Article
Medicine, Research & Experimental
Ubonrat Thamrongwaranggoon, Marutpong Detarya, Wunchana Seubwai, Charupong Saengboonmee, Shinjiro Hino, Tomoaki Koga, Mitsuyoshi Nakao, Sopit Wongkham
Summary: Lactic acidosis upregulates EGFR and ALDH1A3 expression, promoting aggressiveness and drug resistance in CCA cells. The EGFR/ALDH1A3 axis could be a novel therapeutic target for treating metastatic CCA.
Article
Biotechnology & Applied Microbiology
Qiongyue Hu, Hongwei Yu, Lidan Ye
Summary: This study identifies an endogenous enzyme, Hfd1, in Saccharomyces cerevisiae that exhibits high retinal dehydrogenase activity, allowing for efficient biosynthesis of retinoic acid (RA).
BIOTECHNOLOGY AND BIOENGINEERING
(2022)
Article
Biology
Jianfeng Li, Silvia Garavaglia, Zhaofeng Ye, Andrea Moretti, Olga Belyaeva, Alison Beiser, Md Ibrahim, Anna Wilk, Steve McClellan, Alla Klyuyeva, Kelli R. Goggans, Natalia Y. Kedishvili, E. Alan Salter, Andrzej Wierzbicki, Marie E. Migaud, Steven J. Mullett, Nathan A. Yates, Carlos J. Camacho, Menico Rizzi, Robert W. Sobol
Summary: In silico modeling was used to identify a selective inhibitor for ALDH1A3, a potential drug target highly expressed in mesenchymal glioma stem cells. The identified inhibitor, MCI-INI-3, showed efficient inhibition of retinoic acid biosynthesis comparable to ALDH1A3 depletion. Further research is needed to understand the role of ALDH1A3 and retinoic acid biosynthesis in glioma stem cell growth and differentiation.
COMMUNICATIONS BIOLOGY
(2021)
Article
Dermatology
Jeong-Eun Kim, Woo-Hyun Kim, Sehyun Kim, Yongjoo Na, Joonho Choi, Yong-deok Hong, Won-Seok Park, Soon-Mi Shim
Summary: The study aimed to evaluate the uptake and conversion of retinol in human immortalized keratinocytes cells (HaCaT) and artificial skin by measuring cell integrity, transport of retinol, and bioconversion to metabolites. The expression of epidermal differentiation genes significantly increased in differentiated HaCaT. The results suggest that retinol can maintain the integrity of the epidermal barrier and promote skin function.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Oncology
Lauren MacDonagh, Rhyla Mae Santiago, Steven G. Gray, Eamon Breen, Sinead Cuffe, Stephen P. Finn, Kenneth J. O'Byrne, Martin P. Barr
Summary: Despite advances in personalized medicine and immune checkpoints in lung cancer treatment, non-small cell lung cancer remains a leading cause of cancer-related deaths worldwide. Drug resistance is a key factor in the relapse of lung cancer patients due to the unlimited renewal capacity of residual cancer stem cells during chemotherapy. This study suggests that targeting the retinoic acid signaling cascade may be a novel strategy in treating subsets of CSCs in cisplatin resistant lung tumors.
TRANSLATIONAL ONCOLOGY
(2021)
Review
Cell Biology
M. Poturnajova, Z. Kozovska, M. Matuskova
Summary: The review summarizes the role of ALDH in solid tumors, particularly the ALDH1A1 and ALDH1A3 isoforms, including their transcription and regulation mechanisms, as well as their crosstalk with main molecular pathways. Additionally, it discusses the regulatory effect of lnRNA on ALDH1A1 and ALDH1A3.
CELLULAR SIGNALLING
(2021)
Article
Multidisciplinary Sciences
Jinsook Son, Wen Du, Mark Esposito, Kaavian Shariati, Hongxu Ding, Yibin Kang, Domenico Accili
Summary: This study provides evidence of re-differentiation of dedifferentiated beta-cells in type 2 diabetes and identifies ALDH1A3 as a key player in this process. The inhibition of ALDH1A3 is proposed as a treatment method for beta-cell dysfunction in diabetes.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Victoria O. Hunsu, Caroline O. B. Facey, Jeremy Z. Fields, Bruce M. Boman
Summary: Retinoic acid (RA) agents show anti-tumor activity by inducing cellular differentiation, but have not yet been widely used for systemic treatment in most solid tumors. RA signaling is mediated through retinoic receptor subtypes, with mutations in these receptors offering opportunities for target discovery in personalized medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ali I. M. Ibrahim, Balqis Ikhmais, Elisabet Batlle, Waed K. AbuHarb, Vibhu Jha, Khaled T. Jaradat, Rafael Jimenez, Raquel Pequerul, Xavier Pares, Jaume Farres, Klaus Pors
Summary: Aldehyde dehydrogenase 1A3 (ALDH1A3) has been identified as a potential target in cancer treatment, and two benzyloxybenzaldehyde-based compounds (ABMM-15 and ABMM-16) were found to be the most potent and selective inhibitors against ALDH1A3. These compounds showed no significant cytotoxicity and may be considered promising scaffolds for further drug discovery targeting ALDH1A3 for therapeutic intervention.
Review
Chemistry, Medicinal
Neil R. Norcross, Irene Georgiou, Zoe C. Johnston, Franz S. Gruber, Jason R. Swedlow, Kevin D. Read, Christopher LR. Barratt, Ian H. Gilbert
Summary: This article discusses the need for male contraceptives and explores the characteristics and potential development pathways of male contraceptives. It also examines various approaches to discovering male contraceptives and highlights potential targets discussed in the literature.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Meng Pan, Miao Li, Mei Guo, Huiying Zhou, Hui Xu, Fengshu Zhao, Feng Mei, Rui Xue, Jun Dou
Summary: The study demonstrated the regulatory relationship between ALDH1A3, miR-7, and CD44 in breast cancer stem cells (BCSCs), revealing the presence of an ALDH1A3-miR-7-TGFBR2-Smad3-CD44 axis in MDA-MB-231 cells and other breast cancer cell lines. This regulatory axis efficiently inhibited CD44 expression and may offer a potential therapeutic strategy for breast cancer.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Editorial Material
Biochemistry & Molecular Biology
Jolanta Floryszak-Wieczorek, Ewa Sobieszczuk-Nowicka, Magdalena Arasimowicz-Jelonek
Summary: Nitroxyl (HNO), a one-electron reduced and protonated congener of nitric oxide (NO), has been recently discovered in Arabidopsis thaliana. Due to its distinct chemical properties, further studies are needed to determine the impacts of HNO on physiological processes.
TRENDS IN BIOCHEMICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Che-Hong Chen, Benjamin R. Kraemer, Lucia Lee, Daria Mochly-Rosen
Summary: Human ALDH is a multigene family with 19 functional members involved in detoxification and biotransformation. Genetic mutations can lead to toxic aldehyde accumulation and human pathologies. The physiological functions and substrate specificity of many ALDH genes are still unknown.
Article
Biochemistry & Molecular Biology
Tetsuya Ito, Hisaharu Masaki, Koki Fujita, Hiromi Murakami, Motohiro Shizuma, Taro Kiso, Takaaki Kiryu
Summary: Pseudogluconobacter saccharoketogenes produces glucaric acid from d-glucose via two pathways, and the intermediates of these pathways, d-glucaraldehyde and l-guluronic acid, were purified and identified. The study also investigated the substrate specificities of alcohol dehydrogenase, aldehyde dehydrogenase, and gluconate dehydrogenase, as well as the roles of these enzymes in the production of d-glucaric acid. Additionally, the substrate specificities of alcohol and aldehyde dehydrogenases on various compounds were determined.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kyunghee Kim, Jisue Kim, Hyoungseob Kim, Gun Yong Sung
Summary: The pumpless skin-on-a-chip (SOC) technology was used to evaluate the efficacy of alpha-lipoic acid (ALA) on skin tissue and epidermal structure formation. Results showed that ALA has anti-aging effects on the skin and can increase expression of epidermal structural proteins, reducing damage caused by aging. This technology has the potential to be used for functional drug tests of cosmetic materials and contribute to the development of skin disease models in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Heidemarie Rossiter, Dragan Copic, Martin Direder, Florian Gruber, Samuele Zoratto, Martina Marchetti-Deschmann, Christopher Kremslehner, Michaela Sochorova, Ionela-Mariana Nagelreiter, Veronika Mlitz, Maria Buchberger, Barbara Lengauer, Bahar Golabi, Supawadee Sukseree, Michael Mildner, Leopold Eckhart, Erwin Tschachler
Summary: Autophagy in preputial glands delays age-related ductal ectasia, influences lipid droplet morphology, contributes to the complete dissolution of mature sebocytes during holocrine secretion, and regulates phospholipid and fatty acid metabolism, as well as pheromone production.
