Resin-acid derivatives as potent electrostatic openers of voltage-gated K channels and suppressors of neuronal excitability

Epilepsy: new advances

(2015) Solomon L Moshé et al.   LANCET

Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKschannel

(2015) Sara I. Liin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug-induced ion channel opening tuned by the voltage sensor charge profile

(2014) Nina E. Ottosson et al.   JOURNAL OF GENERAL PHYSIOLOGY

Opening paths to novel analgesics: the role of potassium channels in chronic pain

(2014) Christoforos Tsantoulas et al.   TRENDS IN NEUROSCIENCES

Opening the Shaker K+channel with hanatoxin

(2013) Mirela Milescu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA

(2013) T. Hoshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca2+-dependent K+ channels

(2013) T. Hoshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations

(2012) Ernesto Vargas et al.   JOURNAL OF GENERAL PHYSIOLOGY

Dampening of Hyperexcitability in CA1 Pyramidal Neurons by Polyunsaturated Fatty Acids Acting on Voltage-Gated Ion Channels

(2012) Jenny Tigerholm et al.   PLoS One

Molecular mechanism of pharmacological activation of BK channels

(2012) G. Gessner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tracking a complete voltage-sensor cycle with metal-ion bridges

(2012) U. Henrion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Screening quality for Ca2+-activated potassium channel in IonWorks Quattro is greatly improved by using BAPTA-AM and ionomycin

(2012) Katsutoshi Ido et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

An electrostatic potassium channel opener targeting the final voltage sensor transition

(2011) Sara I. Börjesson et al.   JOURNAL OF GENERAL PHYSIOLOGY

Design, synthesis, and characterization of BK channel openers based on oximation of abietane diterpene derivatives

(2010) Yong-Mei Cui et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Electrostatic Tuning of Cellular Excitability

(2010) Sara I. Börjesson et al.   BIOPHYSICAL JOURNAL

Ion Channel Voltage Sensors: Structure, Function, and Pathophysiology

(2010) William A. Catterall   NEURON

Targeting the voltage sensor of Kv7.2 voltage-gated K+ channels with a new gating-modifier

(2010) A. Peretz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel oxime and oxime ether derivatives of 12,14-dichlorodehydroabietic acid: Design, synthesis, and BK channel-opening activity

(2008) Yong-Mei Cui et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Lipoelectric Modification of Ion Channel Voltage Gating by Polyunsaturated Fatty Acids

(2008) Sara I. Börjesson et al.   BIOPHYSICAL JOURNAL

Structure, Function, and Modification of the Voltage Sensor in Voltage-Gated Ion Channels

(2008) Sara I. Börjesson et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Polyunsaturated fatty acids and cerebrospinal fluid from children on the ketogenic diet open a voltage-gated K channel: A putative mechanism of antiseizure action

(2008) Xiang-ping Xu et al.   EPILEPSY RESEARCH

Intractable epilepsy: management and therapeutic alternatives

(2008) Stephan U Schuele et al.   LANCET NEUROLOGY

Optimisation and validation of a medium-throughput electrophysiology-based hNav1.5 assay using IonWorks™

(2007) A.R. Harmer et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS