The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens

T follicular regulatory (Tfr) cells: Dissecting the complexity of Tfr‐cell compartments

(2019) Válter R. Fonseca et al.   IMMUNOLOGICAL REVIEWS

TNFR2 signaling modulates immunity after allogeneic hematopoietic cell transplantation

(2019) Antonella Mancusi et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Crystal structure and activation mechanism of DR3 death domain

(2019) Xueying Yin et al.   FEBS Journal

Activation of the DR3-TL1A Axis in Donor Mice Leads to Regulatory T Cell Expansion and Activation With Reduction in Graft-Versus-Host Disease

(2019) Melissa Mavers et al.   Frontiers in Immunology

TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages

(2019) Harald Wajant et al.   Frontiers in Cell and Developmental Biology

Defining response to TNF-inhibitors in rheumatoid arthritis: the negative impact of anti-TNF cycling and the need for a personalized medicine approach to identify primary non-responders

(2019) Keith J. Johnson et al.   CLINICAL RHEUMATOLOGY

The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability

(2019) Emilie Ronin et al.   Frontiers in Immunology

Immune regulatory cell infusion for graft-versus-host disease prevention and therapy

(2018) Bruce R. Blazar et al.   BLOOD

Spontaneous T Cell Proliferation: A Physiologic Process to Create and Maintain Homeostatic Balance and Diversity of the Immune System

(2018) Booki Min   Frontiers in Immunology

Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity

(2018) Kamar-Sulu N. Atretkhany et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TNF Receptor Superfamily-NF-κB Axis Is Critical to Maintain Effector Regulatory T Cells in Lymphoid and Non-lymphoid Tissues

(2017) Ajithkumar Vasanthakumar et al.   Cell Reports

TNFR2: The new Treg switch?

(2017) José L. Cohen et al.   OncoImmunology

The Immunosuppressive Effect of CTLA4 Immunoglobulin Is Dependent on Regulatory T Cells at Low But Not High Doses

(2016) C. Schwarz et al.   AMERICAN JOURNAL OF TRANSPLANTATION

TNF-α priming enhances CD4 + FoxP3 + regulatory T-cell suppressive function in murine GVHD prevention and treatment

(2016) Antonio Pierini et al.   BLOOD

Control of GVHD by regulatory T cells depends on TNF produced by T cells and TNFR2 expressed by regulatory T cells

(2016) M. Leclerc et al.   BLOOD

DR3 signaling modulates the function of Foxp3+ regulatory T cells and the severity of acute graft-versus-host disease

(2016) H. Nishikii et al.   BLOOD

The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses

(2016) Lindsay K. Ward-Kavanagh et al.   IMMUNITY

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

(2016) Martin Chopra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory T Cell–Dependent and –Independent Mechanisms of Immune Suppression by CD28/B7 and CD40/CD40L Costimulation Blockade

(2016) Isabel Vogel et al.   JOURNAL OF IMMUNOLOGY

Reply to Suppressive activity of human regulatory T cells is maintained in the presence of TNF

(2016) Hong Nie et al.   NATURE MEDICINE

Suppressive activity of human regulatory T cells is maintained in the presence of TNF

(2016) Bruno Zaragoza et al.   NATURE MEDICINE

Belatacept and Long-Term Outcomes in Kidney Transplantation

(2016) Flavio Vincenti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treatment with agonistic DR3 antibody results in expansion of donor Tregs and reduced graft-versus-host disease

(2015) B.-S. Kim et al.   BLOOD

Principles of antibody-mediated TNF receptor activation

(2015) H Wajant   CELL DEATH AND DIFFERENTIATION

The TNF-family cytokine TL1A: from lymphocyte costimulator to disease co-conspirator

(2015) Arianne C. Richard et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Contribution of Regulatory T Cells and Effector T Cell Deletion in Tolerance Induction by Costimulation Blockade

(2014) B. Verbinnen et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Expression of TNFR2 Defines a Maximally Suppressive Subset of Mouse CD4+CD25+FoxP3+ T Regulatory Cells: Applicability to Tumor-Infiltrating T Regulatory Cells

(2014) X. Chen et al.   JOURNAL OF IMMUNOLOGY

Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells

(2014) Shawn A Mahmud et al.   NATURE IMMUNOLOGY

LIGHT/HVEM/LTβR Interaction as a Target for the Modulation of the Allogeneic Immune Response in Transplantation

(2013) M.-L. del Rio et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Development and Maintenance of Regulatory T cells

(2013) Naganari Ohkura et al.   IMMUNITY

TNFR2 Is Critical for the Stabilization of the CD4+Foxp3+ Regulatory T Cell Phenotype in the Inflammatory Environment

(2013) X. Chen et al.   JOURNAL OF IMMUNOLOGY

Clinical targeting of the TNF and TNFR superfamilies

(2013) Michael Croft et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibitory Effects of Belatacept on Allospecific Regulatory T-Cell Generation in Humans

(2013) Josh Levitsky et al.   TRANSPLANTATION

Homogeneous Expansion of Human T-Regulatory Cells Via Tumor Necrosis Factor Receptor 2

(2013) Yoshiaki Okubo et al.   Scientific Reports

Peripheral and Thymic Foxp3+ Regulatory T Cells in Search of Origin, Distinction, and Function

(2013) Chetan Dhamne et al.   Frontiers in Immunology

Lymphodepletion and Homeostatic Proliferation: Implications for Transplantation

(2012) N. K. Tchao et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Deleterious Effect of CTLA4-Ig on a Treg-Dependent Transplant Model

(2012) L. V. Riella et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Tregs Expanded In Vivo by TNFRSF25 Agonists Promote Cardiac Allograft Survival

(2012) Dietlinde Wolf et al.   TRANSPLANTATION

Multiple treg suppressive modules and their adaptability

(2012) James B. Wing et al.   Frontiers in Immunology

Expression of TNFRSF25 on conventional T cells and Tregs

(2011) Vadim Y. Taraban et al.   JOURNAL OF CLINICAL INVESTIGATION

Sustained suppression by Foxp3+regulatory T cells is vital for infectious transplantation tolerance

(2011) Adrian R. Kendal et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+regulatory T cells in human peripheral blood

(2010) Xin Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation

(2010) Taylor H. Schreiber et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of Costimulatory TNFR2 Induces Resistance of CD4+FoxP3- Conventional T Cells to Suppression by CD4+FoxP3+ Regulatory T Cells

(2010) X. Chen et al.   JOURNAL OF IMMUNOLOGY

Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation setting

(2009) L. I. Sanchez-Abarca et al.   BLOOD

Harnessing the physiology of lymphopenia to support adoptive immunotherapy in lymphoreplete hosts

(2009) Y. Cui et al.   BLOOD

Lymphocyte proliferation in immune-mediated diseases

(2009) Shrimati Datta et al.   TRENDS IN IMMUNOLOGY

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology