Performance of Comet and Micronucleus Assays in Metabolic Competent HepaRG Cells to Predict In Vivo Genotoxicity

Safety Evaluation And Risk Assessment Ofd-Limonene

(2013) Young Woo Kim et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Abnormal mitotic spindle assembly and cytokinesis induced by D-Limonene in cultured mammalian cells

(2013) M. Mauro et al.   MUTAGENESIS

A combination of in vitro comet assay and micronucleus test using human lymphoblastoid TK6 cells

(2013) A. Kimura et al.   MUTAGENESIS

Possible involvement of genotoxic mechanisms in estragole-induced hepatocarcinogenesis in rats

(2012) Yuta Suzuki et al.   ARCHIVES OF TOXICOLOGY

Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins

(2012) H. H. J. Gerets et al.   CELL BIOLOGY AND TOXICOLOGY

The HepaRG cell line: a uniquein vitrotool for understanding drug metabolism and toxicology in human

(2012) Tommy B Andersson et al.   Expert Opinion on Drug Metabolism & Toxicology

The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage

(2012) Timothy J. Wendorff et al.   JOURNAL OF MOLECULAR BIOLOGY

Performance of in vitro γH2AX assay in HepG2 cells to predict in vivo genotoxicity

(2012) Maria Tsamou et al.   MUTAGENESIS

Optimization of the HepaRG cell model for drug metabolism and toxicity studies

(2012) Sébastien Anthérieu et al.   TOXICOLOGY IN VITRO

Roles of human sulfotransferases in genotoxicity of carcinogens using genetically engineered umu test strains

(2011) Yoshimitsu Oda et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

An adaptation of the human HepaRG cells to the in vitro micronucleus assay

(2011) R. Josse et al.   MUTAGENESIS

Validation of a genotoxicity test based on p53R2 gene expression in human lymphoblastoid cells

(2011) Taisei Mizota et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Reduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. I. Choice of cell type

(2011) Paul Fowler et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide

(2011) C.-C. Wu et al.   SCIENCE

Mechanisms in cadmium-induced carcinogenicity: recent insights

(2010) Andrea Hartwig   BIOMETALS

How accurate is in vitro prediction of carcinogenicity?

(2010) Richard Maurice Walmsley et al.   BRITISH JOURNAL OF PHARMACOLOGY

Assessment of the genotoxic potential of indirect chemical mutagens in HepaRG cells by the comet and the cytokinesis-block micronucleus assays

(2010) L. Le Hegarat et al.   MUTAGENESIS

Cadmium chloride, benzo[a]pyrene and cyclophosphamide tested in the in vitro mammalian cell micronucleus test (MNvit) in the human lymphoblastoid cell line TK6 at Covance laboratories, Harrogate UK in support of OECD draft Test Guideline 487

(2010) Paul Fowler et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Stable Expression, Activity, and Inducibility of Cytochromes P450 in Differentiated HepaRG Cells

(2009) S. Antherieu et al.   DRUG METABOLISM AND DISPOSITION

Risk assessment of consumption of methylchavicol and tarragon: The genotoxic potential in vivo and in vitro

(2009) Fabrice Nesslany et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The in vitro genotoxicity of ethanol and acetaldehyde

(2009) M.A. Kayani et al.   TOXICOLOGY IN VITRO

Long-Term Functional Stability of Human HepaRG Hepatocytes and Use for Chronic Toxicity and Genotoxicity Studies

(2008) R. Josse et al.   DRUG METABOLISM AND DISPOSITION

Evaluation of HepaRG Cells as an in Vitro Model for Human Drug Metabolism Studies

(2008) K. P. Kanebratt et al.   DRUG METABOLISM AND DISPOSITION

In vivogenotoxic potential of microcystin-LR: A cyanobacterial toxin, investigated both by the unscheduled DNA synthesis (UDS) and the comet assays after intravenous administration

(2008) Julien Gaudin et al.   ENVIRONMENTAL TOXICOLOGY

Recommendations for design of the rat comet assay

(2008) C. C. Smith et al.   MUTAGENESIS

Possible involvement of oxidative stress in trichloroethylene-induced genotoxicity in human HepG2 cells

(2008) Cunli Hu et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests: A follow-up to an ECVAM workshop

(2008) David Kirkland et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

(2008) J. E. Deweese et al.   NUCLEIC ACIDS RESEARCH