Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL

How I treat acute lymphoblastic leukemia in older adolescents and young adults

(2015) E. Curran et al.   BLOOD

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

(2015) Sidi Chen et al.   CELL

Promises and Challenges of Smac Mimetics as Cancer Therapeutics

(2015) S. Fulda   CLINICAL CANCER RESEARCH

Monitoring minimal residual disease in children with high-risk relapses of acute lymphoblastic leukemia: prognostic relevance of early and late assessment

(2015) C Eckert et al.   LEUKEMIA

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Genomics and drug profiling of fatal TCF3-HLF−positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options

(2015) Ute Fischer et al.   NATURE GENETICS

The diverse role of RIP kinases in necroptosis and inflammation

(2015) John Silke et al.   NATURE IMMUNOLOGY

Image-based RNA interference screening reveals an individual dependence of acute lymphoblastic leukemia on stromal cysteine support

(2015) Jeannette Boutter et al.   Oncotarget

RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3

(2014) Christopher P. Dillon et al.   CELL

Birinapant (TL32711), a Bivalent SMAC Mimetic, Targets TRAF2-Associated cIAPs, Abrogates TNF-Induced NF- B Activation, and Is Active in Patient-Derived Xenograft Models

(2014) C. A. Benetatos et al.   MOLECULAR CANCER THERAPEUTICS

The Two Faces of Receptor Interacting Protein Kinase-1

(2014) Ricardo Weinlich et al.   MOLECULAR CELL

Smac mimetics and innate immune stimuli synergize to promote tumor death

(2014) Shawn T Beug et al.   NATURE BIOTECHNOLOGY

Development and function of human innate immune cells in a humanized mouse model

(2014) Anthony Rongvaux et al.   NATURE BIOTECHNOLOGY

In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer

(2014) Ramona Rudalska et al.   NATURE MEDICINE

Small-molecule SMAC mimetics as new cancer therapeutics

(2014) Longchuan Bai et al.   PHARMACOLOGY & THERAPEUTICS

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

(2014) W. J. Kaiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages

(2014) S. McComb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis

(2014) Justine E. Roderick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of Life-or-Death Decisions by RIP1 Kinase

(2013) Dana E Christofferson et al.   Annual Review of Physiology

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

(2013) Dimitry Ofengeim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

(2013) R. J. Thapa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Genomic Characterization of Childhood Acute Lymphoblastic Leukemia

(2013) Charles G. Mullighan   SEMINARS IN HEMATOLOGY

Individualized Systems Medicine Strategy to Tailor Treatments for Patients with Chemorefractory Acute Myeloid Leukemia

(2013) T. Pemovska et al.   Cancer Discovery

How I treat relapsed childhood acute lymphoblastic leukemia

(2012) F. Locatelli et al.   BLOOD

Kinase Pathway Dependence in Primary Human Leukemias Determined by Rapid Inhibitor Screening

(2012) J. W. Tyner et al.   CANCER RESEARCH

Targeting IAP proteins for therapeutic intervention in cancer

(2012) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Xenografts of highly resistant leukemia recapitulate the clonal composition of the leukemogenic compartment

(2011) M. Schmitz et al.   BLOOD

NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling

(2011) Sharon Biton et al.   CELL

Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse

(2011) Emmanuelle Clappier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Cytosolic ATM/NEMO/RIP1 Complex Recruits TAK1 To Mediate the NF- B and p38 Mitogen-Activated Protein Kinase (MAPK)/MAPK-Activated Protein 2 Responses to DNA Damage

(2011) Y. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs

(2011) Tencho Tenev et al.   MOLECULAR CELL

Small-molecule pan-IAP antagonists: a patent review

(2010) John A Flygare et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance

(2010) Laura Bonapace et al.   JOURNAL OF CLINICAL INVESTIGATION

Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi

(2010) Johannes Zuber et al.   NATURE BIOTECHNOLOGY

An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer

(2008) Lars Zender et al.   CELL

Tumor resistance to apoptosis

(2008) Simone Fulda   INTERNATIONAL JOURNAL OF CANCER

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

(2008) Mathieu J.M. Bertrand et al.   MOLECULAR CELL

IAP-targeted therapies for cancer

(2008) E C LaCasse et al.   ONCOGENE

Both cIAP1 and cIAP2 regulate TNF -mediated NF- B activation

(2008) D. J. Mahoney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen-mediated T cell expansion regulated by parallel pathways of death

(2008) I. L. Ch'en et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA