Article
Neurosciences
Sandesh Mohan, Manindra Nath Tiwari, Marija Stanojevic, Yoav Biala, Yoel Yaari
Summary: Stimulation of muscarinic receptors on hippocampal neurons activates multiple signaling pathways that inhibit Na+/K+-ATPase activity, leading to increased intrinsic neuronal excitability through enhanced enzyme phosphorylation. This novel mechanism contributes to cholinergic modulation of hippocampal activity in spatial navigation, learning and memory.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Neurosciences
Richa Awasthi, Naveen Chandra, Edi Barkai
Summary: Training rats in an olfactory discrimination task can accelerate learning and this is maintained at the cellular level by reducing the conductance of a specific current in the brain. This reduction is associated with enhanced repetitive action potential firing. The study explores the role of membrane phosphatidylinositol 4,5-bisphosphate and potassium channels in this process, suggesting that rule learning-induced enhancement in intrinsic neuronal excitability is mediated by reduced conductance of potassium channels.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Georgiana F. Stan, Timothy W. Church, Ellie Randall, Jenna R. M. Harvey, Jon T. Brown, Kevin A. Wilkinson, Jonathan G. Hanley, Neil Marrion
Summary: Accumulation of tau protein in dementia can lead to cognitive impairment. The association between tau protein and Ca-V beta 3 subunit stabilizes L-type channels in the membrane and increases calcium influx.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Joseph Cichon, Andrzej Z. Wasilczuk, Loren L. Looger, Diego Contreras, Max B. Kelz, Alex Proekt
Summary: This study demonstrates that ketamine can cause a switch in the active population of excitatory neurons in the cortical layers, which leads to impairments in sensory processing and dissociative-like state. These findings provide insights into how the brain can become disconnected from the environment while maintaining internal subjective experiences.
NATURE NEUROSCIENCE
(2023)
Editorial Material
Neurosciences
Nora Jamann, Maarten H. P. Kole
Summary: This study investigates the relationship between synaptic inputs and action potential outputs in cortical pyramidal neurons, and reveals that distinct long-range projections to retrosplenial cortex pyramidal neurons are associated with diverse modes of dendritic integration.
Article
Multidisciplinary Sciences
Yao-Yi Wang, Bing Zhao, Meng-Meng Wu, Xiao-Li Zheng, Longnian Lin, Dong-Min Yin
Summary: Increased expression of Nrg1 in GABAergic interneurons can cause cortical disinhibition, leading to various neuropsychiatric disorders. The interaction between NRG1 and Na(v)1.1 inhibits Na-v currents critical for GABAergic interneuron excitability, and activating GABAergic interneurons or restoring NRG1 expression can rescue related symptoms.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Le Gao, Sang Liu, Yanzhi Wang, Qiwen Wu, Lingfeng Gou, Jun Yan
Summary: By studying the complete dendrite and axon morphology of nearly 2,000 neurons in the mouse prefrontal cortex, this study reveals the variations in somata, dendrites, and axons across different layers and subregions. The study also identifies distinct dendrite subtypes and unique axon projection patterns. Furthermore, coherent morphological changes associated with electrophysiological phenotypes are uncovered. The study provides a comprehensive structural repertoire for the reconstruction and analysis of the prefrontal cortex neural network.
NATURE NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Yara Otor, Shay Achvat, Nathan Cermak, Hadas Benisty, Maisan Abboud, Omri Barak, Yitzhak Schiller, Alon Poleg-Polsky, Jackie Schiller
Summary: This study reveals the different tuft computational properties of layer 5 pyramidal tract neurons during motor tasks, indicating the potential morphologically dependent framework for motor computations.
Article
Multidisciplinary Sciences
Xiaofeng Han, Shuxia Guo, Nan Ji, Tian Li, Jian Liu, Xiangqiao Ye, Yi Wang, Zhixi Yun, Feng Xiong, Jing Rong, Di Liu, Hui Ma, Yujin Wang, Yue Huang, Peng Zhang, Wenhao Wu, Liya Ding, Michael Hawrylycz, Ed Lein, Giorgio A. Ascoli, Wei Xie, Lijuan Liu, Liwei Zhang, Hanchuan Peng
Summary: In this study, a unique approach was proposed to collect three-dimensional images of brain neurons by injecting dyes into patients' brain tissues. The research found that human neurons are more diverse across brain regions than by subject age or gender. Furthermore, the strong stereotypy within brain region cohorts allows for the generation of a statistical tensor field of neuron morphology to characterize the anatomical modularity of a human brain.
