Article
Nutrition & Dietetics
Toshio Inui, Namiko Kawamura, Riho Nakama, Akio Inui, Goro Katsuura
Summary: The effects of degalactosylated whey protein on LPS-induced inflammatory responses were observed. It suppressed the decrease in body weight and the increase in inflammatory cytokines. At the cellular level, it reduced the expression of TLR4 and increased the expression of MKP-1.
FRONTIERS IN NUTRITION
(2022)
Article
Anatomy & Morphology
Nahla Reda Sarhan, Eman Mohamed El Nashar, Eman Hamza, Shimaa M. El-Beah, Mansour Abdullah Alghamdi, Khulood Mohammed Al-Khater, Rashid A. Aldahhan, Eman Shaaban Abul-Ela
Summary: This study aimed to explore the anti-aging role of whey protein (WP) against D-galactose induced age-related degenerative changes and oxidative damage in the prefrontal cortex (PFC) and investigate its underlying mechanisms. The results showed that WP can alleviate the D-galactose-induced PFC aging through activating the Nrf2 pathway, reducing cell senescence and gliosis. Therefore, WP may be a potential therapeutic target to retard the aging process.
Article
Immunology
Arturo Gonzalez de la Aleja, Cristina Herrero, Monica Torres-Torresano, Juan Vladimir de la Rosa, Barbara Alonso, Enrique Capa-Sardon, Ittai B. Muller, Gerrit Jansen, Amaya Puig-Kroeger, Miguel A. Vega, Antonio Castrillo, Angel L. Corbi
Summary: LXR activation limits the anti-inflammatory polarization of human macrophages and promotes the acquisition of an inflammatory profile, which is associated with the expression of specific genes and the release of activin A.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jin-Nam Kim, Sung Nim Han, Hye-Kyeong Kim
Summary: Black soybean anthocyanin extract (BSAn) alleviates obesity-induced oxidative stress and inflammation, improves lipid metabolic function in hypertrophied 3T3-L1 adipocytes and RAW264.7 macrophages coculture, and enhances insulin sensitivity.
Article
Biochemistry & Molecular Biology
Rui Liu, Wentao Xu, He Zhu, Zijian Dong, Huke Dong, Shi Yin
Summary: The overexpression of BMP9 in aged livers is directly related to APAP-induced acute liver injury. Excess BMP9 leads to hepatocyte injury and death, inhibits autophagy, and promotes the acquisition of a senescence-associated secretory phenotype (SASP). Furthermore, BMP9 downregulates autophagy in MFs through its effect on autophagy-related genes (ATG3 and ATG7), exacerbating liver injury and SASP acquisition.
CELL AND BIOSCIENCE
(2023)
Review
Cell Biology
Wangrui Lei, Liyuan Jia, Zheng Wang, Zhenxing Liang, Zhao Aizhen, Yanqing Liu, Ye Tian, Lin Zhao, Yawu Chen, Guangyong Shi, Zhi Yang, Yang Yang, Xuezeng Xu
Summary: Fibrosis is an excessive self-repair response in the aging process of various organs. It is necessary to develop therapeutic strategies to restore tissue architecture without side effects. Chemokines play a crucial role in controlling the pathological processes involved in fibrosis, including inflammation, endothelial cell injury, and macrophage recruitment.
AGEING RESEARCH REVIEWS
(2023)
Review
Immunology
Rajat Atre, Rahul Sharma, Gaponenko Vadim, Kundan Solanki, Khandu Wadhonkar, Neha Singh, Pramod Patidar, Rakhi Khabiya, Harshita Samaur, Sreeparna Banerjee, Mirza S. Baig
Summary: This review summarizes the importance of adaptor proteins in regulating immune responses and their roles in macrophage-mediated signaling in chronic diseases. Adaptor molecules serve as bridges between receptors and other molecules in different signaling pathways. Targeting these adaptors could be a promising therapeutic strategy against chronic inflammatory diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Xueyan Zhou, Xiaojing Tian, Li Song, Li Luo, Zhongren Ma, Fumei Zhang
Summary: This study investigated the effects of donkey whey protein and donkey whey hydrolysate on aging mice. The results showed that these substances could improve the body's aging condition, increase beneficial gut bacteria, and decrease harmful bacteria. Additionally, they positively influenced weight gain velocity, SOD activity, and thymus index. These findings contribute to a better understanding of the potential use of donkey whey protein and donkey whey hydrolysate in delaying aging.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Ashley K. Putman, G. Andres Contreras
Summary: Dysregulated inflammation and oxidative stress play significant roles in various diseases. Macrophages are crucial in immune responses and regulate inflammation by exhibiting different phenotypes. IsoPs, as biomarkers of oxidative stress, can promote an anti-inflammatory macrophage phenotype during inflammation, contributing to disease prevention and mitigation.