Article
Medicine, General & Internal
Denise Traxler, Pavla Krotka, Maria Laggner, Michael Mildner, Alexandra Graf, Berthold Reichardt, Ralph Wendt, Johann Auer, Bernhard Moser, Julia Mascherbauer, Hendrik Jan Ankersmit
Summary: This study found that patients aged 50-65 who underwent bioprosthetic aortic valve replacement (B-AVR) had lower long-term survival rates and higher risks compared to mechanical aortic valve replacement (M-AVR). B-AVR also had higher risks of reoperation and myocardial infarction. However, the risk of heart failure and stroke did not significantly differ after AVR in any age group.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Multidisciplinary Sciences
Maria Laggner, Marie-Therese Lingitz, Dragan Copic, Martin Direder, Katharina Klas, Daniel Bormann, Alfred Gugerell, Bernhard Moser, Christine Radtke, Stefan Hacker, Michael Mildner, Hendrik Jan Ankersmit, Thomas Haider
Summary: Burn injuries elicit a unique stress response and can lead to burn injury progression. This study found that levels of neutrophil-derived factors were significantly elevated in burn victims, and leukocyte and neutrophil counts were increased while lymphocytes were decreased. These factors did not predict mortality, but were associated with higher burn severity scores in patients with third-degree burns.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Martin Direder, Tamara Weiss, Dragan Copic, Vera Vorstandlechner, Maria Laggner, Karin Pfisterer, Caterina Selina Mildner, Katharina Klas, Daniel Bormann, Werner Haslik, Christine Radtke, Matthias Farlik, Lisa Shaw, Bahar Golabi, Erwin Tschachler, Konrad Hoetzenecker, Hendrik Jan Ankersmit, Michael Mildner
Summary: This study identifies a unique population of Schwann cells in keloids and highlights the interaction between Schwann cells and macrophages in keloid formation.
Article
Biology
Maria Laggner, Felicitas Oberndorfer, Bahar Golabi, Jonas Bauer, Andreas Zuckermann, Philipp Hacker, Irene Lang, Nika Skoro-Sajer, Christian Gerges, Shahrokh Taghavi, Peter Jaksch, Michael Mildner, Hendrik Jan Ankersmit, Bernhard Moser
Summary: This study investigated the gene expression profiles of hypertrophic and regenerated right hearts of two subtypes of pulmonary hypertension (PH) patients. The findings revealed unique gene alteration signatures in different PH subtypes, as well as the identification of a profibrotic factor, early growth response 1 (EGR1), in both subtypes. These findings may contribute to the identification of therapeutic candidates for PH patients who are not eligible for surgical treatment.
