Targeting Nrf2-Mediated Gene Transcription by Triterpenoids and Their Derivatives

MicroRNAs in cancer management and their modulation by dietary agents

(2012) Tommy Karius et al.   BIOCHEMICAL PHARMACOLOGY

Heme Oxygenase-1 in Tumor Biology and Therapy

(2012) Halina Was et al.   CURRENT DRUG TARGETS

Betulinic Acid Targets YY1 and ErbB2 through Cannabinoid Receptor-Dependent Disruption of MicroRNA-27a:ZBTB10 in Breast Cancer

(2012) X. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Pristimerin, a Triterpenoid, Inhibits Tumor Angiogenesis by Targeting VEGFR2 Activation

(2012) Xianmin Mu et al.   MOLECULES

Oleanolic Acid Reduces Hyperglycemia beyond Treatment Period with Akt/FoxO1-Induced Suppression of Hepatic Gluconeogenesis in Type-2 Diabetic Mice

(2012) Xiao-Yi Zeng et al.   PLoS One

MicroRNAs as biomarkers of disease onset

(2011) Maciej Ciesla et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors

(2011) Sudhakar Chintharlapalli et al.   BMC CANCER

Phase I study of the synthetic triterpenoid, 2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic acid (CDDO), in advanced solid tumors

(2011) Giovanna Speranza et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Synthetic triterpenoid CDDO prevents the progression and metastasis of prostate cancer in TRAMP mice by inhibiting survival signaling

(2011) Dorrah Deeb et al.   CARCINOGENESIS

Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

(2011) Arie Neymotin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia–reperfusion injury

(2011) Yanhong Wei et al.   FREE RADICAL BIOLOGY AND MEDICINE

New Synthetic Triterpenoids: Potent Agents for Prevention and Treatment of Tissue Injury Caused by Inflammatory and Oxidative Stress

(2011) Michael B. Sporn et al.   JOURNAL OF NATURAL PRODUCTS

Synthetic Triterpenoids Prolong Survival in a Transgenic Mouse Model of Pancreatic Cancer

(2010) K. T. Liby et al.   Cancer Prevention Research

Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease

(2010) Cliona Stack et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of astilbic acid on airway hyperresponsiveness and inflammation in a mouse model of allergic asthma

(2010) Ji-Eun Yuk et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Induction of Heme Oxygenase 1 and Inhibition of Tumor Necrosis Factor α-Induced Intercellular Adhesion Molecule Expression by Andrographolide in EA.hy926 Cells

(2010) Ai-Lin Yu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Transcriptional Regulation of Renal Cytoprotective Genes by Nrf2 and Its Potential Use as a Therapeutic Target to Mitigate Cisplatin-Induced Nephrotoxicity

(2010) L. M. Aleksunes et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Methyl 2-Cyano-3,12-dioxooleana-1,9-dien-28-oate Decreases Specificity Protein Transcription Factors and Inhibits Pancreatic Tumor Growth: Role of MicroRNA-27a

(2010) I. Jutooru et al.   MOLECULAR PHARMACOLOGY

Regulation of microRNAs by Natural Agents: An Emerging Field in Chemoprevention and Chemotherapy Research

(2010) Yiwei Li et al.   PHARMACEUTICAL RESEARCH

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

The triterpenoid CDDO limits inflammation in preclinical models of cystic fibrosis lung disease

(2009) David P. Nichols et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Triterpenoids as new promising anticancer drugs

(2009) Alessia Petronelli et al.   ANTI-CANCER DRUGS

Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes

(2009) Scott A. Reisman et al.   BIOCHEMICAL PHARMACOLOGY

Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells through a ROS-dependent mechanism

(2009) Dorrah Deeb et al.   BIOCHEMICAL PHARMACOLOGY

Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide

(2009) Soona Shin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18β-olean-1,12-dien-30-oate in colon cancer cells

(2009) Sudhakar Chintharlapalli et al.   INTERNATIONAL JOURNAL OF CANCER

Targeting NRF2 signaling for cancer chemoprevention

(2009) Mi-Kyoung Kwak et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Heme Oxygenase-1 and the Vascular Bed: From Molecular Mechanisms to Therapeutic Opportunities

(2008) Agnieszka Loboda et al.   ANTIOXIDANTS & REDOX SIGNALING

New insights into generalized hepatoprotective effects of oleanolic acid: Key roles of metallothionein and Nrf2 induction

(2008) Jie Liu et al.   BIOCHEMICAL PHARMACOLOGY

Prevention and Treatment of Experimental Estrogen Receptor-Negative Mammary Carcinogenesis by the Synthetic Triterpenoid CDDO-Methyl Ester and the Rexinoid LG100268

(2008) K. Liby et al.   CLINICAL CANCER RESEARCH

Molecular mechanisms of Nrf2-mediated antioxidant response

(2008) Wenge Li et al.   MOLECULAR CARCINOGENESIS