Back to the tubule: microtubule dynamics in Parkinson’s disease

LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking

(2016) A. Raquel Esteves et al.   NEUROSCIENTIST

Pharmacological modulation of HDAC1 and HDAC6 in vivo in a zebrafish model: Therapeutic implications for Parkinson’s disease

(2016) Brígida R. Pinho et al.   PHARMACOLOGICAL RESEARCH

Microtubule-stabilizing agents: New drug discovery and cancer therapy

(2016) Ying Zhao et al.   PHARMACOLOGY & THERAPEUTICS

Microtubule Minus-End-Targeting Proteins

(2015) Anna Akhmanova et al.   CURRENT BIOLOGY

Coordinating Neuronal Actin–Microtubule Dynamics

(2015) Charlotte H. Coles et al.   CURRENT BIOLOGY

Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy

(2015) Nicholas M. Kanaan et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

The microtubule-stabilizing drug Epothilone D increases axonal sprouting following transection injury in vitro

(2015) Mariana Brizuela et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Regulation of Axonal Transport by Protein Kinases

(2015) Katherine L. Gibbs et al.   TRENDS IN BIOCHEMICAL SCIENCES

Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons

(2015) J C Koch et al.   Cell Death & Disease

Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle

(2015) Jaclyn P. Kerr et al.   Nature Communications

Tau co-organizes dynamic microtubule and actin networks

(2015) Auréliane Elie et al.   Scientific Reports

Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?

(2014) Amy Reeve et al.   AGEING RESEARCH REVIEWS

Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease

(2014) Kurt R. Brunden et al.   BIOORGANIC & MEDICINAL CHEMISTRY

High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis

(2014) Gregory M. Alushin et al.   CELL

Decreased SIRT2 activity leads to altered microtubule dynamics in oxidatively-stressed neuronal cells: Implications for Parkinson's disease

(2014) Vivek P. Patel et al.   EXPERIMENTAL NEUROLOGY

PINK1 and Parkin - mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease

(2014) Agne Kazlauskaite et al.   FEBS Journal

The tubulin code: Molecular components, readout mechanisms, and functions

(2014) Carsten Janke   JOURNAL OF CELL BIOLOGY

MeCP2 deficiency is associated with reduced levels of tubulin acetylation and can be restored using HDAC6 inhibitors

(2014) W. A. Gold et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The Upshot of LRRK2 Inhibition to Parkinson’s Disease Paradigm

(2014) A. R. Esteves et al.   MOLECULAR NEUROBIOLOGY

Regulation of microtubule motors by tubulin isotypes and post-translational modifications

(2014) Minhajuddin Sirajuddin et al.   NATURE CELL BIOLOGY

Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson′s disease

(2014) GerardW O′Keeffe et al.   Neural Regeneration Research

Axonal Transport: Cargo-Specific Mechanisms of Motility and Regulation

(2014) Sandra Maday et al.   NEURON

Novel insights into the neurobiology underlying LRRK2-linked Parkinson's disease

(2014) P. Gómez-Suaga et al.   NEUROPHARMACOLOGY

Comparing clinical features of young onset, middle onset and late onset Parkinson's disease

(2014) Raja Mehanna et al.   PARKINSONISM & RELATED DISORDERS

Extracellular α-Synuclein Leads to Microtubule Destabilization via GSK-3β-Dependent Tau Phosphorylation in PC12 Cells

(2014) Magdalena Gąssowska et al.   PLoS One

Regulating Wnt signaling: a strategy to prevent neurodegeneration and induce regeneration

(2014) K. Harvey et al.   Journal of Molecular Cell Biology

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease

(2014) Ernest Arenas   Journal of Molecular Cell Biology

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations

(2014) Vinay K. Godena et al.   Nature Communications

Phosphorylated Tau as a Candidate Biomarker for Amyotrophic Lateral Sclerosis

(2014) Murray Grossman et al.   JAMA Neurology

Emerging modes of PINK1 signaling: another task for MARK2

(2014) Dorthe Matenia et al.   Frontiers in Molecular Neuroscience

LRRK2 phosphorylates novel tau epitopes and promotes tauopathy

(2013) Rachel M. Bailey et al.   ACTA NEUROPATHOLOGICA

Wnt signaling: Role in LTP, neural networks and memory

(2013) Carolina A. Oliva et al.   AGEING RESEARCH REVIEWS

LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4

(2013) Karina Häbig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cell-autonomous axon growth of young motoneurons is triggered by a voltage-gated sodium channel

