In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy

KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition

(2019) Vincent Magloire et al.   Nature Communications

Epilepsy gene therapy using an engineered potassium channel

(2019) Albert Snowball et al.   JOURNAL OF NEUROSCIENCE

Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs

(2019) Kale Kundert et al.   Nature Communications

Dynorphin‐based “release on demand” gene therapy for drug‐resistant temporal lobe epilepsy

(2019) Alexandra S Agostinho et al.   EMBO Molecular Medicine

dCas9-based Scn1a gene activation restores inhibitory interneuron excitability and attenuates seizures in Dravet syndrome mice

(2019) Gaia Colasante et al.   MOLECULAR THERAPY

Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements

(2018) Michael Kosicki et al.   NATURE BIOTECHNOLOGY

Biochemical autoregulatory gene therapy for focal epilepsy

(2018) Andreas Lieb et al.   NATURE MEDICINE

CRISPR interference-based specific and efficient gene inactivation in the brain

(2018) Yi Zheng et al.   NATURE NEUROSCIENCE

Gene therapy and editing: Novel potential treatments for neuronal channelopathies

(2018) R.C. Wykes et al.   NEUROPHARMACOLOGY

The CRISPR tool kit for genome editing and beyond

(2018) Mazhar Adli   Nature Communications

Gene expression profiling in a mouse model of Dravet syndrome

(2018) Nicole A. Hawkins et al.   EXPERIMENTAL NEUROLOGY

CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency

(2018) Navneet Matharu et al.   SCIENCE

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

(2018) Jichao Sun et al.   Nature Communications

The Kv1-associated molecules TAG-1 and Caspr2 are selectively targeted to the axon initial segment in hippocampal neurons

(2017) Delphine Pinatel et al.   JOURNAL OF CELL SCIENCE

Activity Clamp Provides Insights into Paradoxical Effects of the Anti-Seizure Drug Carbamazepine

(2017) Gareth Morris et al.   JOURNAL OF NEUROSCIENCE

AAV-PHP.B-Mediated Global-Scale Expression in the Mouse Nervous System Enables GBA1 Gene Therapy for Wide Protection from Synucleinopathy

(2017) Giuseppe Morabito et al.   MOLECULAR THERAPY

Kv1.1 channelopathy abolishes presynaptic spike width modulation by subthreshold somatic depolarization

(2017) Umesh Vivekananda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hello from the Other Side: How Autoantibodies Circumvent the Blood–Brain Barrier in Autoimmune Encephalitis

(2017) Maryann P. Platt et al.   Frontiers in Immunology

Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers

(2017) Fei Tang et al.   Frontiers in Neurology

Tet-On Systems For Doxycycline-inducible Gene Expression

(2016) Atze T. Das et al.   CURRENT GENE THERAPY

Optogenetic approaches to treat epilepsy

(2016) Robert C. Wykes et al.   JOURNAL OF NEUROSCIENCE METHODS

In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

(2016) Keiichiro Suzuki et al.   NATURE

A multifunctional AAV–CRISPR–Cas9 and its host response

(2016) Wei Leong Chew et al.   NATURE METHODS

Rapid Conversion of Fibroblasts into Functional Forebrain GABAergic Interneurons by Direct Genetic Reprogramming

(2015) Gaia Colasante et al.   Cell Stem Cell

The New State of the Art: Cas9 for Gene Activation and Repression

(2015) Marie F. La Russa et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

(2015) Silvana Konermann et al.   NATURE

Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation

(2015) Antonia A. Dominguez et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Applications of CRISPR–Cas systems in neuroscience

(2015) Matthias Heidenreich et al.   NATURE REVIEWS NEUROSCIENCE

Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline

(2015) Kyung-Ok Cho et al.   Nature Communications

Bonsai: an event-based framework for processing and controlling data streams

(2015) Gonçalo Lopes et al.   Frontiers in Neuroinformatics

Gene therapy in epilepsy—is it time for clinical trials?

(2014) Dimitri M. Kullmann et al.   Nature Reviews Neurology

Chemical–genetic attenuation of focal neocortical seizures

(2014) Dennis Kätzel et al.   Nature Communications

Profiling status epilepticus-induced changes in hippocampal RNA expression using high-throughput RNA sequencing

(2014) Katelin F. Hansen et al.   Scientific Reports

REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability

(2013) Davide Pozzi et al.   EMBO JOURNAL

Gene therapy for epilepsy

(2013) Michele Simonato   EPILEPSY & BEHAVIOR

AAV9-mediated Expression of a Non-self Protein in Nonhuman Primate Central Nervous System Triggers Widespread Neuroinflammation Driven by Antigen-presenting Cell Transduction

(2013) Lluis Samaranch et al.   MOLECULAR THERAPY

Object recognition test in mice

(2013) Marianne Leger et al.   Nature Protocols

On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy

(2013) Esther Krook-Magnuson et al.   Nature Communications

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Whole transcriptome analysis of the hippocampus: toward a molecular portrait of epileptogenesis

(2012) Oswaldo K Okamoto et al.   BMC GENOMICS

Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration

(2012) H. Thorvaldsdottir et al.   BRIEFINGS IN BIOINFORMATICS

Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

(2012) Eva M Jimenez-Mateos et al.   NATURE MEDICINE

Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex

(2012) Gerard M J Beaudoin et al.   Nature Protocols

Optogenetic and Potassium Channel Gene Therapy in a Rodent Model of Focal Neocortical Epilepsy

(2012) R. C. Wykes et al.   Science Translational Medicine

Drug-Resistant Epilepsy

(2011) Patrick Kwan et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Systems Level, Functional Genomics Analysis of Chronic Epilepsy

(2011) Kellen D. Winden et al.   PLoS One

Gene expression analysis of the emergence of epileptiform activity after focal injection of kainic acid into mouse hippocampus

(2010) Dario Motti et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Episodic ataxia type 1 mutations differentially affect neuronal excitability and transmitter release

(2009) J. H. Heeroma et al.   Disease Models & Mechanisms

Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy

(2008) Francesco Noè et al.   BRAIN