Discovery of a small molecule modulator of the Kv1.1/Kvβ1 channel complex that reduces neuronal excitability and in vitro epileptiform activity

Distinctive role of KV1.1 subunit in the biology and functions of low threshold K+ channels with implications for neurological disease

(2016) Saak V. Ovsepian et al.   PHARMACOLOGY & THERAPEUTICS

Action potential broadening in a presynaptic channelopathy

(2016) Rahima Begum et al.   Nature Communications

Rapamycin reveals an mTOR-independent repression of Kv1.1 expression during epileptogenesis

(2015) Natasha M. Sosanya et al.   NEUROBIOLOGY OF DISEASE

Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex

(2014) Eric Jnoff et al.   ChemMedChem

Brivaracetam Differentially Affects Voltage-Gated Sodium Currents Without Impairing Sustained Repetitive Firing in Neurons

(2014) Isabelle Niespodziany et al.   CNS Neuroscience & Therapeutics

Loss of the Kv1.1 potassium channel promotes pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices

(2013) Timothy A. Simeone et al.   NEUROBIOLOGY OF DISEASE

Potentiation of the Kv1 Family K+ Channel by Cortisone Analogues

(2012) Yaping Pan et al.   ACS Chemical Biology

Optogenetic and Potassium Channel Gene Therapy in a Rodent Model of Focal Neocortical Epilepsy

(2012) R. C. Wykes et al.   Science Translational Medicine

Episodic ataxia type 1 mutations affect fast inactivation of K+ channels by a reduction in either subunit surface expression or affinity for inactivation domain

(2011) Paola Imbrici et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures

(2011) Saeko Ishida et al.   BRAIN RESEARCH

Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy

(2011) Ke-Xin Li et al.   NATURE NEUROSCIENCE

Ancillary Subunits Associated With Voltage-Dependent K+ Channels

(2010) Olaf Pongs et al.   PHYSIOLOGICAL REVIEWS

NMR assignments of a 48 kDa tetramer of the T1 domain of the mammalian voltage gated potassium channel Kv1.4

(2009) Christina Schreier et al.   Biomolecular NMR Assignments

Episodic ataxia type 1 mutations differentially affect neuronal excitability and transmitter release

(2009) J. H. Heeroma et al.   Disease Models & Mechanisms

Participation of Kv1 Channels in Control of Membrane Excitability and Burst Generation in Mesencephalic V Neurons

(2009) Chie-Fang Hsiao et al.   JOURNAL OF NEUROPHYSIOLOGY

Disruption of Kv1.1 N-type inactivation by novel small molecule inhibitors (disinactivators)

(2008) Qiang Lu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cortisone dissociates the Shaker family K+ channels from their β subunits

(2008) Yaping Pan et al.   Nature Chemical Biology

K+ Channels at the Axon Initial Segment Dampen Near-Threshold Excitability of Neocortical Fast-Spiking GABAergic Interneurons

(2008) Ethan M. Goldberg et al.   NEURON