Therapeutic targets in rheumatoid arthritis: the interleukin-6 receptor

Therapeutic Targeting of IL-6 Trans Signaling Counteracts STAT3 Control of Experimental Inflammatory Arthritis

(2014) M. A. Nowell et al.   JOURNAL OF IMMUNOLOGY

Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation

(2010) Shigeru Kotake et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+T cells

(2009) Oliver Dienz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses

(2009) H. G. Evans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-6/sIL-6R trans-signalling, but not TNF-α induced angiogenesis in a HUVEC and synovial cell co-culture system

(2009) Misato Hashizume et al.   RHEUMATOLOGY INTERNATIONAL

IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial

(2008) P. Emery et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: The tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study

(2008) Mark C. Genovese et al.   ARTHRITIS AND RHEUMATISM

Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion

(2008) C. Chizzolini et al.   BLOOD

Elevated circulatory MMP-2 and MMP-9 levels and activities in patients with rheumatoid arthritis and systemic lupus erythematosus

(2008) Yih-Hsin Chang et al.   CLINICAL BIOCHEMISTRY

Th17 cells: a new fate for differentiating helper T cells

(2008) Zhi Chen et al.   IMMUNOLOGIC RESEARCH

Tumor Necrosis Factor Blockade in Chronic Murine Tuberculosis Enhances Granulomatous Inflammation and Disorganizes Granulomas in the Lungs

(2008) S. D. Chakravarty et al.   INFECTION AND IMMUNITY

Interleukin-6 Directly Inhibits Osteoclast Differentiation by Suppressing Receptor Activator of NF-κB Signaling Pathways

(2008) Fumio Yoshitake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial

(2008) Josef S Smolen et al.   LANCET

Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair?

(2008) Gillian Murphy et al.   Nature clinical practice. Rheumatology

Chronic stress and regulation of cellular markers of inflammation in rheumatoid arthritis: Implications for fatigue

(2007) Mary C. Davis et al.   BRAIN BEHAVIOR AND IMMUNITY

Systemic inflammation as a risk factor for atherothrombosis

(2007) S. I. van Leuven et al.   RHEUMATOLOGY