T follicular regulatory (Tfr) cells: Dissecting the complexity of Tfr‐cell compartments

Increased circulating CD4 + CXCR5 + FoxP3 + follicular regulatory T cells correlated with severity of systemic lupus erythematosus patients

(2018) Chen Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Exaggerated follicular helper T-cell responses in patients with LRBA deficiency caused by failure of CTLA4-mediated regulation

(2018) Fayhan J. Alroqi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Spatial distribution and function of T follicular regulatory cells in human lymph nodes

(2018) Ismail Sayin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Deficiency in T follicular regulatory cells promotes autoimmunity

(2018) Weiwei Fu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Is the T follicular regulatory:follicular helper T cell ratio in blood a biomarker for ectopic lymphoid structure formation in Sjögren's syndrome? Comment on the article by Fonseca et al

(2018) Gwenny M. Verstappen et al.   Arthritis & Rheumatology

T follicular regulatory cells are decreased in established treated rheumatoid arthritis patients with active disease

(2018) Vasco C Romão et al.   Arthritis & Rheumatology

The Ratio of Blood T Follicular Regulatory Cells to T Follicular Helper Cells Marks Ectopic Lymphoid Structure Formation While Activated Follicular Helper T Cells Indicate Disease Activity in Primary Sjögren's Syndrome

(2018) Valter R. Fonseca et al.   Arthritis & Rheumatology

PD-1 Controls Follicular T Helper Cell Positioning and Function

(2018) Jingwen Shi et al.   IMMUNITY

High-resolution repertoire analysis reveals a major bystander activation of Tfh and Tfr cells

(2018) Paul-Gydeon Ritvo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells

(2018) Daniel DiToro et al.   SCIENCE

Hepatocyte-derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection

(2017) Dustin A. Cobb et al.   HEPATOLOGY

The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells

(2017) Lifan Xu et al.   IMMUNITY

T follicular regulatory cells in mice and men

(2017) Ana Raquel Maceiras et al.   IMMUNOLOGY

Transcriptional repressor Blimp1 regulates follicular regulatory T-cell homeostasis and function

(2017) Guang Yang et al.   IMMUNOLOGY

EFIS Lecture: Understanding the CTLA-4 checkpoint in the maintenance of immune homeostasis

(2017) Lucy S.K. Walker   IMMUNOLOGY LETTERS

Foxp1 Negatively Regulates T Follicular Helper Cell Differentiation and Germinal Center Responses by Controlling Cell Migration and CTLA-4

(2017) Bi Shi et al.   JOURNAL OF IMMUNOLOGY

Follicular Regulatory T Cells Are Highly Permissive to R5-Tropic HIV-1

(2017) Shannon M. Miller et al.   JOURNAL OF VIROLOGY

Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2

(2017) Naomi McGovern et al.   NATURE

A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers

(2017) James Badger Wing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Making Mouse Models That Reflect Human Immune Responses

(2017) Lili Tao et al.   TRENDS IN IMMUNOLOGY

T follicular helper and T follicular regulatory cells have different TCR specificity

(2017) Ana Raquel Maceiras et al.   Nature Communications

IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2

(2017) Christoph Jandl et al.   Nature Communications

Low proportion of follicular regulatory T cell in renal transplant patients with chronic antibody-mediated rejection

(2017) Wen Chen et al.   Scientific Reports

Attenuation of Follicular Helper T Cell-Dependent B Cell Hyperactivity by Abatacept Treatment in Primary Sjögren's Syndrome

(2017) Gwenny M. Verstappen et al.   Arthritis & Rheumatology

Follicular Helper T Cells

(2016) Carola G. Vinuesa et al.   Annual Review of Immunology

Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients

(2016) Romain Banchereau et al.   CELL

Follicular regulatory T cells repress cytokine production by follicular helper T cells and optimize IgG responses in mice

(2016) Hao Wu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Store-Operated Ca 2+ Entry in Follicular T Cells Controls Humoral Immune Responses and Autoimmunity

(2016) Martin Vaeth et al.   IMMUNITY

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation

(2016) Hu Zeng et al.   IMMUNITY

T follicular regulatory cells

(2016) Peter T. Sage et al.   IMMUNOLOGICAL REVIEWS

Cutting Edge: Adenosine A2a Receptor Signals Inhibit Germinal Center T Follicular Helper Cell Differentiation during the Primary Response to Vaccination

(2016) Shirdi E. Schmiel et al.   JOURNAL OF IMMUNOLOGY

EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells

(2016) Jianhua Li et al.   NATURE

Normalizing the environment recapitulates adult human immune traits in laboratory mice

(2016) Lalit K. Beura et al.   NATURE

Suppression by TFR cells leads to durable and selective inhibition of B cell effector function

(2016) Peter T Sage et al.   NATURE IMMUNOLOGY

Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus

(2016) Jing He et al.   NATURE MEDICINE

Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells

(2016) Meryem Aloulou et al.   Nature Communications

Stat3 Is Important for Follicular Regulatory T Cell Differentiation

(2016) Hao Wu et al.   PLoS One

Humoral autoimmunity: A failure of regulatory T cells?

