P4 ATPases: Flippases in Health and Disease

Two-gate mechanism for phospholipid selection and transport by type IV P-type ATPases

(2013) R. D. Baldridge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arl1p regulates spatial membrane organization at the trans-Golgi network through interaction with Arf-GEF Gea2p and flippase Drs2p

(2013) P.-C. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoinositides and vesicular membrane traffic

(2012) Peter Mayinger   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Vesicle-mediated ER export of proteins and lipids

(2012) Amanda D. Gillon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Phospholipid flippases: Building asymmetric membranes and transport vesicles

(2012) Tessy T. Sebastian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mammalian P4-ATPases and ABC transporters and their role in phospholipid transport

(2012) Jonathan A. Coleman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation

(2012) Huanghe Yang et al.   CELL

Missense mutation in the ATPase, aminophospholipid transporter protein ATP8A2 is associated with cerebellar atrophy and quadrupedal locomotion

(2012) Onur Emre Onat et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

P4-ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite outgrowth

(2012) Qin Xu et al.   FEBS LETTERS

Biochemical Characterization of P4-ATPase Mutations Identified in Patients with Progressive Familial Intrahepatic Cholestasis

(2012) Alex Stone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role for Phospholipid Flippase Complex of ATP8A1 and CDC50A Proteins in Cell Migration

(2012) Utako Kato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylserine Stimulation of Drs2p·Cdc50p Lipid Translocase Dephosphorylation Is Controlled by Phosphatidylinositol-4-phosphate

(2012) Aurore Jacquot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular Localization and Biochemical Analysis of Mammalian CDC50A, a Glycosylated β-subunit for P4 ATPases

(2012) Dineke E. Folmer et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Flippase-mediated phospholipid asymmetry promotes fast Cdc42 recycling in dynamic maintenance of cell polarity

(2012) Arupratan Das et al.   NATURE CELL BIOLOGY

Critical role of a transmembrane lysine in aminophospholipid transport by mammalian photoreceptor P4-ATPase ATP8A2

(2012) J. A. Coleman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of residues defining phospholipid flippase substrate specificity of type IV P-type ATPases

(2012) R. D. Baldridge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in a P-Type ATPase Gene Cause Axonal Degeneration

(2012) Xianjun Zhu et al.   PLoS Genetics

P-Type ATPases

(2011) Michael G. Palmgren et al.   Annual Review of Biophysics

The P4-ATPase TAT-5 Inhibits the Budding of Extracellular Vesicles in C. elegans Embryos

(2011) Ann M. Wehman et al.   CURRENT BIOLOGY

Regulation of protein kinases by lipids

(2011) Thomas A Leonard et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A dual epigenomic approach for the search of obesity biomarkers: DNA methylation in relation to diet-induced weight loss

(2011) Fermin I. Milagro et al.   FASEB JOURNAL

ATP9B, a P4-ATPase (a Putative Aminophospholipid Translocase), Localizes to thetrans-Golgi Network in a CDC50 Protein-independent Manner

(2011) Hiroyuki Takatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Role of the β-Subunit CDC50A in the Stable Expression, Assembly, Subcellular Localization, and Lipid Transport Activity of the P4-ATPase ATP8A2

(2011) Jonathan A. Coleman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P-type ATPases at a glance

(2011) M. Bublitz et al.   JOURNAL OF CELL SCIENCE

Atp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus-dependent learning

(2011) Kelly Levano et al.   JOURNAL OF NEUROCHEMISTRY

ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes

(2011) Mehmet Yabas et al.   NATURE IMMUNOLOGY

The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow

(2011) Owen M Siggs et al.   NATURE IMMUNOLOGY

The flip side of cardiolipin import

(2011) Coen C Paulusma et al.   NATURE MEDICINE

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

(2011) Harvey T. McMahon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genome-Wide Detection of Allele Specific Copy Number Variation Associated with Insulin Resistance in African Americans from the HyperGEN Study

