Structural basis of steroid binding and oxidation by the cytochrome P450 CYP109E1 fromBacillus megaterium

Crystal Structure of CYP106A2 in Substrate-Free and Substrate-Bound Form

(2016) Simon Janocha et al.   CHEMBIOCHEM

Comparison of CYP106A1 and CYP106A2 from Bacillus megaterium – identification of a novel 11-oxidase activity

(2015) Flora Marta Kiss et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Substrate Hunting for the Myxobacterial CYP260A1 Revealed New 1α-Hydroxylated Products from C-19 Steroids

(2015) Yogan Khatri et al.   CHEMBIOCHEM

Regioselective hydroxylation of steroid hormones by human cytochromes P450

(2015) Toshiro Niwa et al.   DRUG METABOLISM REVIEWS

Identification of new substrates for the CYP106A1-mediated 11-oxidation and investigation of the reaction mechanism

(2015) Flora Marta Kiss et al.   FEBS LETTERS

The crystal structure of the versatile cytochrome P450 enzyme CYP109B1 from Bacillus subtilis

(2015) Aili Zhang et al.   Molecular BioSystems

Identification of universal selectivity-determining positions in cytochrome P450 monooxygenases by systematic sequence-based literature mining

(2015) Łukasz Gricman et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Cytochromes P450 as promising catalysts for biotechnological application: chances and limitations

(2014) Rita Bernhardt et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Functional characterization of steroid hydroxylase CYP106A1 derived from Bacillus megaterium

(2014) Ga-Young Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Steroid conversion with CYP106A2 – production of pharmaceutically interesting DHEA metabolites

(2014) Daniela Schmitz et al.   Microbial Cell Factories

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

Enzyme–substrate complex structures of CYP154C5 shed light on its mode of highly selective steroid hydroxylation

(2014) Konrad Herzog et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Regio- and Stereospecific Hydroxylation of Various Steroids at the 16α Position of the D Ring by the Streptomyces griseus Cytochrome P450 CYP154C3

(2013) Takuya Makino et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A new cytochrome P450 system from Bacillus megaterium DSM319 for the hydroxylation of 11-keto-β-boswellic acid (KBA)

(2013) Elisa Brill et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Novel family members of CYP109 fromSorangium cellulosumSo ce56 exhibit characteristic biochemical and biophysical properties

(2013) Yogan Khatri et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Selective steroid oxyfunctionalisation by CYP154C5, a bacterial cytochrome P450

(2013) Paula Bracco et al.   Microbial Cell Factories

MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0

(2013) Koichiro Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Microbial steroid transformations: current state and prospects

(2012) Marina V. Donova et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A Single Active Site Mutation Inverts Stereoselectivity of 16-Hydroxylation of Testosterone Catalyzed by Engineered Cytochrome P450 BM3

(2012) Harini Venkataraman et al.   CHEMBIOCHEM

Is There a Relationship Between the Substrate Preferences and Structural Flexibility of Cytochromes P450?

(2012) Michal Otyepka et al.   CURRENT DRUG METABOLISM

Hydroxylation of the triterpenoid dipterocarpol with CYP106A2 from Bacillus megaterium

(2012) Daniela Schmitz et al.   FEBS Journal

Three-dimensional Structure of Steroid 21-Hydroxylase (Cytochrome P450 21A2) with Two Substrates Reveals Locations of Disease-associated Variants

(2012) Bin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diversity of P450 enzymes in the biosynthesis of natural products

(2012) Larissa M. Podust et al.   NATURAL PRODUCT REPORTS

Biological transformations of steroidal compounds: A review

(2012) Haq Nawaz Bhatti et al.   STEROIDS

iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM

(2011) T. Geoff G. Battye et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A new Bacillus megaterium whole-cell catalyst for the hydroxylation of the pentacyclic triterpene 11-keto-β-boswellic acid (KBA) based on a recombinant cytochrome P450 system

(2011) Sabrina Bleif et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Active Site Substitution A82W Improves the Regioselectivity of Steroid Hydroxylation by Cytochrome P450 BM3 Mutants As Rationalized by Spin Relaxation Nuclear Magnetic Resonance Studies

(2011) V. Rea et al.   BIOCHEMISTRY

Genome Sequences of the Biotechnologically Important Bacillus megaterium Strains QM B1551 and DSM319

(2011) M. Eppinger et al.   JOURNAL OF BACTERIOLOGY

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

(2011) Roman A. Laskowski et al.   Journal of Chemical Information and Modeling

Structural differences between soluble and membrane bound cytochrome P450s

(2011) I.G. Denisov et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

R.E.D. Server: a web service for deriving RESP and ESP charges and building force field libraries for new molecules and molecular fragments

(2011) Enguerran Vanquelef et al.   NUCLEIC ACIDS RESEARCH

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Characterization of the versatile monooxygenase CYP109B1 from Bacillus subtilis

(2010) Marco Girhard et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The CYPome of Sorangium cellulosum So ce56 and Identification of CYP109D1 as a New Fatty Acid Hydroxylase

(2010) Yogan Khatri et al.   CHEMISTRY & BIOLOGY

Cytochromes P450: exploiting diversity and enabling application as biocatalysts

(2010) Gideon Grogan   CURRENT OPINION IN CHEMICAL BIOLOGY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Structure of Mycobacterium tuberculosis CYP125

(2009) Kirsty J. McLean et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PubChem: a public information system for analyzing bioactivities of small molecules

(2009) Y. Wang et al.   NUCLEIC ACIDS RESEARCH

Phylogenetic analysis of Bacillus P450 monooxygenases and evaluation of their activity towards steroids

(2009) Toshiki Furuya et al.   STEROIDS

Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both?

(2008) Dmitri R Davydov et al.   Expert Opinion on Drug Metabolism & Toxicology

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Oxygen activation by cytochrome P450 monooxygenase

(2008) Djemel Hamdane et al.   PHOTOSYNTHESIS RESEARCH