(2013) Andrea Wetzel et al.   Channels

Structure of the human Parkin ligase domain in an autoinhibited state

(2013) Tobias Wauer et al.   EMBO JOURNAL

Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β

(2013) Fumitaka Kawakami et al.   FEBS Journal

Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

(2013) Casey Cook et al.   HUMAN MOLECULAR GENETICS

Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS

(2013) Ines Taes et al.   HUMAN MOLECULAR GENETICS

A Direct Interaction between Leucine-rich Repeat Kinase 2 and Specific β-Tubulin Isoforms Regulates Tubulin Acetylation

(2013) Bernard M. H. Law et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein Oligomers Impair Neuronal Microtubule-Kinesin Interplay

(2013) Iryna Prots et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alpha-synuclein promotes early neurite outgrowth in cultured primary neurons

(2013) Guangwei Liu et al.   JOURNAL OF NEURAL TRANSMISSION

Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through Protein Kinase A

(2013) Ruben K. Dagda et al.   JOURNAL OF NEUROCHEMISTRY

Ordered Recruitment of Dynactin to the Microtubule Plus-End is Required for Efficient Initiation of Retrograde Axonal Transport

(2013) A. J. Moughamian et al.   JOURNAL OF NEUROSCIENCE

Effects of tubulin acetylation and tubulin acetyltransferase binding on microtubule structure

(2013) Stuart C. Howes et al.   MOLECULAR BIOLOGY OF THE CELL

Long-distance retrograde neurotrophic factor signalling in neurons

(2013) Anthony W. Harrington et al.   NATURE REVIEWS NEUROSCIENCE

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

(2013) David J. Irwin et al.   NATURE REVIEWS NEUROSCIENCE

Genetics of Parkinson's disease – state of the art, 2013

(2013) Vincenzo Bonifati   PARKINSONISM & RELATED DISORDERS

GDNF, NGF and BDNF as therapeutic options for neurodegeneration

(2013) Shelley J. Allen et al.   PHARMACOLOGY & THERAPEUTICS

Mechanism for the catastrophe-promoting activity of the microtubule destabilizer Op18/stathmin

(2013) K. K. Gupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

(2013) A. E. Prota et al.   SCIENCE

LRRK2: an éminence grise of Wnt-mediated neurogenesis?

(2013) Daniel C. Berwick et al.   Frontiers in Cellular Neuroscience

αTAT1 is the major α-tubulin acetyltransferase in mice

(2013) Nereo Kalebic et al.   Nature Communications

Microtubule Alterations Occur Early in Experimental Parkinsonism and The Microtubule Stabilizer Epothilone D Is Neuroprotective

(2013) Daniele Cartelli et al.   Scientific Reports

 -Synuclein in Parkinson's Disease

(2013) L. Stefanis   Cold Spring Harbor Perspectives in Medicine

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

(2013) E.-M. Mandelkow et al.   Cold Spring Harbor Perspectives in Medicine

Altered transcription factor trafficking in oxidatively-stressed neuronal cells

(2012) Vivek P. Patel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Zampanolide, a Potent New Microtubule-Stabilizing Agent, Covalently Reacts with the Taxane Luminal Site in Tubulin α,β-Heterodimers and Microtubules

(2012) Jessica J. Field et al.   CHEMISTRY & BIOLOGY

Three decades of Wnts: a personal perspective on how a scientific field developed

(2012) Roel Nusse et al.   EMBO JOURNAL

Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease

(2012) Nambirajan Govindarajan et al.   EMBO Molecular Medicine

Role of Nav1.9 in activity-dependent axon growth in motoneurons

(2012) Narayan Subramanian et al.   HUMAN MOLECULAR GENETICS

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6

(2012) Daniel C. Berwick et al.   HUMAN MOLECULAR GENETICS

Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic

(2012) Daniela M. Arduíno et al.   HUMAN MOLECULAR GENETICS

Microtubule Affinity-regulating Kinase 2 (MARK2) Turns on Phosphatase and Tensin Homolog (PTEN)-induced Kinase 1 (PINK1) at Thr-313, a Mutation Site in Parkinson Disease