(2011) Marguerite R. Irvin et al.   PLoS One

X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C

(2011) O. M. Siggs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progressive Familial Intrahepatic Cholestasis (PFIC) Type 1, 2, and 3: A Review of the Liver Pathology Findings

(2011) Raffaella Morotti et al.   SEMINARS IN LIVER DISEASE

The Distribution and Function of Phosphatidylserine in Cellular Membranes

(2010) Peter A. Leventis et al.   Annual Review of Biophysics

Cholesterol, the central lipid of mammalian cells

(2010) Frederick R Maxfield et al.   CURRENT OPINION IN CELL BIOLOGY

Disruption of the ATP8A2 gene in a patient with a t(10;13) de novo balanced translocation and a severe neurological phenotype

(2010) Pierre Cacciagli et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Phospholipid scramblase: An update

(2010) Edouard M. Bevers et al.   FEBS LETTERS

P4 ATPases - The physiological relevance of lipid flipping transporters

(2010) Coen C. Paulusma et al.   FEBS LETTERS

A flippase-independent function of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1, is required for apical protein expression and microvillus formation in polarized epithelial cells

(2010) Patricia M. Verhulst et al.   HEPATOLOGY

Heteromeric Interactions Required for Abundance and Subcellular Localization of Human CDC50 Proteins and Class 1 P4-ATPases

(2010) Lieke M. van der Velden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CDC50 Proteins Are Critical Components of the Human Class-1 P4-ATPase Transport Machinery

(2010) Susanne Bryde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid map of the mammalian cell

(2010) G. van Meer et al.   JOURNAL OF CELL SCIENCE

Differences in presentation and progression between severe FIC1 and BSEP deficiencies

(2010) Ludmila Pawlikowska et al.   JOURNAL OF HEPATOLOGY

Intracellular Targeting Signals and Lipid Specificity Determinants of the ALA/ALIS P4-ATPase Complex Reside in the Catalytic ALA α-Subunit

(2010) Rosa L. López-Marqués et al.   MOLECULAR BIOLOGY OF THE CELL

Physical aspects of COPI vesicle formation

(2010) Mathieu Pinot et al.   MOLECULAR MEMBRANE BIOLOGY

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Dynamic regulation of cardiolipin by the lipid pump Atp8b1 determines the severity of lung injury in experimental pneumonia

(2010) Nancy B Ray et al.   NATURE MEDICINE

ATPase Class I Type 8B Member 1 and Protein Kinase C ζ Induce the Expression of the Canalicular Bile Salt Export Pump in Human Hepatocytes

(2010) Frank Chen et al.   PEDIATRIC RESEARCH

Disruption of the Lipid-Transporting LdMT-LdRos3 Complex in Leishmania donovani Affects Membrane Lipid Asymmetry but Not Host Cell Invasion

(2010) Adrien Weingärtner et al.   PLoS One

Progressive Familial Intrahepatic Cholestasis Type 1

(2010) Coen Paulusma et al.   SEMINARS IN LIVER DISEASE

Protein-driven membrane stresses in fusion and fission

(2010) Michael M. Kozlov et al.   TRENDS IN BIOCHEMICAL SCIENCES

Coordination of Golgi functions by phosphatidylinositol 4-kinases

(2010) Todd R. Graham et al.   TRENDS IN CELL BIOLOGY

mRNA expression of canine ATP10C, a P4-type ATPase, is positively associated with body condition score

(2010) Sara Roshwalb et al.   VETERINARY JOURNAL

Endocytic Sorting and Recycling Require Membrane Phosphatidylserine Asymmetry Maintained by TAT-1/CHAT-1

(2010) Baohui Chen et al.   PLoS Genetics

Mechanism and significance of P4 ATPase-catalyzed lipid transport: Lessons from a Na+/K+-pump

(2009) Catheleyne F. Puts et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Intracellular sterol dynamics

(2009) Bruno Mesmin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Linking phospholipid flippases to vesicle-mediated protein transport

