Environmental factors in autoimmune diseases and their role in multiple sclerosis

Nutrition Facts in Multiple Sclerosis

(2015) Paolo Riccio et al.   ASN Neuro

Unraveling the Hygiene Hypothesis of helminthes and autoimmunity: origins, pathophysiology, and clinical applications

(2015) Mathilde Versini et al.   BMC Medicine

Cutaneous Na+ Storage Strengthens the Antimicrobial Barrier Function of the Skin and Boosts Macrophage-Driven Host Defense

(2015) Jonathan Jantsch et al.   Cell Metabolism

High salt primes a specific activation state of macrophages, M(Na)

(2015) Wu-Chang Zhang et al.   CELL RESEARCH

Natural killer cell subsets in cerebrospinal fluid of patients with multiple sclerosis

(2015) E. Rodríguez-Martín et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota

(2015) C. T. Peterson et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

(2015) Aiden Haghikia et al.   IMMUNITY

Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells

(2015) Amanda L. Hernandez et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of human autoimmunity

(2015) Michael D. Rosenblum et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic basis of autoimmunity

(2015) Alexander Marson et al.   JOURNAL OF CLINICAL INVESTIGATION

High salt reduces the activation of IL-4– and IL-13–stimulated macrophages

(2015) Katrina J. Binger et al.   JOURNAL OF CLINICAL INVESTIGATION

The biology of innate lymphoid cells

(2015) David Artis et al.   NATURE

Effects of dietary salt levels on monocytic cells and immune responses in healthy human subjects: a longitudinal study

(2015) Buqing Yi et al.   Translational Research

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

(2015) Alison N. Thorburn et al.   Nature Communications

Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation

(2015) W. K. Eddie Ip et al.   Nature Communications

High doses of biotin in chronic progressive multiple sclerosis: A pilot study

(2015) Frédéric Sedel et al.   Multiple Sclerosis and Related Disorders

Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters

(2015) Sachiko Miyake et al.   PLoS One

Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity

(2014) Johanna Breuer et al.   ANNALS OF NEUROLOGY

Diet, Metabolites, and “Western-Lifestyle” Inflammatory Diseases

(2014) Alison N. Thorburn et al.   IMMUNITY

Regulatory T cells in autoimmune neuroinflammation

(2014) Markus Kleinewietfeld et al.   IMMUNOLOGICAL REVIEWS

Sodium intake is associated with increased disease activity in multiple sclerosis

(2014) Mauricio F Farez et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells

(2014) G Bakdash et al.   Mucosal Immunology

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

Global Sodium Consumption and Death from Cardiovascular Causes

(2014) Dariush Mozaffarian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions

(2014) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction between dietary sodium and smoking increases the risk for rheumatoid arthritis: results from a nested case-control study

(2014) B. Sundstrom et al.   RHEUMATOLOGY

Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis

(2014) A. Mortha et al.   SCIENCE

Impact of Diet on Human Intestinal Microbiota and Health

(2014) Anne Salonen et al.   Annual Review of Food Science and Technology

The Impact of Diet and Lifestyle on Gut Microbiota and Human Health

(2014) Michael Conlon et al.   Nutrients

Vitamin D as an Early Predictor of Multiple Sclerosis Activity and Progression

(2014) Alberto Ascherio et al.   JAMA Neurology

Aryl Hydrocarbon Receptor and Kynurenine: Recent Advances in Autoimmune Disease Research

(2014) Nam Trung Nguyen et al.   Frontiers in Immunology

The Hygiene Theory Harnessing Helminths and Their Ova to Treat Autoimmunity

(2013) Dana Ben-Ami Shor et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Role of “Western Diet” in Inflammatory Autoimmune Diseases

(2013) Arndt Manzel et al.   CURRENT ALLERGY AND ASTHMA REPORTS

23 Na Magnetic Resonance Imaging-Determined Tissue Sodium in Healthy Subjects and Hypertensive Patients

(2013) Christoph Kopp et al.   HYPERTENSION

Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation

(2013) Yiqing Yan et al.   IMMUNITY

Immune cells control skin lymphatic electrolyte homeostasis and blood pressure

(2013) Helge Wiig et al.   JOURNAL OF CLINICAL INVESTIGATION

MHC class II–dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies

(2013) Nicolas Molnarfi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Leptin-Induced ROR t Expression in CD4+ T Cells Promotes Th17 Responses in Systemic Lupus Erythematosus

(2013) Y. Yu et al.   JOURNAL OF IMMUNOLOGY

Fatty fish intake is associated with decreased occurrence of multiple sclerosis

(2013) Maria Bäärnhielm et al.   Multiple Sclerosis Journal

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

(2013) Chuan Wu et al.   NATURE

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

(2013) Markus Kleinewietfeld et al.   NATURE

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

Control of pathogens and pathobionts by the gut microbiota

(2013) Nobuhiko Kamada et al.   NATURE IMMUNOLOGY

The role of the immune system in governing host-microbe interactions in the intestine

(2013) Eric M Brown et al.   NATURE IMMUNOLOGY

Variation in Dietary Salt Intake Induces Coordinated Dynamics of Monocyte Subsets and Monocyte-Platelet Aggregates in Humans: Implications in End Organ Inflammation

(2013) Xin Zhou et al.   PLoS One

Salt-Dependent Chemotaxis of Macrophages

(2013) Silke Müller et al.   PLoS One

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Peripheral education of the immune system by the colonic microbiota

(2013) Kristine A. Kuhn et al.   SEMINARS IN IMMUNOLOGY

The plasticity of human Treg and Th17 cells and its role in autoimmunity

(2013) Markus Kleinewietfeld et al.   SEMINARS IN IMMUNOLOGY

Gut Microbiota, Low-grade Inflammation, and Metabolic Syndrome

(2013) Benoit Chassaing et al.   TOXICOLOGIC PATHOLOGY

Therapies for multiple sclerosis: translational achievements and outstanding needs

(2013) Aiden Haghikia et al.   TRENDS IN MOLECULAR MEDICINE

Diminished Th17 (not Th1) responses underlie multiple sclerosis disease abrogation after hematopoietic stem cell transplantation

(2012) Peter J. Darlington et al.   ANNALS OF NEUROLOGY

ω-3 Fatty Acid Treatment in Multiple Sclerosis (OFAMS Study)

(2012) Øivind Torkildsen et al.   ARCHIVES OF NEUROLOGY

The Impact of the Gut Microbiota on Human Health: An Integrative View

(2012) Jose C. Clemente et al.   CELL

Western-Style Fast Food Intake and Cardiometabolic Risk in an Eastern Country

(2012) Andrew O. Odegaard et al.   CIRCULATION

Vitamin D and multiple sclerosis

(2012) Kelly C. Simon et al.   CURRENT OPINION IN NEUROLOGY

Life, death, and miracles: Th17 cells in the intestine

(2012) Samuel Huber et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Multiple sclerosis

(2012) Alyssa Nylander et al.   JOURNAL OF CLINICAL INVESTIGATION

Soluble helminth products suppress clinical signs in murine experimental autoimmune encephalomyelitis and differentially modulate human dendritic cell activation

(2012) Loes M. Kuijk et al.   MOLECULAR IMMUNOLOGY

High body mass index before age 20 is associated with increased risk for multiple sclerosis in both men and women

(2012) Anna K Hedström et al.   Multiple Sclerosis Journal

B cells and antibodies in multiple sclerosis pathogenesis and therapy

(2012) Markus Krumbholz et al.   Nature Reviews Neurology

The evidence for a role of B cells in multiple sclerosis

(2012) G. Disanto et al.   NEUROLOGY

Enriched CD161highCCR6+γδ T Cells in the Cerebrospinal Fluid of Patients With Multiple Sclerosis

(2012) Lucas Schirmer et al.   JAMA Neurology

Twin studies in autoimmune disease: Genetics, gender and environment

(2011) Dimitrios P. Bogdanos et al.   JOURNAL OF AUTOIMMUNITY

Probiotic helminth administration in relapsing–remitting multiple sclerosis: a phase 1 study

(2011) JO Fleming et al.   Multiple Sclerosis Journal

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

(2011) Margarita Dominguez-Villar et al.   NATURE MEDICINE

Gut feelings: the emerging biology of gut–brain communication

(2011) Emeran A. Mayer   NATURE REVIEWS NEUROSCIENCE

Dietary Ligands of the Aryl Hydrocarbon Receptor Induce Anti-Inflammatory and Immunoregulatory Effects on Murine Dendritic Cells

(2011) Jenna M. Benson et al.   TOXICOLOGICAL SCIENCES

The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an update

(2010) H. Okada et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Central Nervous System Demyelinating Disease Protection by the Human Commensal Bacteroides fragilis Depends on Polysaccharide A Expression

(2010) J. Ochoa-Reparaz et al.   JOURNAL OF IMMUNOLOGY

Hypertonic stress regulates T cell function via pannexin-1 hemichannels and P2X receptors

(2010) Tobias Woehrle et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Prostaglandin E2, an Immunoactivator

(2010) Daiji Sakata et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Vitamin D and multiple sclerosis

(2010) Alberto Ascherio et al.   LANCET NEUROLOGY

A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease

(2010) J Ochoa-Repáraz et al.   Mucosal Immunology

Absence of Epstein-Barr virus in the brain and CSF of patients with multiple sclerosis

(2010) S. A. Sargsyan et al.   NEUROLOGY

Mechanisms of modulation of experimental autoimmune encephalomyelitis by chronic Trichinella spiralis infection in Dark Agouti rats

(2010) A. GRUDEN-MOVSESIJAN et al.   PARASITE IMMUNOLOGY

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

(2010) C. De Filippo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Life in the gut: microbial responses to stress in the gastrointestinal tract

(2010) Petra Louis et al.   SCIENCE PROGRESS

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions

(2009) João H. Duarte et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Obesity predisposes to Th17 bias

(2009) Shawn Winer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Salt intakes around the world: implications for public health

(2009) I. J Brown et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Role of Gut Commensal Microflora in the Development of Experimental Autoimmune Encephalomyelitis

(2009) J. Ochoa-Reparaz et al.   JOURNAL OF IMMUNOLOGY

Plasmacytoid Dendritic Cells in Multiple Sclerosis

(2009) Roberto Lande et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Twin studies and the heritability of MS: a conclusion

(2009) CH Hawkes et al.   Multiple Sclerosis Journal

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism

(2009) Agnes Machnik et al.   NATURE MEDICINE

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells

(2008) H. J. P. M. Koenen et al.   BLOOD

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

DC activated via dectin-1 convert Treg into IL-17 producers

(2008) Fabiola Osorio et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Microbes in Gastrointestinal Health and Disease

(2008) Andrew S. Neish   GASTROENTEROLOGY

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

(2008) Xuexian O. Yang et al.   IMMUNITY

Regulatory T cells fail to suppress CD4+ T-bet+T cells in relapsing multiple sclerosis patients

(2008) Giovanni Frisullo et al.   IMMUNOLOGY

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Increasing prevalence and incidence of multiple sclerosis in northern Japan

(2008) H Houzen et al.   Multiple Sclerosis Journal

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY

Compromised CD4+ CD25highregulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level

(2007) Koen Venken et al.   IMMUNOLOGY