The role of β-d-mannuronic acid, as a new non-steroidal anti-inflammatory drug on expression of miR-146a, IRAK1, TRAF6, NF-κB and pro-inflammatory cytokines following a clinical trial in rheumatoid arthritis patients

International multicenter randomized, placebo-controlled phase III clinical trial of β-d-mannuronic acid in rheumatoid arthritis patients

(2019) Zahra Rezaieyazdi et al.   INFLAMMOPHARMACOLOGY

Extracellular vesicles containing miR-146a attenuate experimental colitis by targeting TRAF6 and IRAK1

(2019) Hui Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Oral administration effects of β- d -mannuronic acid (M2000) on Th17 and regulatory T cells in patients with ankylosing spondylitis

(2018) Mohammad Javad Fattahi et al.   BIOMEDICINE & PHARMACOTHERAPY

Dysregulation of microRNAs in autoimmune diseases: Pathogenesis, biomarkers and potential therapeutic targets

(2018) Hai Long et al.   CANCER LETTERS

Anti-angiogenesis effect of β-D-mannuronic acid (M2000) as a novel NSAID with immunosuppressive properties under experimental model

(2018) Mohsen Rastegari-Pouyani et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Cardioprotective effect of β-d-mannuronic acid (M2000) as a novel NSAID on gene expression of oxLDL scavenger receptors in the experimental diabetic model

(2018) Seyed Shahabeddin Mortazavi-Jahromi et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Evaluation of the efficacy and safety of β- d -mannuronic acid in patients with ankylosing spondylitis: A 12-week randomized, placebo-controlled, phase I/II clinical trial

(2018) Mohammad Javad Fattahi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Update on the prevalence and incidence of rheumatoid arthritis in Korea and an analysis of medical care and drug utilization

(2018) Soyoung Won et al.   RHEUMATOLOGY INTERNATIONAL

MicroRNA-146a suppresses rheumatoid arthritis fibroblast-like synoviocytes proliferation and inflammatory responses by inhibiting the TLR4/NF-kB signaling

(2018) Wei Liu et al.   Oncotarget

Anti-diabetic effect of β-D-mannuronic acid (M2000) as a novel NSAID with immunosuppressive property on insulin production, blood glucose, and inflammatory markers in the experimental diabetes model

(2018) Seyed Shahabeddin Mortazavi-Jahromi et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

A phase I/II randomized, controlled, clinical trial for assessment of the efficacy and safety of β-d-mannuronic acid in rheumatoid arthritis patients

(2018) Hossein Ahmadi et al.   INFLAMMOPHARMACOLOGY

Modification of Sexual Hormones in Rheumatoid Arthritis Patients by M2000 (β-D-mannuronic Acid) as a Novel NSAID with Immunosuppressive Property

(2018) Mozhgan Jahanbakhshi et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

(2018) Jacob O'Brien et al.   Frontiers in Endocrinology

Pathogenic Role of Immune Cells in Rheumatoid Arthritis: Implications in Clinical Treatment and Biomarker Development

(2018) Hooi-Yeen Yap et al.   Cells

Introduction of β- d -mannuronic acid (M2000) as a novel NSAID with immunosuppressive property based on COX-1/COX-2 activity and gene expression

(2017) Abbas Mirshafiey et al.   Pharmacological Reports

Pharmacological effects of β- d -mannuronic acid (M2000) on miR-146a, IRAK1, TRAF6 and NF-κB gene expression, as target molecules in inflammatory reactions

(2017) Seyed Shahabeddin Mortazavi-Jahromi et al.   Pharmacological Reports

M2000 (β-D-Mannuronic Acid) as a Novel Antagonist for Blocking the TLR2 and TLR4 Downstream Signalling Pathway

(2017) S. Aletaha et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Targeting of circulating Th17 cells by β-D-mannuronic acid (M2000) as a novel medication in patients with rheumatoid arthritis

(2017) Hossein Ahmadi et al.   INFLAMMOPHARMACOLOGY

Significance of Polymorphism and Expression of miR-146a and NFkB1 Genetic Variants in Patients with Rheumatoid Arthritis

(2016) Katarzyna Bogunia-Kubik et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

miR-146a Attenuates Inflammatory Pathways Mediated by TLR4/NF-κB and TNFαto Protect Primary Human Retinal Microvascular Endothelial Cells Grown in High Glucose

(2016) Eun-Ah Ye et al.   MEDIATORS OF INFLAMMATION

MicroRNAs in rheumatoid arthritis: Altered expression and diagnostic potential

(2015) Alexey V. Churov et al.   AUTOIMMUNITY REVIEWS

The role of cytokines in the pathogenesis of rheumatoid arthritis – Practical and potential application of cytokines as biomarkers and targets of personalized therapy

(2015) Edyta Brzustewicz et al.   CYTOKINE

Preclinical assessment ofβ-d-mannuronic acid (M2000) as a non-steroidal anti-inflammatory drug

(2015) Mohammad Javad Fattahi et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Deregulation of NF-кB–miR-146a negative feedback loop may be involved in the pathogenesis of diabetic neuropathy

(2015) Nasibeh Yousefzadeh et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

The Burden of Disease in Rheumatoid Arthritis

(2014) Till Uhlig et al.   PHARMACOECONOMICS

Prevalence and incidence of rheumatoid arthritis in Italy

(2014) Maurizio Rossini et al.   RHEUMATOLOGY INTERNATIONAL

Interleukin 6 and Rheumatoid Arthritis

(2014) Yuji Yoshida et al.   Biomed Research International

MicroRNA-146a, a Good Biomarker and Potential Therapeutic Target for Rheumatoid Arthritis

(2012) Qiang Xie et al.   Genetic Testing and Molecular Biomarkers

MicroRNAs, new effectors and regulators of NF-κB

(2012) Mark P. Boldin et al.   IMMUNOLOGICAL REVIEWS

Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients

(2012) Kaleb M Pauley et al.   ARTHRITIS RESEARCH & THERAPY

MicroRNA 146a Expression in Rheumatoid Arthritis: Association with Tumor Necrosis Factor–Alpha and Disease Activity

(2011) Abla Abou-Zeid et al.   Genetic Testing and Molecular Biomarkers

Increased microRNA-146a/b, TRAF6 gene and decreased IRAK1 gene expressions in the peripheral mononuclear cells of patients with Sjögren's syndrome

(2011) Erika Zilahi et al.   IMMUNOLOGY LETTERS

miRNA-146a in rheumatoid arthritis: a new therapeutic strategy

(2011) Kaleb M Pauley et al.   Immunotherapy

MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients

(2010) Takuya Niimoto et al.   BMC MUSCULOSKELETAL DISORDERS

A polymorphism in the 3’-UTR of interleukin-1 receptor-associated kinase (IRAK1), a target gene of miR-146a, is associated with rheumatoid arthritis susceptibility

(2010) Anthoula Chatzikyriakidou et al.   JOINT BONE SPINE

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

(2009) Derrick J. Gibbings et al.   NATURE CELL BIOLOGY

Therapeutic targets in rheumatoid arthritis: the interleukin-6 receptor

(2009) Jean-Michel Dayer et al.   RHEUMATOLOGY

Expression of microRNA-146 in rheumatoid arthritis synovial tissue

(2008) Tomoyuki Nakasa et al.   ARTHRITIS AND RHEUMATISM

Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis

(2008) Joanna Stanczyk et al.   ARTHRITIS AND RHEUMATISM