(2009) Baby-Periyanayaki Muthusamy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Differential effects of progressive familial intrahepatic cholestasis type 1 and benign recurrent intrahepatic cholestasis type 1 mutations on canalicular localization of ATP8B1

(2009) Dineke E. Folmer et al.   HEPATOLOGY

Activity of the Bile Salt Export Pump (ABCB11) Is Critically Dependent on Canalicular Membrane Cholesterol Content

(2009) Coen C. Paulusma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Localization, Purification, and Functional Reconstitution of the P4-ATPase Atp8a2, a Phosphatidylserine Flippase in Photoreceptor Disc Membranes

(2009) Jonathan A. Coleman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdc50p Plays a Vital Role in the ATPase Reaction Cycle of the Putative Aminophospholipid Transporter Drs2p

(2009) Guillaume Lenoir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a novel mouse P4-ATPase family member highly expressed during spermatogenesis

(2009) P. Xu et al.   JOURNAL OF CELL SCIENCE

FIC1-mediated stimulation of FXR activity is decreased with PFIC1 mutations in HepG2 cells

(2009) Saori Koh et al.   JOURNAL OF GASTROENTEROLOGY

A P4-ATPase Protein Interaction Network Reveals a Link between Aminophospholipid Transport and Phosphoinositide Metabolism

(2009) Catheleyne F. Puts et al.   JOURNAL OF PROTEOME RESEARCH

Regulation of a Golgi flippase by phosphoinositides and an ArfGEF

(2009) Paramasivam Natarajan et al.   NATURE CELL BIOLOGY

Progressive familial intrahepatic cholestasis

(2009) Anne Davit-Spraul et al.   Orphanet Journal of Rare Diseases

ATP8B1 is essential for maintaining normal hearing

(2009) J. M. Stapelbroek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flippases: still more questions than answers

(2008) L. R. Poulsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Functional roles of Na,K-ATPase subunits

(2008) Käthi Geering   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Abcg5/8 Independent Biliary Cholesterol Excretion in Atp8b1-Deficient Mice

(2008) Annemiek Groen et al.   GASTROENTEROLOGY

ATP8B1 Deficiency Disrupts the Bile Canalicular Membrane Bilayer Structure in Hepatocytes, But FXR Expression and Activity Are Maintained

(2008) Shi–Ying Cai et al.   GASTROENTEROLOGY

The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptor

(2008) Tamara Frankenberg et al.   HEPATOLOGY

Functional Significance of E2State Stabilization by Specific α/β-Subunit Interactions of Na,K- and H,K-ATPase

(2008) Katharina L. Dürr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinases Fpk1p and Fpk2p are Novel Regulators of Phospholipid Asymmetry

(2008) Kenzi Nakano et al.   MOLECULAR BIOLOGY OF THE CELL

P4-ATPase Requirement for AP-1/Clathrin Function in Protein Transport from the trans-Golgi Network and Early Endosomes

(2008) Ke Liu et al.   MOLECULAR BIOLOGY OF THE CELL

Sterols Are Mainly in the Cytoplasmic Leaflet of the Plasma Membrane and the Endocytic Recycling Compartment in CHO Cells

(2008) Mousumi Mondal et al.   MOLECULAR BIOLOGY OF THE CELL

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The gastric HK-ATPase: structure, function, and inhibition

(2008) Jai Moo Shin et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The Arabidopsis P4-ATPase ALA3 Localizes to the Golgi and Requires a  -Subunit to Function in Lipid Translocation and Secretory Vesicle Formation

(2008) L. R. Poulsen et al.   PLANT CELL

Expression of Atp8b3 in murine testis and its characterization as a testis specific P-type ATPase

(2008) Eun-Yeung Gong et al.   REPRODUCTION

The C. elegans P4-ATPase TAT-1 Regulates Lysosome Biogenesis and Endocytosis

(2008) Anne-Françoise Ruaud et al.   TRAFFIC

Candidate Single-Nucleotide Polymorphisms From a Genomewide Association Study of Alzheimer Disease

(2007) Hao Li et al.   ARCHIVES OF NEUROLOGY