Editorial Material
Dermatology
Jodi L. Johnson, Erwin Tschachler
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Dermatology
Michael Koch, Tobias Kockmann, Elke Rodriguez, Ulrike Wehkamp, Paul Hiebert, Maya Ben-Yehuda Greenwald, Dora Stoelzl, Hans-Dietmar Beer, Erwin Tschachler, Stephan Weidinger, Sabine Werner, Ulrich Auf Dem Keller
Summary: Atopic dermatitis is a common inflammatory skin disease characterized by a compromised epidermal barrier and cutaneous inflammation. This study identified the molecular alterations in the epidermis of patients with atopic dermatitis, revealing an impaired NRF2-antioxidant pathway and reduced abundance of mitochondrial proteins involved in key metabolic pathways. These findings provide insights into the pathogenesis of atopic dermatitis and potential targets for pharmaceutical intervention.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Attila Placido Sachslehner, Marta Surbek, Bahar Golabi, Miriam Geiselhofer, Karin Jaeger, Claudia Hess, Ulrike Kuchler, Reinhard Gruber, Leopold Eckhart
Summary: The study focuses on the localization of transglutaminase activity in various integumentary structures in mammals and birds. Transglutaminase activity was found in different layers of human epidermis, sweat glands, hair follicles, and nails. It was also present in claws, feathers, and keratinocytes of feathers in chickens. Additionally, transglutaminase activity was detected in tongue papillae of mice and chickens. The study suggests that transglutamination contributes to the cornification of hard skin appendages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Dragan Copic, Martin Direder, Katharina Klas, Daniel Bormann, Maria Laggner, Hendrik Jan Ankersmit, Michael Mildner
Summary: This study reveals a novel mode of action of ATG in regulating T cell activity and effector functions through the secretion of cytokines and chemokines, as well as the modulation of cell surface ligands and receptors.
Article
Cell Biology
Caterina Barresi, Heidemarie Rossiter, Maria Buchberger, Johannes Pammer, Supawadee Sukseree, Maria Sibilia, Erwin Tschachler, Leopold Eckhart
Summary: Autophagy is a degradation mechanism that plays a critical role in cellular homeostasis. Inhibition of autophagy has been found to slow down the growth of skin tumors.
Review
Dermatology
Daniel Bormann, Alfred Gugerell, Hendrik Jan Ankersmit, Michael Mildner
Summary: Cell secretomes play an important role in wound healing by promoting regeneration. This study reviews the mechanisms of action of cell secretomes in wound healing, important preconditioning strategies to enhance therapeutic efficacy, and clinical trials on secretome-based wound healing.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Cell Biology
Zahra Kargarpour, Layla Panahipour, Michael Mildner, Richard J. Miron, Reinhard Gruber
Summary: Platelet-rich fibrin (PRF) has potent anti-inflammatory activity, however, the components responsible for this effect are unknown. In this study, we investigated whether the lipid fraction of PRF also exhibits anti-inflammatory properties. Our results show that lipids from PRF can significantly reduce the inflammatory response of ST2 bone marrow stromal cells and primary bone marrow macrophages. These findings suggest that the lipid fraction is at least partially responsible for the anti-inflammatory activity of PRF in vitro.
Article
Pharmacology & Pharmacy
Vera Vorstandlechner, Dragan Copic, Katharina Klas, Martin Direder, Bahar Golabi, Christine Radtke, Hendrik J. Ankersmit, Michael Mildner
Summary: This study demonstrates the anti-fibrotic effect of PBMCsec on cutaneous scars in both mouse and human experimental settings. PBMCsec regulates the expression of fibrosis-related genes, attenuates myofibroblast differentiation, and inhibits the breakdown of elastic fibers. These findings suggest that PBMCsec could be a novel therapeutic option for treating skin scarring.
Article
Immunology
Leopold Eckhart, Wolfgang Sipos
Summary: This study identified inactivating mutations of OAS genes in primates through comparative genomics and revealed a diversifying evolution pattern of the OAS gene family. The study also found that camelids lack OAS2 and OAS3 genes, Asian pangolins lack both OASL and OAS3 genes, and a new OAS gene (OAS5) is present in the bat suborder Yangochiroptera. These differences may affect innate immune responses to coronaviruses and other RNA viruses.
Review
Biochemistry & Molecular Biology
Marta Surbek, Supawadee Sukseree, Leopold Eckhart
Summary: The skin protects the body and its metabolism of iron is regulated by differentially expressed genes in the epidermal keratinocytes, supporting the recycling of iron and preventing its release from the skin surface.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
