Kv1.1 Channelopathies: Pathophysiological Mechanisms and Therapeutic Approaches
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Kv1.1 Channelopathies: Pathophysiological Mechanisms and Therapeutic Approaches
Authors
Keywords
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 8, Pages 2935
Publisher
MDPI AG
Online
2020-04-23
DOI
10.3390/ijms21082935
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy
- (2020) Gaia Colasante et al. BRAIN
- Marine Toxins Targeting Kv1 Channels: Pharmacological Tools and Therapeutic Scaffolds
- (2020) Rocio K. Finol-Urdaneta et al. Marine Drugs
- Neuron-specific Kv1.1 deficiency is sufficient to cause epilepsy, premature death, and cardiorespiratory dysregulation
- (2020) Krystle Trosclair et al. NEUROBIOLOGY OF DISEASE
- Epilepsy gene therapy using an engineered potassium channel
- (2019) Albert Snowball et al. JOURNAL OF NEUROSCIENCE
- Cardiorespiratory profiling reveals primary breathing dysfunction in Kcna1-null mice: Implications for sudden unexpected death in epilepsy
- (2019) Hemangini Dhaibar et al. NEUROBIOLOGY OF DISEASE
- ADAM23 is a negative regulator of Kv1.1/Kv1.4 potassium currents
- (2019) Eunjoo Lancaster et al. NEUROSCIENCE LETTERS
- Complete loss of KCNA1 activity causes neonatal epileptic encephalopathy and dyskinesia
- (2019) Edgard Verdura et al. JOURNAL OF MEDICAL GENETICS
- Systematic Review of the Genetics of Sudden Unexpected Death in Epilepsy: Potential Overlap With Sudden Cardiac Death and Arrhythmia‐Related Genes
- (2019) C. Anwar A. Chahal et al. Journal of the American Heart Association
- Atom-by-atom tuning of the electrostatic potassium-channel modulator dehydroabietic acid
- (2018) Malin Silverå Ejneby et al. JOURNAL OF GENERAL PHYSIOLOGY
- mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy
- (2018) Lena H. Nguyen et al. Scientific Reports
- De novo KCNA1 variants in the PVP motif cause infantile epileptic encephalopathy and cognitive impairment similar to recurrent KCNA2 variants
- (2018) Amanda Rogers et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- OUP accepted manuscript
- (2018) BRAIN
- Discovery of a small molecule modulator of the Kv1.1/Kvβ1 channel complex that reduces neuronal excitability and in vitro epileptiform activity
- (2018) Isabelle Niespodziany et al. CNS Neuroscience & Therapeutics
- Regulation of Ion Channels by MicroRNAs and the Implication for Epilepsy
- (2018) Christina Gross et al. Current Neurology and Neuroscience Reports
- Identification of a New de Novo Mutation Underlying Regressive Episodic Ataxia Type I
- (2018) Zeynep S. Karalok et al. Frontiers in Neurology
- Genetic ablation or pharmacological inhibition of Kv1.1 potassium channel subunits impairs atrial repolarization in mice
- (2018) Man Si et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Regulation of brain PPARgamma2 contributes to ketogenic diet anti-seizure efficacy
- (2017) Timothy A. Simeone et al. EXPERIMENTAL NEUROLOGY
- Familial paroxysmal kinesigenic dyskinesia is associated with mutations in the KCNA1 gene
- (2017) Xiao-Meng Yin et al. HUMAN MOLECULAR GENETICS
- A Rational Design of a Selective Inhibitor for Kv1.1 Channels Prevalent in Demyelinated Nerves That Improves Their Impaired Axonal Conduction
- (2017) Ahmed Al-Sabi et al. JOURNAL OF MEDICINAL CHEMISTRY
- LGI1, CASPR2 and related antibodies: a molecular evolution of the phenotypes
- (2017) Sophie N M Binks et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Molecular mechanisms underlying pimaric acid-induced modulation of voltage-gated K + channels
- (2017) Kazuho Sakamoto et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- A novel KCNA1 mutation in a patient with paroxysmal ataxia, myokymia, painful contractures and metabolic dysfunctions
- (2017) Paola Imbrici et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels
- (2017) Michael Seagar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A drug pocket at the lipid bilayer–potassium channel interface
- (2017) Nina E. Ottosson et al. Science Advances
- A channelopathy mutation in the voltage-sensor discloses contributions of a conserved phenylalanine to gating properties of Kv1.1 channels and ataxia
- (2017) Sonia Hasan et al. Scientific Reports
- Ketogenic diet treatment increases longevity inKcna1-null mice, a model of sudden unexpected death in epilepsy
- (2016) Kristina A. Simeone et al. EPILEPSIA
- Dominant-negative mutation p.Arg324Thr in KCNA1 impairs Kv1.1 channel function in episodic ataxia
- (2016) Enriqueta Tristán-Clavijo et al. MOVEMENT DISORDERS
- A novel KCNA1 mutation in a family with episodic ataxia and malignant hyperthermia
- (2016) Tiago A. Mestre et al. NEUROGENETICS
- Action potential broadening in a presynaptic channelopathy
- (2016) Rahima Begum et al. Nature Communications
- The episodic ataxia type 1 mutation I262T alters voltage-dependent gating and disrupts protein biosynthesis of human Kv1.1 potassium channels
- (2016) Szu-Han Chen et al. Scientific Reports
- Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug Discovery
- (2016) Paola Imbrici et al. Frontiers in Pharmacology
- Ketone bodies mediate antiseizure effects through mitochondrial permeability transition
- (2015) Do Young Kim et al. ANNALS OF NEUROLOGY
- Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation
- (2015) Edward Glasscock et al. BASIC RESEARCH IN CARDIOLOGY
- Structure of potassium channels
- (2015) Qie Kuang et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Ion Channel Modulation as a Therapeutic Approach in Multiple Sclerosis
- (2015) R. Arnold et al. CURRENT MEDICINAL CHEMISTRY
- A Disease Mutation Causing Episodic Ataxia Type I in the S1 Links Directly to the Voltage Sensor and the Selectivity Filter in Kv Channels
- (2015) D. Petitjean et al. JOURNAL OF NEUROSCIENCE
- De novo loss- or gain-of-function mutations in KCNA2 cause epileptic encephalopathy
- (2015) Steffen Syrbe et al. NATURE GENETICS
- Rapamycin reveals an mTOR-independent repression of Kv1.1 expression during epileptogenesis
- (2015) Natasha M. Sosanya et al. NEUROBIOLOGY OF DISEASE
- Clinical heterogeneity associated with KCNA1 mutations include cataplexy and nonataxic presentations
- (2015) Catherine A. Brownstein et al. NEUROGENETICS
- Subcellular Localization of K+ Channels in Mammalian Brain Neurons: Remarkable Precision in the Midst of Extraordinary Complexity
- (2015) James S. Trimmer NEURON
- New insights into the pathogenesis and therapeutics of episodic ataxia type 1
- (2015) Maria Cristina D’Adamo et al. Frontiers in Cellular Neuroscience
- Resin-acid derivatives as potent electrostatic openers of voltage-gated K channels and suppressors of neuronal excitability
- (2015) Nina E Ottosson et al. Scientific Reports
- Novel phenotype associated with a mutation in the KCNA1(Kv1.1) gene
- (2015) Maria C. D'Adamo et al. Frontiers in Physiology
- Episodic ataxia type 1: clinical characterization, quality of life and genotype–phenotype correlation
- (2014) Tracey D. Graves et al. BRAIN
- The Kv1.1 null mouse, a model of sudden unexpected death in epilepsy (SUDEP)
- (2014) Brian M. Moore et al. EPILEPSIA
- A novelKCNA1mutation causing episodic ataxia type I
- (2014) Saskia Lassche et al. MUSCLE & NERVE
- Functional Ion Channels in Human Pulmonary Artery Smooth Muscle Cells: Voltage-Dependent Cation Channels
- (2014) Amy L. Firth et al. Pulmonary Circulation
- High-resolution molecular genomic autopsy reveals complex sudden unexpected death in epilepsy risk profile
- (2013) Tara L. Klassen et al. EPILEPSIA
- Clinical, genetic, neurophysiological and functional study of new mutations in episodic ataxia type 1
- (2013) Susan Elizabeth Tomlinson et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Differences between RNA and DNA due to RNA editing in temporal lobe epilepsy
- (2013) Heinz Krestel et al. NEUROBIOLOGY OF DISEASE
- Loss of the Kv1.1 potassium channel promotes pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices
- (2013) Timothy A. Simeone et al. NEUROBIOLOGY OF DISEASE
