NDM-1, the ultimate promiscuous enzyme: substrate recognition and catalytic mechanism

Mechanistic and Spectroscopic Studies of Metallo-β-lactamase NDM-1

(2012) Hao Yang et al.   BIOCHEMISTRY

New Delhi Metallo-β-Lactamase: Structural Insights into β-Lactam Recognition and Inhibition

(2012) Dustin T. King et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Network Context and Selection in the Evolution to Enzyme Specificity

(2012) H. Nam et al.   SCIENCE

Characterization of Purified New Delhi Metallo-β-lactamase-1

(2011) Pei W. Thomas et al.   BIOCHEMISTRY

Crystal structure of NDM-1 reveals a common β-lactam hydrolysis mechanism

(2011) HongMin Zhang et al.   FASEB JOURNAL

Origins of Specificity and Promiscuity in Metabolic Networks

(2011) Pablo Carbonell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study

(2011) Timothy R Walsh et al.   LANCET INFECTIOUS DISEASES

Antibiotic resistance is ancient

(2011) Vanessa M. D’Costa et al.   NATURE

Structure of Apo- and Monometalated Forms of NDM-1—A Highly Potent Carbapenem-Hydrolyzing Metallo-β-Lactamase

(2011) Youngchang Kim et al.   PLoS One

Crystal structure of New Delhi metallo-β-lactamase reveals molecular basis for antibiotic resistance

(2011) Dustin King et al.   PROTEIN SCIENCE

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study

(2010) Karthikeyan K Kumarasamy et al.   LANCET INFECTIOUS DISEASES

NDM-1 — A Cause for Worldwide Concern

(2010) Robert C. Moellering   NEW ENGLAND JOURNAL OF MEDICINE

Updated Functional Classification of  -Lactamases

(2009) K. Bush et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Has the era of untreatable infections arrived?

(2009) D. M. Livermore   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Common Mechanistic Features among Metallo-β-lactamases

(2009) Fabio Simona et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutational analysis of the zinc- and substrate-binding sites in the CphA metallo-β-lactamase fromAeromonas hydrophila

(2008) Carine Bebrone et al.   BIOCHEMICAL JOURNAL

The Mechanisms of Catalysis by Metallo -Lactamases

(2008) Michael I. Page et al.   BIOINORGANIC CHEMISTRY AND APPLICATIONS

Zinc and antibiotic resistance: metallo-β-lactamases and their synthetic analogues

(2008) A. Tamilselvi et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase

(2008) M. P. Blakeley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA