Towards the optical cochlear implant: optogenetic approaches for hearing restoration

Adeno-associated Virus (AAV) versus Immune Response

(2019) Joseph Rabinowitz et al.   Viruses-Basel

Therapeutic AAV Gene Transfer to the Nervous System: A Clinical Reality

(2019) Eloise Hudry et al.   NEURON

Adeno-associated virus as a gene therapy vector: strategies to neutralize the neutralizing antibodies

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Therapeutic Potential of Wnt and Notch Signaling and Epigenetic Regulation in Mammalian Sensory Hair Cell Regeneration

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Near physiological spectral selectivity of cochlear optogenetics

(2019) Alexander Dieter et al.   Nature Communications

Recombinant Adeno-Associated Virus Gene Therapy in Light of Luxturna (and Zolgensma and Glybera): Where Are We, and How Did We Get Here?

(2019) Allison M. Keeler et al.   Annual Review of Virology

Sensory processing at ribbon synapses in the retina and the cochlea

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Novel insights into inner ear development and regeneration for targeted hearing loss therapies

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Severe Toxicity in Nonhuman Primates and Piglets Following High-Dose Intravenous Administration of an Adeno-Associated Virus Vector Expressing Human SMN

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Ancestral Adeno-Associated Virus Vector Delivery of Opsins to Spiral Ganglion Neurons: Implications for Optogenetic Cochlear Implants

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The Neurotropic Properties of AAV-PHP.B Are Limited to C57BL/6J Mice

(2018) Juliette Hordeaux et al.   MOLECULAR THERAPY

Optogenetic stimulation of cochlear neurons activates the auditory pathway and restores auditory-driven behavior in deaf adult gerbils

(2018) Christian Wrobel et al.   Science Translational Medicine

High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics

(2018) Thomas Mager et al.   Nature Communications

Hair Cell Mechanotransduction Regulates Spontaneous Activity and Spiral Ganglion Subtype Specification in the Auditory System

(2018) Shuohao Sun et al.   CELL

Sensory Neuron Diversity in the Inner Ear Is Shaped by Activity

(2018) Brikha R. Shrestha et al.   CELL

Crystal structure of the red light-activated channelrhodopsin Chrimson

(2018) Kazumasa Oda et al.   Nature Communications

Ultrafast optogenetic stimulation of the auditory pathway by targeting‐optimized Chronos

(2018) Daniel Keppeler et al.   EMBO JOURNAL

Intracochlear near infrared stimulation: Feasibility of optoacoustic stimulation in vivo

(2018) Peter Baumhoff et al.   HEARING RESEARCH

Optogenetic Light Sensors in Human Retinal Organoids

(2018) Marcela Garita-Hernandez et al.   Frontiers in Neuroscience

High-Density μLED-Based Optical Cochlear Implant With Improved Thermomechanical Behavior

(2018) Eric Klein et al.   Frontiers in Neuroscience

Multichannel optrodes for photonic stimulation

(2018) Yingyue Xu et al.   Neurophotonics

Emerging Gene Therapies for Genetic Hearing Loss

(2017) Hena Ahmed et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

AAV-mediated delivery of optogenetic constructs to the macaque brain triggers humoral immune responses

(2017) Skyler D. Mendoza et al.   JOURNAL OF NEUROPHYSIOLOGY

Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c

(2017) Bifeng Pan et al.   NATURE BIOTECHNOLOGY

A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear

(2017) Lukas D Landegger et al.   NATURE BIOTECHNOLOGY

Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells

(2017) Karl R Koehler et al.   NATURE BIOTECHNOLOGY

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

(2017) Ken Y Chan et al.   NATURE NEUROSCIENCE

Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics

(2017) Gunchul Shin et al.   NEURON

Let There Be Light—Optoprobes for Neural Implants

(2017) Marie T. Alt et al.   PROCEEDINGS OF THE IEEE

The form and function of channelrhodopsin

(2017) Karl Deisseroth et al.   SCIENCE

Experimental assessment of the safety and potential efficacy of high irradiance photostimulation of brain tissues

(2017) Suhan Senova et al.   Scientific Reports

And Then There Was Light: Perspectives of Optogenetics for Deep Brain Stimulation and Neuromodulation

(2017) Jean Delbeke et al.   Frontiers in Neuroscience

Cochlear gene therapy with ancestral AAV in adult mice: complete transduction of inner hair cells without cochlear dysfunction

(2017) Jun Suzuki et al.   Scientific Reports

Red‐shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina

(2016) Abhishek Sengupta et al.   EMBO Molecular Medicine

The contribution of inferior colliculus activity to the auditory brainstem response (ABR) in mice

(2016) Rüdiger Land et al.   HEARING RESEARCH

Sound coding in the auditory nerve of gerbils

(2016) Antoine Huet et al.   HEARING RESEARCH

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain

(2016) Benjamin E Deverman et al.   NATURE BIOTECHNOLOGY

Emerging therapies for inherited retinal degeneration

(2016) H. P. N. Scholl et al.   Science Translational Medicine

Optoacoustic effect is responsible for laser-induced cochlear responses

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Basic response properties of auditory nerve fibers: a review

(2015) Peter Heil et al.   CELL AND TISSUE RESEARCH

Optogenetic stimulation of the auditory pathway for research and future prosthetics

(2015) Tobias Moser   CURRENT OPINION IN NEUROBIOLOGY

Optogenetics

(2015) Jens Duebel et al.   CURRENT OPINION IN OPHTHALMOLOGY

Considering optogenetic stimulation for cochlear implants

(2015) Marcus Jeschke et al.   HEARING RESEARCH

Infrared neural stimulation fails to evoke neural activity in the deaf guinea pig cochlea

(2015) Alexander C. Thompson et al.   HEARING RESEARCH

Tmc gene therapy restores auditory function in deaf mice

(2015) Charles Askew et al.   Science Translational Medicine

Radiant energy required for infrared neural stimulation

(2015) Xiaodong Tan et al.   Scientific Reports

In Silico Reconstruction of the Viral Evolutionary Lineage Yields a Potent Gene Therapy Vector

(2015) Eric Zinn et al.   Cell Reports

Optogenetic stimulation of the auditory pathway

(2014) Victor H. Hernandez et al.   JOURNAL OF CLINICAL INVESTIGATION

GaN-based micro-LED arrays on flexible substrates for optical cochlear implants

(2014) Christian Goßler et al.   JOURNAL OF PHYSICS D-APPLIED PHYSICS

Laser therapy and photosensitive medication: a review of the evidence

(2014) Ryan L. Kerstein et al.   LASERS IN MEDICAL SCIENCE

Independent optical excitation of distinct neural populations

(2014) Nathan C Klapoetke et al.   NATURE METHODS

Multipoint-Emitting Optical Fibers for Spatially Addressable In Vivo Optogenetics

(2014) Ferruccio Pisanello et al.   NEURON

Optical cochlear implant: evaluation of insertion forces of optical fibres in a cochlear model and of traumata in human temporal bones

(2013) Sven Balster et al.   Biomedical Engineering-Biomedizinische Technik

Immune responses to AAV vectors: overcoming barriers to successful gene therapy

(2013) F. Mingozzi et al.   BLOOD

Optical properties of biological tissues: a review

(2013) Steven L Jacques   PHYSICS IN MEDICINE AND BIOLOGY

In Vivo-Directed Evolution of a New Adeno-Associated Virus for Therapeutic Outer Retinal Gene Delivery from the Vitreous

(2013) D. Dalkara et al.   Science Translational Medicine

Immunology of AAV-Mediated Gene Transfer in the Eye

(2013) Keirnan Willett et al.   Frontiers in Immunology

Assessment of the AAV-mediated expression of channelrhodopsin-2 and halorhodopsin in brainstem neurons mediating auditory signaling

(2012) T. Shimano et al.   BRAIN RESEARCH

Restoration of Hearing in the VGLUT3 Knockout Mouse Using Virally Mediated Gene Therapy

(2012) Omar Akil et al.   NEURON

AAV2 Gene Therapy Readministration in Three Adults with Congenital Blindness

(2012) J. Bennett et al.   Science Translational Medicine

Gallium nitride is biocompatible and non-toxic before and after functionalization with peptides

(2011) Scott A. Jewett et al.   Acta Biomaterialia

Acoustic Events and “Optophonic” Cochlear Responses Induced by Pulsed Near-Infrared LASER

(2011) Ingo Ulrik Teudt et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Spread of cochlear excitation during stimulation with pulsed infrared radiation: inferior colliculus measurements

(2011) C-P Richter et al.   Journal of Neural Engineering

Virally delivered Channelrhodopsin-2 Safely and Effectively Restores Visual Function in Multiple Mouse Models of Blindness

(2011) M Mehdi Doroudchi et al.   MOLECULAR THERAPY

Ultra light-sensitive and fast neuronal activation with the Ca2+-permeable channelrhodopsin CatCh

(2011) Sonja Kleinlogel et al.   NATURE NEUROSCIENCE

An optogenetic toolbox designed for primates

(2011) Ilka Diester et al.   NATURE NEUROSCIENCE

Effect of Stimulation Rate on Cochlear Implant Users’ Phoneme, Word and Sentence Recognition in Quiet and in Noise

(2010) Robert V. Shannon et al.   AUDIOLOGY AND NEURO-OTOLOGY

Molecular and Cellular Approaches for Diversifying and Extending Optogenetics

(2010) Viviana Gradinaru et al.   CELL

Onset Coding Is Degraded in Auditory Nerve Fibers from Mutant Mice Lacking Synaptic Ribbons

(2010) B. N. Buran et al.   JOURNAL OF NEUROSCIENCE

Ultrafast optogenetic control

(2010) Lisa A Gunaydin et al.   NATURE NEUROSCIENCE

Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells

(2010) Tina Pangršič et al.   NATURE NEUROSCIENCE

Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2

(2010) Jessica A Cardin et al.   Nature Protocols

Multiwaveguide implantable probe for light delivery to sets of distributed brain targets

(2010) Anthony N. Zorzos et al.   OPTICS LETTERS

Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa

(2010) V. Busskamp et al.   SCIENCE

High-Power and High-Efficiency InGaN-Based Light Emitters

(2009) Ansgar Laubsch et al.   IEEE TRANSACTIONS ON ELECTRON DEVICES

Gene Therapy for Leber's Congenital Amaurosis is Safe and Effective Through 1.5 Years After Vector Administration

(2009) Francesca Simonelli et al.   MOLECULAR THERAPY

Cochlear Outer Hair Cell Motility

(2008) Jonathan Ashmore   PHYSIOLOGICAL REVIEWS