(2012) Dorthe Matenia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cerebrospinal fluid–based kinetic biomarkers of axonal transport in monitoring neurodegeneration

(2012) Patrizia Fanara et al.   JOURNAL OF CLINICAL INVESTIGATION

Tubulin Binding, Protein-Bound Conformation in Solution, and Antimitotic Cellular Profiling of Noscapine and Its Derivatives

(2012) Youssef L. Bennani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microtubule Stabilizing Agents as Potential Treatment for Alzheimer’s Disease and Related Neurodegenerative Tauopathies

(2012) Carlo Ballatore et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice

(2012) B. Zhang et al.   JOURNAL OF NEUROSCIENCE

TPI-287, a New Taxane Family Member, Reduces the Brain Metastatic Colonization of Breast Cancer Cells

(2012) D. P. Fitzgerald et al.   MOLECULAR CANCER THERAPEUTICS

DJ-1 deficiency perturbs microtubule dynamics and impairs striatal neurite outgrowth

(2012) Chengyu Sheng et al.   NEUROBIOLOGY OF AGING

LRRK2 I2020T mutation is associated with tau pathology

(2012) Sachiko Ujiie et al.   PARKINSONISM & RELATED DISORDERS

LRRK2 Phosphorylates Tubulin-Associated Tau but Not the Free Molecule: LRRK2-Mediated Regulation of the Tau-Tubulin Association and Neurite Outgrowth

(2012) Fumitaka Kawakami et al.   PLoS One

Cap-Gly Proteins at Microtubule Plus Ends: Is EB1 Detyrosination Involved?

(2012) Anouk Bosson et al.   PLoS One

Axonal transport and neurodegenerative disease: Can we see the elephant?

(2012) Lawrence S.B. Goldstein   PROGRESS IN NEUROBIOLOGY

Mitochondrial dynamics in neurodegeneration

(2012) Kie Itoh et al.   TRENDS IN CELL BIOLOGY

Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria

(2012) Song Liu et al.   PLoS Genetics

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

(2011) Xinnan Wang et al.   CELL

PINK1 and Parkin Flag Miro to Direct Mitochondrial Traffic

(2011) Lesley A. Kane et al.   CELL

Safety, Pharmacokinetics, and Activity of GRN1005, a Novel Conjugate of Angiopep-2, a Peptide Facilitating Brain Penetration, and Paclitaxel, in Patients with Advanced Solid Tumors

(2011) R. Kurzrock et al.   MOLECULAR CANCER THERAPEUTICS

HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

(2011) Constantin d'Ydewalle et al.   NATURE MEDICINE

Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions

(2011) Carsten Janke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin

(2011) Agnieszka Szyk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Neuroinflammation in Parkinson's disease

(2011) Etienne C. Hirsch et al.   PARKINSONISM & RELATED DISORDERS

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, α-synuclein, and tau

(2010) Jean-Marc Taymans et al.   BIOESSAYS

Neuronal polarization: The cytoskeleton leads the way

(2010) Michael Stiess et al.   Developmental Neurobiology

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

(2010) Kelly Jean Thomas et al.   HUMAN MOLECULAR GENETICS

Tau protein: Relevance to Parkinson's disease

(2010) Peng Lei et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy

(2010) K. R. Brunden et al.   JOURNAL OF NEUROSCIENCE

LRRK2 G2019S Mutation Induces Dendrite Degeneration through Mislocalization and Phosphorylation of Tau by Recruiting Autoactivated GSK3 

(2010) C.-H. Lin et al.   JOURNAL OF NEUROSCIENCE

Which way to go? Cytoskeletal organization and polarized transport in neurons

(2010) Lukas C. Kapitein et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A novel acetylation of β-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation

(2010) Chih-Wen Chu et al.   MOLECULAR BIOLOGY OF THE CELL

The Nup107-160 complex and γ-TuRC regulate microtubule polymerization at kinetochores

(2010) Ram Kumar Mishra et al.   NATURE CELL BIOLOGY

Microtubule-binding agents: a dynamic field of cancer therapeutics

(2010) Charles Dumontet et al.   NATURE REVIEWS DRUG DISCOVERY

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

(2010) H.L. Melrose et al.   NEUROBIOLOGY OF DISEASE

Genetic Analysis of Pathways to Parkinson Disease

(2010) John Hardy   NEURON

Changes in microtubule turnover accompany synaptic plasticity and memory formation in response to contextual fear conditioning in mice

