Immune responses to stroke: mechanisms, modulation, and therapeutic potential

Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial

(2020) Michael D Hill et al.   LANCET

Inflammation, Autoimmunity, Infection, and Stroke

(2020) Neal S. Parikh et al.   STROKE

Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study

(2019) Sarah T Pendlebury et al.   LANCET NEUROLOGY

Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Catherine Owens Johnson et al.   LANCET NEUROLOGY

Abolition of aberrant neurogenesis ameliorates cognitive impairment after stroke in mice

(2019) María Isabel Cuartero et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanical thrombectomy and the future of acute stroke treatment

(2019) Adam A. Dmytriw et al.   EUROPEAN JOURNAL OF RADIOLOGY

A year-long immune profile of the systemic response in acute stroke survivors

(2019) Amy S Tsai et al.   BRAIN

Intrathecal inflammation in young stroke

(2019) Marie Süße et al.   ACTA NEUROLOGICA SCANDINAVICA

Immune Signaling in Neurodegeneration

(2019) Timothy R. Hammond et al.   IMMUNITY

Cerebral Intraparenchymal Hemorrhage

(2019) Bradley A. Gross et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Stroke incidence in young adults according to age, subtype, sex, and time trends

(2019) Merel S. Ekker et al.   NEUROLOGY

Preventing dementia by preventing stroke: The Berlin Manifesto

(2019) Vladimir Hachinski et al.   Alzheimers & Dementia

Vascular Cognitive Impairment and Dementia

(2019) Costantino Iadecola et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severity

(2019) Qingkun Liu et al.   NATURE IMMUNOLOGY

Location of Neutrophils in Different Compartments of the Damaged Mouse Brain After Severe Ischemia/Reperfusion

(2019) Amaia Otxoa-de-Amezaga et al.   STROKE

Autoimmunity After Ischemic Stroke and Brain Injury

(2019) Ehsan Javidi et al.   Frontiers in Immunology

Neutrophil extracellular trap induced by HMGB1 exacerbates damages in the ischemic brain

(2019) Seung-Woo Kim et al.   Acta Neuropathologica Communications

Racial and Ethnic Disparities in the Utilization of Thrombectomy for Acute Stroke

(2019) Lorenzo Rinaldo et al.   STROKE

Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study

(2019) Christopher A Lane et al.   LANCET NEUROLOGY

Dietary salt promotes cognitive impairment through tau phosphorylation

(2019) Giuseppe Faraco et al.   NATURE

Role of TLR4 (Toll-Like Receptor 4) in N1/N2 Neutrophil Programming After Stroke

(2019) Alicia García-Culebras et al.   STROKE

Brain-to-cervical lymph node signaling after stroke

(2019) Elga Esposito et al.   Nature Communications

Ischaemic stroke

(2019) Bruce C. V. Campbell et al.   Nature Reviews Disease Primers

Meningeal γδ T cell–derived IL-17 controls synaptic plasticity and short-term memory

(2019) Miguel Ribeiro et al.   Science Immunology

Role of the chemokine receptors CCR2 and CX3CR1 in an experimental model of thrombotic stroke

(2018) Giulia Cisbani et al.   BRAIN BEHAVIOR AND IMMUNITY

Non-invasive vagus nerve stimulation reduces blood-brain barrier disruption in a rat model of ischemic stroke

(2018) Yirong Yang et al.   Brain Stimulation

Brain drains: new insights into brain clearance pathways from lymphatic biology

(2018) Neil I. Bower et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Endogenous protection from ischemic brain injury by preconditioned monocytes

(2018) Lidia Garcia-Bonilla et al.   JOURNAL OF NEUROSCIENCE

Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response

(2018) Giuseppe Faraco et al.   NATURE NEUROSCIENCE

Protecting the ischaemic penumbra as an adjunct to thrombectomy for acute stroke

(2018) Jean-Claude Baron   Nature Reviews Neurology

Splenectomy protects aged mice from injury after experimental stroke

(2018) Anjali Chauhan et al.   NEUROBIOLOGY OF AGING

Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts

(2018) Jacob C. Zbesko et al.   NEUROBIOLOGY OF DISEASE

Rates and predictors of futile recanalization in patients undergoing endovascular treatment in a multicenter clinical trial

(2018) Haitham M. Hussein et al.   NEURORADIOLOGY

Loss of neuronal CD200 contributed to microglial activation after acute cerebral ischemia in mice

(2018) Yang Yang et al.   NEUROSCIENCE LETTERS

Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging

(2018) Gregory W. Albers et al.   NEW ENGLAND JOURNAL OF MEDICINE

Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct

(2018) Raul G. Nogueira et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeted complement inhibition salvages stressed neurons and inhibits neuroinflammation after stroke in mice

(2018) Ali Alawieh et al.   Science Translational Medicine

Global Burden of Stroke

(2018) Mira Katan et al.   SEMINARS IN NEUROLOGY

What Do Experimental Models Teach Us About Comorbidities in Stroke?

(2018) Sunghee Cho et al.   STROKE

SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke)

(2018) Craig J. Smith et al.   STROKE

Ischemia-induced Neuronal Cell Death Is Mediated by Chemokine Receptor CX3CR1

(2018) Jinkun Wang et al.   Scientific Reports

Molecular Magnetic Resonance Imaging of Endothelial Activation in the Central Nervous System

(2018) Maxime Gauberti et al.   Theranostics

Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration

(2018) Fanny Herisson et al.   NATURE NEUROSCIENCE

CNS-border associated macrophages respond to acute ischemic stroke attracting granulocytes and promoting vascular leakage

(2018) Jordi Pedragosa et al.   Acta Neuropathologica Communications

Microglial cell loss after ischemic stroke favors brain neutrophil accumulation

(2018) Amaia Otxoa-de-Amezaga et al.   ACTA NEUROPATHOLOGICA

Stroke and dementia risk: A systematic review and meta-analysis

(2018) Elżbieta Kuźma et al.   Alzheimers & Dementia

Mannose-Binding Lectin Drives Platelet Inflammatory Phenotype and Vascular Damage After Cerebral Ischemia in Mice via IL (Interleukin)-1α

(2018) Franca Orsini et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery

(2018) Minako Ito et al.   NATURE

Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull–meninges connections

(2018) Ruiyao Cai et al.   NATURE NEUROSCIENCE

Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Depletion of microglia exacerbates postischemic inflammation and brain injury

(2017) Wei-Na Jin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Innate Control of Adaptive Immunity: Beyond the Three-Signal Paradigm

(2017) Aakanksha Jain et al.   JOURNAL OF IMMUNOLOGY

Choroid plexus-cerebrospinal fluid route for monocyte-derived macrophages after stroke

(2017) Ruimin Ge et al.   Journal of Neuroinflammation

Safety and efficacy of natalizumab in patients with acute ischaemic stroke (ACTION): a randomised, placebo-controlled, double-blind phase 2 trial

(2017) Jacob Elkins et al.   LANCET NEUROLOGY

Subarachnoid Hemorrhage

(2017) Michael T. Lawton et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fostering reproducibility in industry-academia research

(2017) B. R. Jasny et al.   SCIENCE

Multipotent Adult Progenitor Cells Enhance Recovery After Stroke by Modulating the Immune Response from the Spleen

(2017) Bing Yang et al.   STEM CELLS

Poststroke Fatigue: Emerging Evidence and Approaches to Management: A Scientific Statement for Healthcare Professionals From the American Heart Association

(2017) Janice L. Hinkle et al.   STROKE

IL-23 (Interleukin-23)–Producing Conventional Dendritic Cells Control the Detrimental IL-17 (Interleukin-17) Response in Stroke

(2017) Mathias Gelderblom et al.   STROKE

Immature monocytes recruited to the ischemic mouse brain differentiate into macrophages with features of alternative activation

(2016) Francesc Miró-Mur et al.   BRAIN BEHAVIOR AND IMMUNITY

Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production

(2016) A. Houlden et al.   BRAIN BEHAVIOR AND IMMUNITY

Antibodies to myelin basic protein are associated with cognitive decline after stroke

(2016) Kyra J. Becker et al.   JOURNAL OF NEUROIMMUNOLOGY

Spatio-temporal profile, phenotypic diversity, and fate of recruited monocytes into the post-ischemic brain

(2016) Lidia Garcia-Bonilla et al.   Journal of Neuroinflammation

Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice

(2016) S. Wattananit et al.   JOURNAL OF NEUROSCIENCE

Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke

(2016) V. Singh et al.   JOURNAL OF NEUROSCIENCE

Translocation and dissemination of commensal bacteria in post-stroke infection

(2016) Dragana Stanley et al.   NATURE MEDICINE

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

(2016) Corinne Benakis et al.   NATURE MEDICINE

Multifaceted interactions between adaptive immunity and the central nervous system

(2016) J. Kipnis   SCIENCE

Thomas Willis Lecture

(2016) Ulrich Dirnagl   STROKE

Thromboinflammation in Stroke Brain Damage

(2016) Simon F. De Meyer et al.   STROKE

Poststroke Depression: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association

(2016) Amytis Towfighi et al.   STROKE

Endothelial CD36 Contributes to Postischemic Brain Injury by Promoting Neutrophil Activation via CSF3

(2015) L. Garcia-Bonilla et al.   JOURNAL OF NEUROSCIENCE

DAMP Signaling is a Key Pathway Inducing Immune Modulation after Brain Injury

(2015) A. Liesz et al.   JOURNAL OF NEUROSCIENCE

B-Lymphocyte-Mediated Delayed Cognitive Impairment following Stroke

(2015) K. P. Doyle et al.   JOURNAL OF NEUROSCIENCE

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke

(2015) M. Kawabori et al.   JOURNAL OF NEUROSCIENCE

Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia

(2015) Gemma Llovera et al.   Science Translational Medicine

Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke

(2015) Odilo Engel et al.   STROKE

Neutrophil recruitment to the brain in mouse and human ischemic stroke

(2014) Isabel Perez-de-Puig et al.   ACTA NEUROPATHOLOGICA

Role of Spleen-Derived Monocytes/Macrophages in Acute Ischemic Brain Injury

(2014) Eunhee Kim et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inducible Nitric Oxide Synthase in Neutrophils and Endothelium Contributes to Ischemic Brain Injury in Mice

(2014) Lidia Garcia-Bonilla et al.   JOURNAL OF IMMUNOLOGY

CX3CR1 deficiency suppresses activation and neurotoxicity of microglia/macrophage in experimental ischemic stroke

(2014) Zhiwei Tang et al.   Journal of Neuroinflammation

Gastrointestinal complications after ischemic stroke

(2014) Carlos R. Camara-Lemarroy et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

(2014) Daniel Knowland et al.   NEURON

Activation of α-7 Nicotinic Acetylcholine Receptor Reduces Ischemic Stroke Injury through Reduction of Pro-Inflammatory Macrophages and Oxidative Stress

(2014) Zhenying Han et al.   PLoS One

Ischemic neurons recruit natural killer cells that accelerate brain infarction

(2014) Y. Gan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of an immune modulator fingolimod on acute ischemic stroke

(2014) Ying Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Importance of Preclinical Research in the Development of Neuroprotective Strategies for Ischemic Stroke

(2014) Ain A. Neuhaus et al.   JAMA Neurology

Fingolimod for the Treatment of Intracerebral Hemorrhage

(2014) Ying Fu et al.   JAMA Neurology

Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer’s Coordinating Centre

(2013) Jon B. Toledo et al.   BRAIN

Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus

(2013) Ravid Shechter et al.   IMMUNITY

A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion

(2013) Helena W Morrison et al.   Journal of Neuroinflammation

IL-10-producing B-cells limit CNS inflammation and infarct volume in experimental stroke

(2013) Sheetal Bodhankar et al.   METABOLIC BRAIN DISEASE

Forecasting the Future of Stroke in the United States: A Policy Statement From the American Heart Association and American Stroke Association

(2013) B. Ovbiagele et al.   STROKE

Cognitive Decline After Stroke

(2013) Efrat Kliper et al.   STROKE

N2 Neutrophils, Novel Players in Brain Inflammation After Stroke

(2013) María Isabel Cuartero et al.   STROKE

A Concerted Appeal for International Cooperation in Preclinical Stroke Research

(2013) Ulrich Dirnagl et al.   STROKE

The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury

(2012) Gaby Enzmann et al.   ACTA NEUROPATHOLOGICA

Macrophages prevent hemorrhagic infarct transformation in murine stroke models

(2012) Michael Gliem et al.   ANNALS OF NEUROLOGY

Evidence of Intrathecal Immunoglobulin Synthesis in Stroke

(2012) Harald Prüss et al.   ARCHIVES OF NEUROLOGY

Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke

(2012) M. Gelderblom et al.   BLOOD

Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia

(2012) Melanie Greter et al.   IMMUNITY

Delayed Administration of Interleukin-1 Receptor Antagonist Reduces Ischemic Brain Damage and Inflammation in Comorbid Rats

(2012) Jesus M Pradillo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Relationship between plasma high-mobility group box-1 levels and clinical outcomes of ischemic stroke

(2012) Ju-Ming Huang et al.   JOURNAL OF CRITICAL CARE

Neutrophil Cerebrovascular Transmigration Triggers Rapid Neurotoxicity through Release of Proteases Associated with Decondensed DNA

(2012) C. Allen et al.   JOURNAL OF IMMUNOLOGY

Brain-Derived Antigens in Lymphoid Tissue of Patients with Acute Stroke

(2012) A. M. Planas et al.   JOURNAL OF IMMUNOLOGY

Tissue-Resident Ecto-5' Nucleotidase (CD73) Regulates Leukocyte Trafficking in the Ischemic Brain

(2012) D. Petrovic-Djergovic et al.   JOURNAL OF IMMUNOLOGY

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Vagus nerve stimulation reduces infarct size in rat focal cerebral ischemia: An unlikely role for cerebral blood flow