Article
Nanoscience & Nanotechnology
Jun Wan, Jie Yang, Wenrui Lei, Zezhou Xiao, Pengyu Zhou, Shaoyi Zheng, Peng Zhu
Summary: This study developed liposome nanoparticles (SE-LNPs) using Simvastatin (SIM) as a model drug, EGCG as an antioxidant, and distearyl phosphatidylcholine (DSPC) as carriers. The nanoparticles showed good therapeutic effects in vitro and in vivo by resisting oxidation, promoting M2 polarization, reducing blood lipids, and improving atherosclerotic lesions.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Food Science & Technology
Ce Wang, Jia Wang, Yonghai Sun, Kalev Freeman, Monique Alyssa Mchenry, Cuina Wang, Mingruo Guo
Summary: This study successfully developed a method using WP to stabilize zein nanoparticles for the delivery of CBD. The zein-WP nanoparticles showed excellent storage stability and effectively protected CBD against degradation caused by heat and UV light. In vivo pharmacokinetic study demonstrated significantly enhanced Cmax and AUC for CBD in the zein-WP nanoparticles.
Article
Nutrition & Dietetics
Naomi MMP. de Hart, Jonathan J. Petrocelli, Rebekah J. Nicholson, Elena M. Yee, Patrick J. Ferrara, Eric D. Bastian, Loren S. Ward, Brent L. Petersen, Scott A. Summers, Micah J. Drummond
Summary: This study demonstrates that whey bioactive compound GMP can prevent inflammation and atrophy induced by palmitate in muscle cells. The protective mechanism of GMP may be related to targeting catabolic signaling associated with cellular stress and proteolysis.
JOURNAL OF NUTRITION
(2023)
Review
Genetics & Heredity
Lili Qu, Alyssa J. Matz, Keaton Karlinsey, Ziming Cao, Anthony T. Vella, Beiyan Zhou
Summary: Macrophages play a central role in systemic inflammation associated with obesity and aging, known as meta-inflammation and inflammaging. The activities of macrophages in these chronic conditions have both shared and distinct patterns, leading to multifaceted effects in their pathogenic roles. The molecular networks governing the actions of macrophages are directly influenced by environmental cues, resulting in metabolic reprogramming and the development of meta-inflammation in obesity or inflammaging in aging.
Article
Pharmacology & Pharmacy
Chelsea A. Kraynak, Wenbai Huang, Elizabeth C. Bender, Jie-Liang Wang, Mahmoud S. Hanafy, Zhengrong Cui, Laura J. Suggs
Summary: Chronic inflammation is an important pathological process in various diseases. Macrophages play a critical role in inflammation and can switch between pro-inflammatory and anti-inflammatory phenotypes. In this study, a nanoparticle was developed to target inflammation and reduce the inflammatory phenotype of macrophages by mimicking the anti-inflammatory effect of apoptotic cell engulfment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Nutrition & Dietetics
Avneet Oberoi, Caroline Giezenaar, Kylie Lange, Karen L. Jones, Michael Horowitz, Ian Chapman, Stijn Soenen
Summary: This study found that even with relatively low intake of whey protein, there is a risk of blood pressure decrease in older men.
Article
Plant Sciences
Hung-Jen Lin, Ramasamy Mahendran, Hsiang-Yen Huang, Ping-Ling Chiu, Yung-Ming Chang, Cecilia Hsuan Day, Ray-Jade Chen, V. Vijaya Padma, Yang Liang-Yo, Wei-Wen Kuo, Chih-Yang Huang
Summary: Solanum nigrum, traditionally used in Asian countries for various health conditions, shows anti-tumor activity and can attenuate cardiac hypertrophy by suppressing specific protein kinases and signaling pathways. In vivo experiments on rats demonstrate the potential of S. nigrum in reducing heart size and alleviating heart enlargement caused by hypertension.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Sport Sciences
Luthfia Dewi, Yin-Chou Lin, Andrew Nicholls, Giancarlo Condello, Chih-Yang Huang, Chia-Hua Kuo
Summary: This study provides a quantitative estimate of the changes in Pax7(+) muscle stem cells and circulating CD34(+) bone marrow stem cells in humans following acute exercise. The results show that Pax7(+) cells in skeletal muscle increase significantly after resistance exercise, while circulating CD34(+) cells also increase after both resistance exercise and aerobic exercise but quickly return to baseline levels.
Article
Biotechnology & Applied Microbiology
Jing-Ying Lin, Bruce Chi-Kang Tsai, Hui-Chuan Kao, Chien-Yi Chiang, Yun-An Chen, William Shao-Tsu Chen, Tsung-Jung Ho, Chun-Hsu Yao, Wei-Wen Kuo, Chih-Yang Huang
Summary: This study investigated the neuroprotective mechanisms of Lactobacillus reuteri GMNL-263 in streptozotocin-induced diabetic rats. The results showed that GMNL-263 attenuated diabetes-induced hippocampal damage by enhancing cell survival pathways and repressing inflammatory and apoptotic pathways. Histopathological analysis revealed that GMNL-263 prevented structural changes and reduced inflammation and apoptosis in the hippocampus. These findings suggest that GMNL-263 may have potential clinical application for the brain of diabetic individuals.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Toxicology
Indra Putra Taufani, Jiro Hasegawa Situmorang, Rifki Febriansah, Sri Tasminatun, Sunarno Sunarno, Liang-Yo Yang, Yi-Ting Chiang, Chih-Yang Huang
Summary: Ferroptosis is a form of cell death characterized by the accumulation of iron and lipid ROS. In this study, we investigated the role of GPX4 and Nrf2 in regulating ferroptosis. Our findings showed that inhibition of Nrf2 with ML385 enhanced the toxicity of RSL3 by increasing mitochondrial ROS levels and disrupting mitochondrial function. Additionally, the application of Mito TEMPOL prevented the upregulation of ROS and reduced the toxicity of RSL3, restoring the antioxidant capacity and mitochondrial function of the cells.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2023)
Article
Cell Biology
Pei-Rung Wu, Shang-Yin Chiang, Robert Midence, Wen-Chao Kao, Chun-Lun Lai, I-Cheng Cheng, Shen-Ju Chou, Chih-Cheng Chen, Chih-Yang Huang, Ruey-Hwa Chen
Summary: Patients with mutations in the WDR4 gene exhibit cerebellar atrophy and gait phenotypes, but the underlying mechanisms have not been explored. This study reveals a crucial role of Wdr4 in cerebellar development. Deficiency of Wdr4 in granule neuron progenitors (GNPs) leads to reduced foliation, smaller external and internal granular layers, compromised Purkinje neuron organization, and smaller molecular layer, resulting in locomotion defects.
CELL DEATH & DISEASE
(2023)
Article
Environmental Sciences
Cheng-You Lu, Chia-Hua Kuo, Wei-Wen Kuo, Dennis Jine-Yuan Hsieh, Tso-Fu Wang, Cheng-Yen Shih, Pi-Yu Lin, Shinn-Zong Lin, Tsung-Jung Ho, Chih-Yang Huang
Summary: The study found that Ohwia caudata extract (OCE) inhibits inflammatory response and reduces proliferation and activation of fibroblast-like synoviocytes in rheumatoid arthritis (RA) through regulation of suppressors of cytokine signaling 3 (SOCS3) and the JAK2/STAT3 pathway. This suggests that OCE may be further investigated as a candidate anti-inflammatory and anti-arthritic agent.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mei-Chih Chen, Bing-Ze Yang, Wei-Wen Kuo, Shih-Hsin Wu, Tso-Fu Wang, Yu-Lan Yeh, Ming-Cheng Chen, Chih-Yang Huang
Summary: Resistance to chemotherapy is a major obstacle in cancer treatment. This study investigated the molecular mechanisms underlying drug resistance in colon cancer using oxaliplatin-resistant LOVOOR cells. The findings suggest that Aurora-A, a kinase involved in the G2/M phase, may contribute to the resistance of LOVOOR cells to oxaliplatin treatment by depressing p53 signaling. Targeting Aurora-A could be a potential solution for patients who have failed oxaliplatin treatment.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Chih-Ming Su, Tung-Wei Hsu, Hsin-An Chen, Wan-Yu Wang, Chih-Yang Huang, Chih-Chiang Hung, Ming-Hsin Yeh, Yen-Hao Su, Ming-Te Huang, Po-Hsiang Liao
Summary: Metastasis in breast cancer is the main cause of death in clinical patients. Lower levels of Dicer protein in highly invasive breast cancer cells are usually associated with poor clinical outcomes. Our study reveals the regulatory mechanism of Dicer protein degradation through a process called chaperone-mediated autophagy (CMA), which promotes cancer metastasis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Nutrition & Dietetics
Chen-Chan Wei, Giancarlo Condello, Ai-Lun Yang, Szu-Hsien Yu, Yi-Hung Liao, Chung-Yu Chen, Chi-Chieh Hsu, Chi-Yang Huang, Chia-Hua Kuo
Summary: This study aimed to determine the effect of rectal defecation on endurance performance and blood supply to the prefrontal brain and sub-navel regions of elite triathletes. The results showed that defecation improved performance in cycling and increased blood availability to compensate for cerebral deoxygenation during exercise.
JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION
(2023)
Article
Environmental Sciences
Dennis jine Yuan Hsieh, Md. Nazmul Islam, Wei-Wen Kuo, Marthandam Asokan Shibu, Chin-Hu Lai, Pi-Yu Lin, Shinn-Zong Lin, Michael Yu-Chih Chen, Chih-Yang Huang
Summary: This study aimed to investigate the effect of a combination of Artemisia argyi and Ohwia caudata leaf extracts with Isoliquiritigenin on the side effects of chemotherapy drugs. The results showed that this combination could improve cardiac damage and function, making it a potential herbal treatment for cardiac hypertrophy and inflammatory diseases.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Pei-Ying Lee, Bruce Chi-Kang Tsai, Maria Angelina Sitorus, Pi-Yu Lin, Shinn-Zong Lin, Cheng-Yen Shih, Shang-Yeh Lu, Yueh-Min Lin, Tsung-Jung Ho, Chih-Yang Huang
Summary: This study found that Ohwia caudata aqueous extract can effectively suppress doxorubicin-induced mitochondrial dysfunction, maintain the stability of stem cells, and reduce apoptosis rate. The findings provide new directions for the medical application of Ohwia caudata.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Food Science & Technology
Yu-Jung Lin, Chih-Yang Huang, Kannan Ashok Kumar, Bruce Chi-Kang Tsai, Dennis Jine-Yuan Hsieh, Ping-Ling Chiu, Yung-Ming Chang, Tsung-Jung Ho, Wei-Wen Kuo, Da-Tong Ju
Summary: Hericium erinaceus mycelia extract can prevent the accumulation of Aβ and alpha-syn in A53T transgenic mice by regulating SIRT-1/ERK-1/2 mediated autophagy.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Oncology
Farheen Badrealam Khan, Parul Singh, Yahya F. Jamous, Syed Azmal Ali, Abdullah, Shahab Uddin, Qamar Zia, Manoj Kumar Jena, Mohsina Khan, Mohammad Owais, Chih Yang Huang, Venkatesh Chanukuppa, Chrismawan Ardianto, Long Chiau Ming, Waqas Alam, Haroon Khan, Mohammad Akli Ayoub
Summary: This article reviews the use of proteomics to study the molecular details of phytochemicals such as curcumin, genistein, and tanshinone IIA. These phytochemicals have various pharmacological properties that are extensively studied to understand their mechanisms of action. Proteomics technology has proved to be a reliable approach to unravel the molecular intricacies of phytochemicals.
Article
Medicine, Research & Experimental
Chikondi Jassi, Wei-Wen Kuo, Yu-Chun Chang, Tso-Fu Wang, Chi-Cheng Li, Tsung-Jung Ho, Dennis Jine-Yuan Hsieh, Chia-Hua Kuo, Ming-Cheng Chen, Chih-Yang Huang
Summary: The combination of Aloin and CPT-11 has been found to have an enhanced anti-tumor effect in colorectal cancer. This combination reduces cell viability and induces apoptosis, while regulating the expression of miRNA-133b, IGF1R, and their downstream pathways. CPT-11 and Aloin show potential as combination treatment partners against colorectal cancer, with miRNA-133b possibly serving as a co-therapeutic target with IGF1R.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Yu-Jung Lin, Navaneethan Sundhar, Hema Sri Devi, Hsueh-Fa Pien, Shina Fong-Mei Wen, Jenn-Line Sheu, Bruce Chi-Kang Tsai, Chih-Yang Huang
Summary: A novel compound based on chromium (III) was synthesized and evaluated for its antiviral effectiveness against multiple variants of COVID-19. It demonstrated interference with the interaction between the spike protein and ACE2, reduced the expression of ACE2 and TMPRSS2, and inhibited the activity of 3CL and RdRp. This compound effectively inhibited viral infection in vitro and in vivo.