Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4

Dynasore - not just a dynamin inhibitor

(2015) Giulio Preta et al.   Cell Communication and Signaling

Transport through recycling endosomes requires EHD1 recruitment by a phosphatidylserine translocase

(2015) S. Lee et al.   EMBO JOURNAL

Protective role of the dynamin inhibitor Dynasore against the cholesterol-dependent cytolysin of Trueperella pyogenes

(2015) Giulio Preta et al.   FASEB JOURNAL

ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization

(2015) Lucas J.M. Bruurs et al.   JOURNAL OF CELL BIOLOGY

CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance

(2015) Rajesh Rajaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD14, TLR4 and TRAM Show Different Trafficking Dynamics During LPS Stimulation

(2015) Dionne C.G. Klein et al.   TRAFFIC

The lipid flippase heterodimer ATP8B1–CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells

(2014) Vincent A. van der Mark et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Co-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signaling

(2014) Agnieszka Płóciennikowska et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Phospholipid Flippase Activities and Substrate Specificities of Human Type IV P-type ATPases Localized to the Plasma Membrane

(2014) Hiroyuki Takatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid landscapes and pipelines in membrane homeostasis

(2014) Joost C.M. Holthuis et al.   NATURE

Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin

(2013) Marie Jaguin et al.   CELLULAR IMMUNOLOGY

P4 ATPases: Flippases in Health and Disease

(2013) Vincent van der Mark et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phosphatidylserine flipping enhances membrane curvature and negative charge required for vesicular transport

(2013) Peng Xu et al.   JOURNAL OF CELL BIOLOGY

ATP11B mediates platinum resistance in ovarian cancer

(2013) Myrthala Moreno-Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of the Toll Like Receptor (TLR) Radical Cycle in Chronic Inflammation: Possible Treatments Targeting the TLR4 Pathway

(2013) Kurt Lucas et al.   MOLECULAR NEUROBIOLOGY

Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis

(2013) Tasha E Fingerlin et al.   NATURE GENETICS

P4-ATPases: lipid flippases in cell membranes

(2013) Rosa L. Lopez-Marques et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

Phospholipid flippases: Building asymmetric membranes and transport vesicles

(2012) Tessy T. Sebastian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Missense mutation in the ATPase, aminophospholipid transporter protein ATP8A2 is associated with cerebellar atrophy and quadrupedal locomotion

(2012) Onur Emre Onat et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The F-BAR domains from srGAP1, srGAP2 and srGAP3 regulate membrane deformation differently

(2012) J. Coutinho-Budd et al.   JOURNAL OF CELL SCIENCE

The functions of anionic phospholipids during clathrin-mediated endocytosis site initiation and vesicle formation

(2012) Y. Sun et al.   JOURNAL OF CELL SCIENCE

Cellular Localization and Biochemical Analysis of Mammalian CDC50A, a Glycosylated β-subunit for P4 ATPases

(2012) Dineke E. Folmer et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Membrane shaping by the Bin/amphiphysin/Rvs (BAR) domain protein superfamily

(2011) Yijian Rao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Characterization of the EFC/F-BAR domain protein, FCHO2

(2011) Akiyoshi Uezu et al.   GENES TO CELLS

ATP9B, a P4-ATPase (a Putative Aminophospholipid Translocase), Localizes to thetrans-Golgi Network in a CDC50 Protein-independent Manner

(2011) Hiroyuki Takatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylserine is polarized and required for proper Cdc42 localization and for development of cell polarity

(2011) Gregory D. Fairn et al.   NATURE CELL BIOLOGY

The flip side of cardiolipin import

(2011) Coen C Paulusma et al.   NATURE MEDICINE

Heteromeric Interactions Required for Abundance and Subcellular Localization of Human CDC50 Proteins and Class 1 P4-ATPases

(2010) Lieke M. van der Velden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CDC50 Proteins Are Critical Components of the Human Class-1 P4-ATPase Transport Machinery

(2010) Susanne Bryde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differences in presentation and progression between severe FIC1 and BSEP deficiencies

(2010) Ludmila Pawlikowska et al.   JOURNAL OF HEPATOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Dynamic regulation of cardiolipin by the lipid pump Atp8b1 determines the severity of lung injury in experimental pneumonia

(2010) Nancy B Ray et al.   NATURE MEDICINE

The Identification of Markers of Macrophage Differentiation in PMA-Stimulated THP-1 Cells and Monocyte-Derived Macrophages

(2010) Marc Daigneault et al.   PLoS One

Endocytic Sorting and Recycling Require Membrane Phosphatidylserine Asymmetry Maintained by TAT-1/CHAT-1

(2010) Baohui Chen et al.   PLoS Genetics

Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data

(2009) J. M. Ruijter et al.   NUCLEIC ACIDS RESEARCH

Endotoxin tolerance: new mechanisms, molecules and clinical significance

(2009) Subhra K. Biswas et al.   TRENDS IN IMMUNOLOGY

P4-ATPase Requirement for AP-1/Clathrin Function in Protein Transport from the trans-Golgi Network and Early Endosomes

(2008) Ke Liu et al.   MOLECULAR BIOLOGY OF THE CELL

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY

The Arabidopsis P4-ATPase ALA3 Localizes to the Golgi and Requires a  -Subunit to Function in Lipid Translocation and Secretory Vesicle Formation

(2008) L. R. Poulsen et al.   PLANT CELL

Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization

(2008) T. Yeung et al.   SCIENCE

The C. elegans P4-ATPase TAT-1 Regulates Lysosome Biogenesis and Endocytosis

(2008) Anne-Françoise Ruaud et al.   TRAFFIC