(2011) Ilknur Ay et al.   BRAIN RESEARCH

Cytokine changes in the pathophysiology of poststroke depression

(2011) Jian-An Su et al.   GENERAL HOSPITAL PSYCHIATRY

A role for spleen monocytes in post-ischemic brain inflammation and injury

(2011) Yi Bao et al.   Journal of Neuroinflammation

Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice

(2011) Carlo Perego et al.   Journal of Neuroinflammation

Serum cytokine and glucose levels as predictors of poststroke fatigue in acute ischemic stroke patients

(2011) Heidi Ormstad et al.   JOURNAL OF NEUROLOGY

Regulatory B Cells Limit CNS Inflammation and Neurologic Deficits in Murine Experimental Stroke

(2011) X. Ren et al.   JOURNAL OF NEUROSCIENCE

Effect of vagus nerve stimulation during transient focal cerebral ischemia on chronic outcome in rats

(2011) Teruyuki Hiraki et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Mannose-Binding Lectin Deficiency Is Associated With Smaller Infarction Size and Favorable Outcome in Ischemic Stroke Patients

(2011) Michael Osthoff et al.   PLoS One

Functional Innervation of Hepatic iNKT Cells Is Immunosuppressive Following Stroke

(2011) C. H. Y. Wong et al.   SCIENCE

Blood–Brain Barrier Breakdown in Acute and Chronic Cerebrovascular Disease

(2011) Yi Yang et al.   STROKE

Autoimmune Responses to the Brain After Stroke Are Associated With Worse Outcome

(2011) Kyra J. Becker et al.   STROKE

Associations of cytokine gene polymorphisms with post-stroke depression

(2011) Jae-Min Kim et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation

(2010) C. Kleinschnitz et al.   BLOOD

Mast Cells as Early Responders in the Regulation of Acute Blood–Brain Barrier Changes after Cerebral Ischemia and Hemorrhage

(2010) Perttu Johannes Lindsberg et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Novel Characterization of Monocyte-Derived Cell Populations in the Meninges and Choroid Plexus and Their Rates of Replenishment in Bone Marrow Chimeric Mice

(2010) Holly R. Chinnery et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetically-Defined Deficiency of Mannose-Binding Lectin Is Associated with Protection after Experimental Stroke in Mice and Outcome in Human Stroke

(2010) Alvaro Cervera et al.   PLoS One

Insular Cortex Atrophy as an Independent Determinant of Disrupted Diurnal Rhythm of Ambulatory Blood Pressure in Elderly Hypertension

(2009) M. Nagai et al.   AMERICAN JOURNAL OF HYPERTENSION

Brain dendritic cells in ischemic stroke: Time course, activation state, and origin

(2009) Jennifer C. Felger et al.   BRAIN BEHAVIOR AND IMMUNITY

Transient decrease in circulating dendritic cell precursors after acute stroke: potential recruitment into the brain

(2009) Atilla Yilmaz et al.   CLINICAL SCIENCE

Emulating Multicentre Clinical Stroke Trials: A New Paradigm for Studying Novel Interventions in Experimental Models of Stroke

(2009) P. M. W. Bath et al.   International Journal of Stroke

A Rapid and Transient Peripheral Inflammatory Response Precedes Brain Inflammation after Experimental Stroke

(2009) Katie Z Chapman et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis

(2009) Sarah T Pendlebury et al.   LANCET NEUROLOGY

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

(2009) Takashi Shichita et al.   NATURE MEDICINE

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

(2009) Arthur Liesz et al.   NATURE MEDICINE

Neutrophil elastase and neurovascular injury following focal stroke and reperfusion

(2009) Ann M. Stowe et al.   NEUROBIOLOGY OF DISEASE

Differential Affection of Intestinal Immune Cell Populations after Cerebral Ischemia in Mice

(2009) Olaf Schulte-Herbrüggen et al.   NEUROIMMUNOMODULATION

Leukocyte Recruitment and Ischemic Brain Injury

(2009) Gokhan Yilmaz et al.   NEUROMOLECULAR MEDICINE

The Neurology of the Immune System: Neural Reflexes Regulate Immunity

(2009) Mauricio Rosas-Ballina et al.   NEURON

Strong complement activation after acute ischemic stroke is associated with unfavorable outcomes

(2008) Gábor Széplaki et al.   ATHEROSCLEROSIS

Pro-inflammatory and anti-inflammatory cytokines in acute ischemic stroke and their relation to early neurological deficit and stroke outcome

(2008) Vanja Basic Kes et al.   CLINICAL BIOCHEMISTRY

Atrial fibrillation in stroke-free patients is associated with memory impairment and hippocampal atrophy

(2008) S. Knecht et al.   EUROPEAN HEART JOURNAL

Plasma proinflammatory and anti-inflammatory cytokine and catecholamine concentrations as predictors of neurological outcome in acute stroke patients

(2008) Jun Oto et al.   Journal of Anesthesia