Alzheimer’s disease: relevant molecular and physiopathological events affecting amyloid-β brain balance and the putative role of PPARs

Membrane Anchored and Lipid Raft Targeted β-Secretase Inhibitors for Alzheimer's Disease Therapy

(2018) Saoussen Ben Halima et al.   JOURNAL OF ALZHEIMERS DISEASE

Peroxisome Proliferators Reduce Spatial Memory Impairment, Synaptic Failure, and Neurodegeneration in Brains of a Double Transgenic Mice Model of Alzheimer's Disease

(2018) Nibaldo C. Inestrosa et al.   JOURNAL OF ALZHEIMERS DISEASE

Elucidation of the BACE1 Regulating Factor GGA3 in Alzheimer's Disease

(2018) Teemu Natunen et al.   JOURNAL OF ALZHEIMERS DISEASE

The Role of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in the Pathophysiology of Neurodegeneration: A Literature Study

(2018) Barbara Mroczko et al.   JOURNAL OF ALZHEIMERS DISEASE

Presenilin-1 Mutations in Alzheimer's Disease: An Update on Genotype-Phenotype Relationships

(2018) A.J. Larner   JOURNAL OF ALZHEIMERS DISEASE

Testing the Neurovascular Hypothesis of Alzheimer's Disease: LRP-1 Antisense Reduces Blood-brain Barrier Clearance, Increases Brain Levels of Amyloid-β Protein, and Impairs Cognition

(2017) Laura B. Jaeger et al.   JOURNAL OF ALZHEIMERS DISEASE

Caveolin-1 Regulates γ-Secretase-Mediated AβPP Processing by Modulating Spatial Distribution of γ-Secretase in Membrane

(2017) Arun Kapoor et al.   JOURNAL OF ALZHEIMERS DISEASE

Peroxisome Proliferator-Activated Receptor Gamma Enhances the Activity of an Insulin Degrading Enzyme-Like Metalloprotease for Amyloid-β

(2017) Ira Espuny-Camacho et al.   JOURNAL OF ALZHEIMERS DISEASE

Mechanisms of vascular dysfunction in mice with endothelium-specific deletion of the PPAR-δ gene

(2014) Livius V. d'Uscio et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Dual roles for autophagy: Degradation and secretion of Alzheimer's disease Aβ peptide

(2014) Per Nilsson et al.   BIOESSAYS

Retinoids and breast cancer: From basic studies to the clinic and back again

(2014) Enrico Garattini et al.   CANCER TREATMENT REVIEWS

Involvement of peroxisome proliferator-activated receptor β/δ (PPAR β/δ) in BDNF signaling during aging and in Alzheimer disease: Possible role of 4-hydroxynonenal (4-HNE)

(2014) Elisabetta Benedetti et al.   CELL CYCLE

Mitochondrial Dysfunction in Aging Rat Brain Regions upon Chlorpyrifos Toxicity and Cold Stress: An Interactive Study

(2014) P. Mahaboob Basha et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

LXR Agonist Regulates the Carcinogenesis of PCa via the SOCS3 Pathway

(2014) Weihua Fu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cognitive Enhancing Treatment with a PPARγ Agonist Normalizes Dentate Granule Cell Presynaptic Function in Tg2576 APP Mice

(2014) Miroslav N. Nenov et al.   JOURNAL OF NEUROSCIENCE

Role of Sirt1 During the Ageing Process: Relevance to Protection of Synapses in the Brain

(2014) Juan A. Godoy et al.   MOLECULAR NEUROBIOLOGY

Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase

(2014) Virginie Buggia-Prévot et al.   Molecular Neurodegeneration

Trafficking regulation of proteins in Alzheimer’s disease

(2014) Shangtong Jiang et al.   Molecular Neurodegeneration

Polymorphisms in BACE2 may affect the age of onset Alzheimer's dementia in Down syndrome

(2014) Kin Y. Mok et al.   NEUROBIOLOGY OF AGING

Wnt signaling: Role in LTP, neural networks and memory

(2013) Carolina A. Oliva et al.   AGEING RESEARCH REVIEWS

Peroxisome Proliferator-activated Receptor γ, Coactivator 1α Deletion Induces Angiotensin II–Associated Vascular Dysfunction by Increasing Mitochondrial Oxidative Stress and Vascular Inflammation

(2013) Swenja Kröller-Schön et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Brain amyloid-β oligomers in ageing and Alzheimer’s disease

(2013) Sylvain E. Lesné et al.   BRAIN

Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease

(2013) Michelle A Erickson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Vascular cognitive impairment, dementia, aging and energy demand. A vicious cycle