Article
Biochemistry & Molecular Biology
Haifeng Jiao, Dong Jiang, Xiaoyu Hu, Wanqing Du, Liangliang Ji, Yuzhuo Yang, Xiaopeng Li, Takami Sho, Xuan Wang, Ying Li, Yu-Ting Wu, Yau-Huei Wei, Li Yu, Xiaoyu Hu
Summary: Mitocytosis is a migrasome-mediated mitochondrial quality-control process that helps maintain mitochondrial quality in migrating cells. The process involves positioning damaged mitochondria at the cell periphery, which avoids binding to inward motor proteins. Enhanced mitocytosis protects cells from mitochondrial stressor-induced loss of mitochondrial membrane potential and mitochondrial respiration, while blocking mitocytosis causes loss of these functions under normal conditions. Physiologically, mitocytosis is required for maintaining mitochondrial membrane potential and viability in neutrophils in vivo.
Article
Chemistry, Multidisciplinary
Ahmed A. Aldohbeyb, Ahmad O. Alokaily
Summary: Pyramidal neurons and interneurons in the mammalian cortex play crucial roles in regulating neuronal activities. They exhibit different firing patterns and can discriminate between different types of stimuli by changing their action potential onset parameters.
APPLIED SCIENCES-BASEL
(2023)
Article
Multidisciplinary Sciences
A. F. Garcia, E. A. Crummy, I. G. Webb, M. N. Nooney, S. M. Ferguson
Summary: Processing within the anterior cingulate cortex is crucial for appropriate behavior, and dysfunction following chronic drug use is thought to play a major role in drug addiction. Two types of cortical pyramidal projection neurons regulate distinct features of a drug experience, its positive and negative aspects, respectively, supporting a revised theory of cortical function in addiction.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
William E. Medendorp, Andreas Bjorefeldt, Emmanuel L. Crespo, Mansi Prakash, Akash Pal, Madison L. Waddell, Christopher Moore, Ute Hochgeschwender
Summary: In genetic and pharmacological models, neural activity changes in developing neocortical network were observed. Excessive excitation of cortical pyramidal neurons during early postnatal period led to decreased social interaction and increased grooming behavior in adult animals. These findings suggest that enhanced pyramidal firing during development may selectively drive altered adult circuit function and maladaptive changes in behavior.
Article
Multidisciplinary Sciences
Takehiro Kudo, Hiroyuki Takuwa, Manami Takahashi, Takuya Urushihata, Masafumi Shimojo, Kazuaki Sampei, Mitsugu Yamanaka, Yutaka Tomita, Naruhiko Sahara, Tetsuya Suhara, Makoto Higuchi
Summary: In Alzheimer's disease, network hyperexcitability is associated with cognitive impairment, and dysfunction of inhibitory interneurons (INs) is considered to be a key mechanism. However, the impact of tau pathology on the functional status of INs is not well understood. This study found that neuronal activity in cortical INs was decreased in a tauopathy mouse model, along with altered firing properties and disrupted perineuronal nets. These findings suggest that the excitability of cortical INs is reduced due to the disruption of perineuronal nets.
Article
Biochemistry & Molecular Biology
Mathieu Di Miceli, Asma Derf, Benjamin Gronier
Summary: The study found that Methylphenidate (MPH) can modulate neurotransmitter efflux in brain regions enriched with dopamine and/or norepinephrine terminals, resulting in long-lasting alterations of striatal and prefrontal neurotransmission.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
J. Michael Hasse, Elise M. Bragg, Allison J. Murphy, Farran Briggs
JOURNAL OF COMPARATIVE NEUROLOGY
(2019)
Article
Neurosciences
Arielle L. Baker, Ryan J. O'Toole, Allan T. Gulledge
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Neurosciences
Scott A. Alpizar, Arielle L. Baker, Allan T. Gulledge, Michael B. Hoppa
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Clinical Neurology
Keita Onoue, Chad Farris, Hannah Burley, Edward Sung, Mariza Clement, Mohamad Abdalkader, Asim Mian
Summary: This study aimed to evaluate the utility of CSMRI in detecting occult injuries in blunt trauma patients after negative CSCT. CSMRI detected significant injuries in 31% of patients, including cord contusions/infarcts, bone contusions/fractures, spinal canal hemorrhages, and soft tissue injuries. Upper extremity neurological deficit had the highest positive predictive value for detection of CT-occult injury.