(2015) Tessa Dhaeze et al.   AUTOIMMUNITY REVIEWS

Higher frequency of peripheral blood follicular regulatory T cells in patients with new onset ankylosing spondylitis

(2015) Yuxing Shan et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

T Follicular Helper Cells Have Distinct Modes of Migration and Molecular Signatures in Naive and Memory Immune Responses

(2015) Dan Suan et al.   IMMUNITY

Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked–like disorder caused by loss-of-function mutations in LRBA

(2015) Louis-Marie Charbonnier et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies

(2015) Cindy S. Ma et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Spectrum of Phenotypes Associated with Mutations in LRBA

(2015) Omar K. Alkhairy et al.   JOURNAL OF CLINICAL IMMUNOLOGY

ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2

(2015) Jan P. Weber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Circulating Follicular Regulatory T Cells Are Defective in Multiple Sclerosis

(2015) Tessa Dhaeze et al.   JOURNAL OF IMMUNOLOGY

Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies

(2015) Judy H Cho et al.   NATURE MEDICINE

Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy

(2015) B. Lo et al.   SCIENCE

T follicular regulatory cells in the regulation of B cell responses

(2015) Peter T. Sage et al.   TRENDS IN IMMUNOLOGY

Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection

(2015) Brodie Miles et al.   Nature Communications

Distribution of Peripheral Memory T Follicular Helper Cells in Patients with Schistosomiasis Japonica

(2015) Xiaojun Chen et al.   PLoS Neglected Tropical Diseases

Induction of Regulatory T Cells by Intravenous Immunoglobulin: A Bridge between Adaptive and Innate Immunity

(2015) Gabriel N. Kaufman et al.   Frontiers in Immunology

HIV-Infected Spleens Present Altered Follicular Helper T Cell (Tfh) Subsets and Skewed B Cell Maturation

(2015) Lucie Colineau et al.   PLoS One

Abatacept treatment reduces disease activity in early primary Sjögren's syndrome (open-label proof of concept ASAP study)

(2014) P M Meiners et al.   ANNALS OF THE RHEUMATIC DISEASES

Specificity of regulatory T cells that modulate vascular inflammation

(2014) Alessandra Franco et al.   AUTOIMMUNITY

Human T-follicular helper and T-follicular regulatory cell maintenance is independent of germinal centers

(2014) E. F. Wallin et al.   BLOOD

CD25+Bcl6lowT follicular helper cells provide help to maturing B cells in germinal centers of human tonsil

(2014) Haishan Li et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis

(2014) Shimpei Kawamoto et al.   IMMUNITY

Regulatory T Cells Control Antigen-Specific Expansion of Tfh Cell Number and Humoral Immune Responses via the Coreceptor CTLA-4

(2014) James Badger Wing et al.   IMMUNITY

The Coinhibitory Receptor CTLA-4 Controls B Cell Responses by Modulating T Follicular Helper, T Follicular Regulatory, and T Regulatory Cells

(2014) Peter T. Sage et al.   IMMUNITY

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

Circulating T follicular regulatory and helper cells have memory-like properties

(2014) Peter T. Sage et al.   JOURNAL OF CLINICAL INVESTIGATION

Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression

(2014) Martin Vaeth et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: CD25+ Regulatory T Cells Prevent Expansion and Induce Apoptosis of B Cells Specific for Tissue Autoantigens

(2014) I. Ludwig-Portugall et al.   JOURNAL OF IMMUNOLOGY

CTLA-4 Controls Regulatory T Cell Peripheral Homeostasis and Is Required for Suppression of Pancreatic Islet Autoimmunity

