Assessment of the Effect of Sorafenib on Omega-6 and Omega-3 Epoxyeicosanoid Formation in Patients with Hepatocellular Carcinoma

Systemic Therapy for Advanced Hepatocellular Carcinoma in an Evolving Landscape

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Inhibition of Soluble Epoxide Hydrolase Ameliorates Hyperhomocysteinemia-Induced Hepatic Steatosis by Enhancing β-oxidation of Fatty Acid in Mice

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Epoxyeicosatrienoic acids alleviate methionine‐choline‐deficient diet‐induced non‐alcoholic steatohepatitis in mice

(2019) Xiaojing Wang et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Inhibition of Pancreatic Carcinoma Growth Through Enhancing ω-3 Epoxy Polyunsaturated Fatty Acid Profile by Inhibition of Soluble Epoxide Hydrolase

(2019) RONG XIA et al.   ANTICANCER RESEARCH

Immune checkpoint blockade in advanced hepatocellular carcinoma: an update and critical review of ongoing clinical trials

(2018) James J Harding   Future Oncology

Hepatocellular carcinoma

(2018) Alejandro Forner et al.   LANCET

Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation

(2018) Weicang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble epoxide hydrolase inhibition with t-TUCB alleviates liver fibrosis and portal pressure in carbon tetrachloride-induced cirrhosis in rats

(2018) Chi-Hao Zhang et al.   Clinics and Research in Hepatology and Gastroenterology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Hepatic Arterial Infusion of Low-Density Lipoprotein Docosahexaenoic Acid Nanoparticles Selectively Disrupts Redox Balance in Hepatoma Cells and Reduces Growth of Orthotopic Liver Tumors in Rats

(2016) Xiaodong Wen et al.   GASTROENTEROLOGY

Dietary fatty acids and risk of hepatocellular carcinoma in the Singapore Chinese health study

(2015) Woon-Puay Koh et al.   LIVER INTERNATIONAL

Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs

(2015) Melissa Gabbs et al.   Advances in Nutrition

Surveillance for hepatocellular carcinoma

(2014) Morris Sherman   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Fish consumption and n-3 polyunsaturated fatty acids, and risk of hepatocellular carcinoma: systematic review and meta-analysis

(2014) Min Gao et al.   CANCER CAUSES & CONTROL

Lymphangiogenic factors, mechanisms, and applications

(2014) Wei Zheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Dietary omega-3 fatty acids modulate the eicosanoid profile in man primarily via the CYP-epoxygenase pathway

(2014) Robert Fischer et al.   JOURNAL OF LIPID RESEARCH

Cytochrome P450–dependent metabolism of ω-6 and ω-3 long-chain polyunsaturated fatty acids

(2014) Cosima Arnold et al.   Pharmacological Reports

Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides

(2014) Cristina López-Vicario et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis

(2013) G. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer

(2013) Guodong Zhang et al.   PROGRESS IN LIPID RESEARCH

Impact of Soluble Epoxide Hydrolase and Epoxyeicosanoids on Human Health

(2012) Christophe Morisseau et al.   Annual Review of Pharmacology and Toxicology

Consumption of n-3 Fatty Acids and Fish Reduces Risk of Hepatocellular Carcinoma

(2012) Norie Sawada et al.   GASTROENTEROLOGY

Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma

(2012) Hashem B. El-Serag   GASTROENTEROLOGY

Hepatocellular carcinoma

(2012) Alejandro Forner et al.   LANCET

Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study

(2011) Keith T. Flaherty et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF- 

(2011) K. H. Weylandt et al.   CARCINOGENESIS

Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Diet-Induced Metabolic Syndrome in Rats

(2011) Abishek Iyer et al.   Experimental Diabetes Research

Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice

(2011) Dipak Panigrahy et al.   JOURNAL OF CLINICAL INVESTIGATION

Non-mammalian fat-1 gene prevents neoplasia when introduced to a mouse hepatocarcinogenesis modelOmega-3 fatty acids prevent liver neoplasia

(2010) J. Griffitts et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Inhibition of carcinoma cell motility by epoxyeicosatrienoic acid (EET) antagonists

(2010) Kasem Nithipatikom et al.   CANCER SCIENCE

Arachidonic Acid-metabolizing Cytochrome P450 Enzymes Are Targets of ω-3 Fatty Acids

(2010) Cosima Arnold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo

(2009) J.-Y. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking  -catenin and cyclooxygenase-2

(2009) K. Lim et al.   MOLECULAR CANCER THERAPEUTICS

Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases

(2009) John D. Imig et al.   NATURE REVIEWS DRUG DISCOVERY

Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids

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Sorafenib in Advanced Hepatocellular Carcinoma

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