Evolution, role in inflammation, and redox control of leaderless secretory proteins

A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion

(2020) Min Zhang et al.   CELL

ATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-1

(2019) Yu Ran Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tau Secretion: Good and Bad for Neurons

(2019) Camille Pernègre et al.   Frontiers in Neuroscience

Mechanism of membrane pore formation by human gasdermin‐D

(2018) Estefania Mulvihill et al.   EMBO JOURNAL

The unconventional secretion of IL-1β: Handling a dangerous weapon to optimize inflammatory responses

(2018) Roberto Sitia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Unconventional protein secretion: Diversity and consensus

(2018) Walter Nickel et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Unconventional secretion of annexins and galectins

(2018) Stephanie J. Popa et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A direct gateway into the extracellular space: Unconventional secretion of FGF2 through self-sustained plasma membrane pores

(2018) Julia P. Steringer et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Regulatory role of thiol isomerases in thrombus formation

(2018) Anish Sharda et al.   Expert Review of Hematology

Unconventional Secretion Mediates the Trans-cellular Spreading of Tau

(2018) Taxiarchis Katsinelos et al.   Cell Reports

Import and Export of Misfolded α-Synuclein

(2018) Lilia Rodriguez et al.   Frontiers in Neuroscience

DNAJC5 facilitates USP19-dependent unconventional secretion of misfolded cytosolic proteins

(2018) Yue Xu et al.   Cell Discovery

Dephosphorylated rather than hyperphosphorylated Tau triggers a pro-inflammatory profile in microglia through the p38 MAPK pathway

(2018) Juan Ramón Perea et al.   EXPERIMENTAL NEUROLOGY

Secretion of misfolded cytosolic proteins from mammalian cells is independent of chaperone-mediated autophagy

(2018) Juhyung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin 4 is inactivated via selective disulfide-bond reduction by extracellular thioredoxin

(2018) Nicholas M. Plugis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox-Mediated Mechanisms Fuel Monocyte Responses to CXCL12/HMGB1 in Active Rheumatoid Arthritis

(2018) Valentina Cecchinato et al.   Frontiers in Immunology

Progressive waves of IL-1β release by primary human monocytes via sequential activation of vesicular and gasdermin D-mediated secretory pathways

(2018) Claudia Semino et al.   Cell Death & Disease

Secretion of Tau via an Unconventional Non-vesicular Mechanism

(2018) Maria Merezhko et al.   Cell Reports

Cigarette smoke extract induced exosome release is mediated by depletion of exofacial thiols and can be inhibited by thiol-antioxidants

(2017) Birke J. Benedikter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox Regulation of Inflammatory Processes Is Enzymatically Controlled

(2017) Inken Lorenzen et al.   Oxidative Medicine and Cellular Longevity

Pathological α-synuclein exacerbates the progression of Parkinson’s disease through microglial activation

(2017) Qiu-Shuang Zhang et al.   TOXICOLOGY LETTERS

Gasdermins: Effectors of Pyroptosis

(2017) Stephen B. Kovacs et al.   TRENDS IN CELL BIOLOGY

Loss of autophagy enhances MIF/macrophage migration inhibitory factor release by macrophages

(2016) Jacinta P. W. Lee et al.   Autophagy

DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative‐associated proteins

(2016) Sarah N Fontaine et al.   EMBO JOURNAL

The position of lysosomes within the cell determines their luminal pH

(2016) Danielle E. Johnson et al.   JOURNAL OF CELL BIOLOGY

Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides

(2016) Hana M. Russo et al.   JOURNAL OF IMMUNOLOGY

Unconventional secretion of misfolded proteins promotes adaptation to proteasome dysfunction in mammalian cells

(2016) Jin-Gu Lee et al.   NATURE CELL BIOLOGY

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

(2016) Ivan Zanoni et al.   SCIENCE

Thiol–Disulfide Exchange Reactions in the Mammalian Extracellular Environment

(2016) Michael C. Yi et al.   Annual Review of Chemical and Biomolecular Engineering

Secreted APE1/Ref-1 inhibits TNF-α-stimulated endothelial inflammation via thiol-disulfide exchange in TNF receptor

(2016) Myoung Soo Park et al.   Scientific Reports

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Redox Proteomics of the Inflammatory Secretome Identifies a Common Set of Redoxins and Other Glutathionylated Proteins Released in Inflammation, Influenza Virus Infection and Oxidative Stress

(2015) Paola Checconi et al.   PLoS One

Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance

(2015) Sonia Carta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and  -synuclein

(2015) M. Goedert   SCIENCE

Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion

(2015) Min Zhang et al.   eLife

DAMPs from Cell Death to New Life

(2015) Emilie Vénéreau et al.   Frontiers in Immunology

Remodeling of secretory compartments creates CUPS during nutrient starvation

(2014) David Cruz-Garcia et al.   JOURNAL OF CELL BIOLOGY

TLR Costimulation Causes Oxidative Stress with Unbalance of Proinflammatory and Anti-Inflammatory Cytokine Production

(2014) R. Lavieri et al.   JOURNAL OF IMMUNOLOGY

Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses

(2014) A.-M. Bulau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal

(2014) S. Salzano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation, DAMPs, Tumor Development, and Progression: A Vicious Circle Orchestrated by Redox Signaling

(2013) Patrizia Castellani et al.   ANTIOXIDANTS & REDOX SIGNALING

Physiological release of endogenous tau is stimulated by neuronal activity

(2013) Amy M Pooler et al.   EMBO REPORTS

Different Members of the IL-1 Family Come Out in Different Ways: DAMPs vs. Cytokines?

(2013) Sonia Carta et al.   Frontiers in Immunology

Deficient production of IL-1 receptor antagonist and IL-6 coupled to oxidative stress in cryopyrin-associated periodic syndrome monocytes

(2012) Sonia Carta et al.   ANNALS OF THE RHEUMATIC DISEASES

Oxidative Stress Triggers Ca2+-Dependent Lysosome Trafficking and Activation of Acid Sphingomyelinase

(2012) Xiang Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

(2012) Olaf Groß et al.   IMMUNITY

Interleukin 33 as a Mechanically Responsive Cytokine Secreted by Living Cells

(2012) Rahul Kakkar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P2)-dependent Oligomerization of Fibroblast Growth Factor 2 (FGF2) Triggers the Formation of a Lipidic Membrane Pore Implicated in Unconventional Secretion

(2012) Julia P. Steringer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ranking Gene Ontology terms for predicting non-classical secretory proteins in eukaryotes and prokaryotes

(2012) Wen-Lin Huang   JOURNAL OF THEORETICAL BIOLOGY

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

The Rate of Interleukin-1β Secretion in Different Myeloid Cells Varies with the Extent of Redox Response to Toll-like Receptor Triggering

(2011) Sonia Carta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Extracellular Transglutaminase 2 by Thioredoxin

(2011) Xi Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

(2011) James Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unconventional Secretion of Tissue Transglutaminase Involves Phospholipid-Dependent Delivery into Recycling Endosomes

(2011) Evgeny A. Zemskov et al.   PLoS One

Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells

(2011) Christian Münch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ins and Outs of HIV-1 Tat

(2011) Solène Debaisieux et al.   TRAFFIC

Redox Remodeling Allows and Controls B-Cell Activation and Differentiation

(2010) Roberta Vené et al.   ANTIOXIDANTS & REDOX SIGNALING

Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells

(2010) Fabienne Rayne et al.   EMBO JOURNAL

Signaling by ROS drives inflammasome activation

(2010) Fabio Martinon   EUROPEAN JOURNAL OF IMMUNOLOGY

Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion

(2010) Irfan Y. Tamboli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unconventional secretion of Acb1 is mediated by autophagosomes

(2010) Juan M. Duran et al.   JOURNAL OF CELL BIOLOGY

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1  secretion

(2010) S. Tassi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress as an Intercellular Signal: The Emergence of Stress-Associated Molecular Patterns (SAMP)

(2009) Anna Rubartelli et al.   ANTIOXIDANTS & REDOX SIGNALING

SPRED: A machine learning approach for the identification of classical and non-classical secretory proteins in mammalian genomes

(2009) Krishna Kumar Kandaswamy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pathogen-Induced Interleukin-1  Processing and Secretion Is Regulated by a Biphasic Redox Response

(2009) S. Tassi et al.   JOURNAL OF IMMUNOLOGY

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

TRPC channel activation by extracellular thioredoxin

(2008) Shang-Zhong Xu et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1  and IL-18 secretion in an autocrine way

(2008) A. Piccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Secretion without Golgi

(2007) Igor Prudovsky et al.   JOURNAL OF CELLULAR BIOCHEMISTRY