(2013) A. Popa-Wagner et al.   JOURNAL OF NEURAL TRANSMISSION

Troglitazone, a thiazolidinedione, decreases tau phosphorylation through the inhibition of cyclin-dependent kinase 5 activity in SH-SY5Y neuroblastoma cells and primary neurons

(2013) Du-Hyong Cho et al.   JOURNAL OF NEUROCHEMISTRY

Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice

(2013) Katherine D LaClair et al.   Molecular Neurodegeneration

Ushering in the study and treatment of preclinical Alzheimer disease

(2013) Jessica B. Langbaum et al.   Nature Reviews Neurology

Peroxisome proliferator-activated receptor (PPAR)β/δ, a possible nexus of PPARα- and PPARγ-dependent molecular pathways in neurodegenerative diseases: Review and novel hypotheses

(2013) Stepan Aleshin et al.   NEUROCHEMISTRY INTERNATIONAL

MK886 Reduces Cerebral Amyloid Angiopathy Severity in TgCRND8 Mice

(2013) Cheryl A. Hawkes et al.   Neurodegenerative Diseases

Nicotine Prevents Synaptic Impairment Induced by Amyloid-β Oligomers Through α7-Nicotinic Acetylcholine Receptor Activation

(2013) Nibaldo C. Inestrosa et al.   NEUROMOLECULAR MEDICINE

Data, information, knowledge and principle: back to metabolism in KEGG

(2013) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Curcumin Inhibits Transforming Growth Factor-β1-Induced EMT via PPARγ Pathway, Not Smad Pathway in Renal Tubular Epithelial Cells

(2013) Rui Li et al.   PLoS One

Peroxisome Proliferator-Activated Receptor δ Agonist, HPP593, Prevents Renal Necrosis under Chronic Ischemia

(2013) Larisa V. Fedorova et al.   PLoS One

Thiazolidinediones Promote Axonal Growth through the Activation of the JNK Pathway

(2013) Rodrigo A. Quintanilla et al.   PLoS One

Pioglitazone Improves Reversal Learning and Exerts Mixed Cerebrovascular Effects in a Mouse Model of Alzheimer’s Disease with Combined Amyloid-β and Cerebrovascular Pathology

(2013) Panayiota Papadopoulos et al.   PLoS One

Response to Comments on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) G. E. Landreth et al.   SCIENCE

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) N. F. Fitz et al.   SCIENCE

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) A. R. Price et al.   SCIENCE

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer’s Disease

(2013) Marcus O. W. Grimm et al.   Frontiers in Aging Neuroscience

The PSEN1, p.E318G Variant Increases the Risk of Alzheimer's Disease in APOE-ε4 Carriers

(2013) Bruno A. Benitez et al.   PLoS Genetics

Induction of mitochondrial biogenesis and respiration is associated with mTOR regulation in hepatocytes of rats treated with the pan-PPAR activator tetradecylthioacetic acid (TTA)

(2012) Hanne R. Hagland et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pioglitazone treatment increases COX-2-derived prostacyclin production and reduces oxidative stress in hypertensive rats: role in vascular function

(2012) Raquel Hernanz et al.   BRITISH JOURNAL OF PHARMACOLOGY

β−Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB1 or CB2 receptors

(2012) Cristina Benito et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein

(2012) Livius V. d'Uscio et al.   CARDIOVASCULAR RESEARCH

Alzheimer’s Disease and Retinal Neurodegeneration Share a Consistent Stress Response of the Neurovascular Unit

(2012) Stephanie Busch et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity

(2012) Andrew D. Patterson et al.   HEPATOLOGY

Differential Regulation of Amyloid-β Endocytic Trafficking and Lysosomal Degradation by Apolipoprotein E Isoforms

(2012) Jie Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) protects neurons from oxidative death via an Nrf2 astrocyte-specific mechanism independent of PPARγ

(2012) Renée E. Haskew-Layton et al.   JOURNAL OF NEUROCHEMISTRY

LRP1 in Brain Vascular Smooth Muscle Cells Mediates Local Clearance of Alzheimer's Amyloid- 

(2012) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) and Neurodegenerative Disorders

(2012) Yu-Chang Chen et al.   MOLECULAR NEUROBIOLOGY

Impaired mitochondrial function in psychiatric disorders

(2012) Husseini Manji et al.   NATURE REVIEWS NEUROSCIENCE

Alzheimer brain-derived amyloid β-protein impairs synaptic remodeling and memory consolidation

(2012) Gilyana G. Borlikova et al.   NEUROBIOLOGY OF AGING

Preclinical Success against Alzheimer's Disease with an Old Drug

(2012) Frank M. LaFerla   NEW ENGLAND JOURNAL OF MEDICINE

Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease

(2012) C. Frieden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protection from liver fibrosis by a peroxisome proliferator-activated receptor   agonist

