Brain drains: new insights into brain clearance pathways from lymphatic biology

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics

(2017) Antoine Louveau et al.   JOURNAL OF CLINICAL INVESTIGATION

Development and plasticity of meningeal lymphatic vessels

(2017) Salli Antila et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mural lymphatic endothelial cells regulate meningeal angiogenesis in the zebrafish

(2017) Neil I Bower et al.   NATURE NEUROSCIENCE

Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

(2017) Qiaoli Ma et al.   Nature Communications

A novel perivascular cell population in the zebrafish brain

(2017) Marina Venero Galanternik et al.   eLife

Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI

(2017) Martina Absinta et al.   eLife

Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development

(2017) Max van Lessen et al.   eLife

Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

(2017) Alex J Smith et al.   eLife

Lymphatic System in Cardiovascular Medicine

(2016) Aleksanteri Aspelund et al.   CIRCULATION RESEARCH

Spatial model of convective solute transport in brain extracellular space does not support a “glymphatic” mechanism

(2016) Byung-Ju Jin et al.   JOURNAL OF GENERAL PHYSIOLOGY

Lymphatics in Neurological Disorders: A Neuro-Lympho-Vascular Component of Multiple Sclerosis and Alzheimer’s Disease?

(2016) Antoine Louveau et al.   NEURON

How Do Meningeal Lymphatic Vessels Drain the CNS?

(2016) Daniel Raper et al.   TRENDS IN NEUROSCIENCES

Lipid-laden cells differentially distributed in the aging brain are functionally active and correspond to distinct phenotypes

(2016) Marilia Kimie Shimabukuro et al.   Scientific Reports

Glymphatic solute transport does not require bulk flow

(2016) Mahdi Asgari et al.   Scientific Reports

Cerebral nitric oxide represses choroid plexus NF B-dependent gateway activity for leukocyte trafficking

(2015) K. Baruch et al.   EMBO JOURNAL

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

The Glymphatic System: A Beginner’s Guide

(2015) Nadia Aalling Jessen et al.   NEUROCHEMICAL RESEARCH

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Ontogeny and Functions of Central Nervous System Macrophages

(2014) Atsuko Katsumoto et al.   JOURNAL OF IMMUNOLOGY

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

(2013) Jeffrey J. Iliff et al.   JOURNAL OF CLINICAL INVESTIGATION

Cerebral Arterial Pulsation Drives Paravascular CSF-Interstitial Fluid Exchange in the Murine Brain

(2013) J. J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration

(2013) V. Hugh Perry et al.   Seminars in Immunopathology

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine