURE BIOTECHNOLOGY

Off-Resonance Angiography: A New Method to Depict Vessels—Phantom and Rabbit Studies

(2008) Grigorios Korosoglou et al.   RADIOLOGY

Intracellular delivery of core–shell fluorescent silica nanoparticles

(2007) Jason E. Fuller et al.   BIOMATERIALS