(2012) K. Iwaisako et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

New Insights into the Role of Peroxisome Proliferator-Activated Receptors in Regulating the Inflammatory Response after Tissue Injury

(2012) Miriam D. Neher et al.   PPAR Research

Postsynaptic Receptors for Amyloid-β Oligomers as Mediators of Neuronal Damage in Alzheimer’s Disease

(2012) Margarita C. Dinamarca et al.   Frontiers in Physiology

PPARγ Agonist Improves Neuronal Insulin Receptor Function in Hippocampus and Brain Mitochondria Function in Rats with Insulin Resistance Induced by Long Term High-Fat Diets

(2011) Noppamas Pipatpiboon et al.   ENDOCRINOLOGY

Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis

(2011) Catherine Marquer et al.   FASEB JOURNAL

Peroxisome Proliferator-activated Receptor α (PPARα) Induces PPARγ Coactivator 1α (PGC-1α) Gene Expression and Contributes to Thermogenic Activation of Brown Fat

(2011) Elayne Hondares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxisome proliferator-activated receptor-γ activation reduces cyclooxygenase-2 expression in vascular smooth muscle cells from hypertensive rats by interfering with oxidative stress

(2011) Angela Martín et al.   JOURNAL OF HYPERTENSION

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

(2011) Guenter Haemmerle et al.   NATURE MEDICINE

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Amyloid precursor protein (APP) processing genes and cerebrospinal fluid APP cleavage product levels in Alzheimer's disease

(2011) L.M. Bekris et al.   NEUROBIOLOGY OF AGING

PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease

(2011) Ming-Chang Chiang et al.   NEUROBIOLOGY OF DISEASE

Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

(2010) Gunnar K. Gouras et al.   ACTA NEUROPATHOLOGICA

Amyloid β-Peptide Oligomers Stimulate RyR-Mediated Ca2+ Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF

(2010) Andrea C. Paula-Lima et al.   ANTIOXIDANTS & REDOX SIGNALING

Rosiglitazone prevents the progression of renal injury in DOCA-salt hypertensive rats

(2010) Eun Hui Bae et al.   HYPERTENSION RESEARCH

Lack of brain-to-blood efflux transport activity of low-density lipoprotein receptor-related protein-1 (LRP-1) for amyloid-β peptide(1-40) in mouse: involvement of an LRP-1-independent pathway

(2010) Shingo Ito et al.   JOURNAL OF NEUROCHEMISTRY

Neuropathology of Alzheimer's Disease

(2010) Daniel P. Perl   MOUNT SINAI JOURNAL OF MEDICINE

Rosiglitazone Rescues Memory Impairment in Alzheimer's Transgenic Mice: Mechanisms Involving a Reduced Amyloid and Tau Pathology

(2010) Luis Escribano et al.   NEUROPSYCHOPHARMACOLOGY

How do soluble oligomers of amyloid β-protein impair hippocampal synaptic plasticity?

(2010) Li   Frontiers in Cellular Neuroscience

Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease

(2009) Robert D. Bell et al.   ACTA NEUROPATHOLOGICA

Perturbed cellular response to brain injury during aging

(2009) Aurel Popa-Wagner et al.   AGEING RESEARCH REVIEWS

A PPARdelta Agonist Reduces Amyloid Burden and Brain Inflammation in a Transgenic Mouse Model of Alzheimers Disease

(2009) Sergey Kalinin et al.   Current Alzheimer Research

Peroxisome Proliferator-Activated Receptor-α Activation Protects Brain Capillary Endothelial Cells from Oxygen-Glucose Deprivation-Induced Hyperpermeability in the Blood-Brain Barrier

(2009) Caroline Mysiorek et al.   CURRENT NEUROVASCULAR RESEARCH

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Structure-Function Implications in Alzheimers Disease: Effect of Aβ Oligomers at Central Synapses

(2008) Waldo Cerpa et al.   Current Alzheimer Research

The Role of the Cell Surface LRP and Soluble LRP in Blood-Brain Barrier Aβ Clearance in Alzheimers Disease

(2008) R. Deane et al.   CURRENT PHARMACEUTICAL DESIGN

Complete Rescue of Cerebrovascular Function in Aged Alzheimer's Disease Transgenic Mice by Antioxidants and Pioglitazone, a Peroxisome Proliferator-Activated Receptor   Agonist

(2008) N. Nicolakakis et al.   JOURNAL OF NEUROSCIENCE

Acute Kidney Injury Leads to Inflammation and Functional Changes in the Brain

(2008) M. Liu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease

(2008) Nibaldo C Inestrosa et al.   Molecular Neurodegeneration

The coming acceleration of global population ageing

(2008) Wolfgang Lutz et al.   NATURE