A drug pocket at the lipid bilayer–potassium channel interface

Molecular mechanisms underlying pimaric acid-induced modulation of voltage-gated K + channels

(2017) Kazuho Sakamoto et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Actions and Mechanisms of Polyunsaturated Fatty Acids on Voltage-Gated Ion Channels

(2017) Fredrik Elinder et al.   Frontiers in Physiology

KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting

(2016) Eva Wrobel et al.   Nature Communications

The Molecular Basis of Polyunsaturated Fatty Acid Interactions with the Shaker Voltage-Gated Potassium Channel

(2016) Samira Yazdi et al.   PLoS Computational Biology

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist

(2015) S. Ahuja et al.   SCIENCE

Resin-acid derivatives as potent electrostatic openers of voltage-gated K channels and suppressors of neuronal excitability

(2015) Nina E Ottosson et al.   Scientific Reports

Sodium Channels, Inherited Epilepsy, and Antiepileptic Drugs

(2014) William A. Catterall   Annual Review of Pharmacology and Toxicology

Drug-induced ion channel opening tuned by the voltage sensor charge profile

(2014) Nina E. Ottosson et al.   JOURNAL OF GENERAL PHYSIOLOGY

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands

(2013) Ping Li et al.   CELL RESEARCH

Side pockets provide the basis for a new mechanism of Kv channel–specific inhibition

(2013) Stefanie Marzian et al.   Nature Chemical Biology

ZINC: A Free Tool to Discover Chemistry for Biology

(2012) John J. Irwin et al.   Journal of Chemical Information and Modeling

Tracking a complete voltage-sensor cycle with metal-ion bridges

(2012) U. Henrion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MATCH: An atom-typing toolset for molecular mechanics force fields

(2011) Joseph D. Yesselman et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

An electrostatic potassium channel opener targeting the final voltage sensor transition

(2011) Sara I. Börjesson et al.   JOURNAL OF GENERAL PHYSIOLOGY

Intermediate states of the Kv1.2 voltage sensor from atomistic molecular dynamics simulations

(2011) L. Delemotte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design, synthesis, and characterization of BK channel openers based on oximation of abietane diterpene derivatives

(2010) Yong-Mei Cui et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Electrostatic Tuning of Cellular Excitability

(2010) Sara I. Börjesson et al.   BIOPHYSICAL JOURNAL

Targeting the voltage sensor of Kv7.2 voltage-gated K+ channels with a new gating-modifier

(2010) A. Peretz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pd-PEPPSI-IPent: An Active, Sterically Demanding Cross-Coupling Catalyst and Its Application in the Synthesis of Tetra-Ortho-Substituted Biaryls

(2009) Michael G. Organ et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel BK channel openers containing dehydroabietic acid skeleton: Structure–activity relationship for peripheral substituents on ring C

(2008) Yong-Mei Cui et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Lipoelectric Modification of Ion Channel Voltage Gating by Polyunsaturated Fatty Acids

(2008) Sara I. Börjesson et al.   BIOPHYSICAL JOURNAL

Structure, Function, and Modification of the Voltage Sensor in Voltage-Gated Ion Channels

(2008) Sara I. Börjesson et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Polyunsaturated fatty acids and cerebrospinal fluid from children on the ketogenic diet open a voltage-gated K channel: A putative mechanism of antiseizure action

(2008) Xiang-ping Xu et al.   EPILEPSY RESEARCH

Large-Scale Movement within the Voltage-Sensor Paddle of a Potassium Channel—Support for a Helical-Screw Motion

(2008) Amir Broomand et al.   NEURON