JOURNAL OF NEURORADIOLOGY
(2021)
Correction
Neurosciences
Emily K. Stephens, Arielle L. Baker, Allan T. Gulledge
FRONTIERS IN NEURAL CIRCUITS
(2019)
Article
Otorhinolaryngology
Sean Hashemi, Masafumi Oda, Keita Onoue, Krystyne Basa, Samuel J. Rubin, Osamu Sakai, Andrew Salama, Waleed H. Ezzat
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2020)
Article
Mathematical & Computational Biology
Allison J. Murphy, Luke Shaw, J. Michael Hasse, Robbe L. T. Goris, Farran Briggs
Summary: The study found that corticogeniculate feedback can increase information coding capacity by stabilizing the response gain of LGN neurons. Optogenetic activation of corticogeniculate neurons reduces LGN gain variability and enhances information coding capacity.
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Noriyuki Fujima, V. Carlota Andreu-Arasa, Keita Onoue, Peter C. Weber, Richard D. Hubbell, Bindu N. Setty, Osamu Sakai
Summary: The study found that deep learning analysis could be a useful supportive tool in diagnosing otosclerosis on temporal bone CT images. The diagnostic accuracies of VGGNet, GoogLeNet, and ResNet were comparable to that of a subspecialty trained radiologist, with GoogLeNet and ResNet showing non-inferiority compared to the radiologist.
EUROPEAN RADIOLOGY
(2021)
Article
Neurosciences
Chenguang Li, Allan T. Gulledge
Summary: The voltage dependency and kinetics of NMDA receptors synergistically stabilize synaptic integration of excitatory synaptic inputs in neurons, reducing variability in somatic responses across different initial membrane potentials and dendritic domains. The presence of NMDA conductance, in combination with AMPA conductance, compensates for changes in synaptic driving force and distance-dependent attenuation, increasing the fidelity of synaptic integration and EPSP-spike coupling. NMDA receptors convey advantages for synaptic integration independent of their role in coincidence detection and synaptic plasticity.
Article
Radiology, Nuclear Medicine & Medical Imaging
Keita Onoue, Thanh N. Nguyen, Asim Mian, Hormuzdiyar Dasenbrock, Harprit Bedi, Mohamad Abdalkader
Summary: Twig-like MCA is a rare vascular anomaly characterized by a plexiform network of small vessels replacing the M1 segment. Diagnosis can be made through cerebral angiograms, with patients presenting with symptoms like headache or pulsatile tinnitus. It is important to differentiate twig-like MCA from other radiological mimics for appropriate management and prevention of complications.
Article
Otorhinolaryngology
Keita Onoue, Noriyuki Fujima, V. Carlota Andreu-Arasa, Bindu N. Setty, Osamu Sakai
Summary: The study demonstrated that deep learning algorithm has a high diagnostic accuracy in differentiating pathological lymph nodes of PTC, TB, and HPV+OPSCC on CT images, outperforming the diagnostic performances of board-certified neuroradiologists.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2021)
Article
Biochemical Research Methods
Susana Andrea Contreras, Jan-Hendrik Schleimer, Allan T. Gulledge, Susanne Schreiber
Summary: Intense neuronal activity can lead to rapid changes in ionic concentrations and shift neuronal spiking patterns. This transition is caused by a specific change in neuronal voltage dynamics, affecting behavior encoding and network interactions.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Behavioral Sciences
Nicole E. E. DeAngeli, Danielle I. I. Fournier, Allan T. T. Gulledge, Rebecca D. D. Burwell, Travis P. P. Todd, David J. J. Bucci
Summary: The study suggests that the postrhinal cortex plays an important role in the expression of auditory fear conditioning, both in the presence and absence of extinction.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2022)
Meeting Abstract
Oncology
Sumyuktha V. Anand, Alexander G. Skorput, Allan T. Gulledge, Isabella B. Fox, Damian A. Bonnin, Alison L. Young, Matthew C. Havrda
Article
Radiology, Nuclear Medicine & Medical Imaging
Keita Onoue, Noriyuki Fujima, V. Carlota Andreu-Arasa, Bindu N. Setty, Muhammad Mustafa Qureshi, Osamu Sakai
EUROPEAN JOURNAL OF RADIOLOGY
(2020)