- Kv1.1 Channels Act as Mechanical Brake in the Senses of Touch and Pain
- (2013) Jizhe Hao et al. NEURON
- Identification of Selective Inhibitors of the Potassium Channel Kv1.1-1.2(3)by High-Throughput Virtual Screening and Automated Patch Clamp
- (2012) Sören J. Wacker et al. ChemMedChem
- Deficits in Responding to Brief Noise Offsets in Kcna1 −/− Mice Reveal a Contribution of This Gene to Precise Temporal Processing Seen Previously Only for Stimulus Onsets
- (2012) James R. Ison et al. JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
- Kv1.1 knock-in ataxic mice exhibit spontaneous myokymic activity exacerbated by fatigue, ischemia and low temperature
- (2012) Orazio Brunetti et al. NEUROBIOLOGY OF DISEASE
- Episodic ataxia type 1 mutations affect fast inactivation of K+ channels by a reduction in either subunit surface expression or affinity for inactivation domain
- (2011) Paola Imbrici et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures
- (2011) Saeko Ishida et al. BRAIN RESEARCH
- RNA editing of Kv1.1 channels may account for reduced ictogenic potential of 4-aminopyridine in chronic epileptic rats
- (2011) Anne Kathrin Streit et al. EPILEPSIA
- Evidence for Presence and Functional Effects of Kv1.1 Channels in β-Cells: General Survey and Results from mceph/mceph Mice
- (2011) Zuheng Ma et al. PLoS One
- Kv1.3: a potential pharmacological target for diabetes
- (2010) Bok Hee Choi et al. ACTA PHARMACOLOGICA SINICA
- Nerve excitability studies characterize KV1.1 fast potassium channel dysfunction in patients with episodic ataxia type 1
- (2010) Susan E. Tomlinson et al. BRAIN
- Contribution of the central hydrophobic residue in the PXP motif of voltage-dependent K+channels to S6 flexibility and gating properties
- (2010) Paola Imbrici et al. Channels
- Kv1.1 Potassium Channel Deficiency Reveals Brain-Driven Cardiac Dysfunction as a Candidate Mechanism for Sudden Unexplained Death in Epilepsy
- (2010) E. Glasscock et al. JOURNAL OF NEUROSCIENCE
- Nongenetic factors influence severity of episodic ataxia type 1 in monozygotic twins
- (2010) T. D. Graves et al. NEUROLOGY
- Ancillary Subunits Associated With Voltage-Dependent K+ Channels
- (2010) Olaf Pongs et al. PHYSIOLOGICAL REVIEWS
- Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement
- (2010) X. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Episodic ataxia type 1 mutations differentially affect neuronal excitability and transmitter release
- (2009) J. H. Heeroma et al. Disease Models & Mechanisms
- Ketogenic diet treatment abolishes seizure periodicity and improves diurnal rhythmicity in epilepticKcna1-null mice
- (2009) Kristina A. Fenoglio-Simeone et al. EPILEPSIA
- A missense mutation in the Kv1.1 voltage-gated potassium channel–encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia
- (2009) Bob Glaudemans et al. JOURNAL OF CLINICAL INVESTIGATION
- Cell-Type-Dependent Molecular Composition of the Axon Initial Segment
- (2009) A. Lorincz et al. JOURNAL OF NEUROSCIENCE
- A novelKCNA1mutation associated with global delay and persistent cerebellar dysfunction
- (2009) Michelle K. Demos et al. MOVEMENT DISORDERS
- Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy
- (2009) Yu-Dong Zhou et al. NATURE MEDICINE
- A PATIENT WITH EPISODIC ATAXIA AND PARAMYOTONIA CONGENITA DUE TO MUTATIONS IN KCNA1 AND SCN4A
- (2009) S. Rajakulendran et al. NEUROLOGY
- Disruption of Kv1.1 N-type inactivation by novel small molecule inhibitors (disinactivators)
- (2008) Qiang Lu et al. BIOORGANIC & MEDICINAL CHEMISTRY
- A novel KCNA1 mutation identified in an Italian family affected by episodic ataxia type 1
- (2008) P. Imbrici et al. NEUROSCIENCE
- Localization and Targeting of Voltage-Dependent Ion Channels in Mammalian Central Neurons
- (2008) Helene Vacher et al. PHYSIOLOGICAL REVIEWS
- Novel mutation inKCNA1 causes episodic ataxia with paroxysmal dyspnea
- (2007) Steven J. Shook et al. MUSCLE & NERVE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now