(2010) P. Fanara et al.   NEUROSCIENCE

The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies

(2010) Kurt R. Brunden et al.   PHARMACOLOGICAL RESEARCH

The major  -tubulin K40 acetyltransferase  TAT1 promotes rapid ciliogenesis and efficient mechanosensation

(2010) T. Shida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

Repairing the parkinsonian brain with neurotrophic factors

(2010) Liviu Aron et al.   TRENDS IN NEUROSCIENCES

Microtubule depolymerization potentiates alpha-synuclein oligomerization

(2010) A. Raquel Esteves   Frontiers in Aging Neuroscience

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Parkin protects dopaminergic neurons from excessive Wnt/β-catenin signaling

(2009) Nina Rawal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

(2009) Hong Qing et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Scientific rationale for the development of gene therapy strategies for Parkinson's disease

(2009) Tomas Björklund et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Microtubule stabilising agents for cancer chemotherapy

(2009) Ying Zhao et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

α-Synuclein contributes to GSK-3β-catalyzed Tau phosphorylation in Parkinson’s disease models

(2009) Tetyana Duka et al.   FASEB JOURNAL

Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways

(2009) Rosa M. Sancho et al.   HUMAN MOLECULAR GENETICS

Mouse ACF7 and Drosophila Short stop modulate filopodia formation and microtubule organisation during neuronal growth

(2009) N. Sanchez-Soriano et al.   JOURNAL OF CELL SCIENCE

Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability - a point of convergence in Parkinsonian neurodegeneration?

(2009) Frank Gillardon   JOURNAL OF NEUROCHEMISTRY

Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV  -Synucleinopathy

(2009) C. Y. Chung et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis

(2009) L. Parisiadou et al.   JOURNAL OF NEUROSCIENCE

Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment

(2009) K Ray Chaudhuri et al.   LANCET NEUROLOGY

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease

(2009) Yanping Li et al.   NATURE NEUROSCIENCE

Tubulin tyrosination navigates the kinesin-1 motor domain to axons

(2009) Yoshiyuki Konishi et al.   NATURE NEUROSCIENCE

The trip of the tip: understanding the growth cone machinery

(2009) Laura Anne Lowery et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microtubule assembly, organization and dynamics in axons and dendrites

(2009) Cecilia Conde et al.   NATURE REVIEWS NEUROSCIENCE

Tubulin Tyrosination Is Required for the Proper Organization and Pathfinding of the Growth Cone

(2009) Séverine Marcos et al.   PLoS One

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The tau of MARK: a polarized view of the cytoskeleton

(2009) Dorthe Matenia et al.   TRENDS IN BIOCHEMICAL SCIENCES

Role of Axonal Transport in Neurodegenerative Diseases

(2008) Kurt J. De Vos et al.   Annual Review of Neuroscience

In situ blood–brain barrier permeability of a C-10 paclitaxel carbamate

(2008) Carlo Ballatore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Polyglutamylation: a fine-regulator of protein function? ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Carsten Janke et al.   EMBO REPORTS

Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons

(2008) Xuefei Wu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Parkin Protects Dopaminergic Neurons against Microtubule-depolymerizing Toxins by Attenuating Microtubule-associated Protein Kinase Activation

(2008) Yong Ren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Differential trafficking of Kif5c on tyrosinated and detyrosinated microtubules in live cells

(2008) S. Dunn et al.   JOURNAL OF CELL SCIENCE

Characterization of PINK1 processing, stability, and subcellular localization

(2008) William Lin et al.   JOURNAL OF NEUROCHEMISTRY

Loss of PINK1 Function Affects Development and Results in Neurodegeneration in Zebrafish

(2008) O. Anichtchik et al.   JOURNAL OF NEUROSCIENCE

Animal models of Alzheimer's disease and frontotemporal dementia

(2008) Jürgen Götz et al.   NATURE REVIEWS NEUROSCIENCE

Haplotypes and gene expression implicate the MAPT region for Parkinson disease: The GenePD Study

(2008) J. E. Tobin et al.   NEUROLOGY

Knock-out and transgenic mouse models of tauopathies

(2007) Franziska Denk et al.   NEUROBIOLOGY OF AGING