(2014) E. M. Schmidt et al.   JOURNAL OF IMMUNOLOGY

Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development

(2014) Xindong Liu et al.   NATURE

The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells

(2014) Nathalie Schmitt et al.   NATURE IMMUNOLOGY

Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease

(2014) Masaki Miyazaki et al.   NATURE IMMUNOLOGY

A p85α-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells

(2014) Jianmei W Leavenworth et al.   NATURE IMMUNOLOGY

Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations

(2014) Desirée Schubert et al.   NATURE MEDICINE

CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement

(2014) Chun Jing Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

(2014) H. S. Kuehn et al.   SCIENCE

Phenotype and functions of memory Tfh cells in human blood

(2014) Nathalie Schmitt et al.   TRENDS IN IMMUNOLOGY

Interleukin-21 Promotes Germinal Center Reaction by Skewing the Follicular Regulatory T Cell to Follicular Helper T Cell Balance in Autoimmune BXD2 Mice

(2014) Yanna Ding et al.   Arthritis & Rheumatology

Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure

(2013) Jing He et al.   IMMUNITY

Foxp3+ Treg cells in humoral immunity

(2013) James B. Wing et al.   INTERNATIONAL IMMUNOLOGY

TRAF3 regulates the effector function of regulatory T cells and humoral immune responses

(2013) Jae-Hoon Chang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

(2013) Kate S. Smigiel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility

(2013) Heping Xu et al.   NATURE

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Evaluation of Histologic, Serologic, and Clinical Changes in Response to Abatacept Treatment of Primary Sjögren's Syndrome: A Pilot Study

(2013) Sabine Adler et al.   ARTHRITIS CARE & RESEARCH

Deleterious Mutations in LRBA Are Associated with a Syndrome of Immune Deficiency and Autoimmunity

(2012) Gabriela Lopez-Herrera et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells

(2012) T. Kinnunen et al.   BLOOD

Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation

(2012) André Ballesteros-Tato et al.   IMMUNITY

LPS-responsive beige-like anchor (LRBA) gene mutation in a family with inflammatory bowel disease and combined immunodeficiency

(2012) Abdullah Alangari et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood

(2012) Peter T Sage et al.   NATURE IMMUNOLOGY

The development and fate of follicular helper T cells defined by an IL-21 reporter mouse

(2012) Katja Lüthje et al.   NATURE IMMUNOLOGY

Regulatory T Cell-Mediated Control of Autoantibody-Induced Inflammation

(2012) Keishi Fujio et al.   Frontiers in Immunology

Opposing Signals from the Bcl6 Transcription Factor and the Interleukin-2 Receptor Generate T Helper 1 Central and Effector Memory Cells

(2011) Marion Pepper et al.   IMMUNITY

ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

(2011) Youn Soo Choi et al.   IMMUNITY

Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone

(2011) Steven M. Kerfoot et al.   IMMUNITY

B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells

(2011) Sau K. Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Foxp3+ Regulatory T Cells Control Humoral Autoimmunity by Suppressing the Development of Long-Lived Plasma Cells

(2011) E. Jang et al.   JOURNAL OF IMMUNOLOGY

Regulation of the Germinal Center Reaction by Foxp3+ Follicular Regulatory T Cells

(2011) I. Wollenberg et al.   JOURNAL OF IMMUNOLOGY

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

(2011) Yeonseok Chung et al.   NATURE MEDICINE

Foxp3+ follicular regulatory T cells control the germinal center response

(2011) Michelle A Linterman et al.   NATURE MEDICINE

Regulatory T-Cell Responses to Low-Dose Interleukin-2 in HCV-Induced Vasculitis

(2011) David Saadoun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

(2011) John Koreth et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation

(2011) Danelle Eto et al.   PLoS One

Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers

(2011) S.-E. Bentebibel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

TNF Receptor-Associated Factor 3 Is Required for T Cell-Mediated Immunity and TCR/CD28 Signaling

(2010) P. Xie et al.   JOURNAL OF IMMUNOLOGY

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

(2010) Kim L Good-Jacobson et al.   NATURE IMMUNOLOGY

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

(2009) Di Yu et al.   IMMUNITY

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expression

(2009) Magis Mandapathil et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

Bcl6 Mediates the Development of T Follicular Helper Cells

(2009) R. I. Nurieva et al.   SCIENCE

Activation of natural regulatory T cells by IgG Fc-derived peptide "Tregitopes"

(2008) A. S. De Groot et al.   BLOOD

A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells

(2008) Alexis Vogelzang et al.   IMMUNITY

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

(2008) Roza I. Nurieva et al.   IMMUNITY

The role of IL-21 in regulating B-cell function in health and disease

(2008) Rachel Ettinger et al.   IMMUNOLOGICAL REVIEWS

ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity

(2008) Jared M. Odegard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells

(2008) Sokol Haxhinasto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology