Article
Cell Biology
Masakazu Toya, Ning Zhang, Masanori Tsubosaka, Junichi Kushioka, Qi Gao, Xueping Li, Simon Kwoon-Ho Chow, Stuart B. Goodman
Summary: Novel minimally invasive strategies are needed for bone healing in complex fractures and bone defects in the elderly. This study investigated the potential use of CCL2 as a therapeutic target for local cell therapy, as MSCs and macrophages play important roles in bone regeneration and inflammation. Acute stimulation with CCL2 was found to facilitate osteogenesis and macrophage migration in co-culture of MSCs and macrophages.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Kimberley Katleba, Erin Legacki, Trish Berger
Summary: This study examined the initial development of the male reproductive system and the expression of related genes, as well as the effects of androgens and estrogens on these genes. The results showed that interference with steroid signaling had minimal effects on the expression of these genes in testicular tissue and transient effects in the prostate and seminal vesicles.
Article
Oncology
Wei-Min Hu, Ming Li, Jin-Zhuo Ning, Yu-Qi Tang, Tian-Bao Song, Lin-Zhi Li, Fan Zou, Fan Cheng, Wei-Min Yu
Summary: In this study, we investigated the role and mechanism of FAM171B in bladder cancer. We found that FAM171B expression is positively correlated with poor prognosis and advanced stages of bladder cancer. FAM171B promotes bladder cancer growth and metastasis by interacting with a protein called heterogeneous nuclear ribonucleoprotein U, leading to increased recruitment and polarization of tumor-associated macrophages. These findings suggest that FAM171B could be a potential biomarker and therapeutic target for bladder cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yue Li, Chen Chen, Hai-Lin Liu, Zhen-Fa Zhang, Chang-Li Wang
Summary: In this study, the researchers found that LARRPM restricts the progression of lung adenocarcinoma (LUAD) by suppressing the functions of LUAD cells and macrophages. They found that LARRPM interacts with DNA demethylase TET1 to regulate the methylation levels and transcriptional activity of LINC00240 and CSF1. These findings provide new insights into the role of lncRNAs in regulating LUAD progression.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Oncology
Lena Avinery, Valid Gahramanov, Arkadi Hesin, Michael Y. Sherman
Summary: This research identified the mechanism of action of a small molecule that suppresses macrophage infiltration into tumors and exhibits potent anti-cancer activity. They discovered the pathway linking the intracellular protein Hsp70 with the macrophage motility system. This study provides a novel approach to cancer treatment by targeting tumor-associated macrophages.
Review
Immunology
Giovanni Monteleone, Eleonora Franze, Edoardo Troncone, Claudia Maresca, Irene Marafini
Summary: Interleukin-34 (IL-34) plays a crucial role in chronic inflammatory bowel diseases (IBD) by promoting interactions between immune cells and stromal cells, leading to increased mucosal inflammation and production of fibrogenic molecules.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xiufang Kong, Ming Xu, Xiaomeng Cui, Lingying Ma, Huiyong Cheng, Jun Hou, Xiaoning Sun, Lili Ma, Lindi Jiang
Summary: Macrophages undergo phenotype transformation in contributing to vascular pathological changes in patients with TA. CCL2 is an important factor for recruiting macrophages and can serve as a potential biomarker for disease activity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Luka Zivkovic, Yaw Asare, Jurgen Bernhagen, Martin Dichgans, Marios K. Georgakis
Summary: This study systematically reviewed and meta-analyzed studies on the use of CCL2/CCR2 blockade in atheroprone mice. The results showed that CCL2/CCR2 blockade can attenuate atherosclerotic lesion size and improve lesion morphology. However, the majority of existing studies have major quality issues, highlighting the need for additional high-quality research.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Oncology
Yang Zheng, Zhihong Wang, Simeng Wei, Ziling Liu, Guojiang Chen
Summary: Highly invasive and rapidly fatal small-cell lung cancer (SCLC) presents a significant reduction in macrophage infiltration in a stage-dependent manner, attributed to decreased expression of CCL2. The inhibition of CCL2 expression is mediated by EZH2 and DNMT1, and can be reversed by specific compounds. Direct cell-cell contact between SCLC cells and macrophages alters the phenotype of macrophages.
Article
Cell Biology
Xiangjia Zhu, Jiaqi Meng, Chaofeng Han, Qingfeng Wu, Yu Du, Jiao Qi, Ling Wei, Hao Li, Wenwen He, Keke Zhang, Yi Lu
Summary: This study reveals that highly myopic patients exhibit higher anxiety levels and elevated levels of CC chemokine ligand 2 (CCL2) and monocytes in the blood. Using mouse models and various experimental methods, the researchers found that high myopia increases infiltration of monocytes/macrophages into the eyes and brains, leading to disruption of the blood-ocular barrier and blood-brain barrier. However, highly myopic mice deficient in Ccl2 show reduced infiltration and barrier disruption, as well as less anxiety. Furthermore, administration of CCL2-neutralizing antibodies provides significant relief from high myopia-related anxiety.
Article
Geriatrics & Gerontology
Yunjuan Nie, Xiaorun Zhai, Jiao Li, Aijuan Sun, Huilian Che, John W. Christman, Gaoshang Chai, Peng Zhao, Manjula Karpurapu
Summary: NFATc3 plays an important role in idiopathic pulmonary fibrosis by regulating the expression of CCL2 and CXCL2 genes in macrophages.
Article
Geriatrics & Gerontology
Yunjuan Nie, Xiaorun Zhai, Jiao Li, Aijuan Sun, Huilian Che, John W. Christman, Gaoshang Chai, Peng Zhao, Manjula Karpurapu
Summary: NFATc3 plays a crucial role in idiopathic pulmonary fibrosis (IPF) by regulating the expression of CCL2 and CXCL2 genes in macrophages, contributing to the pathogenesis and progression of IPF.
Article
Biochemistry & Molecular Biology
Yao-Hui Huang, Kun Cai, Peng-Peng Xu, Li Wang, Chuan-Xin Huang, Ying Fang, Shu Cheng, Xiao-Jian Sun, Feng Liu, Jin-Yan Huang, Meng-Meng Ji, Wei-Li Zhao
Summary: Epigenetic alterations, especially mutations in genes related to histone modification, play a crucial role in tumor progression of DLBCL by influencing the tumor microenvironment, leading to increased tumor cell proliferation and polarization of M2 macrophages.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Oncology
Xuan Sun, Sarah M. Bernhardt, Danielle J. Glynn, Leigh J. Hodson, Lucy Woolford, Andreas Evdokiou, Cong Yan, Hong Du, Sarah A. Robertson, Wendy Ingman
Summary: Attenuation of TGFB signaling in macrophages resulted in increased alveolar epithelium and macrophage abundance in the mammary gland, with altered inflammatory macrophage markers. This led to a significant decrease in mammary tumor incidence and prolonged tumor-free survival. In human non-neoplastic breast tissue, a significant inverse relationship was observed between latent TGFB1 protein and CD68-positive macrophages.
BREAST CANCER RESEARCH
(2021)
Article
Cell Biology
Anna Kosenko, Tomer Meir Salame, Gilgi Friedlander, Itamar Barash
Summary: Studies have identified macrophages and secreted CSF1 as the energy sensor and paracrine transmitter in the self-renewal of mammary stem cells. Through experiments with conditioned medium and analyses using RNA-Seq, immunohistochemistry, and immunofluorescence, this mechanism was confirmed.
Editorial Material
Biochemistry & Molecular Biology
Wendy V. Ingman
Article
Medicine, General & Internal
Wendy V. Ingman, Bernadette Richards, Jacqueline M. Street, Drew Carter, Mary Rickard, Jennifer Stone, Pallave Dasari
JOURNAL OF CLINICAL MEDICINE
(2020)
Review
Oncology
Sarah M. Bernhardt, Pallave Dasari, David Walsh, Amanda R. Townsend, Timothy J. Price, Wendy Ingman
Review
Cell Biology
Amita G. Ghadge, Pallave Dasari, Jennifer Stone, Erik W. Thompson, Rebecca L. Robker, Wendy Ingman
Summary: The association between mammographic density and breast cancer risk has been well-established, with puberty identified as a critical time for breast development and adult mammographic density. The molecular and cellular mechanisms underlying the development of high mammographic density are still not fully understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Review
Obstetrics & Gynecology
Renee L. Kam, Sarah M. Bernhardt, Wendy Ingman, Lisa H. Amir
Summary: This review systematically examines the impact of modern exogenous exposures on altered mammary gland development, highlighting the association between endocrine disrupting chemicals, obesogenic diet, and changes in mammary gland morphology. Future studies should focus on lactation outcomes, standardize research methods, and allow for better comparison across studies.
EARLY HUMAN DEVELOPMENT
(2021)
Article
Multidisciplinary Sciences
Xuan Sun, Benjamin Cao, Marina Naval-Sanchez, Tony Pham, Yu Bo Yang Sun, Brenda Williams, Shen Y. Heazlewood, Nikita Deshpande, Jinhua Li, Felix Kraus, James Rae, Quan Nguyen, Hamed Yari, Jan Schroder, Chad K. Heazlewood, Madeline Fulton, Jessica Hatwell-Humble, Kaustav Das Gupta, Ronan Kapetanovic, Xiaoli Chen, Matthew J. Sweet, Robert G. Parton, Michael T. Ryan, Jose M. Polo, Christian M. Nefzger, Susan K. Nilsson
Summary: Nicotinamide riboside treatment can restore metabolic capacity of hematopoietic stem cells through various ways and shift aged HSC function, metabolism, and molecular characteristics towards a youthful state.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Sarah M. Bernhardt, Pallave Dasari, Danielle J. Glynn, Lucy Woolford, Lachlan M. Moldenhauer, David Walsh, Amanda R. Townsend, Timothy J. Price, Wendy Ingman
Summary: The stage of the ovarian cycle at the time of tissue collection affects the 21-gene signature in Mmtv-Pymt murine mammary tumors, suggesting that hormonal fluctuations may impact gene expression in breast cancer.
Article
Oncology
Sarah M. Bernhardt, Pallave Dasari, Danielle J. Glynn, Amanda R. Townsend, Timothy J. Price, Wendy V. Ingman
Summary: This study showed that estrogen and progesterone have similar effects on mRNA and protein biomarker expression in hormone-responsive breast cancer xenografts, but there may be differences between cell lines. Further research is needed to investigate the concordance between protein and mRNA biomarkers in premenopausal breast cancer.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Public, Environmental & Occupational Health
Luke E. Grzeskowiak, Moni R. Saha, Wendy Ingman, Hedvig Nordeng, Eivind Ystrom, Lisa H. Amir
Summary: Early-onset mastitis is a modest risk factor for suboptimal breastfeeding outcomes and poorer mental health postpartum. Late-onset mastitis is not associated with poorer breastfeeding outcomes.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2022)
Article
Medicine, General & Internal
Maddison Archer, Pallave Dasari, David Walsh, Kara L. Britt, Andreas Evdokiou, Wendy Ingman
Summary: Mammographic density is associated with increased breast cancer risk. This study found that fibroblasts from high mammographic density breast tissue do not show inherent differences compared to those from low mammographic density, suggesting that the function of fibroblasts in breast cancer risk may be regulated by immune signals from surrounding cells in the microenvironment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Maddison Archer, Pallave Dasari, Andreas Evdokiou, Wendy V. Ingman
Summary: Primary prevention strategies are crucial in combating the rising global burden of breast cancer. Breast density, a significant independent risk factor for breast cancer, presents an exciting potential target for reducing incidence. Further research is needed to understand the biological mechanisms underlying high breast density and potentially develop new prevention strategies, with a focus on immune system factors that may play a role in this process.
Article
Oncology
Xuan Sun, Sarah M. Bernhardt, Danielle J. Glynn, Leigh J. Hodson, Lucy Woolford, Andreas Evdokiou, Cong Yan, Hong Du, Sarah A. Robertson, Wendy Ingman
Summary: Attenuation of TGFB signaling in macrophages resulted in increased alveolar epithelium and macrophage abundance in the mammary gland, with altered inflammatory macrophage markers. This led to a significant decrease in mammary tumor incidence and prolonged tumor-free survival. In human non-neoplastic breast tissue, a significant inverse relationship was observed between latent TGFB1 protein and CD68-positive macrophages.
BREAST CANCER RESEARCH
(2021)
Article
Oncology
Sarah M. Bernhardt, Pallave Dasari, Joseph Wrin, Wendy Raymond, Suzanne Edwards, David Walsh, Amanda R. Townsend, Timothy J. Price, Wendy Ingman
BREAST CANCER RESEARCH
(2020)
Article
Developmental Biology
Vahid Atashgaran, Pallave Dasari, Leigh J. Hodson, Andreas Evdokiou, Simon C. Barry, Wendy V. Ingman
REPRODUCTION FERTILITY AND DEVELOPMENT
(2020)
